Shigeki Matsunaga 研究室

主宰者：Shigeki Matsunaga

京都大学

兼任：北海道大学

AI 要約（直近 5 年の研究成果）

松永茂樹研究室は、有機合成化学における触媒反応の開発に取り組んでいます。特に、従来では困難とされてきた炭素と水素の結合（C-H結合）を選択的に切断・変換する反応系の構築に注力しています。イリジウムやルテニウムなどの遷移金属触媒、あるいはコバルトと光触媒を組み合わせたデュアル触媒系を用いて、複雑な有機分子を効率よく合成する方法を開発しています。これらの手法では、分子内の特定の官能基が反応の方向を導く「指向基」として機能し、多数の異なるC-H結合の中から目的の箇所を認識して反応させることが可能です。さらに研究室では、不斉触媒反応を通じた光学活性化合物の合成にも力を入れています。ラセミ体でない光学純度の高い医薬品や機能性化学物質を触媒的に製造する方法を追求しており、ジルテニウム触媒などの新しい不斉触媒系の設計・開発を行っています。加えて、ハイパーバレント沃素化合物やテトラザジン誘導体といった特殊な活性剤の合成と応用にも取り組み、有機分子変換のための新しい反応試薬や触媒プラットフォームの創出を目指しています。これらの基礎研究成果は、医薬品や機能性材料の製造への応用につながる可能性を持っています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（53 件）

[2026] Synthesis of Sulfonyl Fluorides from Tertiary Sulfonamides via 𝘕-Methylation Using Me-λ³-Iodane
[2026] Synthesis of Sulfonyl Fluorides from Tertiary Sulfonamides via N-Methylation Using Me-λ3-Iodane
DOI: https://doi.org/10.1055/a-2782-6367
[2025] In Situ Generation of Alkyl–λ3–Iodanes as Soft and Highly Reactive Electrophiles
DOI: https://doi.org/10.1002/ceur.202500154
[2025] Enantioselective C( sp 3)–H amination of allyl benzene derivatives enabled by paddle-wheel diruthenium catalysis
DOI: https://doi.org/10.1093/bulcsj/uoaf106
[2025] Rhodium-catalyzed ring contraction of lactams
DOI: https://doi.org/10.1016/j.chempr.2025.102704
[2025] Distal Heteroaryl Ipso‐Migration of Unactivated Alkenes via Cobalt/Photoredox‐Catalyzed Hydrogen/Deuterium Atom Transfer
DOI: https://doi.org/10.1002/asia.202500448
[2025] Multiple Deuterium Atom Transfer Perdeuteration of Unactivated Alkenes under Base‐Assisted Cobalt/Photoredox Dual Catalysis
DOI: https://doi.org/10.1002/anie.202500233
[2025] Enantioselective C–H amidation of sulfondiimines for the synthesis of 1,2,4-benzothiadiazine-1-imines under cobalt catalysis
DOI: https://doi.org/10.1039/d5qo00355e
[2025] Native Amide-Directed C(sp 3 )–H Alkynylation Using an Electron-Deficient Iridium Catalyst with Pyridone Ligand Assistance
DOI: https://doi.org/10.1021/acs.orglett.5c04262
[2024] Correlation Between Elastic Properties and Phase Transformation of Zr50Pd50−xRux High-Temperature Shape Memory Alloys Designed by DFT
DOI: https://doi.org/10.1007/s11661-024-07502-9

続きを表示（残り 43 件）

[2024] Enantioselective Intermolecular Benzylic C–H Amination under Chiral Paddle-Wheel Diruthenium Catalysis
DOI: https://doi.org/10.1021/acscatal.4c06504
[2024] Site‐Selective C( sp 3 )−H and Switchable C( sp 3 )−H/C( sp 2 )−H Functionalization Enabled by Electron‐Deficient Cp* CF3 Ir(III) Catalyst and Photosensitizer
DOI: https://doi.org/10.1002/ange.202421026
[2024] Microstructure Evolution and Mechanical Properties of Ti–6Al–4Zr–4Nb Alloys Fabricated by Spark Plasma Sintering (SPS)
DOI: https://doi.org/10.1007/s11661-024-07422-8
[2024] Cobalt/Photoredox Dual-Catalyzed Cross-Radical Coupling of Alkenes via Hydrogen Atom Transfer and Homolytic Substitution
DOI: https://doi.org/10.1021/acs.orglett.4c01370
[2023] Formation of Isolable Dearomatized [4 + 2] Cycloadducts from Benzenes, Naphthalenes, and N-Heterocycles Using 1,2-Dihydro-1,2,4,5-tetrazine-3,6-diones as Arenophiles under Visible Light Irradiation
DOI: https://doi.org/10.1021/jacs.3c02556
[2023] Iron/Photosensitizer-Catalyzed Directed C–H Activation Triggered by the Formation of an Iron Metallacycle
DOI: https://doi.org/10.1021/acscatal.3c00381
[2023] An Electron‐Deficient CpE Iridium(III) Catalyst: Synthesis, Characterization, and Application to Ether‐Directed C−H Amidation
DOI: https://doi.org/10.1002/anie.202301259
[2023] An Electron‐Deficient CpE Iridium(III) Catalyst: Synthesis, Characterization, and Application to Ether‐Directed C−H Amidation
DOI: https://doi.org/10.1002/ange.202301259
[2023] Evolution of microstructure and texture in Al-containing CoCrNi medium entropy alloys during severe warm-rolling
DOI: https://doi.org/10.1016/j.matchar.2023.113546
[2023] Synthesis of Benzo[c]azepine‐1,3(2H)‐diones via C−H Alkylation/Cyclization with α,β‐Unsaturated Acyl Fluorides
DOI: https://doi.org/10.1002/ajoc.202300218
[2023] Development of Astatine-211 labeling reaction using aryliodonium ylide
DOI: https://doi.org/10.1016/j.nucmedbio.2023.108433
[2023] Enantioselective Synthesis of 1,2‐Benzothiazine 1‐Imines via RuII/Chiral Carboxylic Acid‐Catalyzed C−H Alkylation/Cyclization
DOI: https://doi.org/10.1002/anie.202305480
[2023] Noble-Metal-Free C–H Allylation of Tetrahydroisoquinolines Using a Cobalt-Organophotoredox Dual Catalyst System
DOI: https://doi.org/10.1248/cpb.c22-00520
[2023] Catalytic Enantioselective Amination of Enol Silyl Ethers Using a Chiral Paddle-Wheel Diruthenium Complex
DOI: https://doi.org/10.1021/acs.orglett.3c00940
[2023] Enantioselective Synthesis of 1,2‐Benzothiazine 1‐Imines via RuII/Chiral Carboxylic Acid‐Catalyzed C−H Alkylation/Cyclization
DOI: https://doi.org/10.1002/ange.202305480
[2023] Graphisches Inhaltsverzeichnis: Angew. Chem. 21/2023
DOI: https://doi.org/10.1002/ange.202382111
[2023] Synthesis of Polysubstituted Enamides by Hydrogen Atom Transfer Alkene Isomerization Using Dual Cobalt/Photoredox Catalysis
DOI: https://doi.org/10.1002/chem.202300804
[2022] Native Amide‐Directed C(sp3)−H Amidation Enabled by Electron‐Deficient RhIII Catalyst and Electron‐Deficient 2‐Pyridone Ligand
DOI: https://doi.org/10.1002/ange.202213659
[2022] 1,2-Disubstituted 1,2-Dihydro-1,2,4,5-tetrazine-3,6-dione as a Dynamic Covalent Bonding Unit at Room Temperature
DOI: https://doi.org/10.1021/jacs.1c11665
[2022] Design and Synthesis of Cyclopropane Congeners of Resolvin E3, an Endogenous Pro-Resolving Lipid Mediator, as Its Stable Equivalents
DOI: https://doi.org/10.1021/acs.joc.2c01110
[2022] Cobalt(III)/Chiral Carboxylic Acid‐Catalyzed Enantioselective Synthesis of Benzothiadiazine‐1‐oxides via C−H Activation
DOI: https://doi.org/10.1002/anie.202205341
[2022] Regioselective Deaminative Allylation of Aliphatic Amines via Dual Cobalt and Organophotoredox Catalysis
DOI: https://doi.org/10.1021/acs.orglett.2c00319
[2022] Photocatalytic Deuterium Atom Transfer Deuteration of Electron‐Deficient Alkenes with High Functional Group Tolerance
DOI: https://doi.org/10.1002/anie.202214433
[2022] Photocatalytic Deuterium Atom Transfer Deuteration of Electron‐Deficient Alkenes with High Functional Group Tolerance
DOI: https://doi.org/10.1002/ange.202214433
[2022] Native Amide‐Directed C(sp3)−H Amidation Enabled by Electron‐Deficient RhIII Catalyst and Electron‐Deficient 2‐Pyridone Ligand
DOI: https://doi.org/10.1002/anie.202213659
[2022] Preface - Special Topic Asymmetric C–H Functionalization
DOI: https://doi.org/10.1055/s-0040-1720049
[2022] Photoinduced Nickel‐Catalyzed Carbon–Heteroatom Coupling**
DOI: https://doi.org/10.1002/chem.202202385
[2022] Iron/Photosensitizer Hybrid System Enables the Synthesis of Polyaryl-Substituted Azafluoranthenes
DOI: https://doi.org/10.1021/jacs.2c06993
[2022] Light-Promoted Nickel-Catalyzed Aromatic Halogen Exchange
DOI: https://doi.org/10.1021/acscatal.2c03354
[2022] Cobalt(III)/Chiral Carboxylic Acid‐Catalyzed Enantioselective Synthesis of Benzothiadiazine‐1‐oxides via C−H Activation
DOI: https://doi.org/10.1002/ange.202205341
[2022] Achiral Cp*Rh(III)/Chiral Lewis Base Cooperative Catalysis for Enantioselective Cyclization via C–H Activation
DOI: https://doi.org/10.1021/jacs.2c01223
[2022] Intramolecular Hydrogen Atom Transfer Hydroarylation of Alkenes toward δ-Lactams Using Cobalt-Photoredox Dual Catalysis
DOI: https://doi.org/10.1021/acs.orglett.2c00700
[2021] Structural characteristics of gluconolactone/gluconic acid aqueous solution used for bio battery by molecular dynamics
DOI: https://doi.org/10.1088/1742-6596/1730/1/012045
[2021] Chiral Carboxylic Acid Assisted Enantioselective C–H Activation with Achiral CpxMIII (M = Co, Rh, Ir) Catalysts
DOI: https://doi.org/10.1021/acscatal.1c01351
[2021] Ruthenium(II)/Chiral Carboxylic Acid Catalyzed Enantioselective C–H Functionalization of Sulfoximines
DOI: https://doi.org/10.1055/a-1588-0072
[2021] Cp*Rh(<scp>iii</scp>)/boron hybrid catalysis for directed C–H addition to β-substituted α,β-unsaturated carboxylic acids
DOI: https://doi.org/10.1039/d1cc05956d
[2021] Cp*RhIII/Chiral Disulfonate/CuOAc Catalyst System for the Enantioselective Intramolecular Oxyamination of Alkenes
DOI: https://doi.org/10.1021/acscatal.1c04699
[2021] Metal-Containing Schiff Base/Sulfoxide Ligands for Pd(II)-Catalyzed Asymmetric Allylic C–H Aminations
DOI: https://doi.org/10.1021/acscatal.0c05261
[2021] Silane- and peroxide-free hydrogen atom transfer hydrogenation using ascorbic acid and cobalt-photoredox dual catalysis
DOI: https://doi.org/10.1038/s41467-020-20872-z
[2021] Cp*Ir(<scp>iii</scp>)/chiral carboxylic acid-catalyzed enantioselective C–H alkylation of ferrocene carboxamides with diazomalonates
DOI: https://doi.org/10.1039/d1qo01344k
[2021] Transition-metal-free nucleophilic 211At-astatination of spirocyclic aryliodonium ylides
DOI: https://doi.org/10.1039/d1ob00789k
[2021] Development of Pseudo-C2-symmetric Chiral Binaphthyl Monocarboxylic Acids for Enantioselective C(sp3)–H Functionalization Reactions under Rh(III) Catalysis
DOI: https://doi.org/10.1021/acscatal.1c00765
[2021] Generation of Monoaryl-λ3-iodanes from Arylboron Compounds through ipso-Substitution
DOI: https://doi.org/10.3987/com-20-s(k)45

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AI 要約（直近 5 年の研究成果）

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関連研究室(8 件)

研究成果（53 件）

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