Hiroshi Takashima 研究室

主宰者：Hiroshi Takashima

鹿児島大学・Kagoshima University Hospital

AI 要約（直近 5 年の研究成果）

高島寛史研究室は、神経系疾患、特にウイルス感染に関連した神経障害と遺伝性末梢神経障害の解明に取り組んでいます。主な研究対象はHTLV-1（ヒトT細胞白血病ウイルス1型）に関連する脊髄炎などの神経疾患で、患者の血液や脳脊髄液、脊髄組織からサンプルを採取し、感染細胞の性質や免疫応答の異常を詳しく調べています。また、遺伝性末梢神経障害についても臨床的・遺伝的な特性を広く調査し、診断法の改善に取り組んでいます。 HTLV-1関連疾患の研究では、感染したT細胞がどのように神経組織に浸潤し、神経細胞死を引き起こすのかを明らかにしようとしています。具体的には、免疫細胞の活性化や炎症関連物質の産生、ウイルスの増殖メカニズムなどを細胞レベルの実験により調べ、さらに既存の治療薬の効果を検討しています。一方、遺伝性末梢神経障害については、神経伝導速度測定などの生理学的検査や遺伝学的解析を組み合わせ、複数の遺伝子異変と臨床症状との関連性を大規模に解析しており、より正確な診断と理解の促進を目指しています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（100 件）

[2026] Downregulation of the deubiquitinating enzyme USP10 correlates with neuronal apoptosis in HTLV-1-associated myelopathy
DOI: https://doi.org/10.1038/s41598-026-37271-x
[2026] Cancer-Associated Stroke Complicated by Heparin-Induced Thrombocytopenia: A case report
DOI: https://doi.org/10.2169/internalmedicine.7137-26
[2026] CXCR3/CXCL10 Axis‐Mediated T Cell Infiltration in the Lungs of Patients With HTLV‐1‐Associated Diseases: Implications for Subclinical Pulmonary Involvement
DOI: https://doi.org/10.1002/jmv.70804
[2026] A case of cryptogenic stroke with platypnea-orthodeoxia syndrome and paroxysmal atrial fibrillation
DOI: https://doi.org/10.5692/clinicalneurol.cn-002165
[2026] Bladder paraganglioma with lymph node metastasis treated by surgery with long-term recurrence-free survival: A case report
DOI: https://doi.org/10.1016/j.eucr.2026.103363
[2026] HTLV-1–Infected CD4 + T Cells Drive Spontaneous Lymphoproliferation and Virus-Specific CD8 + Cytotoxic T Lymphocyte Expansion in HAM/TSP
DOI: https://doi.org/10.1212/nxi.0000000000200581
[2026] Cerebral air embolism from oesophageal–pulmonary vein fistula induced by fish bone ingestion
DOI: https://doi.org/10.1136/bcr-2026-272690
[2025] The combination of atrial fibrillation and small vessel disease score worsen spontaneous intracerebral hemorrhage outcomes
DOI: https://doi.org/10.3389/fneur.2025.1682520
[2025] Frameshift and Copy Number Variants in SACS -Related Neuropathy
DOI: https://doi.org/10.1212/nxg.0000000000200318
[2025] A case of adult-onset Krabbe disease diagnosed by galactocerebrosidase gene mutations, presenting with an atypical phenotype
DOI: https://doi.org/10.5692/clinicalneurol.cn-002148

続きを表示（残り 90 件）

[2025] Nationwide Characterization of <scp> MFN2 </scp> ‐Related <scp>CMT</scp> in 176 Japanese Patients: Clinical and Genetic Insights
DOI: https://doi.org/10.1002/acn3.70218
[2025] INF2 ‐Related Charcot–Marie–Tooth Disease in a Japanese Cohort: Genetic and Clinical Insights
DOI: https://doi.org/10.1002/acn3.70205
[2025] Charcot–Marie–Tooth-like presentation in giant axonal neuropathy: clinical variability and prevalence in a large Japanese case series
DOI: https://doi.org/10.1007/s00415-025-13243-5
[2025] High TCR Degeneracy Enhances Antiviral Efficacy of HTLV-1-Specific CTLs by Targeting Variant Viruses in HAM Patients
DOI: https://doi.org/10.3390/ijms26146602
[2025] A case of coexisting heterozygous NOTCH3 and HTRA1 mutations in cerebral small vessel disease
DOI: https://doi.org/10.1038/s41439-025-00317-z
[2025] Lower high-density lipoprotein cholesterol level is associated with hematoma expansion in acute intracerebral hemorrhage: association with hypertensive microangiopathy
DOI: https://doi.org/10.1038/s41440-025-02268-y
[2025] Clinicopathological characterization of vacuolar tauopathy associated with VCP D395G
DOI: https://doi.org/10.1002/alz.70427
[2025] Clinical Characteristics of Parkinsonism in <scp>HTLV</scp>‐1‐Associated Myelopathy
DOI: https://doi.org/10.1002/acn3.70121
[2025] Characteristics of meningitis/encephalitis in adult patients with varicella-zoster virus infection: Experience from tertiary centers in Saga prefecture, Japan
DOI: https://doi.org/10.1016/j.jns.2025.123559
[2025] KIT amplitude-based multiplex droplet digital polymerase chain reaction outperforms direct sequencing for sensitive KIT D816 genotyping in core binding factor acute myeloid leukemia
DOI: https://doi.org/10.1093/labmed/lmaf031
[2025] Real-World Experience with FcRn Inhibitors Efgartigimod and Rozanolixizumab in Myasthenia Gravis: Administration in Multiple Cycles and Transition from Intravenous to Subcutaneous Formulation
DOI: https://doi.org/10.1007/s40120-025-00748-4
[2025] Visual evoked potential in myelin oligodendrocyte glycoprotein antibody-associated disease
DOI: https://doi.org/10.1016/j.msard.2025.106408
[2025] Prevalence, clinical profiles, and prognosis of Isaacs syndrome: A nationwide survey study in Japan
DOI: https://doi.org/10.1016/j.jns.2025.123442
[2025] T-Cell Receptor/CD3 Downregulation and Impaired Signaling in HTLV-1-Infected CD4+ T Cells of HAM Patients
DOI: https://doi.org/10.3390/ijms26041706
[2025] SOD1-related inherited peripheral neuropathies in a Japanese cohort: genetic variants and clinical insights
DOI: https://doi.org/10.1007/s00415-025-12925-4
[2025] M-Sec promotes the accumulation of intracellular HTLV-1 Gag puncta and the incorporation of Env into viral particles
DOI: https://doi.org/10.1371/journal.ppat.1012919
[2025] Brain biopsy and metagenomic sequencing enhance aetiological diagnosis of encephalitis
DOI: https://doi.org/10.1093/braincomms/fcaf165
[2025] A case of recurrent cerebellitis leading to the diagnosis of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS)
DOI: https://doi.org/10.5692/clinicalneurol.cn-002117
[2025] [Charcot-Marie-Tooth Disease: Historical Evolution and Present Understanding].
DOI: https://doi.org/10.11477/mf.188160960770111176
[2025] Fibrosis-4 index and prognosis and hematoma volume: association with lobar and non-lobar intracerebral hemorrhage
DOI: https://doi.org/10.1038/s41440-025-02487-3
[2025] Factors Contributing to Residents’ Interest in Stroke Care: A Questionnaire Survey
DOI: https://doi.org/10.3995/jstroke.11362
[2025] Respiratory complex I deficiency caused by a novel multi-exonic PUS1 deletion
DOI: https://doi.org/10.1038/s10038-025-01437-8
[2025] Dimethyl fumarate as a promising therapeutic candidate for virus-associated myelopathy
DOI: https://doi.org/10.1093/brain/awaf447
[2025] Optimized Flow Cytometry Incorporating t-SNE Enables Minimal Residual Disease Assessment in a Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia at or Near the Lower Detection Limit
DOI: https://doi.org/10.1097/mph.0000000000003142
[2025] HTLV-1–Specific CTL Accumulation in CSF Contributes to Neuroinflammation in HTLV-1–Associated Myelopathy
DOI: https://doi.org/10.1212/nxi.0000000000200508
[2025] A case of X-linked Charcot–Marie–Tooth disease type 1 (CMTX1) diagnosed based on recurrent brain lesions despite peripheral neuropathy responsive to immunotherapy
DOI: https://doi.org/10.5692/clinicalneurol.cn-002127
[2025] Tibial to ulnar nerve amplitude ratio as a marker of length-dependent neuropathy
DOI: https://doi.org/10.1016/j.cnp.2025.10.006
[2024] A Case of Anterior Interosseous Nerve Palsy following Breast Cancer Surgery
DOI: https://doi.org/10.3919/jjsa.85.993
[2024] Frequency of FGF14 intronic GAA repeat expansion in patients with multiple system atrophy and undiagnosed ataxia in the Japanese population
DOI: https://doi.org/10.1038/s41431-024-01743-3
[2024] A novel homozygous HPDL variant in Japanese siblings with autosomal recessive hereditary spastic paraplegia: case report and literature review
DOI: https://doi.org/10.1007/s10048-024-00746-y
[2024] Combining the deployment of only the distal basket segment of the EMBOTRAP III and an aspiration catheter for M2 occlusions: the ONE-SEG technique
DOI: https://doi.org/10.3389/fneur.2024.1424030
[2024] Genetic and pathophysiological insights from autopsied patient with primary familial brain calcification: novel MYORG variants and astrocytic implications
DOI: https://doi.org/10.1186/s40478-024-01847-3
[2024] Linking LRP12 CGG repeat expansion to inherited peripheral neuropathy
DOI: https://doi.org/10.1136/jnnp-2024-333403
[2024] HLA-A*24 Increases the Risk of HTLV-1-Associated Myelopathy despite Reducing HTLV-1 Proviral Load
DOI: https://doi.org/10.3390/ijms25136858
[2024] Visual Evoked Potentials in MOG Antibody-associated Disease (P9-14.007)
DOI: https://doi.org/10.1212/wnl.0000000000204410
[2024] Etiological Insights of Encephalitis and Encephalitis-like Central Nervous System Diseases: Brain Tissue Metagenomic Next-generation Sequencing (S25.003)
DOI: https://doi.org/10.1212/wnl.0000000000205375
[2024] CGG Repeat Expansion in LRP12 Causes Inherited Peripheral Neuropathy (S3.006)
DOI: https://doi.org/10.1212/wnl.0000000000204787
[2024] Geographic characteristics of HTLV-1 molecular subgroups and genetic substitutions in East Asia: Insights from complete genome sequencing of HTLV-1 strains isolated in Taiwan and Japan
DOI: https://doi.org/10.1371/journal.pntd.0011928
[2024] The Japan <scp>MSA</scp> registry: A multicenter cohort study of multiple system atrophy
DOI: https://doi.org/10.1111/ncn3.12809
[2023] A case of severe paraneoplastic glutamic acid decarboxylase antibody‐spectrum disorder with improvement through prior immunotherapy before surgical intervention
DOI: https://doi.org/10.1111/cen3.12764
[2023] Neuromyelitis optica spectrum disorder safely and successfully treated with satralizumab during pregnancy and breastfeeding: a case report
DOI: https://doi.org/10.3389/fneur.2023.1322412
[2023] Writer's Cramps as an Initial Symptom of Spinocerebellar Ataxia Type 14
DOI: https://doi.org/10.2169/internalmedicine.2943-23
[2023] Iliopsoas muscle weakness as a key diagnostic marker in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)
DOI: https://doi.org/10.1016/j.jns.2023.122746
[2023] Identification and tracking of pathological T cell clones in virus-associated neurologic disease
DOI: https://doi.org/10.1016/j.jns.2023.121341
[2023] Efficacy of L-arginine in patients with HTLV-1-associated neurological disease
DOI: https://doi.org/10.1016/j.jns.2023.121314
[2023] Flow cytometric analysis of <scp>CD34</scp>+<scp>CD38</scp>− cells; cell frequency and immunophenotype based on <scp>CD45RA</scp> expression pattern
DOI: https://doi.org/10.1002/cyto.b.22148
[2023] Clinical variability associated with intronic FGF14 GAA repeat expansion in Japan
DOI: https://doi.org/10.1002/acn3.51936
[2023] CANVAS-related RFC1 mutations in patients with immune-mediated neuropathy
DOI: https://doi.org/10.1038/s41598-023-45011-8
[2023] Eagle Syndrome Induced by the Head Retroflexion
DOI: https://doi.org/10.2169/internalmedicine.2704-23
[2023] Dystonia and Parkinsonism in COA7-related disorders: expanding the phenotypic spectrum
DOI: https://doi.org/10.1007/s00415-023-11998-3
[2023] Clinical outcomes of mechanical thrombectomy for acute M2 occlusion
DOI: https://doi.org/10.3995/jstroke.11155
[2023] Microbleed clustering in thalamus sign in CADASIL patients with NOTCH3 R75P mutation
DOI: https://doi.org/10.3389/fneur.2023.1241678
[2023] Identification and tracking of HTLV-1–infected T cell clones in virus-associated neurologic disease
DOI: https://doi.org/10.1172/jci.insight.167422
[2023] Genetic, electrophysiological, and pathological studies on patients with <scp>SCN9A</scp>‐related pain disorders
DOI: https://doi.org/10.1111/jns.12590
[2023] Siblings with Cockayne Syndrome B Type III Presenting with Slowly Progressive Cerebellar Ataxia
DOI: https://doi.org/10.2169/internalmedicine.0061-22
[2023] Spatial Fluctuation of Central Nervous System Lesions in X-linked Charcot-Marie-Tooth Disease with a Novel GJB1 Mutation
DOI: https://doi.org/10.2169/internalmedicine.1713-23
[2023] The Current State of Charcot–Marie–Tooth Disease Treatment
DOI: https://doi.org/10.3390/genes14071391
[2023] Case report: Mitochondrial trifunctional protein deficiency caused by HADHB gene mutation (c.1175C>T) characterized by higher brain dysfunction followed by neuropathy, presented gadolinium enhancement on brain imaging in an adult patient
DOI: https://doi.org/10.3389/fneur.2023.1187822
[2023] HTLV-1-associated myelopathy/tropical spastic paraplegia with sporadic late-onset nemaline myopathy: a case report
DOI: https://doi.org/10.1186/s12891-023-06461-3
[2023] High-dose ubiquinol supplementation in multiple-system atrophy: a multicentre, randomised, double-blinded, placebo-controlled phase 2 trial
DOI: https://doi.org/10.1016/j.eclinm.2023.101920
[2023] Iliopsoas Muscle Weakness as a Key Diagnostic Marker in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP)
DOI: https://doi.org/10.3390/pathogens12040592
[2023] Clinical phenotypic diversity ofNOTCH2NLC-related disease in the largest case series of inherited peripheral neuropathy in Japan
DOI: https://doi.org/10.1136/jnnp-2022-330769
[2023] Charcot-Marie-Tooth Disease with a Novel Variant in Gap Junction Protein Beta 1 Presenting with Visual Field Defects
DOI: https://doi.org/10.2169/internalmedicine.1403-22
[2023] Anti-ganglionic acetylcholine receptor antibodies in functional neurological symptom disorder/conversion disorder
DOI: https://doi.org/10.3389/fneur.2023.1137958
[2023] Gene panel analysis of 119 index patients with suspected periodic paralysis in Japan
DOI: https://doi.org/10.3389/fneur.2023.1078195
[2023] Involvement of autonomic nervous system since middle age in elderly patient with giant axonal neuropathy caused by novel genetic mutation
DOI: https://doi.org/10.5692/clinicalneurol.cn-001822
[2023] A case of Charcot–Marie–Tooth disease type 2 caused by homozygous MME gene mutation
DOI: https://doi.org/10.5692/clinicalneurol.cn-001870
[2023] A case of myofibrillary myopathy due to Bcl2-Associated Athanogene 3 (BAG3) mutation complicated by peripheral neuropathy
DOI: https://doi.org/10.5692/clinicalneurol.cn-001915
[2022] Efficacy of <scp>l</scp>‐Arginine treatment in patients with <scp>HTLV‐1‐associated</scp> neurological disease
DOI: https://doi.org/10.1002/acn3.51715
[2022] Intravenous immunoglobulin for chronic residual peripheral neuropathy in microscopic polyangiitis: A multicentre randomised double-blind trial
DOI: https://doi.org/10.1093/mr/roac137
[2022] Development of Ivy Sign and Infarction in the Lateral Part of the Hemisphere or the Middle Cerebral Artery Territory in Association with Steno-occlusive Involvement of the Posterior Cerebral Artery in Moyamoya Disease
DOI: https://doi.org/10.2169/internalmedicine.0969-22
[2022] Intravenous Thrombolysis With Alteplase at 0.6 mg/kg in Patients With Ischemic Stroke Taking Direct Oral Anticoagulants
DOI: https://doi.org/10.1161/jaha.122.025809
[2022] A case of retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations: Long‐term treatment with repeated courses of immunotherapy
DOI: https://doi.org/10.1111/ncn3.12664
[2022] Multi-type RFC1 repeat expansions as the most common cause of hereditary sensory and autonomic neuropathy
DOI: https://doi.org/10.3389/fneur.2022.986504
[2022] Japanese case of <scp>Charcot–Marie–Tooth</scp> disease type <scp>2Z</scp> with severe retinitis pigmentosa
DOI: https://doi.org/10.1111/ncn3.12660
[2022] Genetic and clinical features of cerebellar ataxia with RFC1 biallelic repeat expansions in Japan
DOI: https://doi.org/10.3389/fneur.2022.952493
[2022] Genetic spectrum and founder effect of non-dystrophic myotonia: a Japanese case series study
DOI: https://doi.org/10.1007/s00415-022-11305-6
[2022] Enhancement of the Ivy Sign during an Ischemic Event in Moyamoya Disease
DOI: https://doi.org/10.2169/internalmedicine.9326-22
[2022] Comprehensive Genetic Analyses of Inherited Peripheral Neuropathies in Japan: Making Early Diagnosis Possible
DOI: https://doi.org/10.3390/biomedicines10071546
[2022] Novel heterozygous variants of <scp>SLC12A6</scp> in Japanese families with <scp>Charcot–Marie–Tooth</scp> disease
DOI: https://doi.org/10.1002/acn3.51603
[2022] A case of successful renal transplantation of <scp>Charcot‐Marie‐Tooth</scp> disease associated with <scp>FSGS</scp> due to mutation of the INF2 gene
DOI: https://doi.org/10.1111/ncn3.12651
[2022] Novel de novo <scp>POLR3B</scp> mutations responsible for demyelinating Charcot–Marie–Tooth disease in Japan
DOI: https://doi.org/10.1002/acn3.51555
[2022] Clinical genetics of Charcot–Marie–Tooth disease
DOI: https://doi.org/10.1038/s10038-022-01031-2
[2022] Complex hereditary peripheral neuropathies caused by novel variants in mitochondrial-related nuclear genes
DOI: https://doi.org/10.1007/s00415-022-11026-w
[2022] An NEFH founder mutation causes broad phenotypic spectrum in multiple Japanese families
DOI: https://doi.org/10.1038/s10038-022-01019-y
[2022] A case of adult-onset Wolfram syndrome with compound heterozygous mutations of the WFS1 gene
DOI: https://doi.org/10.1016/j.ajoc.2022.101315
[2022] High Prevalence of HTLV-1 Carriers Among the Elderly Population in Kagoshima, a Highly Endemic Area in Japan
DOI: https://doi.org/10.1089/aid.2021.0164
[2022] The first case of infantile-onset multisystem neurologic, endocrine, and pancreatic disease caused by novel PTRH2 mutation in Japan
DOI: https://doi.org/10.1007/s10072-021-05817-8
[2022] Elderly patients with suspected Charcot-Marie-Tooth disease should be tested for the TTR gene for effective treatments
DOI: https://doi.org/10.1038/s10038-021-01005-w
[2022] A case of sporadic amyotrophic lateral sclerosis (ALS) with Senataxin (SETX) gene variant
DOI: https://doi.org/10.5692/clinicalneurol.cn-001675

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AI 要約（直近 5 年の研究成果）

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研究成果（100 件）

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