Shota Yokoyama 研究室

主宰者：Shota Yokoyama

北海道大学

AI 要約（直近 5 年の研究成果）

横山研究室は、主に血液がん、特に急性骨髄性白血病（AML）の治療法と予後予測に関する臨床研究を展開しています。研究の中心的な問いは、高齢患者や標準的な強化化学療法が困難な患者に対して、新しい薬物療法がどのような効果をもたらし、どの患者がどの治療に最も恩恵を受けるかを明らかにすることです。研究のアプローチとしては、ホッカイド地域の複数の医療機関から集約した患者データベースを活用した後ろ向き・前向きコホート研究を実施しています。次世代シーケンサーを用いた遺伝子解析により患者の遺伝子変異を詳細に調べ、臨床的転帰との関連を検討する手法を採用しており、これにより従来の検査では検出困難な微小な遺伝子異常も捉えることができます。主な知見として、ベネトクラクスとアザシチジンの併用療法が高齢者AMLの治療選択肢として広がる一方で、患者ごとの遺伝子背景や炎症・栄養状態といった複数の因子が予後を左右することが報告されています。これらの因子を統合的に評価することで、個々の患者に最適な治療戦略を立案することの重要性が明らかになりつつあります。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（44 件）

[2026] Catalytic hydrogenation performance of intermetallic Ni3Al nanoparticles: A comparative study of wet and dry synthesis approaches
DOI: https://doi.org/10.1016/j.surfin.2026.108946
[2026] Philadelphia chromosome–negative but BCR::ABL1-positive acute lymphoblastic leukemia: a real-world multicenter cohort study
DOI: https://doi.org/10.1007/s12185-026-04212-3
[2026] Real-world treatment patterns and clinical outcomes in patients with AML from 65 to 74 years unfit for first-line intensive chemotherapy in Japan
DOI: https://doi.org/10.1007/s12185-026-04193-3
[2025] Efficient bimetallic Co–W catalyst comprising metallic state W for the NaBH4-assisted hydrogenation of 4-nitrophenol at zero degree celsius
DOI: https://doi.org/10.1016/j.ijhydene.2025.151610
[2025] Peposertib suppresses generation of FLT3-internal tandem duplication formed by contralateral double nicks
DOI: https://doi.org/10.1016/j.exphem.2025.104819
[2024] Evaluation of Venetoclax Duration in Venetoclax-Azacitidine Regimen for Untreated Acute Myeloid Leukemia: Real World Experience from Hokkaido Leukemia Net
DOI: https://doi.org/10.1182/blood-2024-200013
[2024] High-Entropy Alloy Al0.2Co1.5CrFeNi1.5Ti0.5 Prepared from High-Entropy Oxide (Al0.2Co1.5CrFeNi1.5Ti0.5)3O4 by a Deoxidation Process via a CaH2-Assisted Molten Salt Method
DOI: https://doi.org/10.3390/met14040443
[2023] Subclinical minute FLT3-ITD clone can be detected in clinically FLT3-ITD-negative acute myeloid leukaemia at diagnosis
[2023] Partial replacement of <scp>d</scp> -glucose with <scp>d</scp> -allose ameliorates peritoneal injury and hyperglycaemia induced by peritoneal dialysis fluid in rats
DOI: https://doi.org/10.1177/08968608231184354
[2023] Environmentally friendly molten salt synthesis of high-entropy AlCoCrFeNi alloy powder with high catalytic hydrogenation activity
DOI: https://doi.org/10.1016/j.ijhydene.2023.04.224

続きを表示（残り 34 件）

[2023] Subclinical minute FLT3‐ITD clone can be detected in clinically FLT3‐<scp>ITD‐negative</scp> acute myeloid leukaemia at diagnosis
DOI: https://doi.org/10.1111/bjh.18800
[2023] Clinical implications of NUP98::NSD1 fusion at diagnosis in adult FLT3‐ITD positive AML
DOI: https://doi.org/10.1111/ejh.14055
[2023] On the regularization and optimization in quantum detector tomography
DOI: https://doi.org/10.1016/j.automatica.2023.111124
[2023] Prognostic impact of FLT3-ITD, NPM1 mutation and CEBPA bZIP domain mutation in cytogenetically normal acute myeloid leukemia: a Hokkaido Leukemia Net study
DOI: https://doi.org/10.1007/s12185-023-03567-1
[2023] Catalytic Hydrogenation of Methyl Orange and Acid Orange 7 Using NaBH4 over Core-shell Multicomponent Alloys
DOI: https://doi.org/10.2965/jwet.23-030
[2023] Molten salt synthesis of CrMnFeNi alloy nanopowder passivated by TiOx–ZrOy shell used as a superior catalyst support in liquid-phase hydrogenation
DOI: https://doi.org/10.1039/d3ra01797d
[2023] ドイツ語の分離前綴りにおける接辞性と接語性
[2023] Efficacy and Safety of Single-dose Pegfilgrastim for CD34+ Cell Mobilization in Healthy Volunteers: A Phase 2 Study
DOI: https://doi.org/10.1097/tp.0000000000004880
[2023] Genetic Mutation and Outcome of Venetoclax-Based Therapy in Newly Diagnosed AML in the Real World: Hokkaido Leukemia Net Study
DOI: https://doi.org/10.1182/blood-2023-173909
[2023] Dominant-negative type of IKZF1 deletion showed a favorable prognosis in adult B-cell acute lymphoblastic leukemia
DOI: https://doi.org/10.1007/s00277-023-05405-0
[2023] P1526: THE RISK OF DEVELOPING PNEUMOCYSTIS JIROVECII PNEUMONIA PERSISTS EVEN AFTER COMPLETION OF IMMUNOSUPPRESSANTS IN ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION RECIPIENTS
DOI: https://doi.org/10.1097/01.hs9.0000972980.83233.fa
[2023] P1414: CRP IS A CONVENIENT PREDICTIVE MARKER OF THE ANTIPYRETIC EFFECT OF TOCILIZUMAB ON CRS DURING CAR-T CELL THERAPY
DOI: https://doi.org/10.1097/01.hs9.0000972544.91452.b7
[2022] Subclinical Minute FLT3-ITD Clone Can be Detected in Clinically FLT3-ITD-Negative Acute Myeloid Leukemia
DOI: https://doi.org/10.1182/blood-2022-162325
[2022] Clinical features of complex karyotype in newly diagnosed acute myeloid leukemia
DOI: https://doi.org/10.1007/s12185-022-03522-6
[2022] A Molten Salt Synthesis Method of the High-Entropy Alloy CrMnFeCoNi for High Catalytic Performance and Low Life Cycle GHG Emissions
DOI: https://doi.org/10.1021/acssuschemeng.2c04007
[2022] Molten Salt Synthesis of Intermetallic Compound TiNi Nanopowder Passivated by TiOx Shell Prepared from NiTiO3 for Catalytic Hydrogenation
DOI: https://doi.org/10.3390/ma15238536
[2022] Core–Shell Multicomponent Alloys with High Specific Surface Areas Prepared by Molten Salt Synthesis for Catalytic Hydrogenation of p-Nitrophenol by NaBH4
DOI: https://doi.org/10.1021/acsaenm.2c00028
[2022] Clinical Features of Complex Karyotype in Newly Diagnosed Acute Myeloid Leukemia
DOI: https://doi.org/10.1182/blood-2022-157874
[2022] Better Prognosis of Dominant-Negative Type of IKZF1 Deletion in BCR-ABL-positive Adult B-Cell Acute Lymphoblastic Leukemia
DOI: https://doi.org/10.1182/blood-2022-157881
[2022] Prognostic Impact of CEBPA bZIP Domain Mutation in Cytogenetically Normal Acute Myeloid Leukemia
DOI: https://doi.org/10.1182/blood-2022-158653
[2022] Antiretroviral therapy achieved metabolic complete remission of hepatic AIDS related Epstein-Barr virus-associated smooth muscle tumor
DOI: https://doi.org/10.1177/13596535221126828
[2022] Personality Traits Estimation of Participants Based on Multimodal Information in Knowledge-Transfer-type Discussion
DOI: https://doi.org/10.1109/iiaiaai55812.2022.00014
[2022] High CRP-albumin ratio predicts poor prognosis in transplant ineligible elderly patients with newly diagnosed acute myeloid leukemia
DOI: https://doi.org/10.1038/s41598-022-12813-1
[2022] Perinatal Management in a Pregnant Woman with Ureteropelvic Junction Obstruction: Case Report and Literature Review
DOI: https://doi.org/10.3390/diagnostics12040913
[2022] Dynamic change in peripheral blood WT1 mRNA levels within three cycles of azacitidine predict treatment response in patients with high-risk myelodysplastic syndromes
DOI: https://doi.org/10.1007/s00277-022-04807-w
[2021] Effect of Oxygen Deficiency on Mechanical and Thermomechanical Properties of Ferroic La0.6Sr0.4Co0.2Fe0.8O3−δ
DOI: https://doi.org/10.1002/adem.202101204
[2021] Molten salt synthesis of high-entropy alloy AlCoCrFeNiV nanoparticles for the catalytic hydrogenation of p-nitrophenol by NaBH4
DOI: https://doi.org/10.1016/j.ijhydene.2021.10.260
[2021] Non-age-related neoplastic loss of sex chromosome correlated with prolonged survival in real-world CBF-AML patients
DOI: https://doi.org/10.1007/s12185-021-03238-z
[2021] High CRP-Albumin Ratio Predicts Poor Prognosis in Transplant Ineligible Elderly Patients with Newly Diagnosed Acute Myeloid Leukemia
DOI: https://doi.org/10.1182/blood-2021-144832
[2021] Non-Age-Related Neoplastic Loss of Sex Chromosomecorrelated to Prolonged Survival in CBF-AML Patients in Real-World Clinical Setting
DOI: https://doi.org/10.1182/blood-2021-146276
[2021] Single-Strand Breaks at Genome Initiate FLT3-ITD Formation
DOI: https://doi.org/10.1182/blood-2021-149451
[2021] Association between physical restraint requirement and unfavorable neurologic outcomes in subarachnoid hemorrhage
DOI: https://doi.org/10.1186/s40560-021-00541-z
[2021] Progression of cervical intraepithelial neoplasia grade 2 lesions among Japanese women harboring different genotype categories of high-risk human papillomaviruses
DOI: https://doi.org/10.2185/jrm.2020-038
[2021] [Emergence of mutation in the colony-stimulating factor 3 receptor gene during follow-up of unclassifiable myeloproliferative neoplasm].
DOI: https://doi.org/10.11406/rinketsu.62.1609

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AI 要約（直近 5 年の研究成果）

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関連研究室(8 件)

研究成果（44 件）

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