Kentaro Semba 研究室

主宰者：Kentaro Semba

早稲田大学

AI 要約（直近 5 年の研究成果）

本研究室は、乳がんをはじめとする悪性腫瘍の発生・進展・転移のメカニズムを、分子レベルから個体レベルまで多角的に解明することを目指しています。特に、乳がんの骨転移、脳転移、肺転移といった臓器特異的な転移現象に着目し、腫瘍細胞の増殖や運動能力、さらには転移先の環境との相互作用に関わる遺伝子・タンパク質の役割を調べています。研究対象には、転写因子やシグナル伝達分子、免疫関連因子など多様な分子が含まれます。研究手法としては、複数の乳がん細胞株を用いた培養実験と、これらの細胞を動物モデルに移植する in vivo 実験を組み合わせています。さらに、RNA解析やゲノム解析といった網羅的な分子解析により、腫瘍細胞や周囲の正常組織における遺伝子発現パターンを詳細に調べています。また、高スループット・スクリーニング系を用いて、がん細胞の増殖を阻害する化合物の探索も行っており、基礎研究から治療開発への応用を視野に入れた研究展開をしています。これまでの研究から、特定の転写因子の活性化や、腫瘍細胞と免疫細胞の相互作用が、転移の促進に重要な役割を果たすことが明らかになっています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

外部リンク

研究成果（32 件）

[2025] Tob negatively regulates NF-κB activation in breast cancer through its association with the TNF receptor complex
DOI: https://doi.org/10.1038/s41417-025-00897-6
[2025] Preclinical Prediction of Resistance Mutations and Proposal of Sequential Treatment Strategies for ALK-positive Lung Cancer Using Next-generation ALK Inhibitors
DOI: https://doi.org/10.1007/s11095-025-03916-1
[2025] Supplementary Figure 8 from Targeting c-Jun Is a Potential Therapy for Luminal Breast Cancer Bone Metastasis
DOI: https://doi.org/10.1158/1541-7786.30732314
[2025] Gene signatures associated with brain-topical proliferative activity in breast cancer
DOI: https://doi.org/10.1016/j.bbrc.2025.152127
[2025] Supplementary Figure 4 from Targeting c-Jun Is a Potential Therapy for Luminal Breast Cancer Bone Metastasis
DOI: https://doi.org/10.1158/1541-7786.30732329
[2025] Supplementary Figure 1 from Targeting c-Jun Is a Potential Therapy for Luminal Breast Cancer Bone Metastasis
DOI: https://doi.org/10.1158/1541-7786.30732338
[2025] Supplementary Figure 2 from Targeting c-Jun Is a Potential Therapy for Luminal Breast Cancer Bone Metastasis
DOI: https://doi.org/10.1158/1541-7786.30732335
[2025] Supplementary Figure 5 from Targeting c-Jun Is a Potential Therapy for Luminal Breast Cancer Bone Metastasis
DOI: https://doi.org/10.1158/1541-7786.30732326
[2025] Supplementary Figure 3 from Targeting c-Jun Is a Potential Therapy for Luminal Breast Cancer Bone Metastasis
DOI: https://doi.org/10.1158/1541-7786.30732332
[2025] Supplementary Figure 6 from Targeting c-Jun Is a Potential Therapy for Luminal Breast Cancer Bone Metastasis
DOI: https://doi.org/10.1158/1541-7786.30732323

続きを表示（残り 22 件）

[2025] <scp>TIE1</scp> Promotes Primary Tumor Growth by Inhibiting Apoptosis and Activating the <scp>AKT</scp> ‐ <scp>p70S6K</scp> Signaling Pathway in Breast Cancer
DOI: https://doi.org/10.1111/gtc.70062
[2024] Identification of a novel RNA transcript TISPL upregulated by stressors that stimulate ATF4
DOI: https://doi.org/10.1016/j.gene.2024.148464
[2024] Analysis of the responsiveness to antiandrogens in multiple breast cancer cell lines
DOI: https://doi.org/10.1111/gtc.13105
[2024] Nuclear receptor profiling for subtype classification and as prognostic markers in 33 cancer types
DOI: https://doi.org/10.1007/s12672-024-01732-4
[2023] Metastatic potentials classified with hypoxia‐inducible factor 1 downstream genes in pan‐cancer cell lines
DOI: https://doi.org/10.1111/gtc.13092
[2023] Collagen induction of immune cells in the mammary glands during pregnancy
DOI: https://doi.org/10.1152/physiolgenomics.00098.2023
[2023] <scp><i>HOXB7</i></scp> induces <scp>STAT3</scp>‐mediated transformation and lung metastasis in immortalized mammary gland <scp>NMuMG</scp> cells
DOI: https://doi.org/10.1111/gtc.13009
[2023] Tyrosine Kinase Inhibitor Profiling Using Multiple Forskolin-Responsive Reporter Cells
DOI: https://doi.org/10.3390/ijms241813863
[2023] Identification of antimycin A as a c-Myc degradation accelerator via high-throughput screening
DOI: https://doi.org/10.1016/j.jbc.2023.105083
[2023] Targeting c-Jun Is a Potential Therapy for Luminal Breast Cancer Bone Metastasis
DOI: https://doi.org/10.1158/1541-7786.mcr-22-0695
[2023] Effect of lonidamine derivatives on the inhibition of transformed cell area expansion
DOI: https://doi.org/10.1016/j.bbrep.2023.101480
[2023] Aberrant accumulation of NIK promotes tumor growth by dysregulating translation and post-translational modifications in breast cancer
DOI: https://doi.org/10.1186/s12935-023-02904-y
[2023] Identification of microbial metabolites that accelerate the ubiquitin-dependent degradation of c-Myc
DOI: https://doi.org/10.32604/or.2023.030248
[2022] Lonidamine and domperidone inhibit expansion of transformed cell areas by modulating motility of surrounding nontransformed cells
DOI: https://doi.org/10.1016/j.jbc.2022.102635
[2022] Prediction of Resistance Mutations Against Upcoming Anaplastic Lymphoma Kinase Inhibitors
DOI: https://doi.org/10.1007/s11523-022-00919-5
[2022] Isolation of Reporter Cells That Respond to Vitamin A and/or D Using a piggyBac Transposon Promoter-Trapping Vector System
DOI: https://doi.org/10.3390/ijms23169366
[2022] Metalloproteinase-Dependent and TMPRSS2-Independent Cell Surface Entry Pathway of SARS-CoV-2 Requires the Furin Cleavage Site and the S2 Domain of Spike Protein
DOI: https://doi.org/10.1128/mbio.00519-22
[2022] Identification of two cancer stem cell-like populations in triple-negative breast cancer xenografts
DOI: https://doi.org/10.1242/dmm.049538
[2022] Metastatic profiling of HER2-positive breast cancer cell lines in xenograft models
DOI: https://doi.org/10.1007/s10585-022-10150-1
[2021] Epithelial cells remove precancerous cells by cell competition via MHC class I–LILRB3 interaction
DOI: https://doi.org/10.1038/s41590-021-01045-6
[2021] A screening system for identifying interacting proteins using biomolecular fluorescence complementation and transposon gene trap
DOI: https://doi.org/10.1371/journal.pone.0251240
[2021] Establishment of reporter cells that respond to glucocorticoids by a transposon-mediated promoter-trapping system
DOI: https://doi.org/10.1016/j.ejps.2021.105819

科研費（0 件）

まだデータがありません（KAKEN 取り込み後に表示）。

所属学会・役職（0 件）

まだデータがありません（学会データ連携後に表示）。

AI 要約（直近 5 年の研究成果）

外部リンク

関連研究室(8 件)

研究成果（32 件）

科研費（0 件）

所属学会・役職（0 件）