Yuki Izawa‐Ishizawa 研究室

主宰者：Yuki Izawa‐Ishizawa

徳島大学

AI 要約（直近 5 年の研究成果）

本研究室は、医薬品の安全性と有効性を総合的に検討する研究を行っています。研究の問いは、既存医薬品の使用時に生じる思わぬ有害事象をいかに予測・予防し、同時に治療効果を最大化するかにあります。例えば、抗がん薬による心障害や末梢神経障害、抗生物質による血管疾患などの副作用の発症機構を明らかにし、その予防策を探索しています。手法として、本研究室は複数の大規模データベース（WHOの医薬品安全情報報告システムVigiBase、日本の医療保険請求データ、有害事象報告データベースなど）を活用した臨床疫学的分析と、細胞培養実験および動物モデルを組み合わせたアプローチを採用しています。これにより、実臨床で報告された副作用の信号を検出し、その生物学的機序を実験的に検証しています。主要な知見として、複数の医薬品について、従来は副作用のリスク因子と考えられていなかった別の医薬品との組み合わせが有害事象を増加させることや、逆に既存薬が予期しない治療効果を持つ可能性が報告されています。こうした成果は、患者の安全性を保証しながら医薬品の適正使用を実現するための基盤となります。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（46 件）

[2025] Trends in the use of sodium-glucose cotransporter-2 inhibitors and characteristics of adverse event reporting in patients with heart failure in Japan: reports from the medical administration database and the adverse event reporting database
DOI: https://doi.org/10.1080/14740338.2025.2539543
[2025] Atractylodes lancea (Thunb.) DC. [Asteraceae] Rhizome-Derived Exosome-like Nanoparticles Suppress Lipopolysaccharide-Induced Inflammation by Reducing Toll-like Receptor 4 Expression in BV-2 Murine Microglial Cells
DOI: https://doi.org/10.3390/ph18081099
[2025] Ursodeoxycholic acid alleviates multiple sclerosis via TGR5-dependent microglial regulation in mice
DOI: https://doi.org/10.1016/j.ejphar.2025.177941
[2025] Pharmacovigilance study for the identification of mogamulizumab-induced immune-related adverse events using a real-world database
DOI: https://doi.org/10.1093/oncolo/oyaf201
[2025] Flunitrazepam increases the risk of lamotrigine‐induced cutaneous adverse reactions: Combined analysis of medical big data and clinical research
DOI: https://doi.org/10.1111/pcn.13866
[2025] MATE are bound to a multiprotein complex containing NHE3, and it's causing functional interactions
DOI: https://doi.org/10.1016/j.dmpk.2025.101425
[2025] Development of a strategy to prevent cisplatin-induced kidney injury by targeting mate-type transporters
DOI: https://doi.org/10.1016/j.dmpk.2025.101129
[2025] Rifampicin in combination treatments for methicillin-resistant staphylococcal prosthetic joint infections: Claims database evaluation using a cohort of 52,588 hip arthroplasty patients
DOI: https://doi.org/10.5414/cp204740
[2025] Unravelling the cardioprotective effects of calcitriol in Sunitinib-induced toxicity: A comprehensive in silico and in vitro study
DOI: https://doi.org/10.1016/j.biopha.2025.118137
[2025] Promotion of the appropriate use of antimicrobial agents by utilizing medical big data
DOI: https://doi.org/10.1254/fpj.24081

続きを表示（残り 36 件）

[2025] Influence of statin intervention on peripheral neuropathy in patients treated with anticancer drugs identified from the insurer database
DOI: https://doi.org/10.1186/s40780-025-00428-3
[2025] Risk factors for clazosentan-induced fluid retention in subarachnoid hemorrhage from the Japanese adverse event database
DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2025.108296
[2025] Effective drug dosage rounding reduces healthcare expenses in the Japanese healthcare system
DOI: https://doi.org/10.1007/s40267-025-01144-6
[2025] Cardiovascular Toxicity Profile of Macrolides Investigated Using VigiBase Data: A Pharmacovigilance Study
DOI: https://doi.org/10.1007/s12012-025-09970-w
[2025] Resuscitated patient after simultaneous intravascular thrombolytic therapy for massive pulmonary embolism and embolization of an injured hepatic artery : a case report
DOI: https://doi.org/10.2152/jmi.72.177
[2024] Development of Preventive Methods for Drug-induced Cardiotoxicity Using a Large-scale Medical Information Database
DOI: https://doi.org/10.1248/yakushi.23-00164-2
[2024] Statins ameliorate oxaliplatin- and paclitaxel-induced peripheral neuropathy via glutathione S-transferase
DOI: https://doi.org/10.1016/j.neuint.2024.105863
[2024] Unveiling the association between fluoroquinolones and aortic diseases using real-world database analysis and pharmacological experiments
DOI: https://doi.org/10.1016/j.biopha.2024.117418
[2024] Asciminib, a novel allosteric inhibitor of <scp>BCR‐ABL1</scp>, shows synergistic effects when used in combination with imatinib with or without drug resistance
DOI: https://doi.org/10.1002/prp2.1214
[2024] Effects of renin-angiotensin system inhibitor and beta-blocker use on mortality in older patients with heart failure with reduced ejection fraction in Japan
DOI: https://doi.org/10.3389/fcvm.2024.1377228
[2024] Atractylodes lancea (Thunb.) DC. [Asteraceae] rhizome-derived exosome-like nanoparticles suppress lipopolysaccharide-induced inflammation in murine microglial cells
DOI: https://doi.org/10.3389/fphar.2024.1302055
[2024] The Association between PDE5 Inhibitors and Aneurysm/Arterial Dissection:A Pharmacovigilance Study Using WHO Safety Database
DOI: https://doi.org/10.2152/jmi.71.134
[2023] Effects of vonoprazan and proton pump inhibitors on the efficacy of bevacizumab: a multicentre retrospective study
DOI: https://doi.org/10.1007/s10238-023-01008-1
[2023] 438P A novel treatment for immune checkpoint inhibitor-related myocarditis
DOI: https://doi.org/10.1016/j.annonc.2023.10.524
[2023] Angiogenesis inhibitor-specific hypertension increases the risk of developing aortic dissection
DOI: https://doi.org/10.1016/j.biopha.2023.115504
[2023] Valproic acid treatment attenuates cisplatin‐induced kidney injury by suppressing proximal tubular cell damage
DOI: https://doi.org/10.1111/cts.13638
[2023] Evaluation of cardiovascular toxicity of the atezolizumab and bevacizumab combination
DOI: https://doi.org/10.3389/fdsfr.2023.1213771
[2023] Cardiovascular Toxicities Associated with Anaplastic Lymphoma Kinase Inhibitors: A Disproportionality Analysis of the WHO Pharmacovigilance Database (VigiBase)
DOI: https://doi.org/10.1007/s40264-023-01300-9
[2023] Vascular endothelial dysfunction is involved in the fluoroquinolone-associated aortic aneurysm and dissection
DOI: https://doi.org/10.1254/jpssuppl.97.0_2-b-yia4-3
[2022] Investigation of drugs for the prevention of doxorubicin-induced cardiac events using big data analysis
DOI: https://doi.org/10.1016/j.ejphar.2022.175083
[2022] Differential effects of proton pump inhibitors and vonoprazan on vascular endothelial growth factor expression in cancer cells
DOI: https://doi.org/10.1002/ddr.22013
[2022] Characterization of Immune Checkpoint Inhibitor–Induced Myasthenia Gravis Using the US Food and Drug Administration Adverse Event Reporting System
DOI: https://doi.org/10.1002/jcph.2187
[2022] Non‐recovery of vancomycin‐associated nephrotoxicity is related to worsening survival outcomes: Combined retrospective analyses of two real‐world databases
DOI: https://doi.org/10.1111/bcpt.13799
[2022] Effects of sodium valproate on cisplatin-induced acute kidney injury
DOI: https://doi.org/10.1254/jpssuppl.95.0_1-ss-48
[2022] The effect of <i>Eucommia ulmoides</i> leaf extract on aortic dissection onset in mice
DOI: https://doi.org/10.1254/jpssuppl.95.0_1-ss-37
[2022] Discovery of preventive drugs for cisplatin‐induced acute kidney injury using big data analysis
DOI: https://doi.org/10.1111/cts.13282
[2022] A web-based survey of educational opportunities of medical professionals based on changes in conference design during the COVID-19 pandemic
DOI: https://doi.org/10.1007/s10639-022-11032-5
[2022] Identification of prophylactic drugs for oxaliplatin-induced peripheral neuropathy using big data
DOI: https://doi.org/10.1016/j.biopha.2022.112744
[2022] The Effect of Combined Bcr-Abl Inhibitor and ALDH Inhibitor on Chronic Myelogenous Leukemia
DOI: https://doi.org/10.1254/jpssuppl.95.0_1-ss-66
[2022] Exploration of preventive drugs for sunitinib-induced heart failure utilizing large-scale medical database
DOI: https://doi.org/10.1254/jpssuppl.95.0_1-ss-35
[2022] Vascular endothelial growth factor inhibitor increases the incidence of aortic dissection in mice
DOI: https://doi.org/10.1254/jpssuppl.96.0_1-b-ss07-3
[2022] Development of a novel mouse model of immune checkpoint inhibitor-associated myocarditis
DOI: https://doi.org/10.1254/jpssuppl.96.0_yia05-2
[2022] Possibilities of statins in oxaliplatin-induced chronic peripheral neuropathy
DOI: https://doi.org/10.1254/jpssuppl.96.0_2-b-o04-6
[2021] Effects of 5‐HT<sub>₃</sub> receptor antagonists on cisplatin‐induced kidney injury
DOI: https://doi.org/10.1111/cts.13045
[2021] Examination of the antiepileptic effects of valacyclovir using kindling mice― search for novel antiepileptic agents by drug repositioning using a large medical information database
DOI: https://doi.org/10.1016/j.ejphar.2021.174099
[2021] HMG-CoA reductase inhibitor ameliorate oxaliplatin-induced peripheral neuropathy via GST in peripheral neuron
DOI: https://doi.org/10.1254/jpssuppl.94.0_1-y-e2-4

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AI 要約（直近 5 年の研究成果）

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研究成果（46 件）

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