Mitsuaki Nishikimi 研究室

主宰者：Mitsuaki Nishikimi

広島大学

AI 要約（直近 5 年の研究成果）

この研究室は、生命が危機的な状態に陥った患者を対象として、臨床データの大規模解析と動物実験を組み合わせた研究を展開しています。特に心停止後の脳障害、重症の呼吸不全、敗血症といった集中治療が必要な疾患に焦点を当てています。全国規模の病院データベースや集中治療室の患者情報を活用し、患者の予後を予測するスコアの開発、治療法の有効性評価、医療資源と患者転帰の関係性を調査しています。生理学的メカニズムの解明も重要な研究テーマです。心停止後の脳や臓器の機能低下を引き起こす主因として、細胞膜の構成成分であるリン脂質の異常に着目し、特定のリン脂質化合物の補充が脳損傷や生存率を改善するかを、ラット実験モデルで検証しています。また、活性酸素の発生メカニズムや免疫細胞の応答異常も調査対象としており、これらの知見に基づいた新しい治療戦略の開発を目指しています。さらに機械学習を用いて、同じ疾患でも患者によって治療への反応が異なることを明らかにし、個別化医療への応用を進めています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（60 件）

[2025] Changes in the neurological status from 30 to 90 days post-cardiac arrest by age: A nationwide retrospective observational study
DOI: https://doi.org/10.1016/j.resplu.2025.100917
[2025] Association between increasing institutional experience with ECPR and outcomes in patients with out-of-hospital cardiac arrest: A nationwide multicenter observational study in Japan (the JAAM–OHCA registry)
DOI: https://doi.org/10.1016/j.resuscitation.2024.110487
[2025] Association between hospital arrival time/day and mortality in pediatric patients with severe trauma: a nationwide retrospective observational study in Japan
DOI: https://doi.org/10.1016/j.injury.2025.112946
[2025] Improved survival and neurological outcomes with lysophosphatidylcholine supplementation in severe cardiac arrest model
DOI: https://doi.org/10.3389/fphar.2025.1587776
[2025] Development and validation of the STeP score for predicting tracheostomy in patients with sepsis using a nationwide ICU database: a retrospective observational study
DOI: https://doi.org/10.1186/s40560-025-00833-8
[2025] Pulse Steroid Therapy for Severe Acute Respiratory Distress Syndrome: A Propensity Score-Matched Analysis
DOI: https://doi.org/10.3390/jcm14155547
[2024] Identifying Subgroups with Differential Responses to Amiodarone among Cardiac Arrest Patients with a Shockable Rhythm at Hospital Arrival using the Machine Learning Approach
DOI: https://doi.org/10.31083/j.rcm2507268
[2024] No improvement in mortality among critically ill patients with carbapenems as initial empirical therapy and more detection of multi-drug resistant pathogens associated with longer use: a post hoc analysis of a prospective cohort study
DOI: https://doi.org/10.1128/spectrum.00342-24
[2024] The Role of Phospholipid Alterations in Mitochondrial and Brain Dysfunction after Cardiac Arrest
DOI: https://doi.org/10.3390/ijms25094645
[2024] Should Transport Ventilators Be Used in Times of Crisis? The Use of Emergency Authorized Nonconventional Ventilators Is Associated With Mortality Among Patients With COVID-19 Acute Respiratory Distress Syndrome*
DOI: https://doi.org/10.1097/ccm.0000000000006252

続きを表示（残り 50 件）

[2024] External validation of the rCAST for patients after in-hospital cardiac arrest: a multicenter retrospective observational study
DOI: https://doi.org/10.1038/s41598-024-54851-x
[2024] Chest CT findings in severe acute respiratory distress syndrome requiring V-V ECMO: J-CARVE registry
DOI: https://doi.org/10.1186/s40560-023-00715-x
[2024] Association between regional critical care capacity and the incidence of invasive mechanical ventilation for coronavirus disease 2019: a population-based cohort study
DOI: https://doi.org/10.1186/s40560-024-00718-2
[2024] External validation of the <scp>sICOP</scp> score for early mortality in mechanically ventilated patients with <scp>COVID</scp>‐19
DOI: https://doi.org/10.1002/ams2.978
[2024] Effect Size of Targeted Temperature Management in Pediatric Patients with Post-Cardiac Arrest Syndrome According to the Severity
DOI: https://doi.org/10.3390/life15010026
[2024] Resuscitation Attempt and Outcomes in Patients With Asystole Out-of-Hospital Cardiac Arrest
DOI: https://doi.org/10.1001/jamanetworkopen.2024.45543
[2024] Increased national critical care demands were associated with a higher mortality of intubated COVID-19 patients in Japan: a retrospective observational study
DOI: https://doi.org/10.1186/s40560-024-00758-8
[2024] Identification of novel sub-phenotypes of severe ARDS requiring ECMO using latent class analysis
DOI: https://doi.org/10.1186/s13054-024-05143-3
[2023] Abstract 396: A Novel Machine Learning Approach for Identifying Subgroups With Differential Responses to Amiodarone in Patients With Cardiac Arrest With Shockable Rhythm
DOI: https://doi.org/10.1161/circ.148.suppl_1.396
[2023] Characteristics of the pulmonary opacities on chest CT associated with difficulty in short-term liberation from veno-venous ECMO in patients with severe ARDS
DOI: https://doi.org/10.1186/s12931-023-02425-2
[2023] Continuously increased generation of ROS in human plasma after cardiac arrest as determined by Amplex Red oxidation
DOI: https://doi.org/10.1080/10715762.2023.2250547
[2023] Neurological Improvement via Lysophosphatidic Acid Administration in a Rodent Model of Cardiac Arrest-Induced Brain Injury
DOI: https://doi.org/10.3390/ijms242417451
[2023] Association between hospital volume and in-hospital mortality in pediatric severe traumatic brain injury: a nationwide retrospective observational study in Japan
DOI: https://doi.org/10.3171/2023.10.peds23425
[2023] Abstract 147: Is Effect Size of Targeted Temperature Management Different for Pediatric Post-Cardiac Arrest Syndrome According to the Severity?
DOI: https://doi.org/10.1161/circ.148.suppl_1.147
[2023] Abstract 166: Novel Mechanism of Docosahexaenoic Acid Reducing Tissue Injury by Targeting Immune Cells and HMGB1 Release
DOI: https://doi.org/10.1161/circ.148.suppl_1.166
[2023] Lung Abscess and Pyothorax in Critically Ill COVID-19 Patients: A Single-Center Retrospective Study
DOI: https://doi.org/10.1097/cce.0000000000000919
[2023] Abstract 157: Differences in Mid-Term Neurological Changes From 30 to 90 Days According to Age; is Plasticity Following Brain Injury After Cardiac Arrest Observed in Children or Young Adults?
DOI: https://doi.org/10.1161/circ.148.suppl_1.157
[2023] Prediction of the neurological outcomes post-cardiac arrest: A prospective validation of the CAST and rCAST
DOI: https://doi.org/10.1016/j.ajem.2023.10.028
[2023] High versus low positive end-expiratory pressure setting in patients receiving veno-venous extracorporeal membrane oxygenation support for severe acute respiratory distress syndrome: study protocol for the multicentre, randomised ExPress SAVER Trial
DOI: https://doi.org/10.1136/bmjopen-2023-072680
[2023] Multi-Drug Cocktail Therapy Improves Survival and Neurological Function after Asphyxial Cardiac Arrest in Rodents
DOI: https://doi.org/10.3390/cells12111548
[2023] Predictive Accuracy of the ROX Index for Re-Intubation in Mechanically Ventilated Patients With COVID-19
DOI: https://doi.org/10.4187/respcare.10549
[2023] Three Novel Chest CT Subtypes Identified by Latent Class Analysis Among Severe ARDS Patients Requiring ECMO: Potential for Importance of Differential Management During ECMO According to the Subtype
DOI: https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6059
[2023] Increase in Burden of Patients With Severe COVID-19 Nationwide Was Associated With Higher Mortality Rate of Patients With COVID-19 Requiring Mechanical Ventilation: An Observational Study of a National Database in Japan
DOI: https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6552
[2023] Impact of Antimicrobial Use at the Start of Mechanical Ventilation on Ventilator-associated Lower Respiratory Tract Infections in Patients With Acute Respiratory Distress Syndrome Related to Coronavirus Disease 2019
DOI: https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a5126
[2023] Exogenous mitochondrial transplantation improves survival and neurological outcomes after resuscitation from cardiac arrest
DOI: https://doi.org/10.1186/s12916-023-02759-0
[2022] Alarming of Severe Respiratory Failure Requiring ECMO Caused by the SARS-CoV-2 Omicron Variant
DOI: https://doi.org/10.31662/jmaj.2022-0049
[2022] External Validation of the sICOP Score for Early Mortality in Mechanically Ventilated Patients with COVID-19
DOI: https://doi.org/10.2139/ssrn.4308579
[2022] The finger-to-nose test improved diagnosis of cerebrovascular events in patients presenting with isolated dizziness in the emergency department.
DOI: https://doi.org/10.18999/nagjms.84.3.621
[2022] Quantification of respiratory sounds by a continuous monitoring system can be used to predict complications after extubation: a pilot study
DOI: https://doi.org/10.1007/s10877-022-00884-4
[2022] Prediction of Prehospital Change of the Cardiac Rhythm From Nonshockable to Shockable in Out‐of‐Hospital Patients With Cardiac Arrest: A Post Hoc Analysis of a Nationwide, Multicenter, Prospective Registry
DOI: https://doi.org/10.1161/jaha.121.025048
[2022] COVID-19-Associated Portal Vein Thrombosis Post-Cholecystitis
DOI: https://doi.org/10.1055/s-0042-1743409
[2022] Abstract 101: Distinctive Individual Effects of LPC(18:2) and LPC(22:6) on Survival and Neurological Outcomes After Cardiac Arrest: Combination As A Future Therapy
DOI: https://doi.org/10.1161/circ.146.suppl_1.101
[2022] Preserving Brain <scp>LPC‐DHA</scp> by Plasma Supplementation Attenuates Brain Injury after Cardiac Arrest
DOI: https://doi.org/10.1002/ana.26296
[2022] 891: ARE NONCONVENTIONAL VENTILATORS ASSOCIATED WITH MORTALITY IN COVID ARDS? A MULTICENTER STUDY
DOI: https://doi.org/10.1097/01.ccm.0000909292.45423.ff
[2021] Sequential Use of Romiplostim after Eltrombopag for Refractory Thrombocytopenia in Hydrocarbon-Induced Myelodysplasia
DOI: https://doi.org/10.1055/s-0041-1726366
[2021] Understanding physiologic phospholipid maintenance in the context of brain mitochondrial phospholipid alterations after cardiac arrest
DOI: https://doi.org/10.1016/j.mito.2021.08.009
[2021] Right Ventricle Embolization of IVC Filter Fragments: An Incidental Finding
DOI: https://doi.org/10.1055/s-0041-1730451
[2021] Failure of non-invasive respiratory support after 6 hours from initiation is associated with ICU mortality
DOI: https://doi.org/10.1371/journal.pone.0251030
[2021] Outcome Related to Level of Targeted Temperature Management in Postcardiac Arrest Syndrome of Low, Moderate, and High Severities: A Nationwide Multicenter Prospective Registry
DOI: https://doi.org/10.1097/ccm.0000000000005025
[2021] Effects of Post‐Resuscitation Normoxic Therapy on Oxygen‐Sensitive Oxidative Stress in a Rat Model of Cardiac Arrest
DOI: https://doi.org/10.1161/jaha.120.018773
[2021] The evaluation of pituitary damage associated with cardiac arrest: An experimental rodent model
DOI: https://doi.org/10.1038/s41598-020-79780-3
[2021] Assessment of Cerebral Blood Oxygenation by Near-Infrared Spectroscopy before and after Resuscitation in a Rat Asphyxia Cardiac Arrest Model
DOI: https://doi.org/10.1007/978-3-030-48238-1_49
[2021] Pneumatosis Intestinalis in the Setting of COVID-19: A Single Center Case Series From New York
DOI: https://doi.org/10.3389/fmed.2021.638075
[2021] Hydrogen gas with extracorporeal cardiopulmonary resuscitation improves survival after prolonged cardiac arrest in rats
DOI: https://doi.org/10.1186/s12967-021-03129-1
[2021] Abstract 14456: Rethinking The Treatment Of Cardiac Arrest To Include Non-oxygen Metabolite Supplementation: Plasma Lysophosphatidylcholine Level Maintenance After Cardiac Arrest Is Critical For Survival
DOI: https://doi.org/10.1161/circ.144.suppl_2.14456
[2021] Abstract 9180: Importance of Preventing Decreased Levels of Lysophosphatidylcholine—DHA in Brain and Plasma for Attenuating Brain Injury After Cardiac Arrest
DOI: https://doi.org/10.1161/circ.144.suppl_2.9180
[2021] The interplay between bystander cardiopulmonary resuscitation and ambient temperature on neurological outcome after cardiac arrest: A nationwide observational cohort study
DOI: https://doi.org/10.1016/j.resuscitation.2021.05.008
[2021] Abstract 14580: Methodological Challenges Conducting In Vitro Ischemia and Reperfusion: A Fundamental Problem in Cell Viability Determination
DOI: https://doi.org/10.1161/circ.144.suppl_2.14580
[2021] Intubated COVID-19 predictive (ICOP) score for early mortality after intubation in patients with COVID-19
DOI: https://doi.org/10.1038/s41598-021-00591-1
[2021] The rCAST score is useful for estimating the neurological prognosis in pediatric patients with post-cardiac arrest syndrome before ICU admission: External validation study using a nationwide prospective registry
DOI: https://doi.org/10.1016/j.resuscitation.2021.09.025

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AI 要約（直近 5 年の研究成果）

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研究成果（60 件）

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