Hiroyuki Hao 研究室

主宰者：Hiroyuki Hao

日本大学

AI 要約（直近 5 年の研究成果）

Hiroyuki Hao研究室では、心臓と血管の疾患を中心に、その発症メカニズムの解明と治療法の開発に取り組んでいます。急性大動脈解離、心筋梗塞後の合併症、心不全、末梢動脈疾患など、生命に関わる循環器疾患を対象としており、各疾患における組織の変化や細胞の機能異常を詳しく調べることで、病態の本質的な理解を目指しています。研究アプローチは多角的で、動物モデルを用いた生体内実験、剖検サンプルを含む病理組織学的解析、医用画像診断との比較検討、さらに遺伝子発現解析や機械学習を組み合わせた手法を活用しています。特に、豚やイヌなどの大型動物モデルを用いて実際の組織温度測定やカテーテル治療の効果検証を行うとともに、ヒト臨床サンプルに対する詳細な病理学的検索を重視しています。これらの研究を通じて、血管壁の構造的崩壊と血管平滑筋細胞の性質変化の関係性、カルシウム沈着が血栓形成に至るメカニズム、新規治療法による組織反応の特性などが明らかにされつつあります。各疾患の根本的な原因解明と、より安全で効果的な治療戦略の開発につながる知見が蓄積されています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（40 件）

[2025] Familial non-inflammatory, non-atherosclerotic vasculopathy presented with acute coronary syndrome
DOI: https://doi.org/10.1093/ehjimp/qyaf039
[2025] Cardiomyopathy diagnosis model from endomyocardial biopsy specimens: Appropriate feature space and class boundary in small sample size data
DOI: https://doi.org/10.3934/bioeng.2025014
[2025] Intraperitoneal haemorrhage with elevated alpha-fetoprotein level in the absence of liver tumours
DOI: https://doi.org/10.1136/flgastro-2025-103391
[2025] A Case of an Infected Right Ventricular Pseudo-False Aneurysm
DOI: https://doi.org/10.7759/cureus.92999
[2025] Efficacy of vocal fold injection of dedifferentiated fat cells in treating glottis closure insufficiency: Insights from a rat model of recurrent laryngeal nerve resection
DOI: https://doi.org/10.1371/journal.pone.0324965
[2025] Intravascular Imaging and Pathological Features of Drug-Coated Balloon Angioplasty in Atherosclerotic Porcine Peripheral Arteries
DOI: https://doi.org/10.5551/jat.65558
[2025] Relationship Between Vascular Smooth Muscle Cell Phenotype and Degeneration of Elastin in the Aortic Media in Patients With Acute Aortic Dissection
DOI: https://doi.org/10.1016/j.cjco.2025.03.020
[2025] Safety and efficacy of edoxaban monotherapy after bioabsorbable polymer everolimus-eluting stent implantation in a human-like coronary atherosclerotic porcine model
DOI: https://doi.org/10.1016/j.athplu.2025.01.002
[2025] In Vivo Tissue Temperature Characteristics of Contact Force Catheter With a Mesh‐Shaped Irrigation Tip: A Porcine Study
DOI: https://doi.org/10.1111/pace.15147
[2024] Comparisons of magnetic resonance imaging, histopathological and Ki-67 labeling index findings in a single myxofibrosarcoma: a case report
DOI: https://doi.org/10.1186/s13256-024-04693-y

続きを表示（残り 30 件）

[2024] ROLE OF FILAMIN A IN THORACIC AORTIC DISSECTION
DOI: https://doi.org/10.1016/s0735-1097(24)04209-8
[2024] Sjögren’s syndrome positive for isolated anti-Ro52/SS-A antibody and anti-centromere antibody
DOI: https://doi.org/10.1177/03000605241293986
[2024] Subjective Symptoms and Disease Activity Related to Serum Zinc Concentration in Primary Sjögren’s Syndrome
DOI: https://doi.org/10.3390/jcm13164672
[2023] Pathology of Critical Limb Ischemia; Comparison of Plaque Characteristics Between Anterior and Posterior Tibial Arteries
DOI: https://doi.org/10.5551/jat.64259
[2023] Case report: Anti-N-methyl-D-aspartate receptor antibody-associated autoimmunity triggered by primary central nervous system B-cell lymphoma
DOI: https://doi.org/10.3389/fneur.2022.1048953
[2023] Abstract 18152: Clinical Impact and Mechanism of De Novo Aortic Insufficiency During Percutaneous Ventricular Assist Device Support for Cardiogenic Shock
DOI: https://doi.org/10.1161/circ.148.suppl_1.18152
[2023] A Case of Duodenal Jejunal Anastomosis after Partial Resection for a Duodenal GIST
DOI: https://doi.org/10.4264/numa.82.5_309
[2023] Frequency and Distribution of Sheet and Nodular Calcification in Coronary Arteries in Japanese Patients
DOI: https://doi.org/10.1536/ihj.23-149
[2023] Intravenous Semaphorin 3A Administration Maintains Cardiac Contractility and Improves Electrical Remodeling in a Mouse Model of Isoproterenol-Induced Heart Failure
DOI: https://doi.org/10.1536/ihj.22-705
[2022] Potential of optical frequency domain imaging for differentiation between early and advanced coronary atherosclerosis
DOI: https://doi.org/10.1007/s10554-022-02600-4
[2022] SAFETY AND EFFICACY OF EDOXABAN MONOTHERAPY AFTER BIOABSORBABLE POLYMER EVEROLIMUS-ELUTING STENT IMPLANTATION IN A HUMAN-LIKE CORONARY ATHEROSCLEROTIC PORCINE MODEL
DOI: https://doi.org/10.1016/s0735-1097(22)02756-5
[2022] In vivo tissue temperatures during 90 W/4 sec‐very high power‐short‐duration (vHPSD) ablation versus ablation index‐guided 50 W‐HPSD ablation: A porcine study
DOI: https://doi.org/10.1111/jce.15782
[2022] Abstract 12340: Vascular Pathology of Critical Limb Ischemia; Comparison of Plaque Characteristics Between Anterior and Posterior Tibial Arteries
DOI: https://doi.org/10.1161/circ.146.suppl_1.12340
[2022] Abstract 12487: Ex Vivo Assessments of Human Nodular Calcification: Optical Frequency Domain Imaging and Histopathology
DOI: https://doi.org/10.1161/circ.146.suppl_1.12487
[2022] [Giant Anastomotic Aneurysm Associated with Albumin/Glutaraldehyde Sealant as a Late Complication after Acute Aortic Dissection Surgery:Report of a Case].
[2022] In vivo tissue temperature during lesion size index‐guided 50W ablation versus 30W ablation: A porcine study
DOI: https://doi.org/10.1111/jce.15722
[2022] Autopsy and Cardiac Magnetic Resonance Image Case of Bevacizumab-Related Cardiomyopathy
DOI: https://doi.org/10.3390/jcdd9070208
[2021] Rosai-Dorfman disease of thymus with elevated serum anti-acetylcholine receptor antibody: a case report.
[2021] Diagnostic accuracy of optical coherence tomography for the identification of in-stent fibroatheroma following stent implantation: an ex vivo histological validation study
DOI: https://doi.org/10.1007/s10554-020-02125-8
[2021] Actual tissue temperature during ablation index‐guided high‐power short‐duration ablation versus standard ablation: Implications in terms of the efficacy and safety of atrial fibrillation ablation
DOI: https://doi.org/10.1111/jce.15282
[2021] Immunohistochemical evaluation of placentae obtained from women infected with COVID-19 during pregnancy
DOI: https://doi.org/10.1016/j.placenta.2021.08.017
[2021] Diagnostic Accuracy of Optical Frequency Domain Imaging for Identifying Necrotic Cores with Intraplaque Hemorrhage in Advanced Human Carotid Plaques
DOI: https://doi.org/10.1016/j.amjcard.2021.06.040
[2021] Pathology of Pulmonary Vein Isolation in a Patient With Transthyretin-Related Amyloidosis
DOI: https://doi.org/10.1253/circrep.cr-21-0073
[2021] Automated classification of coronary atherosclerotic plaque in optical frequency domain imaging based on deep learning
DOI: https://doi.org/10.1016/j.atherosclerosis.2021.06.003
[2021] Multimodal Findings of COVID-19-Related Rhabdomyolysis Complicated With Pericarditis Mimicking Fulminant Myocarditis
DOI: https://doi.org/10.1253/circrep.cr-21-0055
[2021] Pathological findings after third- and second-generation everolimus-eluting stent implantations in coronary arteries from autopsy cases and an atherosclerotic porcine model
DOI: https://doi.org/10.1038/s41598-021-85740-2
[2021] Fatal Embolic ST-Elevation Myocardial Infarction Secondary to Healed-Phase Mitral Valve Infective Endocarditis
DOI: https://doi.org/10.1536/ihj.20-548
[2021] Effect of obesity and epicardial fat/fatty infiltration on electrical and structural remodeling associated with atrial fibrillation in a novel canine model of obesity and atrial fibrillation: A comparative study
DOI: https://doi.org/10.1111/jce.14955
[2021] Exophytic cavernous hemangioma arising from the right ventricle: Report of a rare case
DOI: https://doi.org/10.1111/pin.13075
[2021] Cardiac calcified amorphous tumor with sustained ventricular tachycardia
DOI: https://doi.org/10.1177/02184923211013999

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AI 要約（直近 5 年の研究成果）

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