Yoshiki Katayama 研究室

主宰者：Yoshiki Katayama

九州大学・Kyushu University Hospital

AI 要約（直近 5 年の研究成果）

本研究室は、疾患の治療に向けた生体材料と分子設計を組み合わせた研究を進めています。特に、ナノ粒子などの微小な担体を用いて、薬物や生体分子を患部に効率的に送達する技術の開発に取り組んでいます。がんや炎症性疾患といった難治性疾患を対象に、従来の治療法では到達しにくい臓器や組織への薬物到達を実現することを目指しています。免疫療法の領域では、設計した物質が特定の免疫細胞を活性化・制御する仕組みを活用しています。例えば、ナノ粒子により制御物質を特定の細胞へ集積させることで、その細胞が免疫抑制から免疫活性の状態へ転換する現象を報告しています。また、腫瘍組織の酸性環境や活性化した酵素など、疾患部位の特有の性質を認識する分子設計を行い、治療効果の向上と副作用の低減を目指しています。さらに本研究室では、生体試料中のタンパク質検出や微量成分の分析に用いる新しい酵素や化学試薬の開発も進めており、医学診断の精度向上にも貢献しています。これらの基礎的な手法開発が、臨床応用に向けた材料設計の基盤となっています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（53 件）

[2026] Screening the Human Proteome for Peptides Targeting the Acidic Environment of Tumor Tissues
DOI: https://doi.org/10.1248/cpb.c25-00569
[2026] A transient, B cell–targeted tolerance switch using nanoparticles loaded with metabolizable AhR agonists for antigen-specific immune regulation
DOI: https://doi.org/10.1016/j.jconrel.2026.115059
[2025] Preparation of PLGA Nanoparticles Co-Incorporated with Protein and Hydrophobic Drugs as a Formulation of Oral Immunotherapy
DOI: https://doi.org/10.1142/s1793292025501061
[2025] Block-copolymer-based coacervates enabling constant and sustained release of siRNA-containing polyion complex micelles
DOI: https://doi.org/10.1038/s41428-025-01124-7
[2025] PSOAS muscle volume index at 6 months after esophagectomy was associated with duration of preoperative gum-chewing training and tongue pressure in patients with thoracic esophageal cancer
DOI: https://doi.org/10.1016/j.clnesp.2025.07.983
[2025] Thermosensitive Nanostructured Coacervates Developed by Mixing ABA‐ and AB‐Block Copolymers and Their Unique Sustained Release of Nano‐Micelles in a Regulated Manner
DOI: https://doi.org/10.1002/smll.202505876
[2025] Intravenous Administration of Antisense Oligonucleotide Incorporated into PLGA Nanoparticles Alters the Pattern of Organ Distribution and Gene Knockdown Effects
DOI: https://doi.org/10.1021/acs.molpharmaceut.5c00414
[2025] Screening of Human M2 Macrophage-Specific Markers for Preparation of Humanized Inflammation-Triggering Engineered Macrophage (MacTrigger)
DOI: https://doi.org/10.1248/bpb.b25-00112
[2025] Designable synthetic complex coacervates enabling protein delivery to cells
DOI: https://doi.org/10.1038/s41428-025-01043-7
[2025] The strategy used by naïve anti-PEG antibodies to capture flexible and featureless PEG chains
DOI: https://doi.org/10.1016/j.jconrel.2025.02.001

続きを表示（残り 43 件）

[2025] Inflammation-triggering Engineered Macrophages (MacTriggers) Are Promising Cell-based Therapeutic Avenues for Chemoresistant Solid Tumors
DOI: https://doi.org/10.21873/anticanres.17525
[2025] GC/MS-based quantitative analysis of sulfide ion in whole blood using ethenesulfonyl fluoride as a derivatization reagent
DOI: https://doi.org/10.1007/s11419-025-00712-9
[2024] Orthogonality of α-Sulfoquinovosidase in Human Cells and Development of Its Fluorescent Substrate
DOI: https://doi.org/10.18494/sam4816
[2024] Bisphosphonate-Modified Serum Albumin as an Effective Inhibitor of Calciprotein Particle Maturation with Long Plasma Retention Time
DOI: https://doi.org/10.1007/s12247-024-09910-1
[2024] Ligand Design with Accelerated Disulfide Formation with Serum Albumin to Extend Blood Retention
DOI: https://doi.org/10.1021/acsmedchemlett.4c00503
[2024] Inflammation-Triggering Engineered Macrophages (MacTriggers) Enhance Reactivity of Immune Checkpoint Inhibitor Only in Tumor Tissues
DOI: https://doi.org/10.3390/cancers16223787
[2024] A Stealthiness Evaluation of Main Chain Carboxybetaine Polymer Modified into Liposome
DOI: https://doi.org/10.3390/pharmaceutics16101271
[2024] Impact of hydrophobic modification on biocompatibility of Alaska pollock gelatin microparticles
DOI: https://doi.org/10.1007/s44211-024-00643-2
[2024] Establishment of an in vitro evaluation method for immunomodulatory functions of yeast strains
DOI: https://doi.org/10.1007/s44211-024-00641-4
[2024] Accurate evaluation of drug effect on the LDH activity of live cells: dual measurement of live cell number by fluorescent staining of nucleus and LDH activity by formazan
DOI: https://doi.org/10.1007/s44211-024-00631-6
[2024] In vitro evaluation of novel SN-38 prodrug activated by α-rhamnosidase of exogenous enzyme
DOI: https://doi.org/10.1007/s44211-024-00593-9
[2024] Oral Administration of PLGA Nanoparticles to Deliver Antisense Oligonucleotides to Inflammatory Lesions in the Gastrointestinal Tract
DOI: https://doi.org/10.1248/bpb.b23-00769
[2024] Activated tyrosine kinase c‐Src‐responsive artificial gene carrier: in vitro and in vivo evaluation
DOI: https://doi.org/10.1002/slct.202303331
[2024] Effective design of PEGylated polyion complex (PIC) nanoparticles for enhancing PIC internalisation in cells utilising block copolymer combinations with mismatched ionic chain lengths
DOI: https://doi.org/10.1039/d3tb02049e
[2024] The effect of Fc region affinity of protein-based antibody-recruiting molecules on antibody-dependent cellular cytotoxicity
DOI: https://doi.org/10.1039/d4ra03391d
[2023] Dynamic frustrated charge hotspots created by charge density modulation sequester globular proteins into complex coacervates
DOI: https://doi.org/10.1039/d3sc00993a
[2023] Facile preparation of hexagonal nanosheets via polyion complex formation from α-helical polypeptides and polyphosphate-based molecules
DOI: https://doi.org/10.1039/d2cc05137k
[2023] First GC/MS identification of aqueous ammonia: utilization of ethenesulfonyl fluoride as a selective and rapid derivatization reagent of ammonia in aqueous media
DOI: https://doi.org/10.1039/d3ay01071f
[2023] One-pot preparation of mannan-coated antigen nanoparticles using human serum albumin as a matrix for tolerance induction
DOI: https://doi.org/10.1016/j.jcis.2023.06.170
[2023] Engineered macrophages acting as a trigger to induce inflammation only in tumor tissues
DOI: https://doi.org/10.1016/j.jconrel.2023.04.010
[2023] Characterization of polypropyleneimine as an alternative transfection reagent
DOI: https://doi.org/10.1007/s44211-023-00284-x
[2023] What Enhances Food Intake? – Silent Eating or Conversing while Eating with Others
DOI: https://doi.org/10.12691/jfnr-11-5-4
[2023] A human cell orthogonal enzyme β-<scp>d</scp>-galacturonidase for sensitive detection of antigen proteins
DOI: https://doi.org/10.1039/d3an00314k
[2023] Safe and efficient oral allergy immunotherapy using one-pot-prepared mannan-coated allergen nanoparticles
DOI: https://doi.org/10.1016/j.biomaterials.2023.122381
[2023] Near-infrared photoluminescent detection of serum albumin using single-walled carbon nanotubes locally functionalized with a long-chain fatty acid
DOI: https://doi.org/10.1016/j.carbon.2023.118533
[2023] Development of novel tracers for sentinel node identification in cervical cancer
DOI: https://doi.org/10.1111/cas.15927
[2022] Signal Amplification Enzymes for Bioanalysis of Cells and Tissues
DOI: https://doi.org/10.2116/bunsekikagaku.71.101
[2022] A Model of Transcriptional Activation of DNA by Loosening of Chromatin Structure
DOI: https://doi.org/10.1246/cl.220392
[2022] Development of Polynucleotide-loaded Nanoparticles for the Regulation of Intracellular Nucleotide Levels
DOI: https://doi.org/10.1246/cl.220318
[2022] Quiescent B Cells Acquire Sensitivity to Cell Cycle Arresting Agents by B Cell Receptor Stimulation
DOI: https://doi.org/10.1248/bpb.b22-00176
[2022] Nanostructure Control of an Antibiotic‐Based Polyion Complex Using a Series of Polycations with Different Side‐Chain Modification Rates
DOI: https://doi.org/10.1002/marc.202200316
[2022] Old but Still Useful [γ-32P]ATP —Development of Peptide Substrates for Protein Kinases by 32P-Based Enzyme Activity Assay—
DOI: https://doi.org/10.2116/bunsekikagaku.71.179
[2022] Answering to social issues – How can we build and utilize a backcasting-approach-based open innovation platform?
DOI: https://doi.org/10.2745/dds.37.45
[2021] Preparation of a PEGylated liposome that co-encapsulates <scp>l</scp>-arginine and doxorubicin to achieve a synergistic anticancer effect
DOI: https://doi.org/10.1039/d1ra06514a
[2021] Synthesis and biological evaluation of a monocyclic Fc-binding antibody-recruiting molecule for cancer immunotherapy
DOI: https://doi.org/10.1039/d0md00337a
[2021] α-<scp>l</scp>-Arabinofuranosidase as an Orthogonal Enzyme for Human Cells
DOI: https://doi.org/10.1246/cl.210231
[2021] Comparative Evaluation of Natural Killer Cell-mediated Cell Killing Assay Based on the Leakage of an Endogenous Enzyme or a Pre-loaded Fluorophore
DOI: https://doi.org/10.2116/analsci.21p117
[2021] Effect of Size and Loading of Retinoic Acid in Polyvinyl Butyrate Nanoparticles on Amelioration of Colitis
DOI: https://doi.org/10.3390/polym13091472
[2021] Protein Kinase C α-Responsive Gene Carrier for Cancer-Specific Transgene Expression and Cancer Therapy
DOI: https://doi.org/10.1021/acsbiomaterials.1c00213
[2021] A FRET-based Protein Kinase Assay Using Phos-tag-modified Quantum Dots and Fluorophore-labeled Peptides
DOI: https://doi.org/10.2116/analsci.20p443
[2021] Inducible Dynamic Behavior of Polyion Complex Vesicles by Disrupting Charge Balance
DOI: https://doi.org/10.1246/cl.210037
[2021] Polyvinyl Butyrate Nanoparticles as Butyrate Donors for Colitis Treatment
DOI: https://doi.org/10.1021/acsabm.0c01105
[2021] Specific adsorption of a β-lactam antibiotic in vivo by an anion-exchange resin for protection of the intestinal microbiota
DOI: https://doi.org/10.1039/d1bm00958c

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AI 要約（直近 5 年の研究成果）

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関連研究室(8 件)

研究成果（53 件）

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