Mitsuhiro Arisawa 研究室

主宰者：Mitsuhiro Arisawa

大阪大学

AI 要約（直近 5 年の研究成果）

本研究室は、遷移金属触媒を用いた有機合成化学を主軸に、複雑な分子骨格を効率的に構築する方法の開発に取り組んでいます。特にロジウムやニッケルなどの金属触媒を活用し、アルケンの長距離異性化、環化、および水素化などの複数の反応を一つの触媒系で順序立てて実行する「マルチタスキング触媒」の研究を進めています。また、ひずみを持つ小環化合物（ビシクロブタンやシクロプロパンなど）のC-C結合を選択的に開裂・再構成することで、医薬品に含まれるベンゾフランやピロリジンなどの複雑な複素環構造を作り出しています。加えて、本研究室は医薬品開発と連携した合成化学にも注力しており、海洋天然物やHIVラテンシー逆転剤などの生物活性分子の全合成を実現し、その生物学的性質を詳細に解析しています。有機小分子触媒（ホウ素酸など）を用いた不斉合成、および化学反応と生物触媒を組み合わせた「ケモ・バイオハイブリッド」プロセスも展開しており、光学活性なアミンやアルコール誘導体の高効率・高選択的な製造法を開発しています。これらの研究を通じ、原子レベルでの分子骨格の改造（スケレタル・エディティング）や電気化学的酸化カップリングなど、既存手法の限界を超えた革新的な合成戦略の構築を目指しています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

外部リンク

研究成果（57 件）

[2026] Rhodium Multitasking Catalysis Integrating Long‐Range Isomerization, Cycloisomerization, and Hydrosilylation of 1,n‐Dienes to Give 2,3‐Disubstituted Dihydrobenzofurans: Mechanistic Insight Into Functionalization‐Controlled Reactivity
DOI: https://doi.org/10.1002/adsc.70276
[2026] Chiral Borinic Acid-Catalyzed Enantioselective Passerini-type Multicomponent Reaction
DOI: https://doi.org/10.1021/acs.joc.5c03042
[2026] Electrosynthetic access to unsymmetrical oxaza[8]helicenes with high chiral stability and strong circularly polarized luminescence (CPL)
DOI: https://doi.org/10.3762/bjoc.22.25
[2026] Metal-Free Aerobic Radical Ring Opening–Cyclization of Bicyclo[1.1.0]butylamides to Oxazolidin-4-ones
DOI: https://doi.org/10.1248/cpb.c25-00744
[2026] Long-range isomerisation/cyclopropane isomerisation/cycloisomerisation/aromatisation reactions using multifunctional rhodium catalysts
DOI: https://doi.org/10.1039/d6ob00534a
[2025] Development of Suzuki–Miyaura Coupling between 4-Pyridine Boronate Derivatives and Aryl Halide to Suppress Phenylated Impurities Derived from Phosphorus Ligands
DOI: https://doi.org/10.1248/cpb.c24-00874
[2025] Effects of Oxygen Atom Position in Linear Side Chains of Ansellone Analogues on HIV Latency-Reversing Activity
DOI: https://doi.org/10.1021/acsmedchemlett.5c00214
[2025] Total Synthesis of (±)-Minimiflorin and Its Na+/K+-ATPase and H+/K+-ATPase Inhibitory Activities
DOI: https://doi.org/10.1021/acs.jnatprod.5c00463
[2025] Diversity-oriented synthesis of poly-substituted benzofuran derivatives bearing amino groups at 2- or 3-positions: Rh- or Ni-catalyzed cycloisomerization between ynamides and enol ethers
DOI: https://doi.org/10.1039/d5qo01123j
[2025] Remodelling molecular frameworks via atom-level surgery: recent advances in skeletal editing of (hetero)cycles
DOI: https://doi.org/10.1039/d4qo02157f

続きを表示（残り 47 件）

[2025] Grignard Method for Preparing Thioesters from Esters and Its Application to One-Pot Synthesis of Ketones and Aldehydes
DOI: https://doi.org/10.1021/acsomega.4c10622
[2024] Impact of helical elongation of symmetric oxa[n]helicenes on their structural, photophysical, and chiroptical characteristics
[2024] Multitasking rhodium-catalyzed remote C(sp3)–H functionalization reactions of acyclic dienes to yield benzene-fused heterocycles
DOI: https://doi.org/10.1039/d4gc04927f
[2024] Absorption, Fluorescence, and Two‐Photon Excitation Ability of 5‐o‐Tolyl‐11 (or 13)‐o‐tolylisoindolo[2,1‐a]quinolines Prepared by Ring‐Closing Metathesis and [2+3] Cycloaddition
DOI: https://doi.org/10.1002/asia.202401073
[2024] Synthesis of Dibenzoxasilepine Using Ring Expansion Reaction of a Pentacoordinate Silicon Intermediate
DOI: https://doi.org/10.1002/adsc.202401125
[2024] Enantioselective Synthesis of Secondary Amines by Combining Oxidative Rearrangement and Biocatalysis in a One-Pot Process
DOI: https://doi.org/10.1021/acs.joc.4c00459
[2024] Oxidative Rearrangement Approach for the Ring Contraction of N−H Piperidines to Pyrrolidines
DOI: https://doi.org/10.1002/adsc.202400484
[2024] Total Synthesis and Antibacterial Activity of Marine Tris-indole Alkaloid Tulongicin A
DOI: https://doi.org/10.1021/acs.jnatprod.4c00129
[2024] Impact of helical elongation of symmetric oxa[n]helicenes on their structural, photophysical, and chiroptical characteristics
DOI: https://doi.org/10.1002/chir.23673
[2024] Chemical Constituents and Anticancer Activities of Marine-Derived Fungus Trichoderma lixii
DOI: https://doi.org/10.3390/molecules29092048
[2024] Synthesizing Silyl Arylsulfonyl Hydrazones as Silyldiazomethane Precursors and Their Use in Rhodium‐Catalyzed Reactions
DOI: https://doi.org/10.1002/adsc.202400172
[2024] Brønsted acid-catalyzed synthesis of spirocyclobutanes via heteroannulation of vinyloxyphenylbicyclobutanes with water
DOI: https://doi.org/10.1039/d4ob00451e
[2023] Axially Chiral Borinic Acid Catalysts: Design, Synthesis, and Application in Alkylative Desymmetrization of 1,2-Diols
DOI: https://doi.org/10.1021/acs.joc.3c01143
[2023] A versatile Plasmodium falciparum reporter line expressing NanoLuc enables highly sensitive multi-stage drug assays
DOI: https://doi.org/10.1038/s42003-023-05078-5
[2023] Synthesis and Biological Evaluation of Simplified Ansellone Analogues with Lipophilic Side Chains as HIV Latency‐Reversing Agents
DOI: https://doi.org/10.1002/chem.202300677
[2023] Design and synthesis of 4-acetoxypentanamide derivatives of spliceostatin A and their biological evaluation towards prostate cancer treatment
DOI: https://doi.org/10.1016/j.bmcl.2023.129333
[2023] Palladium-Catalyzed Intramolecular Migratory Cycloisomerization of 3-Phenoxy Acrylic Acid Ester via C–O Bond Cleavage and C–O/C–C Bonds Formation for 2,3-Disubstituted Benzofurans Synthesis
DOI: https://doi.org/10.1248/cpb.c22-00555
[2023] Absorption, fluorescence, and two-photon excitation ability of 5-phenyl-13-arylisoindolo[2,1-a]quinolines prepared by one-pot reaction of ring-closing metathesis and 1,3-dipolar cycloaddition
DOI: https://doi.org/10.1016/j.dyepig.2023.111118
[2023] Ligand-free reductive coupling of aldehydes with 1,3-dienes using a sulfur-modified Au-supported nickel nanoparticle catalyst
DOI: https://doi.org/10.1039/d3nj00354j
[2023] Heteroannulation of bicyclobutane derivativesviaAu-catalyzed hydration to enol ethers and intramolecular cyclization giving spirocyclobutanes
DOI: https://doi.org/10.1039/d3cc01955a
[2023] Development of Cycloisomerization with Rearrangement of a Tosyl Group Using N-Tosyl-o-allenylaniline
DOI: https://doi.org/10.1021/acs.joc.3c00625
[2023] Data-driven Electrochemical One-pot Synthesis of Double Hetero[7]dehydrohelicene
DOI: https://doi.org/10.5796/electrochemistry.23-67092
[2022] Total Synthesis of Ansellone G and Phorbadione
DOI: https://doi.org/10.1021/acs.joc.2c02278
[2022] Substrate-Assisted Reductive Elimination Determining the Catalytic Cycle: A Theoretical Study on the Ni-Catalyzed 2,3-Disubstituted Benzofuran Synthesis via C–O Bond Activation
DOI: https://doi.org/10.1021/acs.organomet.2c00419
[2022] Design, Synthesis, and Monoamine Oxidase B Selective Inhibitory Activity of N-Arylated Heliamine Analogues
DOI: https://doi.org/10.1021/acsmedchemlett.2c00228
[2022] Carbon(sp2)‐carbon(sp3) Bond‐forming Cross‐coupling Reactions Using Sulfur‐Modified Au‐Supported Nickel Nanoparticle Catalyst
DOI: https://doi.org/10.1002/ajoc.202200229
[2022] Carbon(sp2)-carbon(sp3) Bond-forming Cross-coupling Reactions Using Sulfur-Modified Au-Supported Nickel Nanoparticle Catalyst
[2022] Reagent‐Controlled Regioselective Intramolecular [2+2] Cycloaddition between Vinylsilanes and Allenes
DOI: https://doi.org/10.1002/chem.202203556
[2022] A New Tetracyclic Bromopyrrole-Imidazole Derivative through Direct Chemical Diversification of Substances Present in Natural Product Extract from Marine Sponge Petrosia (Strongylophora) sp.
DOI: https://doi.org/10.3390/molecules28010143
[2022] Double Ring Expansion Strategy for Fused 3-Benzazepines: Alternative Synthesis of the Dolby–Weinreb Enamine
DOI: https://doi.org/10.1021/acs.joc.2c02475
[2022] Design and synthesis of ether derivatives of spliceostatin A and their biological evaluation towards prostate cancer treatment
DOI: https://doi.org/10.1016/j.tetlet.2022.154288
[2021] Design, Synthesis, and Monoamine Oxidase Inhibitory Activity of (+)-Cinchonaminone and Its Simplified Derivatives
DOI: https://doi.org/10.1021/acsmedchemlett.1c00310
[2021] Structure-activity Relationship of Indomethacin Derivatives as IDO1 Inhibitors
DOI: https://doi.org/10.21873/anticanres.15004
[2021] Non-Directed β- or γ-C(sp3)–H Functionalization of Saturated Nitrogen-Containing Heterocycles
DOI: https://doi.org/10.1055/a-1483-4575
[2021] Total Synthesis and Biological Evaluation of the Potent HIV Latency-Reversing Agent Ansellone A and its Analogues
DOI: https://doi.org/10.1021/acs.orglett.1c00151
[2021] Inhibitory Activity and Proposed Binding Model of γ-Glutamyl Cysteine, the Precursor of Glutathione, on Angiotensin Converting Enzyme
DOI: https://doi.org/10.1248/bpbreports.4.4_116
[2021] Selective Reduction and Dihydroxylation of α,β-Unsaturated Esters in the Presence of Enals: One-Pot Synthesis of a 2,5-Disubstituted Tetrahydrofuran
DOI: https://doi.org/10.3987/com-20-s(k)15
[2021] Carbo- and Heterocycle Syntheses via Reactions between Two Multiple Bonds; Involving Heteroatom-Substituted Unsaturated Bonds
DOI: https://doi.org/10.5059/yukigoseikyokaishi.79.22
[2021] Design, Synthesis, Physical Properties and Indoleamine 2, 3-Dioxygenase 1 Inhibitory Activity of Substituted Indole Derivatives with N-H, N-Methoxymethyl, or N-Mehylthiomethyl Group toward Fragment-Based Drug Discovery
DOI: https://doi.org/10.3987/com-20-s(k)35
[2021] A New Bitterness Evaluation Index Obtained Using the Taste Sensor for 48 Active Pharmaceutical Ingredients of Pediatric Medicines
DOI: https://doi.org/10.1248/cpb.c20-01014
[2021] Preparation of a platinum nanoparticle catalyst located near photocatalyst titanium oxide and its catalytic activity to convert benzyl alcohols to the corresponding ethers
DOI: https://doi.org/10.1039/d1ra00988e
[2021] Product selective reaction controlled by the combination of palladium nanoparticles, continuous microwave irradiation, and a co-existing solid; ligand-free Buchwald–Hartwig aminationvs.aryne amination
DOI: https://doi.org/10.1039/d1gc01782a
[2021] Iridium-Catalyzed Isomerization/Cycloisomerization/Aromatization of N-Allyl-N-sulfonyl-o-(λ1-silylethynyl)aniline Derivatives to Give Substituted Indole Derivatives
DOI: https://doi.org/10.1021/acs.orglett.1c01231
[2021] Revisiting Chiral Recognition Mechanism on Chicken Alpha 1-Acid Glycoprotein: Location of Chiral Binding Sites and Insight into Chiral Binding Mechanism
DOI: https://doi.org/10.3390/separations8060073
[2021] Carbon–Carbon Bond Formation between N-Heterocyclic Carbene Ligand on Ruthenium Carbene Catalysts and 1,4-Naphthoquinone via Intramolecular Carbon(sp3)–Hydrogen Bond Activation
DOI: https://doi.org/10.1021/acs.organomet.1c00350
[2021] Double isomerization/cycloisomerization/aromatization of 1-(allyloxy)-2-(cyclopropylmethyl)benzenes to give 2-ethyl-3-isopropylbenzofurans using a multitasking single rhodium catalyst
DOI: https://doi.org/10.1039/d1cc06163a
[2021] Recent Advances in Metal-Nanoparticle-Catalyzed Coupling Reactions Assisted by Microwave Irradiation
DOI: https://doi.org/10.1055/a-1505-0916

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AI 要約（直近 5 年の研究成果）

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関連研究室(8 件)

研究成果（57 件）

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