Takashi Ohnishi 研究室

主宰者：Takashi Ohnishi

北海道大学

AI 要約（直近 5 年の研究成果）

大西貴史研究室は、脊椎疾患の診断・治療に関する多角的な研究を展開しています。頸椎から腰椎にかけての様々な疾患を対象とし、脊椎圧迫による神経障害や脊椎変形に対する手術治療の効果と安全性を検討しています。特に、椎間板ヘルニアや脊椎後縦靱帯骨化症などの患者に対する低侵襲手術法の開発と改善に注力しており、長期的な臨床経過の追跡調査を通じて手術成績を評価しています。組織工学的アプローチとしては、椎間板変性を抑制する再生医療に取り組んでいます。生分解性ゲルと骨髄由来の幹細胞を組み合わせた治療法を動物モデルで検証し、椎間板損傷後の修復促進の可能性を探索しています。加えて、遺伝学的手法を用いて椎間板内の異常な骨化機構を解明する基礎研究も実施しており、分子レベルでの病態理解を進めています。さらに、深層学習や画像解析技術を応用した診断補助システムの開発も行っています。三次元画像から脊椎変形の程度を自動判定したり、手術の適応判定を支援するAI技術の実用化を目指しており、臨床診断の精度向上に貢献する技術開発を推進しています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（32 件）

[2026] Lumbar ossification of the posterior longitudinal ligament as a distinct phenotype of diffuse spinal ligament ossification
DOI: https://doi.org/10.1016/j.spinee.2026.01.023
[2025] Duration Mismatch Negativity in Adults With Autism Spectrum Disorder Versus Healthy Controls
DOI: https://doi.org/10.2147/ndt.s492766
[2025] Visceral fat obesity predicts ossification of the posterior longitudinal ligament: annual health examination data-based evidence
DOI: https://doi.org/10.1016/j.spinee.2025.01.032
[2025] Four-dimensional anatomical spinal reconstruction using pre-bent rods in thoracic adolescent idiopathic scoliosis
DOI: https://doi.org/10.1038/s41598-024-84578-8
[2025] Only One Occurrence of Postoperative White Cord Syndrome in Sequential 244 Cases of Cervical Spine Laminoplasty in 20 Years in a Single Institute
DOI: https://doi.org/10.1097/bsd.0000000000001991
[2025] Actinide separation by column method using polyvinylpolypyrrolidone
DOI: https://doi.org/10.1007/s10967-025-10539-8
[2025] The Potential Role of the Posterior Elements in Lumbar Spine Laminoplasty to Protect the Intervertebral Disc and Improve Walking Ability—Retrospective Comparative Study
DOI: https://doi.org/10.3390/jcm14124014
[2025] Prediction of cervical spondylotic myelopathy from a plain radiograph using deep learning with convolutional neural networks
DOI: https://doi.org/10.1007/s00586-025-08908-8
[2025] Artificial intelligence-driven 3D MRI of lumbosacral nerve root anomalies: accuracy, incidence, and clinical utility
DOI: https://doi.org/10.1007/s00234-025-03574-5
[2025] Acellular, bioresorbable, ultra-purified alginate gel implantation for intervertebral disc herniation: Phase 1/2, open-label, non-randomized clinical trials
DOI: https://doi.org/10.1038/s41467-025-59715-0

続きを表示（残り 22 件）

[2024] Spinal Echinococcosis With Paralysis Successfully Treated With Posterior Stabilization and Antiparasitic Drugs
DOI: https://doi.org/10.2106/jbjs.cc.24.00342
[2024] Bone Marrow Aspirate Concentrate Combined with Ultra-Purified Alginate Bioresorbable Gel Enhances Intervertebral Disc Repair in a Canine Model: A Preclinical Proof-of-Concept Study
DOI: https://doi.org/10.3390/cells13110987
[2024] Evaluation of magnetic susceptibility of trace paramagnetic materials by time series data during generation of high-gradient magnetic force using GAN
DOI: https://doi.org/10.1299/jsmedsd.2024.34.1301
[2024] Reduced dopamine transporter availability in drug‐naive adult attention‐deficit/hyperactivity disorder
DOI: https://doi.org/10.1002/pcn5.177
[2024] Comparative Study between Full-Endoscopic Transforaminal Approach Lumbar Interbody Fusion (TF-LIF) Using PETLIF System and Minimally Invasive TLIF for Degenerative Lumbar Spine Disorders
DOI: https://doi.org/10.22603/ssrr.2024-0254
[2024] Duckbill Release Technique for the Outside-in Method in Full-Endoscopic Spine Surgery via Transforaminal Approach: A Technical Note
DOI: https://doi.org/10.1016/j.wneu.2024.10.120
[2024] Deep learning-based detection of lumbar spinal canal stenosis using convolutional neural networks
DOI: https://doi.org/10.1016/j.spinee.2024.06.009
[2023] Disrupted structural connectivity and less efficient network system in patients with the treatment-naive adult attention-deficit/hyperactivity disorder
DOI: https://doi.org/10.3389/fpsyt.2023.1093522
[2023] Influence of Lateral Translation of Lowest Instrumented Vertebra on L4 Tilt and Coronal Balance for Thoracolumbar and Lumbar Curves in Adolescent Idiopathic Scoliosis
DOI: https://doi.org/10.3390/jcm12041389
[2023] Development of Notch-Free, Pre-Bent Rod Applicable for Posterior Corrective Surgery of Thoracolumbar/Lumbar Adolescent Idiopathic Scoliosis
DOI: https://doi.org/10.3390/jcm12175750
[2023] Loss of function mutation in Ank causes aberrant mineralization and acquisition of osteoblast-like-phenotype by the cells of the intervertebral disc
DOI: https://doi.org/10.1038/s41419-023-05893-y
[2023] Evaluation of Surgical Indications for Full Endoscopic Discectomy at Lumbosacral Disc Levels Using Three-Dimensional Magnetic Resonance/Computed Tomography Fusion Images Created with Artificial Intelligence
DOI: https://doi.org/10.3390/medicina59050860
[2023] Prediction of Cobb Angle Using Deep Learning Algorithm with Three-Dimensional Depth Sensor Considering the Influence of Garment in Idiopathic Scoliosis
DOI: https://doi.org/10.3390/jcm12020499
[2023] Enhancing the interpretability of anomaly detection methods for the prediction of foreign object contamination
DOI: https://doi.org/10.1299/jsmeidecon.2023.0_49
[2022] Long-Term Clinical Course of Patients After Decompression and Posterior Instrumented Fusion Surgery for Thoracic Ossification of the Posterior Longitudinal Ligament: An Average Follow-Up of 18 years
DOI: https://doi.org/10.1177/21925682221135548
[2022] Prediction of foreign material contamination in fluid transfer lines using outlier detection method
DOI: https://doi.org/10.1299/jsmedsd.2022.32.3205
[2022] Posterolateral full-endoscopic debridement and irrigation is effective in treating thoraco-lumbar pyogenic spondylodiscitis, except in cases with large abscess cavities
DOI: https://doi.org/10.1007/s00586-022-07470-x
[2021] Magnetic field array optimization and qualification based on demagnetization prediction
DOI: https://doi.org/10.1299/jsmemecj.2021.j121-03
[2021] Morphologic Changes in the Vertebral Artery Subsequent to Cervical Spine Degeneration and Aging: Analyses by Computed Tomography Angiography Using Multiplanar and 3-Dimensional Reconstructions
DOI: https://doi.org/10.1016/j.wneu.2021.03.080
[2021] Early Improvement of Psychiatric Symptoms with Long-Acting Injectable Antipsychotic Predicts Subsequent Social Functional Remission in Patients with Schizophrenia
DOI: https://doi.org/10.2147/ndt.s294503
[2021] Qualification of suitability based on demagnetization prediction that confirms to food manufacturing standards
DOI: https://doi.org/10.1299/jsmedsd.2021.31.2111
[2021] Development of a standardized histopathology scoring system using machine learning algorithms for intervertebral disc degeneration in the mouse model—An <scp>ORS</scp> spine section initiative
DOI: https://doi.org/10.1002/jsp2.1164

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AI 要約（直近 5 年の研究成果）

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関連研究室(8 件)

研究成果（32 件）

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