Masato Konishi 研究室

AI 要約（直近 5 年の研究成果）

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

研究成果（12 件）

• [2026] A novel selective stabilizer of the ryanodine receptor 2 prevents stress‐induced ventricular arrhythmias without impairing cardiac function
  DOI: https://doi.org/10.1111/bph.70459
• [2025] Selective serotonin reuptake inhibitors (SSRIs) suppress Na+- dependent Mg2+ efflux in rat ventricular myocytes
  DOI: https://doi.org/10.1016/j.jphyss.2025.100025
• [2025] RyR1-mediated Ca ²⁺ -induced Ca ²⁺ release plays a negligible role in excitation–contraction coupling of normal skeletal muscle
  DOI: https://doi.org/10.1073/pnas.2500449122
• [2024] Effects of a high-affinity and selective RyR2 inhibitor on Ca2+ signals in cardiomyocytes and arrhythmias in CPVT model mice
  DOI: https://doi.org/10.1016/j.bpj.2023.11.247
• [2023] Effects of a novel RyR2 specific inhibitor on arrhythmias in catecholaminergic polymorphic ventricular tachycardia (CPVT) model mice
  DOI: https://doi.org/10.1254/jpssuppl.97.0_1-b-o03-1
• [2023] Mg2+ extrusion activated by hydrogen peroxide in rat ventricular myocytes
  DOI: https://doi.org/10.1016/j.bpj.2022.11.2102
• [2023] Reduction of intracellular Mg²⁺ caused by reactive oxygen species in rat ventricular myocytes
  DOI: https://doi.org/10.1152/ajpcell.00490.2022
• [2023] Arrhythmia severity in mouse models harboring RyR2 mutations with varied extent of channel activity
  DOI: https://doi.org/10.1016/j.bpj.2022.11.1395
• [2022] Anti-arrhythmic effects of novel RyR2 inhibitors screened from well-characterized drug library by ER Ca<sup>2+</sup> monitoring.
  DOI: https://doi.org/10.1254/jpssuppl.95.0_3-o-107
• [2021] A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke
  DOI: https://doi.org/10.1038/s41467-021-24644-1

科研費（0 件）

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所属学会・役職（0 件）

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