Takeyuki Kiguchi 研究室

主宰者：Takeyuki Kiguchi

京都大学

AI 要約（直近 5 年の研究成果）

本研究室は、心停止後の患者の生命予後と神経学的予後（脳機能の回復状態）を改善することを目指し、多角的な臨床研究を展開しています。特に院外心停止患者を中心に、救急搬送から集中治療段階までの治療効果を検証しており、日本全国の医療機関のデータを統合した大規模登録研究を活用しています。研究の問いは、どのような患者が特定の治療から恩恵を受けやすいのか、また治療実施のタイミングや医療機関の経験がどの程度患者成績に影響するのかという点に集約されます。手法としては、全国多施設から収集された患者データを後ろ向き・前向きに分析する観察研究と、治療方法の効果を比較する介入試験の両方を実施しています。血液検査値（乳酸値やアルブミン値など）、脳血流動態の非侵襲的測定、さらには機械的蘇生補助装置の使用効果など、具体的な臨床指標と患者成績の関連性を統計的に評価しています。また動物実験モデルを用いて、蘇生時の脳血流維持メカニズムを詳細に検討する基礎研究も並行しています。主な知見として、患者到着時の血液生化学指標が予後予測に有用であること、温度管理の実施速度が神経学的転帰に関連すること、そして治療の種類や実施体制が患者成績に影響することが複数の研究で示唆されています。これらの成果は、救急患者の危機的状態をより正確に評価し、各患者に最適な治療戦略を選択するための医学的根拠となります。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（94 件）

[2026] Temporal Trends in Outcomes After Out-of-Hospital Cardiac Arrest Transported to Critical Care Medical Centers in Japan, 2014–2022: A Nationwide Retrospective Observational Study
DOI: https://doi.org/10.1097/ccm.0000000000007104
[2026] Development and validation of a clinical prediction model for postpartum hemorrhage after elective cesarean section
DOI: https://doi.org/10.1007/s00540-026-03671-6
[2026] Modeling the Cost-Effectiveness of Incorporating Extracorporeal Cardiopulmonary Resuscitation Strategy in Out-of-Hospital Cardiac Arrest Patients
DOI: https://doi.org/10.1097/ccm.0000000000007153
[2026] Serum lactate/albumin ratio at hospital arrival and neurological outcomes in patients who received targeted temperature management after out‐of‐hospital cardiac arrest: A nationwide, multicenter, observational study
DOI: https://doi.org/10.1002/hkj2.70100
[2025] 1098: TRAINING INITIATIVES FOR RAPID RESPONSE TEAM MEMBERS USING INSTRUCTIONAL DESIGN
DOI: https://doi.org/10.1097/01.ccm.0001103056.60562.1c
[2025] Impact of the COVID-19 pandemic on favourable neurological outcome after EMS-witnessed out-of-hospital cardiac arrest: a prospective nationwide observational study
DOI: https://doi.org/10.1016/j.resuscitation.2025.110758
[2025] Effectiveness of Real-Time Feedback, Debriefing, and Retraining System for Patients with Out-of-Hospital Cardiac Arrest: A Cluster Parallel-Group Randomized Controlled Trial
DOI: https://doi.org/10.1016/s0300-9572(25)00386-7
[2025] Association between Cerebral Perfusion Indices by NIRS and ROSC During CPR in Out-of-Hospital Cardiac Arrest Patients
DOI: https://doi.org/10.1016/s0300-9572(25)00613-6
[2025] Characteristics of out-of-hospital cardiac arrest from 2018 to 2021 across the world: third report from the International Liaison Committee on Resuscitation (ILCOR) research and registries committee
DOI: https://doi.org/10.1016/j.resuscitation.2025.110852
[2025] Serum lactate to albumin ratio at hospital arrival and neurological outcome of out-of-hospital cardiac arrest: a nationwide multicenter observational study
DOI: https://doi.org/10.15441/ceem.24.339

続きを表示（残り 84 件）

[2025] Abstract Sat1101: Serum Lactate/Albumin Ratio at Hospital Arrival and 30-day Neurological Outcome in Patients Receiving Targeted Temperature Management after Out-of-hospital Cardiac Arrest
DOI: https://doi.org/10.1161/circ.152.suppl_3.sat1101
[2025] Association between base excess level at hospital arrival and neurological outcomes in adult out-of-hospital cardiac arrest: A multicentre cohort study
DOI: https://doi.org/10.1016/j.resplu.2025.101055
[2025] Neurological outcomes with hypothermia versus normothermia in patients with moderate initial illness severity following resuscitation from out-of-hospital cardiac arrest: protocol for a multicentre randomised controlled trial (R-CAST OHCA)
DOI: https://doi.org/10.1136/bmjopen-2025-101809
[2025] Factors associated with automated external defibrillator use in out-of-hospital cardiac arrest by type of lay rescuers: a Japanese nationwide, population-based descriptive study
DOI: https://doi.org/10.1016/j.resuscitation.2025.110691
[2025] Rationale, Design, Feasibility, and Profile of the Japanese Circulation Society Chest Pain Registry　― Single-Center Pilot Study ―
DOI: https://doi.org/10.1253/circj.cj-24-0832
[2025] Underlying Cause of Out‐of‐Hospital Cardiac Arrests in Japan in Survivors Versus Nonsurvivors
DOI: https://doi.org/10.1161/jaha.124.036968
[2025] Association Between Annual Procedural Volume and Outcomes in Extracorporeal Cardiopulmonary Resuscitation for Out-of-Hospital Cardiac Arrest: A Nationwide Cohort Study in Japan (the JAAM-OHCA Registry)
DOI: https://doi.org/10.1097/mat.0000000000002450
[2025] Evaluation of interventions in prehospital and in-hospital settings and outcomes for out-of-hospital cardiac arrest patients meeting the termination of resuscitation rule in Japan: A nationwide database study (The JAAM-OHCA Registry)
DOI: https://doi.org/10.1016/j.resuscitation.2025.110530
[2025] Warfarin overdose successfully treated using prophylactic vitamin K infusion without severe coagulopathy: A case report
DOI: https://doi.org/10.1002/ams2.70036
[2025] 1537: EFFECT OF A RAPID RESPONSE SYSTEM ON THE INCIDENCE OF IN-HOSPITAL CARDIAC ARREST
DOI: https://doi.org/10.1097/01.ccm.0001104812.76564.d8
[2024] Impact of pre-existing medical conditions on mortality in geriatric trauma: a nationwide study in Japan
DOI: https://doi.org/10.1007/s00068-024-02570-3
[2024] Association of pre-hospital tracheal intubation with outcomes after out-of-hospital cardiac arrest by drowning comparing to supraglottic airway device: A nationwide propensity score-matched cohort study
DOI: https://doi.org/10.1016/j.resuscitation.2024.110129
[2024] Early prediction for massive fresh frozen plasma transfusion based on fibrinogen/fibrin degradation products and D-dimer in patients with blunt trauma: a single-center, retrospective cohort study
DOI: https://doi.org/10.1007/s00068-024-02452-8
[2024] Non-linear association between the time required to reaching temperature targets and the neurological outcome in patients undergoing targeted temperature management after out-of-hospital cardiac arrest: Observational multicentre cohort study
DOI: https://doi.org/10.1016/j.resplu.2024.100607
[2024] External Validation of Updated Prediction Models for Neurological Outcomes at 90 Days in Patients With Out‐of‐Hospital Cardiac Arrest
DOI: https://doi.org/10.1161/jaha.123.033824
[2024] Strategies for Reducing Sudden Cardiac Death by Raising Public Awareness　― A Statement From the Education and Implementation for Cardiac Emergency Committee of the Japanese Circulation Society ―
DOI: https://doi.org/10.1253/circj.cj-24-0599
[2024] The “invisible ceiling” of bystander CPR in three Asian countries: Descriptive study of national OHCA registry
DOI: https://doi.org/10.1016/j.resuscitation.2024.110445
[2024] Abstract Su904: The association between base excess on arrival at the hospital and neurological outcome of adult out-hospital cardiac arrest: observational study
DOI: https://doi.org/10.1161/circ.150.suppl_1.su904
[2024] Abstract Sa1006: Association between Increment of Near-Infrared Spectroscopy-Derived Cerebral Perfusion Index and Return of Spontaneous Circulation in Out-of-Hospital Cardiac Arrest Patients: A Prospective Observational Study
DOI: https://doi.org/10.1161/circ.150.suppl_1.sa1006
[2024] Abstract Sa904: Relationship between time of occurrence and survival of in-hospital cardiac arrests triggered by medical adverse events(Nationwide medical adverse events database in Japan)
DOI: https://doi.org/10.1161/circ.150.suppl_1.sa904
[2024] Abstract Sa503: Serum lactate/albumin ratio at hospital arrival and neurological outcome of patients 30 days after the occurrence of out-of-hospital cardiac arrest: a nationwide multicenter observational study
DOI: https://doi.org/10.1161/circ.150.suppl_1.sa503
[2024] Abstract Sa203: Association between dynamic cerebral perfusion indices by NIRS and cerebral microvascular flow during CPR in a porcine cardiac arrest model
DOI: https://doi.org/10.1161/circ.150.suppl_1.sa203
[2024] 31 The “ceiling effect” of bystander CPR among three Asian countries: descriptive study of national OHCA databases
DOI: https://doi.org/10.1016/s0300-9572(24)00350-2
[2024] Effects of Concomitant Traumatic Spinal Cord and Brain Injury on In-Hospital Mortality: A Retrospective Analysis of a Nationwide Trauma Registry in Japan
DOI: https://doi.org/10.1089/neu.2024.0168
[2023] Intra-Aortic Balloon Pump among Shockable Out-of-Hospital Cardiac Arrest Patients: A Propensity-Weighted Analysis in a Multicenter, Nationwide Observational Study in Japan (The JAAM-OHCA Registry)
DOI: https://doi.org/10.3390/jcm12185945
[2023] Comparing outcomes of out-of-hospital cardiac arrest patients with initial shockable rhythm in Singapore and Osaka using population-based databases
DOI: https://doi.org/10.1186/s13054-023-04771-5
[2023] In-hospital extracorporeal cardiopulmonary resuscitation for patients with out-of-hospital cardiac arrest: an analysis by time-dependent propensity score matching using a nationwide database in Japan
DOI: https://doi.org/10.1186/s13054-023-04732-y
[2023] Abstract 150: Non-Linear Association Between the Time of Reaching the Targeted Temperature and the Neurological Outcome in Patients Undergoing Targeted Temperature Management After Out-of-Hospital Cardiac Arrest Observational Multicenter Cohort Study
DOI: https://doi.org/10.1161/circ.148.suppl_1.150
[2023] Abstract 390: Pre-Hospital Administered Adrenaline in the Presence of a Physician and Neurological Status of Patients With Out-of-Hospital Cardiac Arrest: A Multi-Center Prospective Cohort Study
DOI: https://doi.org/10.1161/circ.148.suppl_1.390
[2023] Association between pregnant women fasting duration and neonatal hypoglycemia: A prospective cohort study
DOI: https://doi.org/10.1002/ijgo.15228
[2023] Association of prehospital tracheal intubation with outcomes comparing to supraglottic airway device during out-of-hospital cardiac arrest by drowning: nationwide cohort study in Japan
DOI: https://doi.org/10.1093/eurheartj/ehad655.3010
[2023] 103 Underlying Etiology of Sudden Out-of-Hospital Cardiac Arrest in Survivors vs Non-Survivors After Initial Resuscitation in Japan
DOI: https://doi.org/10.1016/s0300-9572(23)00445-8
[2023] Trends and characteristics of severe road traffic injuries in children: a nationwide cohort study in Japan
DOI: https://doi.org/10.1007/s00068-023-02372-z
[2023] Diagnostic test accuracy of life-threatening electrocardiographic findings (ST-elevation myocardial infarction equivalents) for acute coronary syndrome after out-of-hospital cardiac arrest without ST-segment elevation
DOI: https://doi.org/10.1016/j.resuscitation.2023.109700
[2023] Outcome assessment for out-of-hospital cardiac arrest patients in Singapore and Japan with initial shockable rhythm
DOI: https://doi.org/10.1186/s13054-023-04636-x
[2023] Timing of computed tomography imaging in adult patients with severe trauma: A nationwide cohort study in Japan
DOI: https://doi.org/10.1016/j.ajem.2023.08.004
[2023] Three-year trends in out-of-hospital cardiac arrest across the world: Second report from the International Liaison Committee on Resuscitation (ILCOR)
DOI: https://doi.org/10.1016/j.resuscitation.2023.109757
[2023] Pre-hospital airway management and neurological status of patients with out-of-hospital cardiac arrest: A retrospective cohort study
DOI: https://doi.org/10.1016/j.resplu.2023.100422
[2023] Impact of the <scp>COVID</scp>‐19 pandemic on epidemiology, treatment, and outcome of major trauma in Japan in 2020: a retrospective observational nationwide registry‐based study
DOI: https://doi.org/10.1002/ams2.817
[2022] Abstract 281: External Validation Of The Tips65 Score For Predicting Good Neurological Outcome In Out-of-hospital Cardiac Arrest Patients Treated With Extracorporeal Cardiopulmonary Resuscitation
DOI: https://doi.org/10.1161/circ.146.suppl_1.281
[2022] Association between blood urea nitrogen to creatinine ratio and neurologically favourable outcomes in out-of-hospital cardiac arrest in adults: A multicentre cohort study
DOI: https://doi.org/10.1016/j.jjcc.2022.11.009
[2022] Epidemiology and outcomes of pregnant trauma patients in Japan: a nationwide descriptive study
DOI: https://doi.org/10.1007/s00068-022-02165-w
[2022] Abstract 282: Extracorporeal Resuscitation For Out-of-Hospital Cardiac Arrest Patients: Analysis By Time-Dependent Propensity Score Matching Using Nationwide Database In Japan
DOI: https://doi.org/10.1161/circ.146.suppl_1.282
[2022] Abstract 248: Current Status Of In-hospital Cardiac Arrest And Issues Of Collecting Data Using The Latest In-hospital Utstein-style Reporting Templates
DOI: https://doi.org/10.1161/circ.146.suppl_1.248
[2022] Abstract 196: Association Between Continuous Carotid Blow Flow And Continuous Cerebral Perfusion Indexes Assessment By NIRS In A Porcine Model Of Ventricular Fibrillation During CPR
DOI: https://doi.org/10.1161/circ.146.suppl_1.196
[2022] Abstract 231: Volume And Direction Of Carotid Blood Flow During Cardiopulmonary Resuscitation In A Porcine Model Of Ventricular Fibrillation
DOI: https://doi.org/10.1161/circ.146.suppl_1.231
[2022] Abstract 157: Diagnostic Test Accuracy Of The ST-segment Elevation Myocardial Infarction Equivalents In Electrocardiogram After Return Of Spontaneous Circulation Among Out-of-hospital Cardiac Arrest Patients Without ST-segment Elevation
DOI: https://doi.org/10.1161/circ.146.suppl_1.157
[2022] Abstract 173: Update And External Validation Of A Prognostic Model To Predict Neurological Outcomes At 90 Days In Out-of-hospital Patients With Cardiac Arrest
DOI: https://doi.org/10.1161/circ.146.suppl_1.173
[2022] Public-access defibrillation and favorable neurological outcome after out-of-hospital cardiac arrest during the COVID-19 pandemic in Japan
DOI: https://doi.org/10.1186/s13054-022-04220-9
[2022] Characteristics and outcomes of severe sports-related injury in children and adults: a nationwide cohort study in Japan
DOI: https://doi.org/10.1007/s00068-022-02144-1
[2022] Incidence and Characteristics of Cranial Nerve Injuries: A Nationwide Observational Study in Japan
DOI: https://doi.org/10.3390/jcm11164852
[2022] Factors Associated with Cardiac/Pericardial Injury among Blunt Injury Patients: A Nationwide Study in Japan
DOI: https://doi.org/10.3390/jcm11154534
[2022] Factors Associated with Traumatic Diaphragmatic Rupture among Patients with Chest or Abdominal Injury: A Nationwide Study from Japan
DOI: https://doi.org/10.3390/jcm11154462
[2022] Clinical outcomes among out-of-hospital cardiac arrest patients treated by extracorporeal cardiopulmonary resuscitation: The CRITICAL study in Osaka
DOI: https://doi.org/10.1016/j.resuscitation.2022.06.007
[2022] Relationship between in‐hospital mortality and abdominal angiography among patients with blunt liver injuries: a propensity score‐matching from a nationwide trauma registry of Japan
DOI: https://doi.org/10.1002/ams2.725
[2022] Association between initial body temperature on hospital arrival and neurological outcome among patients with out-of-hospital cardiac arrest: a multicenter cohort study (the CRITICAL study in Osaka, Japan)
DOI: https://doi.org/10.1186/s12873-022-00641-5
[2022] Impact of the COVID-19 Pandemic on Prehospital Intervention and Survival of Patients With Out-of-Hospital Cardiac Arrest in Osaka City, Japan
[2022] Assessing the impact of the national traffic safety campaign: a nationwide cohort study in Japan
DOI: https://doi.org/10.1136/bmjopen-2021-054295
[2022] Early prognostic impact of serum sodium level among out-of-hospital cardiac arrest patients: a nationwide multicentre observational study in Japan (the JAAM-OHCA registry)
DOI: https://doi.org/10.1007/s00380-022-02020-3
[2022] Clustering out‐of‐hospital cardiac arrest patients with non‐shockable rhythm by machine learning latent class analysis
DOI: https://doi.org/10.1002/ams2.760
[2022] Oxyhaemoglobin Level Measured Using Near-Infrared Spectrometer Is Associated with Brain Mitochondrial Dysfunction After Cardiac Arrest in Rats
DOI: https://doi.org/10.1007/978-3-031-14190-4_63
[2022] External validation of the TiPS65 score for predicting good neurological outcomes in patients with out-of-hospital cardiac arrest treated with extracorporeal cardiopulmonary resuscitation
DOI: https://doi.org/10.1016/j.resuscitation.2022.11.018
[2022] Outcomes associated with intra-arrest hyperoxaemia in out-of-hospital cardiac arrest: A registry-based cohort study
DOI: https://doi.org/10.1016/j.resuscitation.2022.11.008
[2021] Effect of Adrenaline on Cerebral Blood Oxygenation Measured by NIRS in a Rat Asphyxia Cardiac Arrest Model
DOI: https://doi.org/10.1007/978-3-030-48238-1_6
[2021] RETRACTED CHAPTER: Effect of Adrenaline on Cerebral Blood Oxygenation Measured by NIRS in a Rat Asphyxia Cardiac Arrest Model
DOI: https://doi.org/10.1007/978-3-030-48238-1_44
[2021] Impact of medical reimbursement revision on ambulance transport of self‐inflicted injury patients: a nationwide study in Japan
DOI: https://doi.org/10.1002/ams2.693
[2021] Epinephrine administration for adult out-of-hospital cardiac arrest patients with refractory shockable rhythm: time-dependent propensity score-sequential matching analysis from a nationwide population-based registry
DOI: https://doi.org/10.1093/ehjcvp/pvab013
[2021] Trends in In-Hospital Advanced Management and Survival of Out-of-Hospital Cardiac Arrest Among Adults From 2013 to 2017　― A Multicenter, Prospective Registry in Osaka, Japan ―
DOI: https://doi.org/10.1253/circj.cj-20-1022
[2021] Influence of COVID-19 pandemic on bystander interventions, emergency medical service activities, and patient outcomes in out-of-hospital cardiac arrest in Osaka City, Japan
DOI: https://doi.org/10.1016/j.resplu.2021.100088
[2021] Effect of fluid administration on scene to traffic accident patients by EMS personnel: a propensity score-matched study using population-based ambulance records and nationwide trauma registry in Japan
DOI: https://doi.org/10.1007/s00068-020-01590-z
[2021] Association between serum lactate level during cardiopulmonary resuscitation and survival in adult out-of-hospital cardiac arrest: a multicenter cohort study
DOI: https://doi.org/10.1038/s41598-020-80774-4
[2021] Evaluation of the Quality of Chest Compression with Oxyhemoglobin Level by Near-Infrared Spectroscopy in a Rat Asphyxia Cardiac Arrest Model
DOI: https://doi.org/10.1007/978-3-030-48238-1_42
[2021] Assessment of Cerebral Blood Oxygenation by Near-Infrared Spectroscopy before and after Resuscitation in a Rat Asphyxia Cardiac Arrest Model
DOI: https://doi.org/10.1007/978-3-030-48238-1_49
[2021] An Association of Influenza Epidemics in Children With Mobile App Data: Population-Based Observational Study in Osaka, Japan
DOI: https://doi.org/10.2196/31131
[2021] Patient age affects sex-based differences in post-traumatic mortality: a national trauma registry study in Japan
DOI: https://doi.org/10.1007/s00068-021-01840-8
[2021] Abstract 10100: Early Prediction of Neurological Outcome at 30 Days After Return of Spontaneous Circulation From Out-of-Hospital Cardiac Arrest
DOI: https://doi.org/10.1161/circ.144.suppl_2.10100
[2021] Physician’s presence in pre-hospital setting improves one-month favorable neurological survival after out-of-hospital cardiac arrest: A propensity score matching analysis of the JAAM-OHCA Registry
DOI: https://doi.org/10.1016/j.resuscitation.2021.08.010
[2021] Characteristics and outcomes of pediatric blunt renal trauma: a nationwide cohort study in Japan
DOI: https://doi.org/10.1007/s00068-021-01795-w
[2021] Development and validation of early prediction for neurological outcome at 90 days after return of spontaneous circulation in out-of-hospital cardiac arrest
DOI: https://doi.org/10.1016/j.resuscitation.2021.09.027
[2021] Clinical Phenotyping of Out-of-Hospital Cardiac Arrest Patients With Shockable Rhythm　― Machine Learning-Based Unsupervised Cluster Analysis ―
DOI: https://doi.org/10.1253/circj.cj-21-0675
[2021] Abstract 8883: Pre-hospital Physician’s Presence and Neurological Outcome Among Patients Performed Pre-hospital Advanced Airway Management: A Nationwide Multicenter Observational Study in Japan (the Japanese Association for Acute Medicine-out-of-Hospital Cardiac Arrest Registry)
DOI: https://doi.org/10.1161/circ.144.suppl_2.8883
[2021] A Mobile App for Self-Triage for Pediatric Emergency Patients in Japan: 4 Year Descriptive Epidemiological Study
DOI: https://doi.org/10.2196/27581
[2021] Predictive value of sarcopenic findings in the psoas muscle on CT imaging among patients with sepsis
DOI: https://doi.org/10.1016/j.ajem.2021.04.011
[2021] Association Between Resuscitative Time on the Scene and Survival After Pediatric Out-of-Hospital Cardiac Arrest
DOI: https://doi.org/10.1253/circrep.cr-21-0021

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AI 要約（直近 5 年の研究成果）

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研究成果（94 件）

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