Tadashi Shimizu 研究室

主宰者：Tadashi Shimizu

神戸大学

AI 要約（直近 5 年の研究成果）

清水研究室は、医薬品の安全性と有効性を実臨床データから明らかにすることを主な目標としています。大規模な医療データベースや医療機関における自発報告システムを活用して、様々な治療薬における有害事象の発生パターンや発症時期、患者背景による違いなどを統計的に分析する研究を展開しています。特に、がん治療薬や糖尿病治療薬、眼科用薬など多様な医療用医薬品を対象とし、臨床現場で実際に起きている副作用を網羅的に把握することで、医療安全の向上に貢献しています。また、基礎研究の側面では、既存医薬品の新たな治療応用の可能性を検討しています。脳腫瘍であるグリオブラスト―マに対して、偏頭痛治療薬や精神科用薬など、本来の適応外の医薬品がもつ抗腫瘍効果をin vitro実験系で評価し、標準治療薬との併用効果なども調べています。さらに、薬学教育の充実や医療現場での薬剤師業務の質向上に関わる臨床的研究にも取り組んでおり、医薬品に関する包括的な知見を臨床と基礎の両面から構築する研究室です。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（59 件）

[2026] Severe anemia as a risk factor in Japanese patients with ovarian cancer receiving olaparib: a retrospective study
DOI: https://doi.org/10.1186/s12885-026-16148-2
[2026] Cardiovascular Adverse Events Associated With Carfilzomib, Bortezomib, and Ixazomib: A Disproportionality Analysis Using the Japanese Adverse Drug Event Report Database With Anticancer Agents as the Reference Group
DOI: https://doi.org/10.21873/invivo.14257
[2026] Drug-induced Aseptic Meningitis: Pharmacovigilance Analysis of Japanese Adverse Event Reporting Database
DOI: https://doi.org/10.21873/invivo.14277
[2026] Analysis of the Adverse Event Profiles of Medications for Alcohol Use Disorder: Insights from a Japanese Pharmacovigilance Database
DOI: https://doi.org/10.1007/s11469-026-01638-y
[2026] Impact of sodium-glucose cotransporter 2 (SGLT2) inhibitors on hematologic malignancy risk: Insights from Japanese claims data
DOI: https://doi.org/10.1093/jnci/djag038
[2025] Analysis of Esophageal Ulcers Using the Japanese Adverse Drug Event Report Database
DOI: https://doi.org/10.1097/mcg.0000000000002212
[2025] Effects of Azelastine on Glioblastoma Cells
DOI: https://doi.org/10.21873/anticanres.17645
[2025] Disproportionality analysis of cardiac adverse events associated with sorafenib using Spontaneous Reporting Database in Japanese
DOI: https://doi.org/10.31083/ph.2025.4624
[2025] Adverse events of antibody-drug conjugates: comparative analysis of agents with a common payload using the adverse event spontaneous reporting database
DOI: https://doi.org/10.1093/oncolo/oyaf298
[2025] Disproportionality Analysis of Intravitreal Ranibizumab, Aflibercept, and Brolucizumab for Cardiovascular and Cerebrovascular Events
DOI: https://doi.org/10.1002/jcph.70094

続きを表示（残り 49 件）

[2025] Comprehensive Analysis of Proteinuria and Nephrotic Syndrome Using the Japanese Adverse Drug Event Reporting Database
DOI: https://doi.org/10.21873/invivo.14002
[2024] Evaluation of time-to-onset and outcome of cardiac adverse events related to pembrolizumab using post-marketing surveillance in Japanese patients
DOI: https://doi.org/10.1007/s40199-024-00516-z
[2024] Hyperfine couplings between the paramagnetic moment and nuclei in the metallic phase of low silica X zeolite loaded with potassium
DOI: https://doi.org/10.1039/d4dt00599f
[2024] Evaluation of Lung Adverse Events Associated With Lenvatinib: A Post-marketing Surveillance Study
DOI: https://doi.org/10.21873/invivo.13834
[2024] Evaluation of Times-to-onset and Outcomes of Lung Adverse Events Associated With Sorafenib Using JADER
DOI: https://doi.org/10.21873/invivo.13836
[2024] Disproportionality Analysis of Hepatotoxic and Gastrointestinal Adverse Events Associated With Nintedanib Using the Japanese Adverse Drug Event Report (JADER) Database
DOI: https://doi.org/10.21873/invivo.13841
[2024] 788P Analyses of long-term safety and blood levels of daratumumab in patients with multiple myeloma after switching from intravenous to subcutaneous administration
DOI: https://doi.org/10.1016/j.annonc.2024.10.818
[2024] Disproportionality analysis of cardiac adverse events associated with lenvatinib using the Japanese Adverse Drug Event Report database
DOI: https://doi.org/10.1111/bcp.16237
[2024] Slow dynamics observed on highly shifted spectral component of $${^{23}}$$Na NMR in low silica X zeolite loaded with potassium for saturating level
DOI: https://doi.org/10.1007/s10751-024-02040-7
[2024] Effects of Lomerizine and Its Metabolite on Glioblastoma Cells
DOI: https://doi.org/10.21873/anticanres.17106
[2024] Evaluation of a Novel Medication Follow-Up Support Sheet Administered to Patients with Diabetes by Community Pharmacists
DOI: https://doi.org/10.5649/jjphcs.50.248
[2024] Disproportionality Analysis of Stomatitis Associated with Anticancer Drugs Using the Japanese Adverse Drug Event Report Database
DOI: https://doi.org/10.1159/000535331
[2023] Cardiac Adverse Events Associated with Multiple Myeloma Patients Treated with Proteasome Inhibitors
DOI: https://doi.org/10.1159/000529341
[2023] Safety and blood levels of daratumumab after switching from intravenous to subcutaneous administration in patients with multiple myeloma
DOI: https://doi.org/10.1007/s10637-023-01392-1
[2023] Solution and solid‐state 33S NMR studies of 33S‐labeled taurine
DOI: https://doi.org/10.1002/mrc.5387
[2023] Evaluation of lung adverse events with nivolumab using the spontaneous reporting system in Japan
DOI: https://doi.org/10.1038/s41598-023-35602-w
[2023] Optical Pumping NMR and Optically Induced Nuclear Spin–Spin Couplings in Semiconductors: Double Resonance NMR Experiments under Light Illumination
DOI: https://doi.org/10.7566/jpscp.38.011185
[2023] Effect of Blonanserin on the Proliferation and Migration of Glioblastoma Cells
DOI: https://doi.org/10.31083/ph.2023.1821
[2023] A Survey of Pharmacy Students’ Satisfaction with a Basic Life Support Course and an Exploration of Factors Related to Awareness Change Before and After the Course
DOI: https://doi.org/10.1248/yakushi.22-00194
[2023] Evaluation of Cardiac Adverse Events with Nivolumab Using a Japanese Real-World Database
DOI: https://doi.org/10.1007/s40261-023-01246-x
[2023] New Approach To Understanding the Experimental 133Cs NMR Chemical Shift of Clay Minerals via Machine Learning and DFT-GIPAW Calculations
DOI: https://doi.org/10.1021/acs.jpca.2c08880
[2023] The Influence of the Rapid Increase in the Number of Adverse Event Reports for COVID-19 Vaccine on the Disproportionality Analysis Using JADER
DOI: https://doi.org/10.21873/invivo.13085
[2023] Evaluation of the Time to Onset and Outcome of Lenalidomide-induced Thrombosis and Embolism Using Spontaneous Reporting Database
DOI: https://doi.org/10.21873/invivo.13201
[2023] Assessment of Time-to-onset and Outcome of Lung Adverse Events With Pomalidomide from a Pharmacovigilance Study
DOI: https://doi.org/10.21873/invivo.13168
[2023] Evaluation of Time to Onset and Outcome of Cardiac Adverse Events Associated with Nilotinib using Post-Marketing Surveillance
DOI: https://doi.org/10.1159/000533325
[2023] Evaluation of Cardiac Adverse Events with Ponatinib Using a Spontaneous Reporting Database
DOI: https://doi.org/10.1159/000529768
[2023] Evaluation of Time to Onset and Outcome of Lung Adverse Events Related to Pembrolizumab Using Marketing Surveillance
DOI: https://doi.org/10.1159/000533302
[2023] Adverse Event Profile of Azacitidine: Analysis by Route of Administration Using Japanese Pharmacovigilance Database
DOI: https://doi.org/10.1159/000531390
[2022] Evaluation of Lung Toxicity With Lenalidomide Using the Pharmacovigilance Database
DOI: https://doi.org/10.21873/anticanres.16101
[2022] Evaluation of lung adverse events with trastuzumab using the Japanese pharmacovigilance database
DOI: https://doi.org/10.1007/s12032-022-01805-w
[2022] Evaluation of lung toxicity with bevacizumab using the spontaneous reporting database
DOI: https://doi.org/10.1038/s41598-022-19887-x
[2022] Evaluation of Durvalumab-induced Lung Toxicity Using a Spontaneous Reporting Database
DOI: https://doi.org/10.21873/anticanres.15844
[2022] Isolated bursal-side infraspinatus tear diagnosed by computed tomography bursography: a case series
DOI: https://doi.org/10.1186/s13256-022-03472-x
[2022] Comprehensive Analysis of Adverse Events Induced by PARP Inhibitors Using JADER and Time to Onset
DOI: https://doi.org/10.3390/life12091355
[2022] Evaluation of Lung Toxicity Related to the Treatment With Alectinib Using a Pharmacovigilance Database
DOI: https://doi.org/10.21873/anticanres.15799
[2022] Optically induced nuclear spin–spin couplings in GaAs manifested by spin echo decays under optical pumping
DOI: https://doi.org/10.1038/s41534-022-00571-x
[2022] Elucidating the Atomic Structures of the Gel Layer Formed during Aluminoborosilicate Glass Dissolution: An Integrated Experimental and Simulation Study
DOI: https://doi.org/10.1021/acs.jpcc.1c10463
[2022] Time to Onset of Bendamustine-associated Skin Damage Using the Spontaneous Reporting System
DOI: https://doi.org/10.21873/anticanres.15752
[2022] Influence of the Pore Structure of Molybdic Acid Immobilized Silica-alumina Hollow Spheres on Acid-promoted Hydrogen Evolution from Ammonia Borane
DOI: https://doi.org/10.3775/jie.101.76
[2022] Enhancing Radio-frequency Pulses Using a Field Shielding Device in a Solid-state NMR Sample Tube
DOI: https://doi.org/10.1246/cl.220049
[2022] Comprehensive analysis of everolimus‐induced adverse events using the Japanese real‐world database
DOI: https://doi.org/10.1111/jcpt.13648
[2022] Comprehensive Analysis of Ixazomib-Induced Adverse Events Using the Japanese Pharmacovigilance Database
DOI: https://doi.org/10.1159/000524806
[2021] Survival Rate and Shunt Infection Incidence Following Gastrostomy in Adult Patients with an Existing Ventriculoperitoneal Shunt
DOI: https://doi.org/10.2176/nmc.oa.2021-0165
[2021] Comprehensive Analysis of Bortezomib-Induced Adverse Events Using the Japanese Real-World Database
DOI: https://doi.org/10.1159/000521448
[2021] Evaluation of Cardiac Adverse Events Associated with Carfilzomib Using a Japanese Real-World Database
DOI: https://doi.org/10.1159/000519687
[2021] Disposable Nitric Oxide Generator Based on a Structurally Deformed Nitrite-Type Layered Double Hydroxide
DOI: https://doi.org/10.1021/acs.inorgchem.1c00456
[2021] High-Temperature Pulsed-Field-Gradient 7Li-NMR Measurements of Li2CO3 over 700 K
DOI: https://doi.org/10.2116/analsci.21a001
[2021] Quaternary Wurtzitic Nitrides (1 – x)ZnGeN2–2xGaN (x = 0.02, 0.05): Disorder-Induced Band-Gap Narrowing and Potentiality as a Solar-Active Photocatalyst
DOI: https://doi.org/10.1021/acs.inorgchem.0c02894
[2021] Measurement of Blood Methadone Concentration and Investigation of the Possibility of Early Effect Assessment in Japanese Patients with Cancer Pain
DOI: https://doi.org/10.2512/jspm.16.231

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AI 要約（直近 5 年の研究成果）

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関連研究室(8 件)

研究成果（59 件）

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