Masanobu Uchiyama 研究室
主宰者：Masanobu Uchiyama
東京大学
兼任：福岡大学・Fukuoka University Hospital
AI 要約（直近 5 年の研究成果）
本研究室は有機合成化学と医療応用の両面から研究を展開しています。有機合成の面では、光や特定の触媒を用いて、従来は合成困難であった分子構造を効率的に構築する方法の開発に取り組んでいます。特に、赤外線や可視光といった異なる波長の光を活用した反応系の設計、ホウ素やゲルマニウムなど異なる元素を含む有機化合物の合成法、および緊張した環状構造を持つ医薬品候補分子の合成に関する研究が行われています。これらの手法は計算科学による理論的な検証も伴いながら進められ、反応機構の解明に役立てられています。
一方、医療・臨床応用の分野では、がん患者の化学療法に伴う副作用管理に関する臨床研究が複数進行しており、嘔気・嘔吐、神経障害、皮膚毒性などの症状軽減に関わる医薬品の効果や安全性について、実際の患者データに基づいた調査が実施されています。さらに感染症治療薬の有効性評価や薬物の予期しない作用の検出などの薬剤疫学的研究も行われており、より安全で有効な治療選択肢の提供を目指した活動が展開されています。
※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。
外部リンク
関連研究室(8 件)
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研究成果（207 件）
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続きを表示（残り 197 件）閉じる
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- DOI: https://doi.org/10.1186/s40780-025-00516-4
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- DOI: https://doi.org/10.1038/s44160-023-00318-2
- DOI: https://doi.org/10.1038/s44160-023-00318-2
- DOI: https://doi.org/10.1248/cpb.c23-00179
- DOI: https://doi.org/10.1248/cpb.c23-00179
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- [2022] Stereoselectivity and Substrate Specificity of the Fe(II)/α-Ketoglutarate-Dependent Oxygenase TqaLDOI: https://doi.org/10.1021/jacs.2c08116
- [2022] Stereoselectivity and Substrate Specificity of the Fe(II)/α-Ketoglutarate-Dependent Oxygenase TqaLDOI: https://doi.org/10.1021/jacs.2c08116
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- DOI: https://doi.org/10.1021/jacs.1c08336
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