Takuya Nagashima 研究室

主宰者：Takuya Nagashima

日本大学

AI 要約（直近 5 年の研究成果）

長島拓也研究室は、肺がんの外科治療と予後に関する臨床研究を中心に展開しています。特に、小型で放射線学的に充実成分が主体の非小細胞肺がんに対する肺区域切除と肺葉切除の有効性を比較検討し、患者の肺機能温存と生存予後のバランスを取ることを主要な研究テーマとしています。複数の施設から収集した数百例から数千例の患者データを用いた大規模な後ろ向きコホート研究により、腫瘍の位置（中枢部対末梢部）、画像所見、喫煙歴などの臨床的特徴が予後に与える影響を分析しています。手法としては、複合施設での外科切除後のデータを多変量解析や傾向スコアマッチングを用いて統計的に処理し、リンパ節転移や再発パターンを詳細に分類することで、より正確な危険度層別化システムを構築しています。さらに、免疫化学療法後の複雑な気管支形成手術の実現可能性も検討するなど、手術技術の最適化にも取り組んでいます。これらの研究を通じて、個々の患者の特性に応じた治療戦略の確立を目指しており、電子カルテデータを活用した大規模疫学研究も並行して進めています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（59 件）

[2026] Atypical type D extended sleeve resection. The video provides a summary of the actual surgical procedure. At the site of dissection near the hilum, fibrosis is not particularly noticeable, and it can be seen that the tumor was successfully dissected from the vessel wall. For the anastomosis between the right main bronchus and B2+3, a telescoping technique was used. The central-to-distal suture pitch was adjusted to manage the marked caliber mismatch, and the knots were placed outside the bronchial lumen.
DOI: https://doi.org/10.21037/asvide.2026.163
[2026] Atypical type D extended sleeve resection after neoadjuvant chemoimmunotherapy in a 69-year-old man with locally advanced lung cancer and a tracheobronchial branching anomaly: a case report
DOI: https://doi.org/10.21037/tlcr-2026-1-0199
[2026] Drug-Induced Liver Injury with Eosinophilia: A Case–Control Study Using Electronic Medical Records
DOI: https://doi.org/10.1248/bpb.b25-00620
[2026] A preoperative risk scoring system for survival prediction in clinical stage IB lung adenocarcinoma: a multicenter study
DOI: https://doi.org/10.3389/fonc.2025.1712276
[2025] Impact of Phrenic Nerve Repair Using Intercostal Nerve Graft on Diaphragm Function after Thoracic Tumour Resection
DOI: https://doi.org/10.1093/icvts/ivaf302
[2025] Association between daily dose of dipeptidyl peptidase-4 inhibitors and change in glycated hemoglobin in patients with type 2 diabetes: interpretation of mixed-effects machine-learning models using electronic medical records
DOI: https://doi.org/10.1186/s40360-025-01055-2
[2025] Loco-regional Recurrence After Segmentectomy for Peripheral and Radiologically Solid-dominant Tumours
DOI: https://doi.org/10.1093/ejcts/ezaf416
[2025] Recurrence Risk Stratification by Station- and Zone-Based Nodal Classification in Resected Non-Small Cell Lung Cancer
DOI: https://doi.org/10.1093/ejcts/ezaf338
[2025] EP.09.13 Prognostic Analysis of Patients With Incidentally Diagnosed Pathological Stage IVA Non-Small Cell Lung Cancer After Anatomical Resection
DOI: https://doi.org/10.1016/j.jtho.2025.09.1502
[2025] EP.07.07 Prognostic Analysis and Molecular Characteristics of Bubble-Like Appearance-Type Lung Adenocarcinoma
DOI: https://doi.org/10.1016/j.jtho.2025.09.1388

続きを表示（残り 49 件）

[2025] Lymph node dissection as a local control during segmentectomy for small-sized and radiologically solid dominant and pure solid tumors
DOI: https://doi.org/10.1093/jjco/hyaf126
[2025] Prognostic implications of MDM2 expression in surgically resected epidermal growth factor receptor mutant lung cancer with pathological lymph node metastasis
DOI: https://doi.org/10.21037/tlcr-2025-143
[2025] Prognosis, imaging characteristics, and clinicopathological features of heavy smokers with clinical stage I lung adenocarcinoma: a multicenter study
DOI: https://doi.org/10.1007/s11748-025-02166-7
[2025] Comparison of the Changes in Visceral Adipose Tissue After Lobectomy and Segmentectomy for Patients With Early‐Stage Lung Cancer
DOI: https://doi.org/10.1002/jcsm.13751
[2025] Segmentectomy versus lobectomy for centrally located small-sized and radiologically pure-solid non–small cell lung cancer
DOI: https://doi.org/10.1016/j.xjon.2025.03.028
[2025] Bronchoplasty to Preserve Pulmonary Function in Lung Cancer
DOI: https://doi.org/10.2468/jbes.76.60
[2025] Comparative oncological features of centrally and peripherally located small-sized radiologically solid-dominant non-small-cell lung cancer
DOI: https://doi.org/10.1093/ejcts/ezaf072
[2025] Pulmonary Carcinosarcoma Imitating Teratocarcinosarcoma: A Case Report
DOI: https://doi.org/10.1111/pin.70006
[2025] Total arch replacement for resection of a dedifferentiated liposarcoma of anterior mediastinal origin invading the aorta, left common carotid artery, and left subclavian artery: a case report
DOI: https://doi.org/10.1186/s44215-025-00191-9
[2025] Role of 18F-fluorodeoxyglucose accumulation in radiological ground-glass opacity of non-small cell lung cancer
DOI: https://doi.org/10.1093/jjco/hyae185
[2025] Non‐Linear Dose–Response Relationship for Metformin in Japanese Patients With Type 2 Diabetes: Analysis of Irregular Longitudinal Data by Interpretable Machine Learning Models
DOI: https://doi.org/10.1002/prp2.70055
[2025] Segmentectomy versus lobectomy in younger patients with early-stage non-small cell lung cancer
DOI: https://doi.org/10.1093/icvts/ivaf024
[2024] Long‐term benefit of <scp>SGLT2</scp> inhibitors to prevent heart failure hospitalization in patients with diabetes, with potential time‐varying benefit
DOI: https://doi.org/10.1111/cts.70088
[2024] P2.07B.07 Multi-Institutional Retrospective Analysis of Segmentectomy Versus Lobectomy for Non-Small Cell Lung Cancer Larger Than 3 cm in Diameter
DOI: https://doi.org/10.1016/j.jtho.2024.09.426
[2024] Mediastinal lymph node dissection in segmentectomy for peripheral c-stage IA (≤2 cm) non–small-cell lung cancer
DOI: https://doi.org/10.1016/j.jtcvs.2024.09.003
[2024] Late development of OCD-like phenotypes in Dlgap1 knockout mice
DOI: https://doi.org/10.1007/s00213-024-06668-9
[2024] Feasibility and comparative prognosis of segmentectomy versus lobectomy in centrally located small and solid dominant cN0 non–small cell lung cancer
DOI: https://doi.org/10.1016/j.jtcvs.2024.06.016
[2024] Comparison of <scp>SP263</scp> and <scp>22C3 pharmDx</scp> assays to test <scp>programmed death ligand‐1</scp> (PD‐L1) expression in surgically resected non‐small cell lung cancer
DOI: https://doi.org/10.1111/1759-7714.15319
[2024] Right middle lobe and S6 sleeve lobectomy for pulmonary mucoepidermoid carcinoma originating from the bronchus intermedius: A case report
DOI: https://doi.org/10.1016/j.xjtc.2024.03.026
[2024] Omitting Lymph Node Dissection for Small Ground-Glass Opacity–Dominant Tumors
DOI: https://doi.org/10.1016/j.athoracsur.2024.03.013
[2024] Right <scp>S3</scp> segmentectomy for lung cancer with partial anomalous pulmonary venous return in the right upper pulmonary vein: A case report
DOI: https://doi.org/10.1111/1759-7714.15266
[2024] Mutation profile and programmed death ligand 1 status of patients with non‐small cell lung cancer diagnosed with “adenocarcinoma” and “non‐small cell carcinoma favor adenocarcinoma”
DOI: https://doi.org/10.1111/1759-7714.15214
[2024] Sublobar Resection in Early Non-Small Cell Lung Cancer With Epidermal Growth Factor Receptor Mutant
DOI: https://doi.org/10.1016/j.athoracsur.2023.12.009
[2023] Detection of potential drug-drug interactions for risk of acute kidney injury: a population-based case-control study using interpretable machine-learning models
DOI: https://doi.org/10.3389/fphar.2023.1176096
[2023] A case of aortic dissection after placing a thoracic endovascular stent to perform left lung surgery
DOI: https://doi.org/10.2995/jacsurg.37.185
[2023] EP07.04-11 Clinicopathological Features and Postoperative Prognosis of Bubble-like Appearance Type Lung Adenocarcinoma
DOI: https://doi.org/10.1016/j.jtho.2023.09.1024
[2023] Successful recovery of an anastomotic fistula in right sleeve pneumonectomy after excessive radiotherapy
DOI: https://doi.org/10.1016/j.xjtc.2023.10.001
[2023] Impact of RBM10 and PD-L1 expression on the prognosis of pathologic N1–N2 epidermal growth factor receptor mutant lung adenocarcinoma
DOI: https://doi.org/10.21037/tlcr-23-355
[2023] Successful repair of acquired intrathoracic nonmalignant tracheoesophageal fistulas using thoracoacromial artery perforator flap through a midsternal incision approach: a report of three cases
DOI: https://doi.org/10.21037/jtd-23-1128
[2023] Wedge resection vs. segmentectomy for lung cancer measuring ≤ 2 cm with consolidation tumor ratio > 0.25
DOI: https://doi.org/10.3389/fonc.2023.1253414
[2023] Increased expression of glutathione peroxidase 3 prevents tendinopathy by suppressing oxidative stress
DOI: https://doi.org/10.3389/fphar.2023.1137952
[2023] Early Detection of Adverse Drug Reaction Signals by Association Rule Mining Using Large-Scale Administrative Claims Data
DOI: https://doi.org/10.1007/s40264-023-01278-4
[2023] Vitamin D supplementation is effective for olanzapine-induced dyslipidemia
DOI: https://doi.org/10.3389/fphar.2023.1135516
[2023] Benzodiazepine-related dementia risks and protopathic biases revealed by multiple-kernel learning with electronic medical records
DOI: https://doi.org/10.1177/20552076231178577
[2023] [Thoracoscopic Segmentectomy Using Three-dimensional Image Simulation of the Pulmonary Artery Perfusion Area and Indocyanine Green( ICG) Intravenous Injection Method].
[2022] Identifying Antidepressants Less Likely to Cause Hyponatremia: Triangulation of Retrospective Cohort, Disproportionality, and Pharmacodynamic Studies
DOI: https://doi.org/10.1002/cpt.2573
[2022] Detection of Synergistic Interaction on an Additive Scale Between Two Drugs on Abnormal Elevation of Serum Alanine Aminotransferase Using Machine-Learning Algorithms
DOI: https://doi.org/10.3389/fphar.2022.910205
[2022] Identifying antidepressants less likely to cause hyponatremia: triangulation of retrospective cohort, disproportionality, and pharmacodynamic studies
DOI: https://doi.org/10.1254/jpssuppl.96.0_yia09-5
[2022] Increased Expression of Glutathione Peroxidase 3 Prevents Tendinopathy Induced Commonly by Fluoroquinolones and Aging
DOI: https://doi.org/10.2139/ssrn.4258948
[2022] An early and versatile detection scheme of adverse drug reactions using large-scale administrative claims data
DOI: https://doi.org/10.1254/jpssuppl.96.0_4-b-p-324
[2022] Identification of the therapeutic target for tendinopathy through the combination of real world data analysis and pharmacological experiments
DOI: https://doi.org/10.1254/jpssuppl.96.0_yia05-3
[2021] P07.07 Computed Tomography of Lymph Nodes to Predict Occult pN2 Disease in Non-Small-Cell Lung Cancer
DOI: https://doi.org/10.1016/j.jtho.2021.01.418
[2021] Signal Detection of Potential Hepatotoxic Drugs: Case-Control Study Using Both a Spontaneous Reporting System and Electronic Medical Records
DOI: https://doi.org/10.1248/bpb.b21-00407
[2021] Drug Repurposing Prediction and Validation From Clinical Big Data for the Effective Treatment of Interstitial Lung Disease
DOI: https://doi.org/10.3389/fphar.2021.635293
[2021] Anatomical location and number of metastatic lymph nodes for prognosis of non-small cell lung cancer
DOI: https://doi.org/10.21037/jtd-21-390
[2021] Striatal TRPV1 activation by acetaminophen ameliorates dopamine D2 receptor antagonist–induced orofacial dyskinesia
DOI: https://doi.org/10.1172/jci.insight.145632
[2021] Usefulness of monitoring intrapleural pressure with digital chest drainage system for the management of air leakage after lung resection
DOI: https://doi.org/10.1093/icvts/ivab122
[2021] 4. Clinical Pharmacological Research Using Medical Big Data from 22 Million Patients over 15 Years in Nihon University School of Medicine
DOI: https://doi.org/10.3999/jscpt.52.51
[2021] Striatal TRPV1 activation by acetaminophen improves tardive dyskinesia induced by dopamine D<sub>2</sub> receptor blockers
DOI: https://doi.org/10.1254/jpssuppl.94.0_3-o-e5-2

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AI 要約（直近 5 年の研究成果）

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研究成果（59 件）

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