Yoshiro Maezawa 研究室

主宰者：Yoshiro Maezawa

千葉大学

AI 要約（直近 5 年の研究成果）

前田町研究室は、加齢関連疾患とその基礎機序を解明する研究に取り組んでいます。特にウェルナー症候群という遺伝性の早期老化疾患を中心的な研究対象としており、この疾患の患者では細胞内のエネルギー代謝物質であるNAD+が低下していることに着目しています。研究室では、この物質の補充による治療効果を臨床試験で検証するほか、細胞培養系やマウスモデルを用いてNAD+低下と細胞機能障害の関係を調べています。同時に、糖尿病やその合併症の発症メカニズムも重要な研究テーマです。特に最近承認された薬剤「SGLT2阻害薬」という糖尿病治療薬に注目し、この薬が糖尿病網膜症や腎障害の進行を抑える仕組みを、動物実験や臨床データ分析によって明らかにしようとしています。さらに、脂質異常症や肥満に伴う炎症反応、細胞老化と関連する遺伝子発現の変化なども調査しており、代謝疾患全般における加齢や炎症のプロセスを包括的に理解することを目指しています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（60 件）

[2026] Successful Long-Term Remission of Hyperchylomicronemia Caused by GPIHBP1 Autoantibodies: with Insights into Antibody Epitope Effects
DOI: https://doi.org/10.1016/j.jacl.2026.06.009
[2026] Ocular Manifestations in Patients with Werner Syndrome
DOI: https://doi.org/10.3390/ijms27073187
[2025] Efficacy and safety of <scp>SGLT2</scp> inhibitor on insulin resistance and hyperglycemia in Werner syndrome—A case report
DOI: https://doi.org/10.1111/jdi.70203
[2025] Little Evidence of Atherosclerosis in a Middle-Aged Japanese Woman with Familial Hypercholesterolemia Carrying PCSK9 (p.Glu32Lys) and ABCG8 (p.Ile419Asn) Variants Despite Elevated Lipoprotein(a) Levels
DOI: https://doi.org/10.2169/internalmedicine.6559-25
[2025] Short-Term Treatment for Immune-Mediated Acquired Lecithin–Cholesterol Acyltransferase Deficiency Restores the High-Density Lipoprotein Function: A Case Report
DOI: https://doi.org/10.5551/jat.65784
[2025] Tcf21 modulates fibroblast activation and promotes cardiac fibrosis after injury via Pdgfrb signaling
DOI: https://doi.org/10.1038/s41598-025-13102-3
[2025] Concerted Actions of FoxO1 and PPARα in Hepatic Gene Expression and Metabolic Adaptation
DOI: https://doi.org/10.2337/db24-1173
[2025] Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double‐Blind Randomized Crossover Placebo‐Controlled Trial
DOI: https://doi.org/10.1111/acel.70093
[2025] Decreased mitochondrial NAD+ in WRN deficient cells links to dysfunctional proliferation
DOI: https://doi.org/10.18632/aging.206236
[2024] Sodium‐glucose co‐transporter 2 inhibitor therapy reduces the administration frequency of anti‐vascular endothelial growth factor agents in patients with diabetic macular oedema with a history of anti‐vascular endothelial growth factor agent use: A cohort study using the Japanese health insurance claims database
DOI: https://doi.org/10.1111/dom.15454

続きを表示（残り 50 件）

[2024] Predictive risk factors for early-stage renal dysfunction: An analysis of specific health checkup data for the general Japanese population
DOI: https://doi.org/10.1016/j.numecd.2024.103813
[2024] Less frequent skin ulcers among patients with Werner syndrome treated with pioglitazone: findings from the Japanese Werner Syndrome Registry
DOI: https://doi.org/10.18632/aging.206161
[2024] 163P A comparison of the dietary intake after surgery in gastric cancer patients between laparoscopic-assisted and conventional gastrectomy
DOI: https://doi.org/10.1016/j.annonc.2024.10.187
[2024] Insulinoma with suspected mutant somatostatin receptor expression according to histological examination
DOI: https://doi.org/10.1002/ccr3.9390
[2024] Novel pathogenic variant in the LCAT gene in a compound heterozygous patient with fish-eye disease and a mild phenotype
DOI: https://doi.org/10.1016/j.jacl.2024.09.013
[2024] Dapagliflozin Attenuates Tubular Injury and Ferroptosis after AKI in Diabetic and Nondiabetic Mice
DOI: https://doi.org/10.1681/asn.2024vsfhwkwp
[2024] Hypoalbuminemia on admission in diabetic patients correlates with severity of illness in COVID-19: A retrospective clinical study and literature review
DOI: https://doi.org/10.1016/j.endmts.2024.100196
[2024] A Japanese Case of Familial Hypercholesterolemia with a Protein-truncating Variant in LDLR and a PCSK9 Variant without Significant Atherosclerosis but Showing Remarkable Achilles Tendon Thickening
DOI: https://doi.org/10.2169/internalmedicine.2726-23
[2024] Sodium–glucose cotransporter 2 inhibitor therapy reduces the administration frequency of steroid injection in patients with diabetic macular edema: A cohort study using the Japanese health insurance claims database
DOI: https://doi.org/10.1111/jdi.14253
[2024] Retrotransposons in Werner syndrome-derived macrophages trigger type I interferon-dependent inflammation in an atherosclerosis model
DOI: https://doi.org/10.1038/s41467-024-48663-w
[2024] Real-time imaging of human endothelial-to-hematopoietic transition in vitro using pluripotent stem cell derived hemogenic endothelium
DOI: https://doi.org/10.2142/biophysico.bppb-v21.s015
[2023] Senescence-associated inflammation and inhibition of adipogenesis in subcutaneous fat in Werner syndrome
DOI: https://doi.org/10.18632/aging.205078
[2023] Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2022
DOI: https://doi.org/10.5551/jat.gl2022
[2023] Sex differences in symptom presentation and their impact on diagnostic accuracy in <scp>Werner</scp> syndrome
DOI: https://doi.org/10.1111/ggi.14752
[2023] Metabolomic analysis of serum samples from a clinical study on ipragliflozin and metformin treatment in Japanese patients with type 2 diabetes: Exploring human metabolites associated with visceral fat reduction
DOI: https://doi.org/10.1002/phar.2884
[2023] <scp>Imeglimin‐mediated</scp> glycemic control in maternally inherited deafness and diabetes
DOI: https://doi.org/10.1111/jdi.14085
[2023] Updates on dyslipidemia in patients with diabetes
DOI: https://doi.org/10.1111/jdi.14042
[2023] Weight loss improves inflammation by T helper 17 cells in an obese patient with psoriasis at high risk for cardiovascular events
DOI: https://doi.org/10.1111/jdi.14037
[2023] Insulin Sensitivity Initially Worsens but Later Improves With Aging in Male C57BL/6N Mice
DOI: https://doi.org/10.1093/gerona/glad126
[2023] Renal dysfunction, malignant neoplasms, atherosclerotic cardiovascular diseases, and sarcopenia as key outcomes observed in a three-year follow-up study using the Werner Syndrome Registry
DOI: https://doi.org/10.18632/aging.204681
[2023] Identification of Novel Senescent Markers in Small Extracellular Vesicles
DOI: https://doi.org/10.3390/ijms24032421
[2023] Quality of life in Werner syndrome and associated subjective foot/ankle symptoms: A cross‐sectional survey
DOI: https://doi.org/10.1111/ggi.14541
[2022] RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells
DOI: https://doi.org/10.1038/s42003-022-04369-7
[2022] Optical coherence tomography findings in three patients with Werner syndrome
DOI: https://doi.org/10.1186/s12886-022-02660-z
[2022] First-in-human autologous implantation of genetically modified adipocytes expressing LCAT for the treatment of familial LCAT deficiency
DOI: https://doi.org/10.1016/j.heliyon.2022.e11271
[2022] Role of Cellular Senescence and Epigenetic Drift in Interstitial Fibrosis of Diabetic Kidney Disease
DOI: https://doi.org/10.1681/asn.20223311s1111b
[2022] Homozygous familial lipoprotein lipase deficiency without obvious coronary artery stenosis
DOI: https://doi.org/10.1016/j.clinbiochem.2022.07.001
[2022] LCAT-trial-24 weeks: Protocol for a clinical study to evaluate the safety of regenerative medicine and gene therapy by the autologous transplantation of human lecithin:cholesterol acyltransferase gene-transduced human pre-adipocytes
DOI: https://doi.org/10.1016/j.conctc.2022.100946
[2022] Semaphorin 3G exacerbates joint inflammation through the accumulation and proliferation of macrophages in the synovium
DOI: https://doi.org/10.1186/s13075-022-02817-7
[2022] Predictive model and risk engine web application for surgical site infection risk in perioperative patients with type 2 diabetes
DOI: https://doi.org/10.1007/s13340-022-00587-w
[2022] Targeted long-read sequencing identifies missing pathogenic variants in unsolved Werner syndrome cases
DOI: https://doi.org/10.1136/jmedgenet-2022-108485
[2022] Stromal Transcription Factor 21 Regulates Development of the Renal Stroma via Interaction with Wnt/β-Catenin Signaling
DOI: https://doi.org/10.34067/kid.0005572021
[2022] Correction of Hypercortisolemia with an Improved Cognitive Function and Muscle Mass after Transsphenoidal Surgery in an Older Patient with Cushing's Disease
DOI: https://doi.org/10.2169/internalmedicine.8326-21
[2022] A high prevalence of myeloid malignancies in progeria with Werner syndrome is associated with p53 insufficiency
DOI: https://doi.org/10.1016/j.exphem.2022.02.005
[2022] Rothmund‐Thomson syndrome investigated by two nationwide surveys in Japan
DOI: https://doi.org/10.1111/ped.15120
[2021] Calcification in Werner syndrome associated with lymphatic vessels aging
DOI: https://doi.org/10.18632/aging.203789
[2021] Stromal Transcription Factor 21 Is Critical for Development of the Interstitium and Nephron Progenitor Cells via Interaction with Wnt/β-Catenin Signaling
DOI: https://doi.org/10.1681/asn.20213210s1227c
[2021] Serum anti-AP3D1 antibodies are risk factors for acute ischemic stroke related with atherosclerosis
DOI: https://doi.org/10.1038/s41598-021-92786-9
[2021] Serum anti-DIDO1, anti-CPSF2, and anti-FOXJ2 antibodies as predictive risk markers for acute ischemic stroke
DOI: https://doi.org/10.1186/s12916-021-02001-9
[2021] Suppressor of cytokine signalling 3 (SOCS3) expressed in podocytes attenuates glomerulonephritis and suppresses autoantibody production in an imiquimod-induced lupus model
DOI: https://doi.org/10.1136/lupus-2020-000426
[2021] Generation of disease-specific and CRISPR/Cas9-mediated gene-corrected iPS cells from a patient with adult progeria Werner syndrome
DOI: https://doi.org/10.1016/j.scr.2021.102360
[2021] Central administration of sodium-glucose cotransporter-2 inhibitors increases food intake involving adenosine monophosphate-activated protein kinase phosphorylation in the lateral hypothalamus in healthy rats
DOI: https://doi.org/10.1136/bmjdrc-2020-002104
[2021] Effects of Sodium Glucose Co-Transporter 2 Inhibitors in Type 1 Diabetes Mellitus on Body Composition and Glucose Variabilities: Single-Arm, Exploratory Trial
DOI: https://doi.org/10.1007/s13300-021-01047-5
[2021] Fibroblasts from different body parts exhibit distinct phenotypes in adult progeria Werner syndrome
DOI: https://doi.org/10.18632/aging.202696
[2021] A novel podocyte protein, R3h domain containing-like, inhibits TGF-β-induced p38 MAPK and regulates the structure of podocytes and glomerular basement membrane
DOI: https://doi.org/10.1007/s00109-021-02050-w
[2021] Management guideline for Werner syndrome 2020. 5. Infection associated with Werner syndrome
[2021] Management guideline for Werner syndrome 2020. 4. Osteoporosis associated with Werner syndrome
[2021] Management guideline for Werner syndrome 2020. 6. Skin ulcers associated with Werner syndrome: Prevention and non-surgical and surgical treatment
[2021] First-in-Human Autologous Implantation of Genetically Modified Adipocytes Expressing LCAT for the Treatment of Familial LCAT Deficiency
DOI: https://doi.org/10.2139/ssrn.3915012
[2021] First-in-Human Autologous Implantation of Genetically Modified Adipocytes Expressing LCAT for the Treatment of Familial LCAT Deficiency
DOI: https://doi.org/10.2139/ssrn.3948386

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AI 要約（直近 5 年の研究成果）

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