Nobuaki Kambe 研究室

主宰者：Nobuaki Kambe

大阪大学

AI 要約（直近 5 年の研究成果）

Kambe研究室では、有機合成化学を中心に、医薬品や機能性化合物の製造法開発に取り組んでいます。特に、金属触媒を活用した炭素-炭素結合や炭素-ヘテロ原子結合の形成反応に注力しており、銅やニッケル、パラジウムなどの遷移金属を用いて、従来は困難だった構造を効率良く合成する方法を開発しています。これらの反応では、日常的に入手できる原料から出発し、複数の官能基を同時に導入できる特徴を持ちます。さらに同研究室では、ビスマス（Bi）やアンチモン（Sb）といった重金属元素を含む有機金属試薬の開発にも力を入れており、これらを用いた新規な結合形成反応を報告しています。また、光化学的手法やフッ素含有試薬（トリメチルシリルトリフルオロメタン）を活用した反応開発も進めており、環境負荷が低い合成プロセスの構築を目指しています。こうした基礎研究の成果は、医薬品候補物質や生物活性分子の合成に応用され、実際の創薬開発へも貢献する研究が展開されています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（38 件）

[2025] γ‐Cyclodextrin–Imidazolium Salt‐Based Bioinspired Nanoreactor: Enantioselective Rhodium‐Catalyzed Arylation of Unprotected Isatin with Arylboronic Acids
DOI: https://doi.org/10.1002/chem.202502481
[2025] Mechanism‐Driven Bioactive Indazole Frameworks: Photoinitiated Demethylation–Aromatization Synthesis and Biosensing Applications
DOI: https://doi.org/10.1002/ange.202507163
[2025] Synthesis and application of organostibines
DOI: https://doi.org/10.1016/j.ccr.2025.217200
[2025] Fe/Mn-Synergistic Promoted C(sp3)–Bi Cross-Coupling of Alkyl Chlorides with Chlorobismuthanes to Access Air-Stable Alkylbismuthanes
DOI: https://doi.org/10.1021/acs.orglett.5c00623
[2025] Mechanism‐Driven Bioactive Indazole Frameworks: Photoinitiated Demethylation–Aromatization Synthesis and Biosensing Applications
DOI: https://doi.org/10.1002/anie.202507163
[2024] Cu(II)/Base Synergistic Promoted [2 + 1 + 3] Cyclization of Cyclic Ketones with α,β-Unsaturated Aldehydes/Ketones and NH4I to Access Fused Pyridines
DOI: https://doi.org/10.1021/acs.orglett.4c02628
[2024] Rapid copper-catalyzed friedel-crafts alkylation of indoles in 25 Minutes
DOI: https://doi.org/10.1016/j.jorganchem.2024.123119
[2024] Base-Promoted One-Pot Four-Component Domino Strategy Involving Aldehydes and Ketones to Access Multifunctionalized Dihydropyridinones
DOI: https://doi.org/10.1021/acs.joc.4c01636
[2024] Catalyst-Free, Zn-Mediated Decarboxylative Coupling of Chlorostibines to Access Alkylstibines with Stable C(sp3)–Sb Bonds
DOI: https://doi.org/10.1021/acs.orglett.4c02132
[2023] Nickel-Catalyzed C(sp3)–Sb Coupling of Chlorostibines with Unactivated Alkyl Chlorides and In Vitro Anticancer Activity of Products
DOI: https://doi.org/10.1021/acs.orglett.3c04008

続きを表示（残り 28 件）

[2023] Trivalent Organostibines: Sb,N Ligands in Double N-Arylation of Primary Amines toward Functionalized Carbazoles
DOI: https://doi.org/10.1021/acs.joc.3c01863
[2023] Selectfluor-Promoted Reactions of Aryl Methyl Ketones with Dimethyl Sulfoxide to Give 2,5-Diacylthiophenes and β-Acyl Allylic Methylsulfones
DOI: https://doi.org/10.1021/acs.orglett.2c04101
[2023] Nickel-Catalyzed Site-Selective C3–H Functionalization of Quinolines with Electrophilic Reagents at Room Temperature
DOI: https://doi.org/10.1021/acscatal.3c01553
[2023] Copper-Catalyzed Cyclization of 2-Alkynylanilines to Give 2-Haloalkoxy-3-alkyl(aryl)quinolines
DOI: https://doi.org/10.1021/acs.orglett.2c04314
[2022] Co-Catalyzed Dual C5/C8–H Bond Functionalization of Imidazo[1,2-a]pyrazines with Disulfides and Grignard Reagents
DOI: https://doi.org/10.1021/acs.orglett.2c02937
[2022] Mechanistic Insight into Rh-Catalyzed C(sp2)–O Bond Cleavage Applied to Cross-Coupling Reaction of Benzofurans with Aryl Grignard Reagents
DOI: https://doi.org/10.1021/acscatal.2c01974
[2022] FeO(OH)@C‐Catalyzed Selective Hydrazine Substitution of p‐Nitro‐Aryl Fluorides and their Application for the Synthesis of Phthalazinones
DOI: https://doi.org/10.1002/open.202200023
[2022] A pH-Dependent rhodamine fluorophore with antiproliferative activity of bladder cancer in Vitro/Vivo and apoptosis mechanism
DOI: https://doi.org/10.1016/j.ejmech.2022.114293
[2022] DTBP-mediated cross-dehydrogenative coupling of 3-aryl benzofuran-2(3H)-ones with toluenes/phenols for all-carbon quaternary centers
DOI: https://doi.org/10.1039/d2ra06231c
[2022] One-pot synthesis of phosphorylnaphth[2,1-d]oxazoles and products as P,N-ligands in C–N and C–C formation
DOI: https://doi.org/10.1039/d2ob00565d
[2022] Cu(I)-Catalyzed C–H Alkenylation of Tertiary C(sp3)–H Bonds of 3-Aryl Benzofuran-2(3H)-ones to Give Z- and E-Styrene Containing Quaternary Carbon Centers with 99/1 Regioselectivity
DOI: https://doi.org/10.1021/acs.joc.2c00325
[2022] Copper-Catalyzed Regioselective Iodoformylation of Terminal Alkynes to Access Versatile Electrophiles (E)-β-Iodo-α,β-Unsaturated Aldehydes
DOI: https://doi.org/10.1021/acs.orglett.2c02838
[2022] Base-Promoted Reactions of Organostibines with Alkynes and Organic Halides to Give Chalcogenated (Z)-Olefins and Ethers
DOI: https://doi.org/10.1021/acs.orglett.2c02369
[2022] Copper-Catalyzed Regioselective Olefination and Trifluoromethylation of Carboxylic Acids To Give (Z)-Trifluoromethyl Enol Esters
DOI: https://doi.org/10.1021/acs.orglett.2c02027
[2022] CF3SO2Na-Mediated Five-Component Carbonylation of Triarylboroxines with TMSCF3 and THF/LiOH/NaI to Give Aroyloxyalkyl Iodides
DOI: https://doi.org/10.1021/acs.joc.2c00662
[2022] Synthesis of (Deoxy)difluoromethylated Phosphines by Reaction of R2P(O)H with TMSCF3 and Their Application in Cu(I) Clusters in Sonogashira Coupling
DOI: https://doi.org/10.1021/acs.joc.2c00308
[2022] Pd-Catalyzed Cross-Coupling of Sb-Aryl Stibines with Halogenomethyl Arenes to Give Unsymmetirc Diarylmethanes
DOI: https://doi.org/10.1021/acs.orglett.2c00879
[2022] Cu-catalyzed cross-coupling of chlorostibine with terminal alkynes to give Sb-alkynyl stibines and products transformation
DOI: https://doi.org/10.1016/j.jorganchem.2022.122352
[2022] Cu-Catalyzed Dual C–O Bonds Cleavage of Cyclic Ethers with Carboxylic Acids, NaI, and TMSCF3 to Give Iodoalkyl Ester
DOI: https://doi.org/10.1021/acs.orglett.2c00732
[2022] UV-Light-Induced Dehydrogenative N-Acylation of Amines with 2-Nitrobenzaldehydes To Give 2-Aminobenzamides
DOI: https://doi.org/10.1055/a-1736-4388
[2021] 2-Aryl-perfluorobenzoxazoles: synthesis, fluorescence properties and synthetic applications in cubic platinum nanoparticles
DOI: https://doi.org/10.1039/d1tc03338g
[2021] Photo-Induced N–N Coupling of o-Nitrobenzyl Alcohols and Indolines To Give N-Aryl-1-amino Indoles
DOI: https://doi.org/10.1021/acs.orglett.1c02227
[2021] UV-Light-Induced N-Acylation of Amines with α-Diketones
DOI: https://doi.org/10.1021/acs.orglett.1c01599
[2021] Pd-Catalyzed Cross-Coupling of Organostibines with Styrenes to Give Unsymmetric (E)-Stilbenes and (1E,3E)-1,4-Diarylbuta-1,3-dienes and Fluorescence Properties of the Products
DOI: https://doi.org/10.1021/acs.orglett.1c01532
[2021] Nickel-Catalyzed N,N-Diarylation of 8-Aminoquinoline with Large Steric Aryl Bromides and Fluorescence of Products
DOI: https://doi.org/10.1021/acs.orglett.1c00463
[2021] Nickel- and Palladium-Catalyzed Cross-Coupling of Stibines with Organic Halides: Site-Selective Sequential Reactions with Polyhalogenated Arenes
DOI: https://doi.org/10.1021/acscatal.1c04533
[2021] Bio-inspired asymmetric aldehyde arylations catalyzed by rhodium-cyclodextrin self-inclusion complexes
DOI: https://doi.org/10.1039/d1ob02014e
[2021] Recent Advances on Benzofuranones: Synthesis and Transformation via C–H Functionalization
DOI: https://doi.org/10.1055/a-1405-5761

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AI 要約（直近 5 年の研究成果）

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関連研究室(8 件)

研究成果（38 件）

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