Toru Ogura 研究室

主宰者：Toru Ogura

三重大学・Mie University Hospital

AI 要約（直近 5 年の研究成果）

Ogura研究室では、医療データベースを活用した薬剤安全性の実証的な解析を中心に研究を行っています。米国の医薬品有害事象報告システムなどの大規模な自発報告データベースから、複数の医薬品や治療法の安全プロフィールを比較し、臨床現場での意思決定に役立つ情報を抽出することを目指しています。小児白血病の化学療法、臓器移植後の免疫抑制療法、高血圧や高コレステロール血症の薬物治療、抗菌薬や抗癌剤など、多岐にわたる治療領域において、有害事象の発生パターンや年齢による違いを統計的に検討しています。同時に、医療現場で得られた臨床記録を用いた観察研究も展開しており、薬物相互作用が安全性に及ぼす影響、特定の患者背景における有害事象の予測因子の同定、および治療成績の向上に関する研究を実施しています。また、胆管狭窄症の内視鏡治療やがん患者の手術療法など、侵襲的治療法の安全性と有効性の向上に向けた臨床研究も行われており、統計学的な手法の開発を含め、幅広いアプローチで医療の質と安全性を高める研究に取り組んでいます。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（58 件）

[2026] Hypothesis-Generating Analysis of Four Immunosuppressive Regimens After Simultaneous Pancreas-Kidney Transplantation Using the United States Food and Drug Administration Adverse Event Reporting System
DOI: https://doi.org/10.7759/cureus.107193
[2026] Reporting patterns of renal failure associated with immunosuppressant combinations following liver transplantation: a retrospective analysis
DOI: https://doi.org/10.4285/ctr.25.0051
[2026] Cholecalciferol Supplementation and Transplant Outcomes Across Immunosuppressive Regimens in Renal Transplant Recipients Using the United States Food and Drug Administration Adverse Event Reporting System
DOI: https://doi.org/10.7759/cureus.105141
[2026] Comparative Safety of Six First-Line Antiepileptic Monotherapies in Pediatric Epilepsy Using the United States FDA Adverse Event Reporting System
DOI: https://doi.org/10.7759/cureus.105027
[2026] Comparison of Adverse Events Associated With Six Common Antibiotics in Lower Respiratory Tract Infections Using the United States Food and Drug Administration Adverse Event Reporting System
DOI: https://doi.org/10.7759/cureus.103809
[2026] Comparative effectiveness of two first-line, ICI-based regimens for advanced HCC: a target trial emulation using an electronic medical record network
DOI: https://doi.org/10.3389/fonc.2026.1776032
[2026] Impact of everolimus-based immunosuppression on transplant rejection or death in lung transplant recipients using the United States Food and Drug Administration Adverse Event Reporting System
DOI: https://doi.org/10.1016/j.trim.2026.102345
[2026] Improved hypopharyngeal visibility and early cancer detection using the modified Killian method during esophagogastroduodenoscopy in patients at high risk of head and neck cancer
DOI: https://doi.org/10.1007/s10388-026-01220-4
[2026] Comparative Adverse Event Reporting of Asparaginase-Containing Induction Regimens in Pediatric Acute Lymphoblastic Leukemia Using the United States Food and Drug Administration Adverse Event Reporting System
DOI: https://doi.org/10.7759/cureus.108119
[2025] An improved estimator of the logarithmic odds ratio for small sample sizes using a Bayesian approach
DOI: https://doi.org/10.1515/ijb-2024-0105

続きを表示（残り 48 件）

[2025] Role of Repeated Radiofrequency Ablation for Patients with Lung Metastases of Head and Neck Adenoid Cystic Carcinoma: Long-term Single-center Study in 16 Patients with 289 Tumors
DOI: https://doi.org/10.22575/interventionalradiology.2024-0015
[2025] Approach to Detecting Beneficial and Detrimental Drug-Drug Interactions in Complex Pharmacotherapy
DOI: https://doi.org/10.7759/cureus.78746
[2025] 6-mm vs 10-mm diameter fully covered self-expandable metal stents in patients with unresectable malignant distal bile duct stricture (COSMIC UNISON): study protocol for a multicenter, randomized controlled trial
DOI: https://doi.org/10.1186/s13063-025-08771-4
[2025] Adverse events associated with single-ingredient folic acid in pregnancy: A descriptive analysis of the United States Food and Drug Administration Adverse Event Reporting System (2004–2025)
DOI: https://doi.org/10.1177/02601060251397348
[2025] Distinct changes in tissue-resident memory T cells following dupilumab treatment in atopic dermatitis
DOI: https://doi.org/10.1016/j.alit.2025.05.006
[2025] Parameter estimation of the initial failure period for a three-parameter Weibull distribution in a small sample
DOI: https://doi.org/10.1080/00949655.2025.2552417
[2025] Early postnatal neonatal surgery is associated with a low risk of surgical site infections
DOI: https://doi.org/10.1007/s00595-025-03060-8
[2025] Comparing drug combinations for graft-versus-host disease prophylaxis using the U.S. Food and Drug Administration Adverse Event Reporting System
DOI: https://doi.org/10.4285/ctr.24.0049
[2025] Comparison of Adverse Events Among Angiotensin Receptor Blockers in Hypertension Using the United States Food and Drug Administration Adverse Event Reporting System
DOI: https://doi.org/10.7759/cureus.81912
[2025] Comparative Analysis of Adverse Event Profiles Among Seven Statins for Hypercholesterolemia Management Using the United States FDA Adverse Event Reporting System
DOI: https://doi.org/10.7759/cureus.81260
[2025] Postoperative Pain Reduction and Clinical Value of Uniportal Video-Assisted Thoracic Surgery: A Secondary Analysis of the J-RATSIG 01 Study
DOI: https://doi.org/10.1016/j.cllc.2025.05.001
[2024] Evaluation of Pharmacy Students’ Understanding of Clinical Trials and Research through Questionnaires Before and After the Hospital Practical Training
DOI: https://doi.org/10.1248/yakushi.23-00202
[2024] Comparison of adverse events of poly adenosine diphosphate ribose polymerase inhibitors in patients with ovarian cancer using the United States Food and Drug Administration Adverse Event Reporting System
DOI: https://doi.org/10.1080/14740338.2024.2418333
[2024] Influence of loop diuretics on denosumab-induced hypocalcaemia in osteoporosis: a retrospective observational analysis
DOI: https://doi.org/10.1186/s40780-024-00380-8
[2024] A prospective multi-institutional study to verify the non-inferiority of postoperative pain in robot-assisted thoracic surgery in comparison with video-assisted thoracoscopic surgery for lung cancer: The Japanese RATS interest group 01 (J-RATSIG 01)
DOI: https://doi.org/10.1016/j.lungcan.2024.107961
[2024] Association between age and onset of daptomycin-induced adverse events using the U.S. food and drug administration adverse event reporting system
DOI: https://doi.org/10.1016/j.jiac.2024.08.016
[2024] An investigation of broad-spectrum antibiotic-induced liver injury based on the FDA Adverse Event Reporting System and retrospective observational study
DOI: https://doi.org/10.1038/s41598-024-69279-6
[2024] Hyperkalemic effect of drug–drug interaction between esaxerenone and trimethoprim in patients with hypertension: a pilot study
DOI: https://doi.org/10.1186/s40780-024-00366-6
[2024] Comparison of Adverse Events Following Immunosuppressant Administration for Pediatric Patients With Renal Transplants Categorized by Two-Year Age Increments Using the U.S. Food and Drug Administration Adverse Event Reporting System
DOI: https://doi.org/10.7759/cureus.65300
[2024] Exploratory rivaroxaban trial for isolated calf deep vein thrombosis with a risk factor of thrombosis extension: an open-label, multicenter, randomized controlled trial
DOI: https://doi.org/10.1016/j.rpth.2024.102515
[2024] Estimation of three-parameter Fréchet distribution for the number of days from drug administration to remission in small sample sizes
DOI: https://doi.org/10.3233/mas-231466
[2024] Efficacy and Safety of Non-Vitamin K Antagonist Oral Anticoagulants for Japanese Patients With Venous Thromboembolism　― The Primary Results From the KUROSIO Study ―
DOI: https://doi.org/10.1253/circj.cj-23-0954
[2024] Efficacy of Prednisone Avoidance in Patients With Liver Transplant Using the U.S. Food and Drug Administration Adverse Event Reporting System
DOI: https://doi.org/10.7759/cureus.60193
[2024] Diagnostic performance of fluoroscopic video analysis for pulmonary embolism: a prospective observational study
DOI: https://doi.org/10.1007/s10554-024-03121-y
[2024] Risk stratification for synchronous/metachronous recurrence after endoscopic submucosal dissection for Barrett’s esophageal adenocarcinoma using the length of Barrett’s esophagus
DOI: https://doi.org/10.1007/s10388-024-01058-8
[2024] Analysis of Adverse Events Following Phenobarbital Administration for Pediatric Patients Categorized by One-Year Age Increments Using the U.S. Food and Drug Administration Adverse Event Reporting System
DOI: https://doi.org/10.7759/cureus.56418
[2024] Prevalence and risk factors of ankle osteoarthritis in a population-based study
DOI: https://doi.org/10.1016/j.fas.2024.02.009
[2023] The usefulness of image-enhanced endoscopy to distinguish gastric carcinoma in tumors initially diagnosed as adenomas by endoscopic biopsy: A retrospective study
DOI: https://doi.org/10.1097/md.0000000000032881
[2023] Comparison of Adverse Events Occurred During Administration of Dipeptidyl Peptidase-4 Inhibitor in Patients with Diabetes Using FDA Adverse Event Reporting System
DOI: https://doi.org/10.1007/s40261-022-01242-7
[2023] Hyperkalemia by eplerenone or esaxerenone in the presence or absence of clarithromycin in hypertensive patients: a retrospective observational cohort study
DOI: https://doi.org/10.1097/hjh.0000000000003372
[2023] A PROSPECTIVE, MULTI-INSTITUTIONAL, NON-INFERIORITY STUDY OF POSTOPERATIVE PAIN BETWEEN ROBOTIC-ASSISTED AND VIDEO-ASSISTED THORACOSCOPIC SURGERY FOR LUNG CANCER, J-RATSIG 01
DOI: https://doi.org/10.1016/j.chest.2023.07.1088
[2023] Analysis of death avoidance by concomitant use of prednisone in patients with renal transplant using the Food and Drug Administration Adverse Event Reporting System
DOI: https://doi.org/10.1016/j.trim.2023.101900
[2023] Efficacy and Safety of Warfarin for the Treatment of Venous Thromboembolism　― A Multicenter Prospective Observational Cohort Study in Japan (AKAFUJI Study) ―
DOI: https://doi.org/10.1253/circj.cj-23-0158
[2023] Analysis of Clinical Factors in Olaparib-related Anemia Using Adverse Drug Event Reporting Databases
DOI: https://doi.org/10.21873/anticanres.16231
[2022] Tadalafil treatment for fetuses with early-onset growth restriction: a protocol for a multicentre, randomised, placebo-controlled, double-blind phase II trial (TADAFER IIb)
DOI: https://doi.org/10.1136/bmjopen-2021-054925
[2022] Parameter estimation of Weibull distribution for the number of days between drug administration and early onset adverse event
DOI: https://doi.org/10.1080/10543406.2022.2154940
[2022] Psychological characteristics of Japanese patients and their family members receiving genetic counseling: A single‐institute exploratory study
DOI: https://doi.org/10.1002/jgc4.1629
[2022] Predictive risk factors for early recurrence in patients with localized pancreatic ductal adenocarcinoma who underwent curative-intent resection after preoperative chemoradiotherapy
DOI: https://doi.org/10.1371/journal.pone.0264573
[2022] Cutoff Value for Wilcoxon-Mann-Whitney Test by Minimum P-value: Application to COVID-19 Data
DOI: https://doi.org/10.5539/ijsp.v11n3p1
[2022] Principal Canonical Correlation Analysis with Missing Data in Small Samples
DOI: https://doi.org/10.13189/ms.2022.100217
[2022] Platelet-Rich Plasma Releasate versus Corticosteroid for the Treatment of Discogenic Low Back Pain: A Double-Blind Randomized Controlled Trial
DOI: https://doi.org/10.3390/jcm11020304
[2022] Estimation of highly heterogeneous multinomial probabilities observed at the beginning of COVID-19
DOI: https://doi.org/10.1080/24709360.2022.2064693
[2021] Spent mushroom substrate performance for pyrolysis, steam co-gasification, and ash melting
DOI: https://doi.org/10.1016/j.biombioe.2020.105954
[2021] Factors affecting serum phenobarbital concentration changes in pediatric patients receiving elixir and powder formulations
DOI: https://doi.org/10.1186/s40780-021-00190-2
[2021] Parameters Estimation for Wear-out Failure Period of Three-Parameter Weibull Distribution
DOI: https://doi.org/10.5539/ijsp.v11n1p40
[2021] Improving the Prognosis of Pancreatic Cancer Through Early Detection: Protocol for a Prospective Observational Study
DOI: https://doi.org/10.2196/26898
[2021] Impact of a multi‐professional expert team on EOL care of children with cancer
DOI: https://doi.org/10.1111/ped.14626
[2021] Is locomotion training effective for middle-aged workers?
DOI: https://doi.org/10.1002/1348-9585.12303

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AI 要約（直近 5 年の研究成果）

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研究成果（58 件）

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