Hideoki Ogawa 研究室

主宰者：Hideoki Ogawa

順天堂大学

AI 要約（直近 5 年の研究成果）

本研究室では、アレルギー疾患と皮膚バリア機能の障害の発症メカニズムを解明する研究を行っています。特に食物アレルギー、花粉症関連アレルギー、アトピー性皮膚炎などを対象として、マウスモデルを用いた実験的アプローチにより、これらの疾患がどのようにして発症するのかを調べています。例えば、腸内肥満細胞の異常増殖や皮膚バリア機能の低下がアレルギー反応を促進する過程、あるいは環境中のタンパク質分解酵素が皮膚を通じてアレルギー感作を引き起こす仕組みなどを研究しています。さらに本研究室では、皮膚が持つ防御機能を強化する物質や分子の作用メカニズムを調査しています。抗菌ペプチドやビタミンD関連物質など天然由来の生理活性物質が、皮膚の細胞間結合を修復し、バリア機能を回復させることで、アレルギー症状の軽減や傷の治癒促進につながることを明らかにしています。これらの成果は、既存の治療法では十分な効果が得られないアレルギー疾患や創傷治癒の新しい治療戦略の開発につながる基礎研究となっています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（40 件）

[2025] <scp>MHC</scp> Class <scp>II</scp> ‐Expressing Mucosal Mast Cells Promote Intestinal Mast Cell Hyperplasia in a Mouse Model of Food Allergy
DOI: https://doi.org/10.1111/all.16477
[2024] Calcitriol modulates epidermal tight junction barrier function in human keratinocytes
DOI: https://doi.org/10.1016/j.jdermsci.2024.02.001
[2024] Identification of IgE Cross-reactive Allergens Causing Food Allergies Using Murine Models
DOI: https://doi.org/10.14789/jmj.jmj23-0045-r
[2024] Intranasal administration of ceramide liposome suppresses allergic rhinitis by targeting CD300f in murine models
DOI: https://doi.org/10.1038/s41598-024-58923-w
[2023] Investigation of the individual genetic evolution of SARS-CoV-2 in a small cluster during the rapid spread of the BF.5 lineage in Tokyo, Japan
DOI: https://doi.org/10.3389/fmicb.2023.1229234
[2023] Murine model identifies tropomyosin as IgE cross-reactive protein between house dust mite and coho salmon that possibly contributes to the development of salmon allergy
DOI: https://doi.org/10.3389/fimmu.2023.1238297
[2023] Phylactic role of anti-lipoarabinomannan IgM directed against mannan core during mycobacterial infection in macrophages
DOI: https://doi.org/10.1016/j.tube.2023.102391
[2023] Calcitriol, an Active Form of Vitamin D3, Mitigates Skin Barrier Dysfunction in Atopic Dermatitis NC/Nga Mice
DOI: https://doi.org/10.3390/ijms24119347
[2023] Antigen Protease Activity with a Detergent Induces Severe Skin Inflammation with Itch and Robust T Helper 17/T Helper 22 Differentiation in Mice
DOI: https://doi.org/10.1016/j.jid.2023.03.1685
[2023] Staphylococcus aureus δ-toxin present on skin promotes the development of food allergy in a murine model
DOI: https://doi.org/10.3389/fimmu.2023.1173069

続きを表示（残り 30 件）

[2023] The protective role of conjunctival goblet cell mucin sialylation
DOI: https://doi.org/10.1038/s41467-023-37101-y
[2023] The Antimicrobial Peptide AMP-IBP5 Suppresses Dermatitis-like Lesions in a Mouse Model of Atopic Dermatitis through the Low-Density Lipoprotein Receptor-Related Protein-1 Receptor
DOI: https://doi.org/10.3390/ijms24065200
[2023] The utility of macadamia nut legumin Mac i 2 and its conformational epitopes in the diagnosis of macadamia nut allergy
DOI: https://doi.org/10.1016/j.jaip.2023.11.019
[2023] A nerve-goblet cell association promotes allergic conjunctivitis through rapid antigen passage
DOI: https://doi.org/10.1172/jci.insight.168596
[2023] Antigen Protease Activity on Intact or Tape-Stripped Skin Induces Acute Itch and T Helper Sensitization Leading to Airway Eosinophilia in Mice
DOI: https://doi.org/10.1016/j.xjidi.2023.100239
[2022] Human β-defensin-3 attenuates atopic dermatitis–like inflammation through autophagy activation and the aryl hydrocarbon receptor signaling pathway
DOI: https://doi.org/10.1172/jci156501
[2022] Cathelicidin LL-37 Activates Human Keratinocyte Autophagy through the P2X₇, Mechanistic Target of Rapamycin, and MAPK Pathways
DOI: https://doi.org/10.1016/j.jid.2022.10.020
[2022] COVID-19 Severity and Thrombo-Inflammatory Response Linked to Ethnicity
DOI: https://doi.org/10.3390/biomedicines10102549
[2022] Experimental and Clinical Evidence Suggests That Treatment with Betacellulin Can Alleviate Th2-Type Cytokine-Mediated Impairment of Skin Barrier Function
DOI: https://doi.org/10.3390/ijms231911520
[2022] The Antimicrobial Peptides Human β-Defensins Induce the Secretion of Angiogenin in Human Dermal Fibroblasts
DOI: https://doi.org/10.3390/ijms23158800
[2022] Development of mouse model for oral allergy syndrome to identify IgE cross-reactive pollen and food allergens: ragweed pollen cross-reacts with fennel and black pepper
DOI: https://doi.org/10.3389/fimmu.2022.945222
[2022] Candidalysin, a Virulence Factor of Candida albicans, Stimulates Mast Cells by Mediating Cross-Talk Between Signaling Pathways Activated by the Dectin-1 Receptor and MAPKs
DOI: https://doi.org/10.1007/s10875-022-01267-9
[2022] A Pancancer Analysis of the Oncogenic Role of S100 Calcium Binding Protein A7 (S100A7) in Human Tumors
DOI: https://doi.org/10.3390/biology11020284
[2022] Antimicrobial peptide derived from insulin‐like growth factor‐binding protein 5 improves diabetic wound healing
DOI: https://doi.org/10.1111/wrr.12997
[2022] Psoriatic lesional expression of SARS-CoV-2 receptor ACE2 is reduced by blockade of IL-17 signaling but not by other biologic treatments
DOI: https://doi.org/10.1016/j.jaad.2022.01.041
[2022] Identification of anti-lipoarabinomannan antibodies against mannan core and their effects on phagocytosis of mycobacteria by human neutrophils
DOI: https://doi.org/10.1016/j.tube.2022.102165
[2022] Skin Treatment with Detergent Induces Dermatitis with H1-Antihistamine-Refractory Itch and Upregulates IL-4 and Th17/Th22 Cytokine Gene Expression in C57BL/6 Mice
DOI: https://doi.org/10.1159/000525656
[2021] Inhibition of Both Cyclooxygenase-1 and -2 Promotes Epicutaneous Th2 and Th17 Sensitization and Allergic Airway Inflammation on Subsequent Airway Exposure to Protease Allergen in Mice
DOI: https://doi.org/10.1159/000514975
[2021] Identification of Fungi by Conventional Microscopy Combined with Novel MALDI-TOF MS Mass Spectrometry
DOI: https://doi.org/10.14789/jmj.2021.67.jmj20-re02
[2021] Mucosal Mast Cell–Specific Gene Expression Is Promoted by Interdependent Action of Notch and TGF-β Signaling
DOI: https://doi.org/10.4049/jimmunol.2100112
[2021] The Antimicrobial Peptide Human β-Defensin-3 Accelerates Wound Healing by Promoting Angiogenesis, Cell Migration, and Proliferation Through the FGFR/JAK2/STAT3 Signaling Pathway
DOI: https://doi.org/10.3389/fimmu.2021.712781
[2021] Pollen shells and soluble factors play non-redundant roles in the development of allergic conjunctivitis in mice
DOI: https://doi.org/10.1016/j.jtos.2021.08.009
[2021] Topical Gynura procumbens as a Novel Therapeutic Improves Wound Healing in Diabetic Mice
DOI: https://doi.org/10.3390/plants10061122
[2021] 617 AMP-IBP5 improves diabetic wound healing via activation of EGFR/STAT/MAPK pathways
DOI: https://doi.org/10.1016/j.jid.2021.02.646
[2021] 117 Effect of the antimicrobial peptide derived from insulin-like growth factor-binding protein 5 on skin barrier regulation
DOI: https://doi.org/10.1016/j.jid.2021.02.136
[2021] 108 Antimicrobial peptide hBD-3 improves Th2 cytokine-mediated impairment of tight junction barrier through autophagy activation
DOI: https://doi.org/10.1016/j.jid.2021.02.127
[2021] Regulatory T Cells Exhibit Interleukin-33-Dependent Migratory Behavior during Skin Barrier Disruption
DOI: https://doi.org/10.3390/ijms22147443
[2021] Lysophosphatidylglucoside is a GPR55 -mediated chemotactic molecule for human monocytes and macrophages
DOI: https://doi.org/10.1016/j.bbrc.2021.06.090
[2021] A Possible Association Between a Nucleotide‐Binding Domain LRR‐Containing Protein Family PYD‐Containing Protein 1 Mutation and an Autoinflammatory Disease Involving Liver Cirrhosis
DOI: https://doi.org/10.1002/hep.31818
[2021] Epicutaneous vaccination with protease inhibitor-treated papain prevents papain-induced Th2-mediated airway inflammation without inducing Th17 in mice
DOI: https://doi.org/10.1016/j.bbrc.2020.12.090

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AI 要約（直近 5 年の研究成果）

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関連研究室(8 件)

研究成果（40 件）

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