Masashi Akiyama 研究室
主宰者：Masashi Akiyama
名古屋大学
AI 要約（直近 5 年の研究成果）
秋山 雅志研究室は、皮膚疾患とそれに関連する全身疾患の診断と治療に関する研究を行っています。特に遺伝性皮膚疾患や自己免疫関連疾患に着目し、臨床観察と分子生物学的な解析を組み合わせたアプローチで研究を進めています。例えば、生まれつき皮膚のバリア機能に異常を来す疾患や、膠原病に伴う筋肉萎縮などについて、その発症メカニズムを明らかにする研究を数多く報告しています。
研究室の大きな特徴は、患者の血液や組織を調べることで、特定のタンパク質に対する自己抗体を検出する新しい診断法の開発に力を入れていることです。これまで見落とされていた自己免疫疾患の患者を正確に診断することで、より適切な治療につながる可能性があります。同時に、皮膚病の遺伝的背景を解析し、遺伝子異常がどのように皮膚機能の障害を招くのかを調べる研究も行っています。さらに、免疫チェックポイント阻害薬などの新しい治療法における副作用の実態調査や、難治性皮膚疾患の患者の生活への影響を評価する臨床研究も展開しており、基礎的な知見を臨床診療の向上に活かす姿勢が貫かれています。
※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。
外部リンク
関連研究室(8 件)
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研究成果（100 件）
- Three‐Year Follow‐Up of the PACI Randomized Controlled Trial (PACI‐ON): Effects of Early Intervention for Atopic Dermatitis on Atopic MarchDOI: https://doi.org/10.1111/all.70262
- Cutaneous Lesions and Lung Squamous Cell Carcinoma Both Successfully Controlled With Chemoradiotherapy in a Patient With Cancer‐Associated Clinically Amyopathic Dermatomyositis With Anti‐Nuclear Matrix Protein 2 AntibodiesDOI: https://doi.org/10.1111/1346-8138.70281
- Paraspinal Muscle Atrophy on Chest <scp>CT</scp> as a Prognostic Marker for Anti‐Aminoacyl‐ <scp>tRNA</scp> Synthetase Antibody‐Positive MyositisDOI: https://doi.org/10.1111/1346-8138.70305
- Novel Heterozygous Hypomorphic <i>MPO</i> Variant Identified in Impetigo HerpetiformisDOI: https://doi.org/10.1111/1346-8138.70226
- DOI: https://doi.org/10.3803/enm.2024.2180
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- Conradi-Hünermann-Happle syndrome with adult onset of typical erythemaDOI: https://doi.org/10.1684/ejd.2025.4879
- Intrafamilial/interfamilial heterogeneity in hereditary hemorrhagic telangiectasia subtype 2 due to ACVRL1 variantsDOI: https://doi.org/10.4103/ds.ds-d-24-00127
- The origin of hydroxy-cyclohexenone fatty acids from skin barrier protein and relevance to covalent binding of ceramidesDOI: https://doi.org/10.1016/j.jlr.2025.100843
- Susceptibility to Dermatophytosis in <scp> <i>SDR9C7</i> </scp> ‐Nonsyndromic Epidermal Differentiation Disorder: Observation of Cutaneous Inflammation Involving <scp>IRF4</scp> and <scp>IL</scp> ‐17DOI: https://doi.org/10.1111/1346-8138.70048
続きを表示（残り 90 件）閉じる
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- Expanding the relevance of anti-Ki/SL beyond systemic lupus erythematosus to systemic sclerosis and dermatomyositis in in-house enzyme-linked immunosorbent assay analysesDOI: https://doi.org/10.1093/ced/llaf166
- Immune‐Mediated Necrotizing Myopathy Overlapping With Anti‐ <scp>RuvBL1</scp> /2 Antibody‐Positive Systemic SclerosisDOI: https://doi.org/10.1111/1346-8138.70057
- Thymoma-associated graft-versus-host disease-like skin eruptions: a case series and reviewDOI: https://doi.org/10.1093/ced/llaf297
- Second‐hit somatic variant in a basal cell carcinoma of a basal cell nevus syndrome patient with a germline <i>SUFU</i> variantDOI: https://doi.org/10.1111/ddg.15940
- Safety and efficacy of retreatment with immune checkpoint inhibitors after severe immune-related adverse eventsDOI: https://doi.org/10.1093/oncolo/oyaf120
- Management of congenital ichthyoses: guidelines of care: Part two: 2024 updateDOI: https://doi.org/10.1093/bjd/ljaf077
- [2025] 非症候群性表皮分化異常症：病因に基づく治療への新分類Nonsyndromic epidermal differentiation disorders: a new classification toward pathogenesis-based therapyDOI: https://doi.org/10.1093/bjd/ljaf154
- Proposing an immune-inclusive lens to the new epidermal differentiation disorders classification: reply from authorsDOI: https://doi.org/10.1093/bjd/ljaf188
- The First Reported Japanese Case of <i>PNPLA1</i>‐Nonsyndromic Epidermal Differentiation Disorder (<i>PNPLA1</i>‐<scp>nEDD</scp>) Associated With an Unreported 92‐Base‐Pair Duplication VariantDOI: https://doi.org/10.1111/exd.70130
- DOI: https://doi.org/10.1093/bjd/ljaf111
- DOI: https://doi.org/10.1093/bjd/ljaf054
- 273 Broadening the phenotypic spectrum of ABCA12-related nonsyndromic epidermal differentiation disorder (nEDD)DOI: https://doi.org/10.1016/j.jid.2025.10.281
- DOI: https://doi.org/10.1684/ejd.2025.4837
- DOI: https://doi.org/10.2340/actadv.v105.41072
- Comment on ‘A proposal for a new pathogenesis-guided classification for inherited epidermal differentiation disorders’: reply from authorsDOI: https://doi.org/10.1093/bjd/ljaf162
- Prevalence of FOXA1 and ERBB2 activating mutations in extramammary Paget’s disease: A retrospective multicenter analysis of 99 cases from Japanese and Taiwanese cohortsDOI: https://doi.org/10.1016/j.jdermsci.2025.08.001
- Novel serum autoantibodies against alpha thalassemia/mental retardation syndrome X-linked, a component of promyelocytic leukaemia nuclear bodies, in dermatomyositisDOI: https://doi.org/10.1093/rheumatology/keaf596
- Polyarteritis nodosa with cutaneous manifestations localized to the upper limb, possibly caused by traumaDOI: https://doi.org/10.1684/ejd.2025.4913
- 418 Low-temperature plasma-activated Ringer’s lactate solution has an anti-cancer effect on malignant melanoma cells by downregulating heat shock proteins and mitochondrial dysfunctionDOI: https://doi.org/10.1016/j.jid.2025.10.427
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- DOI: https://doi.org/10.1016/j.jid.2024.04.036
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- [2023] IchthyosisDOI: https://doi.org/10.5281/zenodo.8347771
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- [2022] UVB-Induced Skin Autoinflammation Due to Nlrp1b Mutation and Its Inhibition by Anti-IL-1β AntibodyDOI: https://doi.org/10.3389/fimmu.2022.876390
- DOI: https://doi.org/10.1038/s41389-022-00403-9
- DOI: https://doi.org/10.1111/1346-8138.16563
- DOI: https://doi.org/10.1038/s41598-022-16449-z
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- DOI: https://doi.org/10.1016/j.thromres.2022.09.005
- DOI: https://doi.org/10.2336/nishinihonhifu.84.418
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