Tomoaki Sato 研究室

主宰者：Tomoaki Sato

鹿児島大学

AI 要約（直近 5 年の研究成果）

本研究室は、脳神経系の機能異常と関連する疾患の発症メカニズムの解明に取り組んでいます。特に、神経細胞の活動を制御する塩化物イオン輸送体（KCC2）の発現低下が、統合失調症やうつ病などの神経精神疾患に関与することに注目し、その原因となるストレスや脳内炎症の過程を調べています。また、薬物乱用による依存性や離脱症状についても、神経細胞内のシグナル伝達経路を介したメカニズム研究を進めており、新たな治療標的の発見を目指しています。研究手法としては、マウスの行動実験と培養細胞を用いた分子生物学的解析を組み合わせています。マウスに対して様々な薬物や生理活性物質を投与し、行動変化を詳細に観察する一方で、脳組織や神経細胞のタンパク質発現やシグナル伝達の変化を分析しています。さらに、放射線感受性がん細胞を用いた放射線治療耐性に関する研究や、伝統生薬の神経保護効果の検証など、基礎医学から臨床応用につながる多角的な研究を展開しています。これらの研究を通じて、本研究室は神経機能調節のメカニズムを分子レベルで理解し、神経精神疾患や薬物依存症、がん治療抵抗性といった難治性疾患の新しい治療戦略の開発につながる知見の蓄積を目指しています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（62 件）

[2025] Unlocking the potential of mitochondrial transplantation: overcoming challenges and paving the way for routine therapeutic application
DOI: https://doi.org/10.1007/s10616-025-00805-8
[2025] [Successful Emergent Open Stent Grafting for a Ruptured Aortic Arch Aneurysm:Report of a Case].
[2025] Unravelling the effects of specific ingredients of kamishoyosan in reducing aggressive biting behavior in chronically isolated mice to inanimate objects
DOI: https://doi.org/10.1016/j.jphs.2025.05.001
[2025] Amoxicillin, a β-lactam antibiotic, enhances cisplatin sensitivity in cancer cells affecting mitochondria
DOI: https://doi.org/10.1016/j.bbrc.2025.151888
[2025] Pretreatment with LY2090314, a potent glycogen synthase kinase-3 inhibitor, suppresses methamphetamine-induced stereotyped behavior but not hyperlocomotion in mice
DOI: https://doi.org/10.1097/fbp.0000000000000853
[2025] Uniportal Video-Assisted Left Upper Segmentectomy With a Minimally Invasive Chest Wall Resection Technique for Pancoast Lung Cancer
DOI: https://doi.org/10.1016/j.atssr.2025.06.018
[2025] The radioresistance of clinically relevant radioresistant cell-derived tumors is determined by the cancer cells themselves, rather than by the surrounding stromal cells
DOI: https://doi.org/10.1016/j.jds.2025.06.024
[2024] Silver Nanoparticles Reduce ACE2 Expression via Changing Mitochondrial Function in Human Fibroblast-Like Lung Cell and Periodontal Ligament Fibroblast Cells
DOI: https://doi.org/10.1007/s12668-024-01630-7
[2024] An isoflavone catabolism gene cluster underlying interkingdom interactions in the soybean rhizosphere
DOI: https://doi.org/10.1093/ismeco/ycae052
[2024] Opioid receptor antagonists reduce motivated wheel-running behavior in mice
DOI: https://doi.org/10.1097/fbp.0000000000000769

続きを表示（残り 52 件）

[2024] Protein phosphatase 2A inhibitors: a possible pharmacotherapy for benzodiazepine dependence
DOI: https://doi.org/10.1093/jpp/rgae136
[2023] Kamishoyosan and Kamikihito protect against decreased KCC2 expression induced by the P. gingivalis lipopolysaccharide treatment in PC-12 cells and improve behavioral abnormalities in male mice
DOI: https://doi.org/10.1016/j.heliyon.2023.e22784
[2023] Therapeutic potential for KCC2-targeted neurological diseases
DOI: https://doi.org/10.1016/j.jdsr.2023.11.001
[2023] Alkali Wet Chemicals for Ru with Advanced Semiconductor Technology Nodes
DOI: https://doi.org/10.4028/p-08chsp
[2023] Human umbilical cord-derived mesenchymal stem cells-harvested mitochondrial transplantation improved motor function in TBI models through rescuing neuronal cells from apoptosis and alleviating astrogliosis and microglia activation
DOI: https://doi.org/10.1016/j.intimp.2023.110106
[2023] Mitochondrial transfer in PC-3 cells fingerprinted in ferroptosis sensitivity: a brand new approach targeting cancer metabolism
DOI: https://doi.org/10.1007/s13577-023-00896-5
[2023] Glycogen Synthase Kinase-3 Inhibitors Block Morphine-Induced Locomotor Activation, Straub Tail, and Depression of Rearing in Mice Via a Possible Central Action
DOI: https://doi.org/10.1007/s11064-023-03902-2
[2023] Development of a sensitive double TaqMan Probe-based qPCR Angle-Degree method to detect mutation frequencies
DOI: https://doi.org/10.1016/j.mito.2023.02.010
[2023] The reversibility of cancer radioresistance: a novel potential way to identify factors contributing to tumor radioresistance
DOI: https://doi.org/10.1007/s13577-023-00871-0
[2023] The effect of diazepam on aggressive biting behavior of isolation-reared ddY mouse is different between male and female.
DOI: https://doi.org/10.1254/jpssuppl.97.0_1-b-yia3-3
[2023] Effects of pretreatment with LY2090314, a potent glycogen synthase kinase-3 inhibitor, on methamphetamine-induced hyperlocomotion and stereotypy in mice
DOI: https://doi.org/10.1254/jpssuppl.97.0_3-b-p-075
[2023] A psychedelic substance 2,5-dimethoxy-4-iodoamphetamine induces impairments in spatial short-term memory and retrieval and mood in mice
DOI: https://doi.org/10.1254/jpssuppl.97.0_3-b-p-070
[2023] Pretreatment with CHIR-99021, a GSK-3 inhibitor, attenuates morphine-induced Straub tail reaction and withdrawal.
DOI: https://doi.org/10.1254/jpssuppl.97.0_3-b-p-105
[2023] Expression analysis of equilibrative nucleoside transporter 3 (ENT3) in cultured astrocytes
DOI: https://doi.org/10.1254/jpssuppl.97.0_2-b-p-016
[2023] Effects of a single administration with opioid receptor antagonist naloxone on motivative behavior and brain monoamine turnover in mice
DOI: https://doi.org/10.1254/jpssuppl.97.0_3-b-p-071
[2023] Wortmannin, a potent phosphatidylinositol 3-kinase inhibitor, suppresses methamphetamine-induced stereotyped sniffing and biting, ameliorating the frequency of total stereotypy in mice
DOI: https://doi.org/10.1254/jpssuppl.97.0_3-b-p-077
[2023] Decreased Fe2+ amount returns to the parental levels when clinically relevant radioresistant cells lose their radio-resistance
DOI: https://doi.org/10.1254/jpssuppl.97.0_2-b-p-048
[2023] Characteristics of behavioral abnormalities induced by a psychedelic substance 2,5-dimethoxy-4-iodoamphetamine in mice
DOI: https://doi.org/10.1254/jpssuppl.97.0_3-b-p-076
[2022] CRISPR/Cas9-mediated knockout of Lcn2 in human breast cancer cell line MDA-MB-231 ameliorates erastin-mediated ferroptosis and increases cisplatin vulnerability
DOI: https://doi.org/10.1016/j.lfs.2022.120704
[2022] Neuroprotective effect of oxytocin on cognitive dysfunction, DNA damage, and intracellular chloride disturbance in young mice after cranial irradiation
DOI: https://doi.org/10.1016/j.bbrc.2022.04.099
[2022] Are Histamine H3 Antagonists the Definitive Treatment for Acute MethamphetamineIntoxication?
DOI: https://doi.org/10.2174/2589977514666220414122847
[2022] miR-7-5p inhibition induces ferroptosis by increasing ROS and Fe2+ in clinically relevant radioresistant cells
DOI: https://doi.org/10.1254/jpssuppl.95.0_3-p-282
[2022] Expression of equilibrative nucleoside transporters and activity regulation by hydrogen peroxide in cultured astrocytes
DOI: https://doi.org/10.1254/jpssuppl.95.0_1-p-019
[2022] Non-coding RNAs in ferroptotic cancer cell death pathway: meet the new masters
DOI: https://doi.org/10.1007/s13577-022-00699-0
[2022] Glycogen synthase kinase-3 inhibitors suppress morphine-induced Straub‘s tail reaction via a centrally acting mechanism
DOI: https://doi.org/10.1254/jpssuppl.95.0_3-p-212
[2022] Expression and function of equilibrative nucleoside transporters in cultured astrocytes
DOI: https://doi.org/10.1254/jpssuppl.96.0_4-b-p-287
[2022] RAGE, which is the receptor for advanced glycation end-products, is involved in the regulation of KCC2 expression by the Porphyromonas gingivalis LPS treatment in PC-12 cells.
DOI: https://doi.org/10.1254/jpssuppl.96.0_2-b-p-175
[2022] Effect of μ-opioid receptor selective antagonist β-funaltrexamine on spontaneous behavior in mice
DOI: https://doi.org/10.1254/jpssuppl.96.0_1-b-p-034
[2022] Pretreatment with CHIR-99021, a GSK-3 inhibitor, partially attenuates methamphetamine-induced stereotyped behavior in mice
DOI: https://doi.org/10.1254/jpssuppl.96.0_1-b-p-035
[2022] Oxytocin administration to head gamma-irradiated mice results in increased KCC2 mRNA expression through decreased phosphorylated CREB
DOI: https://doi.org/10.1254/jpssuppl.96.0_4-b-p-306
[2022] [Open Stent Grafting for Aortic Arch Aneurysm in a Patient with Fuctional Coronary Bypass Grafts:Report of a Case].
[2022] 4-Methylumebelliferone Enhances Radiosensitizing Effects of Radioresistant Oral Squamous Cell Carcinoma Cells via Hyaluronan Synthase 3 Suppression
DOI: https://doi.org/10.3390/cells11233780
[2022] Natural killer cell immunotherapy in glioblastoma
DOI: https://doi.org/10.1007/s12672-022-00567-1
[2022] Tumor radioresistance caused by radiation-induced changes of stem-like cell content and sub-lethal damage repair capability
DOI: https://doi.org/10.1038/s41598-022-05172-4
[2022] What symptoms are associated with aggressive biting behavior of isolation-reared mice?
DOI: https://doi.org/10.1254/jpssuppl.95.0_1-p-036
[2022] Effects of pretreatment with a glycogen synthase kinase-3 inhibitor on methamphetamine-induced hyperlocomotion, stereotypy and reward in mice
DOI: https://doi.org/10.1254/jpssuppl.95.0_3-p-211
[2022] Mitochondria: how eminent in ageing and neurodegenerative disorders?
DOI: https://doi.org/10.1007/s13577-022-00833-y
[2022] History of Scientific Calculator Development Through the Technical Innovation
DOI: https://doi.org/10.1541/ieejjournal.142.774
[2022] エルゴチオネインとその生体内作用
[2021] Oxytocin ameliorates KCC2 decrease induced by oral bacteria-derived LPS that affect rat primary cultured cells and PC-12 cells
DOI: https://doi.org/10.1016/j.peptides.2021.170734
[2021] Kamishoyosan (a Japanese traditional herbal formula), which effectively reduces the aggressive biting behavior of male and female mice, and potential regulation through increase of Tph1, Tph2, and Esr2 mRNA levels
DOI: https://doi.org/10.1016/j.brainres.2021.147580
[2021] Inhibitory effect of SB216763, a selective glycogen synthase kinase-3 inhibitor, on morphine-induced Straub’s tail reaction in mice
DOI: https://doi.org/10.1254/jpssuppl.94.0_3-p1-11
[2021] Kamishoyosan reduces aggressive behavior of isolated-reared mice toward inanimate objects and involvement of estrogen receptor β
DOI: https://doi.org/10.1254/jpssuppl.94.0_2-p1-37
[2021] Study of immunocytochemistry in expression of nucleoside transporter ENT3 in astrocytes
DOI: https://doi.org/10.1254/jpssuppl.94.0_1-p1-19
[2021] LPS decrease KCC2 expression in primary rat cerebral cortex cells and PC-12 cells
DOI: https://doi.org/10.1254/jpssuppl.94.0_2-p1-18
[2021] Mitochondrial Dysfunction in Diseases, Longevity, and Treatment Resistance: Tuning Mitochondria Function as a Therapeutic Strategy
DOI: https://doi.org/10.3390/genes12091348
[2021] Metoprine, a histamine N-methyltransferase inhibitor, attenuates methamphetamine-induced hyperlocomotion via activation of histaminergic neurotransmission in mice
DOI: https://doi.org/10.1016/j.pbb.2021.173257
[2021] Pharmacological Targeting of Ferroptosis in Cancer Treatment
DOI: https://doi.org/10.2174/1568009621666211202091523
[2021] Decreased mitochondrial membrane potential is an indicator of radioresistant cancer cells
DOI: https://doi.org/10.1016/j.lfs.2021.120051
[2021] Cashing in on ferroptosis against tumor cells: Usher in the next chapter
DOI: https://doi.org/10.1016/j.lfs.2021.119958
[2021] Enlightenment Activities on Science and Technology Using Mechanical Engineering Heritage
DOI: https://doi.org/10.1299/jsmemecj.2021.s202-01
[2021] MiR-7-5p Is Involved in Ferroptosis Signaling and Radioresistance Thru the Generation of ROS in Radioresistant HeLa and SAS Cell Lines
DOI: https://doi.org/10.3390/ijms22158300

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AI 要約（直近 5 年の研究成果）

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研究成果（62 件）

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