Yoichi Ishitsuka 研究室

主宰者：Yoichi Ishitsuka

熊本大学

AI 要約（直近 5 年の研究成果）

本研究室は、医療における薬物療法の安全性向上と遺伝性疾患の治療法開発に取り組んでいます。医療では複数の薬剤を同時に用いることが多いため、薬同士の相互作用がしばしば問題となります。研究室では、日本の医薬品有害事象報告データベースを活用し、複数の薬剤を併用した場合に予期しない健康被害が生じやすくなるかどうかを統計的に分析しています。これまで、利尿薬と骨粗鬆症治療薬、抗菌薬と利尿薬、抗てんかん薬と医療用ビタミンなど、様々な薬の組み合わせに関する相互作用を検出し、臨床の現場で役立つ情報を提供しています。同時に、生遺伝性疾患のニーマン・ピック病C型に対する治療開発も進めています。この疾患は細胞内にコレステロールが異常蓄積することが原因で、神経変性を引き起こします。研究室では、シクロデキストリンという環状糖類が細胞内のコレステロール輸送を改善できることに着目し、その構造を工夫することで治療効果を高めつつ、聴覚障害などの副作用を低減する新規化合物を開発しています。これらの化合物については、疾患モデルマウスでの有効性評価や、患者への長期投与経過の報告も行っており、実現可能な治療法の実現を目指しています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（36 件）

[2026] Drug-drug interaction signals between carbonic anhydrase inhibitors and vitamin D preparations in urinary tract stones: disproportionality analysis evaluation from Japanese spontaneous reports of adverse events
DOI: https://doi.org/10.1186/s40780-026-00574-2
[2026] Additional file 2 of Drug-drug interaction signals between carbonic anhydrase inhibitors and vitamin D preparations in urinary tract stones: disproportionality analysis evaluation from Japanese spontaneous reports of adverse events
DOI: https://doi.org/10.6084/m9.figshare.32656006
[2026] Additional file 2 of Drug-drug interaction signals between carbonic anhydrase inhibitors and vitamin D preparations in urinary tract stones: disproportionality analysis evaluation from Japanese spontaneous reports of adverse events
DOI: https://doi.org/10.6084/m9.figshare.32656006.v1
[2026] Additional file 1 of Drug-drug interaction signals between carbonic anhydrase inhibitors and vitamin D preparations in urinary tract stones: disproportionality analysis evaluation from Japanese spontaneous reports of adverse events
DOI: https://doi.org/10.6084/m9.figshare.32656003.v1
[2026] Additional file 1 of Drug-drug interaction signals between carbonic anhydrase inhibitors and vitamin D preparations in urinary tract stones: disproportionality analysis evaluation from Japanese spontaneous reports of adverse events
DOI: https://doi.org/10.6084/m9.figshare.32656003
[2026] Effectiveness of pharmacist-led management of candidemia in a tertiary care hospital without a full-time infectious disease specialist
DOI: https://doi.org/10.18999/nagjms.88.2.243
[2026] Molecular and histological characterizations reveal two distinct senescent microglia populations in Niemann–Pick disease type C mouse model
DOI: https://doi.org/10.1007/s11357-026-02244-5
[2026] Spiral ligament dysfunction and endocochlear potential loss drive hearing impairment in Niemann–Pick C1 mice
DOI: https://doi.org/10.1016/j.brainresbull.2026.111846
[2026] Seasonality of drug-related hypoglycemia in Japan: A study using spontaneous reporting system data
DOI: https://doi.org/10.64898/2026.01.08.26343703
[2025] Evaluation of an educational program for community pharmacists involved in pharmacotherapy for patients with impaired renal function: a preliminary study
DOI: https://doi.org/10.1007/s10157-025-02698-5

続きを表示（残り 26 件）

[2025] Effect of 2-Hydroxypropyl-<i>γ</i>-cyclodextrin on Renal Inflammation in Alport Mouse Model
DOI: https://doi.org/10.1248/bpb.b25-00417
[2025] Signal Detection of Drug–Drug Interactions Between Topical Vitamin D3 Analogs and Oral Thiazide Diuretics in Hypercalcemia: Analysis of the Japanese Drug Event Report Database
DOI: https://doi.org/10.1111/1346-8138.17889
[2025] Inability of α-cyclodextrins to accommodate cholesterol potentially underlies their lack of efficacy and ototoxicity in Niemann-Pick disease type C treatment
DOI: https://doi.org/10.1038/s41598-025-15599-0
[2024] Evaluation of a creatinine clearance correction equation based on body fat mass in older Japanese patients with diabetes
DOI: https://doi.org/10.3389/fmed.2024.1228383
[2024] Influence of loop diuretics on denosumab-induced hypocalcaemia in osteoporosis: a retrospective observational analysis
DOI: https://doi.org/10.1186/s40780-024-00380-8
[2024] Efficient breeding system of infertile Niemann–Pick disease type C model mice by in vitro fertilization and embryo transfer
DOI: https://doi.org/10.1177/00236772231194112
[2024] Intracerebroventricular 2-hydroxypropyl-γ-cyclodextrin alleviates hepatic manifestations without distributing to the liver in a murine model of Niemann–Pick disease type C
DOI: https://doi.org/10.1016/j.lfs.2024.122776
[2024] A case of hypophosphatemia and elevated intact fibroblast growth factor 23 levels after short-term saccharated ferric oxide administration in a young woman and database analysis of adverse drug reactions in Japan
DOI: https://doi.org/10.1016/j.bonr.2024.101754
[2024] Long-term efficacy of intrathecal cyclodextrin in patients with Niemann-Pick disease type C
DOI: https://doi.org/10.1016/j.braindev.2024.03.002
[2024] Hyperkalemic effect of drug–drug interaction between esaxerenone and trimethoprim in patients with hypertension: a pilot study
DOI: https://doi.org/10.1186/s40780-024-00366-6
[2024] Factors promoting research activities among Japanese pharmacists: a questionnaire survey
DOI: https://doi.org/10.1038/s41598-024-53454-w
[2023] Drug–drug interaction signals between loop diuretics and teicoplanin during acute kidney injury evaluated using Japanese spontaneous adverse drug event reports
DOI: https://doi.org/10.1038/s41598-023-41095-4
[2023] Different solubilizing ability of cyclodextrin derivatives for cholesterol in Niemann–Pick disease type C treatment
DOI: https://doi.org/10.1002/ctm2.1350
[2023] Fasudil inhibits the expression of C/EBP homologous protein to protect against liver injury in acetaminophen-overdosed mice
DOI: https://doi.org/10.1016/j.bbrc.2023.149166
[2023] A system that delivers an antioxidant to mitochondria for the treatment of drug-induced liver injury
DOI: https://doi.org/10.1038/s41598-023-33893-7
[2022] Fine-tuned cholesterol solubilizer, mono-6-O-α-D-maltosyl-γ-cyclodextrin, ameliorates experimental Niemann–Pick disease type C without hearing loss
DOI: https://doi.org/10.1016/j.biopha.2022.113698
[2022] Cyclodextrins applied to the treatment of lysosomal storage disorders
[2022] Effects of 6-O-α-maltosyl-β cyclodextrin on lipid metabolism in Npc1-deficient Chinese hamster ovary cells
DOI: https://doi.org/10.1016/j.ymgme.2022.09.007
[2022] In-Hospital Prescription Checking System for Hospitalized Patients with Decreased Glomerular Filtration Rate
DOI: https://doi.org/10.34067/kid.0001552022
[2022] Lactose-Appended Hydroxypropyl-β-Cyclodextrin Lowers Cholesterol Accumulation and Alleviates Motor Dysfunction in Niemann–Pick Type C Disease Model Mice
DOI: https://doi.org/10.1021/acsabm.2c00233
[2022] Fine-Tuned Cholesterol Solubilizer, Mono-6-O-α-D-Maltosyl-γ-Cyclodextrin, Ameliorates Experimental Niemann–Pick Disease Type C Without Hearing Loss
DOI: https://doi.org/10.2139/ssrn.4037153
[2022] Basic study to evaluate the risk of liver injury of acetaminophen use in Niemann-Pick disease type C
DOI: https://doi.org/10.1254/jpssuppl.95.0_1-yia-27
[2021] Intracerebroventricular Treatment with 2-Hydroxypropyl-β-Cyclodextrin Decreased Cerebellar and Hepatic Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Expression in Niemann–Pick Disease Type C Model Mice
DOI: https://doi.org/10.3390/ijms22010452
[2021] Improved Formula for Predicting Hemodialyzability of Intravenous and Oral Drugs
DOI: https://doi.org/10.1159/000513152
[2021] Correction to: Awareness and current implementation of drug dosage adjustment by pharmacists in patients with chronic kidney disease in Japan: a web-based survey
DOI: https://doi.org/10.1186/s12913-021-06631-w
[2021] Differential mode of cholesterol inclusion with 2‐hydroxypropyl‐cyclodextrins increases safety margin in treatment of Niemann‐Pick disease type C
DOI: https://doi.org/10.1111/bph.15464

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AI 要約（直近 5 年の研究成果）

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研究成果（36 件）

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