Munetaka Kunishima 研究室

主宰者：Munetaka Kunishima

金沢大学

AI 要約（直近 5 年の研究成果）

国島研究室は、有機合成化学と生物活性物質の開発を中心に研究を進めています。特に、1,3,5-トリアジン骨格を基盤とした新規な脱水縮合試薬やエポキシ化試薬の開発に力を入れており、これらの試薬を用いてアミド結合やエステル結合の効率的な合成を実現しています。従来の有機溶媒に代わる環境親和的なアプローチも追求しており、水を反応媒体とするペプチド合成法の開発にも取り組んでいます。電子供与性を持つ新規な含窒素官能基の設計・合成も重要なテーマです。複素環アンモニウム構造を組み込んだ「アミドイル」基や「キヌクリジニオアミドイル」基などの開発を通じて、π共役系分子の光学特性を制御しています。これらの分子設計は計算化学による理論的検討と組み合わされ、反応性や吸収特性の予測と最適化に活用されています。さらに同研究室は、開発した化学試薬をがん細胞の増殖制御や肝臓の薬物代謝酵素活性の評価といった生物医学応用へ展開しています。放射性ヨウ素でラベルした化合物を用いた医用画像化プローブの開発や、抗体の部位選択的修飾法の開発など、基礎有機合成と応用生命科学を融合させた研究を行っています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

外部リンク

研究成果（33 件）

[2026] Silicon-Tether Strategy for the Synthesis of Tetraphenylammonium
DOI: https://doi.org/10.26434/chemrxiv.15000294/v1
[2026] Traceless Silicon-Tether Strategy for the Synthesis of a Tetraphenylammonium Salt
DOI: https://doi.org/10.1021/acs.orglett.6c00906
[2026] Silicon-Tether Strategy for the Synthesis of Tetraphenylammonium
DOI: https://doi.org/10.26434/chemrxiv.15000294/v2
[2026] Nanoassembly-enabled aqueous solid-phase peptide synthesis (ASPPS): a practical DMF-free approach based on the Fmoc strategy
DOI: https://doi.org/10.1039/d6ra00715e
[2026] Development of a novel xCT transporter imaging using a radiopharmaceutical with inhibitor-type compounds
DOI: https://doi.org/10.1016/j.nucmedbio.2026.109625
[2025] L-type voltage-dependent calcium channels in the ventromedial orbitofrontal and prefrontal cortices mediate the inhibitory effects of (S)-ketamine but not (R)-ketamine on marble burying in male mice
DOI: https://doi.org/10.1016/j.ejphar.2025.178301
[2025] Effects of the (Trialkyl)ammonium Structures in (Ammonio)amidyl Groups on π-Electron Donating Ability and Thermal Stability: Experimental and Computational Study
DOI: https://doi.org/10.1248/cpb.c25-00260
[2025] L-type voltage-dependent calcium channels in the ventromedial orbitofrontal and prefrontal cortices mediate the inhibitory effects of (S)-ketamine but not (R)-ketamine on marble burying in male mice
DOI: https://doi.org/10.24517/0002003924
[2024] Development of a Purely Isolable (Dimorpholino)triazine-Based Reagent for the Epoxidation of Alkenes
DOI: https://doi.org/10.1055/a-2356-8451
[2024] Drug–drug conjugates of MEK and Akt inhibitors for RAS-mutant cancers
DOI: https://doi.org/10.1016/j.bmc.2024.117674

続きを表示（残り 23 件）

[2024] Carbocationoids, a concept for controlling highly reactive cationic species
DOI: https://doi.org/10.1038/s42004-024-01139-w
[2024] Alkoxy Exchange Strategy for the Synthesis of N,N′-Dimethylated (Alkoxy)triazinediones as Solid Reagents for Acid-Catalyzed O-Alkylation
DOI: https://doi.org/10.1021/acs.joc.4c01406
[2024] Bicyclic-Ammonium-Incorporated Ylidic Nitrogen Groups for Strong π-Electron Donation in Push–Pull Benzene π-Conjugated Systems
DOI: https://doi.org/10.1021/acs.orglett.4c02378
[2024] Phototriggered Generation of Ynol Ethers and Their Rearrangement to Ketenes
DOI: https://doi.org/10.1021/acs.joc.4c00947
[2024] Development of radioiodine-labeled mequitazine for evaluation of hepatic CYP2D activity
DOI: https://doi.org/10.3389/fphar.2024.1397288
[2024] Development of a Triazinyluronium-Based Dehydrative Condensing Reagent with No Heteroatomic Bonds
DOI: https://doi.org/10.1021/acs.joc.4c02075
[2023] Phototriggered Butenolide Formation from a Cyclobutenedione and an Acidic Nucleophile
DOI: https://doi.org/10.1021/acs.orglett.3c04054
[2023] Development of a radiotheranostics agent with albumin binder aiming to increase the therapeutic effects for At-211 labeled RGD peptide
DOI: https://doi.org/10.1016/j.nucmedbio.2023.108793
[2023] Epitope-Based Specific Antibody Modifications
DOI: https://doi.org/10.1021/acs.bioconjchem.3c00340
[2023] The Human Resource Development Policy of the Faculty of Pharmaceutical Sciences at Kanazawa University and Our Initiatives toward Its Realization
DOI: https://doi.org/10.1248/yakushi.23-00083-5
[2022] Discovery of a Novel Aminocyclopropenone Compound That Inhibits BRD4-Driven Nucleoporin NUP210 Expression and Attenuates Colorectal Cancer Growth
DOI: https://doi.org/10.3390/cells11030317
[2022] Hydrophobic‐Substrate‐Selective Dehydrative Condensations at the Emulsion Interface under Conditions where Competitive Reactions Proceed in the Bulk Aqueous Phase
DOI: https://doi.org/10.1002/ajoc.202200602
[2022] 有機化学者としての心得
DOI: https://doi.org/10.5059/yukigoseikyokaishi.80.897
[2022] Measurement of Hepatic CYP3A4 and 2D6 Activity Using Radioiodine-Labeled O-Desmethylvenlafaxine
DOI: https://doi.org/10.3390/ijms231911458
[2022] Ideal Thesis Research and Clinical Training as Pharmaceutical Practice in 6-year Pharmaceutical Education and Study System
DOI: https://doi.org/10.1248/yakushi.22-00004-3
[2022] Synthesis and characterization of tetraphenylammonium salts
DOI: https://doi.org/10.1038/s41467-022-30282-y
[2022] Nucleophilic substitution reactions of unbranched alkyl amines using triazine reagents
DOI: https://doi.org/10.1016/j.tetlet.2022.153692
[2021] A versatile iodo(<scp>iii</scp>)etherification of terminal ethynylsilanes using BF3–OiPr2and alkyl benzyl ethers
DOI: https://doi.org/10.1039/d1ob00479d
[2021] Development of a triazinedione-based dehydrative condensing reagent containing 4-(dimethylamino)pyridine as an acyl transfer catalyst
DOI: https://doi.org/10.1039/d1ob00450f
[2021] Efficiency Enhancement of a Photocatalytic Decarbonylation of an Aminocyclopropenone by Benzothiophene Substitution
DOI: https://doi.org/10.1021/acs.joc.0c02997
[2021] N-Acyltriazinedione; a Novel Acylating Reagent Synthesized from a Triazinone-Type Condensing Reagent
DOI: https://doi.org/10.1248/cpb.c20-00952
[2021] Conjugation of 4-(dimethylamino)pyridine to primary amines in aqueous buffer solutions using an N-hydroxysuccinimide ester reagent
DOI: https://doi.org/10.1016/j.tetlet.2021.153343
[2021] Synthesis of N-Aminated Salts of Aliphatic tert-Amines, (Trialkyl)amidines, and (Pentaalkyl)guanidines by Electrophilic Amination in an Ethereal Solvent
DOI: https://doi.org/10.1248/cpb.c21-00673

科研費（0 件）

まだデータがありません（KAKEN 取り込み後に表示）。

所属学会・役職（0 件）

まだデータがありません（学会データ連携後に表示）。

AI 要約（直近 5 年の研究成果）

外部リンク

関連研究室(8 件)

研究成果（33 件）

科研費（0 件）

所属学会・役職（0 件）