Yuji Owada 研究室

主宰者：Yuji Owada

東北大学

AI 要約（直近 5 年の研究成果）

この研究室は、脂肪酸結合タンパク質（FABP）ファミリーと脂質代謝が、脳機能と全身の健康にどのように影響するかを明らかにする研究を行っています。特に、脳に豊富に存在するFABP7やFABP3といったタンパク質が、多価不飽和脂肪酸などの脂質物質の細胞内輸送や遺伝子発現制御に関わることに注目しています。これらのタンパク質が正常に機能しなくなると、自閉症スペクトラム障害や統合失調症といった神経発達障害や、てんかんなどの神経疾患が発症することを、マウスモデルを用いた実験で調査しています。さらに、妊娠中の栄養不良や免疫活性化といった環境要因が、胎児の脳発達にどのような長期的な影響を与えるのかについても研究しています。脳内の脂質環境がアルツハイマー病やがんの進行に関連することも報告しており、基礎研究から臨床応用に向けた知見を蓄積しています。研究方法としては、遺伝子改変マウスの作成・解析、RNA解析、細胞培養実験、行動試験など多角的なアプローチを組み合わせています。これにより、脂質代謝と脳・全身の機能の関係を分子レベルから個体レベルまで総合的に理解することを目指しています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（55 件）

[2026] Unpredictable Chronic Mild Stress Upregulates Dopamine Receptor Expression Independent of Fatty Acid-Binding Protein 7 Gene Deletion
DOI: https://doi.org/10.1007/s11064-026-04753-3
[2026] Maternal granulocyte colony-stimulating factor alters synaptic maturation and social behaviors in offspring
DOI: https://doi.org/10.1016/j.bbi.2026.106534
[2026] Maternal fasting during early gestation induces epigenetic alterations and schizophrenia-related phenotypes
DOI: https://doi.org/10.1038/s41380-026-03629-w
[2025] Astrocyte FABP7 Modulates Seizure Activity-Dependent Protein Expression in Mouse Brain
DOI: https://doi.org/10.3390/neuroglia6030033
[2025] Fatty acid binding proteins 5 and 7 differentially modulate phenotypic response to acute Δ9-tetrahydrocannabinol in female mice
DOI: https://doi.org/10.1016/j.physbeh.2025.114999
[2025] ETS1 promotes the expression of Ctsb and Mmp13 during the differentiation of septoclasts from pericytes
DOI: https://doi.org/10.1007/s00441-025-03979-x
[2025] High-Fat Diet-Induced Excessive Accumulation of Cerebral Cholesterol Esters and Microglial Dysfunction Exacerbate Alzheimer's Disease Pathology in APPNL−G−F mice
DOI: https://doi.org/10.1007/s12035-025-05052-8
[2025] Astrocyte Fabp7 modulates nocturnal seizure threshold and activity-dependent gene expression in mouse brain
DOI: https://doi.org/10.1093/pnasnexus/pgaf146
[2025] Loss of fatty acid-binding protein 7 promotes B16F10 melanoma metastasis
DOI: https://doi.org/10.1038/s41598-024-80874-5
[2025] Gene Expression Profiling in the Cortex of Fabp4 Knockout Mice
DOI: https://doi.org/10.1002/npr2.70006

続きを表示（残り 45 件）

[2025] FABP7 in Hepatic Macrophages Promotes Fibroblast Activation and CD4 + T‐Cell Migration by Regulating M2 Polarization During Liver Fibrosis
DOI: https://doi.org/10.1155/jimr/6987981
[2025] FGF7 as an essential mediator for the onset of ankylosing enthesitis related to psoriatic dermatitis
DOI: https://doi.org/10.26508/lsa.202403073
[2025] Perichondrium origin of pericyte‐septoclast lineage in endochondral bone development
DOI: https://doi.org/10.1111/joa.70081
[2025] Effects of pharmacological inhibition of FABP4 during gestation and lactation on offspring neurodevelopment and behavior
DOI: https://doi.org/10.1016/j.neulet.2025.138199
[2024] Innovative Training Approach for Hyaluronic Acid Injections: Utilizing Fresh Frozen Cadavers and Colored Ultrasound Gel
DOI: https://doi.org/10.1097/gox.0000000000005758
[2024] Fatty acid binding protein 7 plays an important modulatory sex-dependent role on brain endocannabinoid levels and THC metabolism
DOI: https://doi.org/10.1371/journal.pone.0313091
[2024] Integrated Transcriptome Profiling and Pan-Cancer Analyses Reveal Oncogenic Networks and Tumor-Immune Modulatory Roles for FABP7 in Brain Cancers
DOI: https://doi.org/10.3390/ijms252212231
[2024] Fatty acid-binding protein 7 gene deletion promotes decreases in brain cannabinoid type 1 receptor binding
DOI: https://doi.org/10.1016/j.neulet.2024.138040
[2024] Fatty acid preference for beta‐oxidation in mitochondria of murine cultured astrocytes
DOI: https://doi.org/10.1111/gtc.13144
[2024] The role of fatty acid-binding protein 5 and 7 on locomotor, anxiety and social behavior: Interaction with NMDA signaling
DOI: https://doi.org/10.1016/j.neulet.2024.137862
[2024] Polyunsaturated fatty acids-induced ferroptosis suppresses pancreatic cancer growth
DOI: https://doi.org/10.1038/s41598-024-55050-4
[2023] Effects of Ndufs4 Deletion on Hearing after Various Acoustic Exposures
DOI: https://doi.org/10.1620/tjem.2023.j031
[2023] Fatty acid binding protein type 7 deficiency preserves auditory function in noise-exposed mice
DOI: https://doi.org/10.1038/s41598-023-48702-4
[2023] INVESTIGATING THE EFFECTS OF MATERNAL IMMUNE ACTIVATION ON BEHAVIORAL AND HISTOLOGICAL PHENOTYPES IN MOUSE OFFSPRING
DOI: https://doi.org/10.1016/j.ibneur.2023.08.103
[2023] Should oral medication dose be adjusted in Alzheimer’s disease?
DOI: https://doi.org/10.1002/alz.065402
[2023] Pyrolyzed deketene curcumin controls regulatory T cell generation and gastric cancer metabolism cooperate with 2-deoxy-d-glucose
DOI: https://doi.org/10.3389/fimmu.2023.1049713
[2023] Integrin expression and extracellular matrix adhesion of septoclasts, pericytes, and endothelial cells at the chondro‐osseous junction and the metaphysis of the proximal tibia in young mice
DOI: https://doi.org/10.1111/joa.13820
[2023] Curcumin analog GO-Y030 inhibits tumor metastasis and glycolysis
DOI: https://doi.org/10.1093/jb/mvad066
[2023] Alteration of gen expression in the medial prefrontal cortex (mPFC) of FABP3 KO mice
DOI: https://doi.org/10.1254/jpssuppl.97.0_2-b-p-020
[2022] Microglia with fatty acid‐binding protein 5 deficiency exhibit proinflammatory phenotype contributing to neuroinflammation
DOI: https://doi.org/10.1002/alz.069149
[2022] Oleic acid‐bound <scp>FABP7</scp> drives glioma cell proliferation through regulation of nuclear lipid droplet formation
DOI: https://doi.org/10.1111/febs.16672
[2022] Fabp7 Is Required for Normal Sleep Suppression and Anxiety-Associated Phenotype following Single-Prolonged Stress in Mice
DOI: https://doi.org/10.3390/neuroglia3020005
[2022] Unpredictable chronic mild stress differentially impacts resting brain glucose metabolism in fatty acid-binding protein 7 deficient mice
DOI: https://doi.org/10.1016/j.pscychresns.2022.111486
[2022] Spatial and chronological localization of septoclasts in the mouse Meckel’s cartilage
DOI: https://doi.org/10.1007/s00418-022-02085-1
[2022] Environmental enrichment sex-dependently rescues memory impairment in FABP5 KO mice not mediated by brain-derived neurotrophic factor
DOI: https://doi.org/10.1016/j.bbr.2022.113814
[2022] Usefulness of Thiel-Embalmed Cadavers for Training in Organ Procurement
DOI: https://doi.org/10.1016/j.transproceed.2021.10.026
[2022] Possible involvement of FABPs in psychiatric disorders
DOI: https://doi.org/10.1254/jpssuppl.96.0_4-b-s44-1
[2022] Role of fatty acid-binding protein 3 on the development of the medial prefrontal cortex
DOI: https://doi.org/10.1254/jpssuppl.95.0_1-p-005
[2021] Ndufs4 ablation decreases synaptophysin expression in hippocampus
DOI: https://doi.org/10.1038/s41598-021-90127-4
[2021] Glyoxalase I disruption and external carbonyl stress impair mitochondrial function in human induced pluripotent stem cells and derived neurons
DOI: https://doi.org/10.1038/s41398-021-01392-w
[2021] Functional Analysis of the Transcriptional Regulator IκB-ζ in Intestinal Homeostasis
DOI: https://doi.org/10.1007/s10620-021-06958-8
[2021] Ligand Bound Fatty Acid Binding Protein 7 (FABP7) Drives Melanoma Cell Proliferation Via Modulation of Wnt/β-Catenin Signaling
DOI: https://doi.org/10.1007/s11095-021-03009-9
[2021] Suppression of α-synuclein propagation after intrastriatal injection in FABP3 null mice
DOI: https://doi.org/10.1016/j.brainres.2021.147383
[2021] Expression and enhancement of FABP4 in septoclasts of the growth plate in FABP5-deficient mouse tibiae
DOI: https://doi.org/10.1007/s00418-020-01953-y
[2021] Crucial Role of FABP3 in αSyn-Induced Reduction of Septal GABAergic Neurons and Cognitive Decline in Mice
DOI: https://doi.org/10.3390/ijms22010400
[2021] マウス小腸における上皮内リンパ球(IEL)の活性化,出口および再構成【JST・京大機械翻訳】|||
[2021] Nuclear FABP7 regulates cell proliferation of wild‐type IDH1 glioma through caveolae formation
DOI: https://doi.org/10.1002/1878-0261.13130
[2021] SGLT‐1‐specific inhibition ameliorates renal failure and alters the gut microbial community in mice with adenine‐induced renal failure
DOI: https://doi.org/10.14814/phy2.15092
[2021] Fatty acid‐binding protein 3 knockout mice exhibit astrocyte‐mediated neuroinflammation and cognitive impairment
DOI: https://doi.org/10.1002/alz.049489
[2021] Learning deficits occurs prior to memory retrieval impairment in female Senescence Accelerated Mouse (SAMP8)
DOI: https://doi.org/10.1002/alz.058418
[2021] Fatty acid‐binding protein 5 controls lung tumor metastasis by regulating the maturation of natural killer cells in the lung
DOI: https://doi.org/10.1002/1873-3468.14106
[2021] Alteration of parvalbumin expression and perineuronal nets formation in the anterior cingulate cortex of Fabp3 KO mice
DOI: https://doi.org/10.1254/jpssuppl.94.0_1-p1-07
[2021] Curcumin analog GO‐Y030 boosts the efficacy of anti‐PD‐1 cancer immunotherapy
DOI: https://doi.org/10.1111/cas.15136
[2021] Fatty acid‐binding protein 5 limits the generation of Foxp3+ regulatory T cells through regulating plasmacytoid dendritic cell function in the tumor microenvironment
DOI: https://doi.org/10.1002/ijc.33777
[2021] The Curcumin Analog GO-Y030 Controls the Generation and Stability of Regulatory T Cells
DOI: https://doi.org/10.3389/fimmu.2021.687669

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AI 要約（直近 5 年の研究成果）

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研究成果（55 件）

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