Hiroyuki Osada 研究室

主宰者：Hiroyuki Osada

理化学研究所・RIKEN Center for Sustainable Resource Science

AI 要約（直近 5 年の研究成果）

要約はまだ生成されていません。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

外部リンク

研究成果（97 件）

[2026] Revitalizing microbial secondary metabolites in drug discovery: current challenges and emerging solutions
DOI: https://doi.org/10.1093/bulcsj/uoag062
[2026] Artificial intelligence-based phenotypic screening using Aspergillus oryzae identified a novel antifungal RK-1205-I
DOI: https://doi.org/10.1038/s41429-026-00937-9
[2025] GENI as an AMPK Activator Binds α and γ Subunits and Improves the Memory Dysfunction of Alzheimer’s Disease Mouse Models via Autophagy and Neuroprotection
DOI: https://doi.org/10.3390/antiox14010057
[2025] Biosynthesis of reveromycin derivatives by altering the regioselectivity of cytochrome P450revI
DOI: https://doi.org/10.1039/d5sc01355k
[2025] Programmable synthesis of alkaloidal frameworks integrating Michael acceptor generates covalent probes for targeting POLE3 in HBV replication
DOI: https://doi.org/10.1039/d5cb00268k
[2025] Podophyllotoxin and α-peltatin inhibit nuclear factor κB activation and gene expression stimulated by a double-stranded RNA analogue in human umbilical vein endothelial cells
DOI: https://doi.org/10.1093/bbb/zbaf108
[2025] Enzymatic Construction of Rare Pyrazino[1,2-a]indole Framework: Side Chain Migration-Driven Pictet–Spengler Activity of McbB
DOI: https://doi.org/10.1021/acschembio.5c00455
[2025] Isolation of Elasnin and Antimycin Derivatives from Syo_1.56 SARP-Expressing Streptomyces sp. RK18-A0406 and Their Biological Activities
DOI: https://doi.org/10.1021/acsomega.5c02831
[2025] Proof of Concept for Transmission of Station Platform Video to Railway Trains
DOI: https://doi.org/10.23919/comex.2025col0002
[2025] Identification of Pyrrolizilactone Biosynthetic Gene Cluster with Unique Short‐Chain Dehydrogenase Gene for 3‐Methylproline Formation
DOI: https://doi.org/10.1002/ceur.202500099

続きを表示（残り 87 件）

[2025] Identification of defects and impurities in hydrothermally grown ZnO single crystals by ESR
DOI: https://doi.org/10.1007/s10854-025-14951-4
[2025] A Novel Gastrodin Derivative with Neuroprotection Promotes NGF-Mimic Activity by Targeting INSR and ACTN4 to Activate PI3K/Akt Signaling Pathway in PC12 Cells
DOI: https://doi.org/10.3390/antiox14030344
[2025] Inhibitory effect of copper chelators on the budding in Candida albicans
DOI: https://doi.org/10.1128/aac.00033-25
[2025] All-Solid-State Ion-Selective Electrode Inspired from All-Solid-State Li-Ion Batteries
DOI: https://doi.org/10.1021/acs.analchem.4c06470
[2024] Structural and Functional Analyses of Inhibition of Human Dihydroorotate Dehydrogenase by Antiviral Furocoumavirin
DOI: https://doi.org/10.1021/acs.biochem.4c00120
[2024] Pyricularia oryzae enhances Streptomyces griseus growth via non‐volatile alkaline metabolites
DOI: https://doi.org/10.1111/1758-2229.70012
[2024] Porphyrin derivatives inhibit tumor necrosis factor α-induced gene expression and reduce the expression and increase the cross-linked forms of cellular components of the nuclear factor κB signaling pathway
DOI: https://doi.org/10.1016/j.ejphar.2024.176747
[2024] Identification of a family of species-selective complex I inhibitors as potential anthelmintics
DOI: https://doi.org/10.1038/s41467-024-47331-3
[2024] BIL7 enhances plant growth by regulating the transcription factor BIL1/BZR1 during brassinosteroid signaling ‡
DOI: https://doi.org/10.1111/tpj.17212
[2024] Reprogramming of flagellin receptor responses with surrogate ligands
DOI: https://doi.org/10.1038/s41467-024-54271-5
[2024] Synergistic involvement of the NZF domains of the LUBAC accessory subunits HOIL-1L and SHARPIN in the regulation of LUBAC function
DOI: https://doi.org/10.1038/s41419-024-07199-z
[2024] Modulation of fungal phosphate homeostasis by the plant hormone strigolactone
DOI: https://doi.org/10.1016/j.molcel.2024.09.004
[2024] Expression of Syo_1.56 SARP Regulator Unveils Potent Elasnin Derivatives with Antibacterial Activity
DOI: https://doi.org/10.1021/acs.jnatprod.4c00259
[2024] Reclassification of a reveromycin-producer and the proposals of Actinacidiphila reveromycinica sp. nov. and Actinacidiphila acidipaludis comb. nov.
DOI: https://doi.org/10.1093/bbb/zbae032
[2024] Amiodarone inhibits the Toll-like receptor 3-mediated nuclear factor κB signaling pathway by blocking organelle acidification
DOI: https://doi.org/10.1016/j.bbrc.2024.149801
[2024] Production of Kinanthraquinone D with Antimalarial Activity by Heterologous Gene Expression and Biotransformation in Streptomyces lividans TK23
DOI: https://doi.org/10.1021/acs.jnatprod.3c01076
[2024] Alantolactone derivatives inhibit the tumor necrosis factor α-induced nuclear factor κB pathway by a different mechanism from alantolactone
DOI: https://doi.org/10.1016/j.ejphar.2024.176458
[2024] Total synthesis, stereochemical assignment, and biological evaluation of opantimycin A and analogues thereof
DOI: https://doi.org/10.1039/d4ob01475h
[2023] Identification of microbial metabolites that accelerate the ubiquitin-dependent degradation of c-Myc
DOI: https://doi.org/10.32604/or.2023.030248
[2023] Heaven helps those who help themselves
DOI: https://doi.org/10.5059/yukigoseikyokaishi.81.1194
[2023] cis-Decalin-containing tetramic acids as inhibitors of insect steroidogenic glutathione S-transferase Noppera-bo
DOI: https://doi.org/10.1371/journal.pone.0290851
[2023] Identification of α-Tocopherol succinate as an RFFL-substrate interaction inhibitor inducing peripheral CFTR stabilization and apoptosis
DOI: https://doi.org/10.1016/j.bcp.2023.115730
[2023] Identification of antimycin A as a c-Myc degradation accelerator via high-throughput screening
DOI: https://doi.org/10.1016/j.jbc.2023.105083
[2023] 3-[[(3S)-1,2,3,4-Tetrahydroisoquinoline-3-Carbonyl]Amino]Propanoic Acid (THICAPA) Is Protective Against Aβ42-Induced Toxicity In Vitro and in an Alzheimer’s DiseaseDrosophila
DOI: https://doi.org/10.1093/gerona/glad169
[2023] Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity
DOI: https://doi.org/10.1016/j.chembiol.2023.06.005
[2023] Isolation and characterization of β-transducin repeat-containing protein ligands screened using a high-throughput screening system
DOI: https://doi.org/10.32604/or.2023.030240
[2023] Identification of small-molecule inhibitors against the interaction of RNA-binding protein PSF and its target RNA for cancer treatment
DOI: https://doi.org/10.1093/pnasnexus/pgad203
[2023] Wakodecaline C, new tetrahydrofuran-fused decalin metabolite isolated from fungus Pyrenochaetopsis sp. RK10-F058
DOI: https://doi.org/10.1038/s41429-023-00613-2
[2023] Allantopyrone A interferes with the degradation of hypoxia-inducible factor 1α protein by reducing proteasome activity in human fibrosarcoma HT-1080 cells
DOI: https://doi.org/10.1038/s41429-023-00610-5
[2023] 3,6-Epidioxy-1,10-bisaboladiene induces ferroptosis-like cell death through lipid peroxidation
DOI: https://doi.org/10.1080/10715762.2023.2229005
[2023] A new gentiopicroside derivative improves cognitive deficits of AD mice via activation of Wnt signaling pathway and regulation of gut microbiota homeostasis
DOI: https://doi.org/10.1016/j.phymed.2023.154730
[2023] Identification of a derivative of the alkaloid emetine as an inhibitor of the YAP–TEAD interaction and its potential as an anticancer agent
DOI: https://doi.org/10.1093/bbb/zbad022
[2023] Fungal NRPS-PKS Hybrid Enzymes Biosynthesize New γ-Lactam Compounds, Taslactams A-D, Analogous to Actinomycete Proteasome Inhibitors
DOI: https://doi.org/10.1021/acschembio.2c00830
[2023] Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling
DOI: https://doi.org/10.32604/or.2023.030241
[2022] Establishment of a Monoclonal Antibody against Human NTCP That Blocks Hepatitis B Virus Infection
DOI: https://doi.org/10.1128/jvi.01686-21
[2022] Application of the Luminescence Syncytium Induction Assay to Identify Chemical Compounds That Inhibit Bovine Leukemia Virus Replication
DOI: https://doi.org/10.3390/v15010004
[2022] Lonidamine and domperidone inhibit expansion of transformed cell areas by modulating motility of surrounding nontransformed cells
DOI: https://doi.org/10.1016/j.jbc.2022.102635
[2022] BIONIC: biological network integration using convolutions
DOI: https://doi.org/10.1038/s41592-022-01616-x
[2022] Crystal structure of Arabidopsis DWARF14‐LIKE2 (DLK2) reveals a distinct substrate binding pocket architecture
DOI: https://doi.org/10.1002/pld3.446
[2022] N‐(3,4‐dimethoxyphenethyl)‐6‐methyl‐2,3,4,<scp>9‐tetrahydro‐1</scp>H‐carbazol‐1‐amine inhibits bladder cancer progression by suppressing <scp>YAP1</scp>/<scp>TAZ</scp>
DOI: https://doi.org/10.1111/gtc.12979
[2022] Phenylboronic Ester-Activated Aryl Iodide-Selective Buchwald–Hartwig-Type Amination toward Bioactivity Assay
DOI: https://doi.org/10.1021/acsomega.2c01092
[2022] Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation
DOI: https://doi.org/10.1038/s41467-022-31308-1
[2022] CmLec4, a lectin from the fungus Cordyceps militaris, controls host infection and fruiting body formation
DOI: https://doi.org/10.1016/j.ijbiomac.2022.06.106
[2022] Gastrodin From Gastrodia elata Enhances Cognitive Function and Neuroprotection of AD Mice via the Regulation of Gut Microbiota Composition and Inhibition of Neuron Inflammation
DOI: https://doi.org/10.3389/fphar.2022.814271
[2022] New antimalarials identified by a cell-based phenotypic approach: Structure–activity relationships of 2,3,4,9-tetrahydro-1H-β-carboline derivatives possessing a 2-((coumarin-5-yl)oxy)alkanoyl moiety
DOI: https://doi.org/10.1016/j.bmc.2022.116830
[2022] Isolation of new lucilactaene derivatives from P450 monooxygenase and aldehyde dehydrogenase knockout Fusarium sp. RK97-94 strains and their biological activities
DOI: https://doi.org/10.1038/s41429-022-00529-3
[2022] Development of Low-Molecular-Weight Compounds Targeting the Cancer-Associated KLF5 Transcription Factor
DOI: https://doi.org/10.1021/acsmedchemlett.1c00721
[2022] Identification of Scytalone Dehydratase Inhibitors Effective against Melanin Biosynthesis Dehydratase Inhibitor-Resistant Pyricularia oryzae
DOI: https://doi.org/10.1021/acs.jafc.1c04984
[2022] Identification of a Small Molecule That Enhances Ferroptosis via Inhibition of Ferroptosis Suppressor Protein 1 (FSP1)
DOI: https://doi.org/10.1021/acschembio.2c00028
[2022] β-Methyltryptamine Provoking the Crucial Role of Strictosidine Synthase Tyr151-OH for Its Stereoselective Pictet−Spengler Reactions to Tryptoline-type Alkaloids
DOI: https://doi.org/10.1021/acschembio.1c00844
[2022] Isoquercitrin from Apocynum venetum L. produces an anti-obesity effect on obese mice by targeting C-1-tetrahydrofolate synthase, carbonyl reductase, and glutathione S-transferase P and modification of the AMPK/SREBP-1c/FAS/CD36 signaling pathway in mice in vivo
DOI: https://doi.org/10.1039/d2fo02438a
[2022] Two-dimensional electrophoresis–cellular thermal shift assay (2DE-CETSA) for target identification of bioactive compounds
DOI: https://doi.org/10.1016/bs.mie.2022.07.018
[2021] Controlling the production of phytotoxin pyriculol in Pyricularia oryzae by aldehyde reductase
DOI: https://doi.org/10.1093/bbb/zbaa035
[2021] Dihydrolucilactaene, a Potent Antimalarial Compound from Fusarium sp. RK97-94
DOI: https://doi.org/10.1021/acs.jnatprod.1c00677
[2021] Exploiting diverse chemical collections to uncover novel antifungals
DOI: https://doi.org/10.1099/acmi.cc2021.po0006
[2021] Oxicam-type non-steroidal anti-inflammatory drugs inhibit NPR1-mediated salicylic acid pathway
DOI: https://doi.org/10.1038/s41467-021-27489-w
[2021] Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment
DOI: https://doi.org/10.1016/j.isci.2021.103497
[2021] Introduction and commentaries for the special issue: “Arnold L. Demain—A life lived”
DOI: https://doi.org/10.1093/jimb/kuab082
[2021] Tenuazonic acid production is dispensable for virulence, but its biosynthetic gene expression pattern is associated with the infection of Pyricularia oryzae
DOI: https://doi.org/10.1093/bbb/zbab195
[2021] Identification of Dihydroorotate Dehydrogenase Inhibitors─Indoluidins─That Inhibit Cancer Cell Growth
DOI: https://doi.org/10.1021/acschembio.1c00625
[2021] 2-Methylthio-N7-methyl-cis-zeatin, a new antimalarial natural product isolated from a Streptomyces culture
DOI: https://doi.org/10.1093/bbb/zbab192
[2021] Cesium tolerance is enhanced by a chemical which binds to BETA-GLUCOSIDASE 23 in Arabidopsis thaliana
DOI: https://doi.org/10.1038/s41598-021-00564-4
[2021] Privileged Biorenewable Secologanin‐Based Diversity‐Oriented Synthesis for Pseudo‐Natural Alkaloids: Uncovering Novel Neuroprotective and Antimalarial Frameworks
DOI: https://doi.org/10.1002/cssc.202101868
[2021] Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock
DOI: https://doi.org/10.1038/s42003-021-02701-1
[2021] Thiolactomide: A New Homocysteine Thiolactone Derivative from Streptomyces sp. with Neuroprotective Activity
DOI: https://doi.org/10.4014/jmb.2108.08015
[2021] Controlled lipid β-oxidation and carnitine biosynthesis by a vitamin D metabolite
DOI: https://doi.org/10.1016/j.chembiol.2021.08.008
[2021] New Abscisic Acid Derivatives Revealed Adequate Regulation of Stomatal, Transcriptional, and Developmental Responses to Conquer Drought
DOI: https://doi.org/10.1021/acschembio.1c00451
[2021] Screening of tenuazonic acid production-inducing compounds and identification of NPD938 as a regulator of fungal secondary metabolism
DOI: https://doi.org/10.1093/bbb/zbab143
[2021] Innentitelbild: Molecular Basis for Two Stereoselective Diels–Alderases that Produce Decalin Skeletons (Angew. Chem. 41/2021)
DOI: https://doi.org/10.1002/ange.202109381
[2021] Improving Measures of Chemical Structural Similarity Using Machine Learning on Chemical–Genetic Interactions
DOI: https://doi.org/10.1021/acs.jcim.0c00993
[2021] Identification of the kinanthraquinone biosynthetic gene cluster by expression of an atypical response regulator
DOI: https://doi.org/10.1093/bbb/zbaa082
[2021] Identification of a Small-Molecule Glucose Transporter Inhibitor, Glutipyran, That Inhibits Cancer Cell Growth
DOI: https://doi.org/10.1021/acschembio.1c00480
[2021] Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation
DOI: https://doi.org/10.1111/cas.15079
[2021] 6,9-Dihydroxytetrangulol, a novel angucyclinone antibiotic accumulated in kiqO gene disruptant in the biosynthesis of kinanthraquinone
DOI: https://doi.org/10.1038/s41429-021-00442-1
[2021] Zealpeptaibolin, an 11-mer cytotoxic peptaibol group with 3 Aib-Pro motifs isolated from Trichoderma sp. RK10-F026
DOI: https://doi.org/10.1038/s41429-021-00429-y
[2021] Molecular Basis for Two Stereoselective Diels–Alderases that Produce Decalin Skeletons**
DOI: https://doi.org/10.1002/anie.202106186
[2021] Molecular Basis for Two Stereoselective Diels–Alderases that Produce Decalin Skeletons**
DOI: https://doi.org/10.1002/ange.202106186
[2021] Local administration of ReveromycinA ointment suppressed alveolar bone loss in mice
DOI: https://doi.org/10.1016/j.jphs.2021.05.011
[2021] The Insulin Receptor: A Potential Target of Amarogentin Isolated from Gentiana rigescens Franch That Induces Neurogenesis in PC12 Cells
DOI: https://doi.org/10.3390/biomedicines9050581
[2021] CSE1L promotes nuclear accumulation of transcriptional coactivator TAZ and enhances invasiveness of human cancer cells
DOI: https://doi.org/10.1016/j.jbc.2021.100803
[2021] Targeting Epigenetic and Posttranscriptional Gene Regulation by PSF Impairs Hormone Therapy–Refractory Cancer Growth
DOI: https://doi.org/10.1158/0008-5472.can-20-3819
[2021] Glyoxalase I disruption and external carbonyl stress impair mitochondrial function in human induced pluripotent stem cells and derived neurons
DOI: https://doi.org/10.1038/s41398-021-01392-w
[2021] N-Acetyl-α-hydroxy-β-oxotryptamine, a racemic natural product isolated from Streptomyces sp. 80H647
DOI: https://doi.org/10.1038/s41429-021-00420-7
[2021] Dihydropyriculol produced by Pyricularia oryzae inhibits the growth of Streptomyces griseus
DOI: https://doi.org/10.1093/bbb/zbab021
[2021] Dutomycin Induces Autophagy and Apoptosis by Targeting the Serine Protease Inhibitor SERPINB6
DOI: https://doi.org/10.1021/acschembio.0c00889
[2021] Discovery of a σ1 receptor antagonist by combination of unbiased cell painting and thermal proteome profiling
DOI: https://doi.org/10.1016/j.chembiol.2021.01.009
[2021] A new peptaibol, RK-026A, from the soil fungusTrichodermasp. RK10-F026 by culture condition-dependent screening
DOI: https://doi.org/10.1093/bbb/zbaa051

科研費（0 件）

まだデータがありません（KAKEN 取り込み後に表示）。

所属学会・役職（0 件）

まだデータがありません（学会データ連携後に表示）。

AI 要約（直近 5 年の研究成果）

外部リンク

関連研究室(8 件)

研究成果（97 件）

科研費（0 件）

所属学会・役職（0 件）