Katsumi Higaki 研究室

AI 要約（直近 5 年の研究成果）

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

研究成果（14 件）

• [2026] Spiral ligament dysfunction and endocochlear potential loss drive hearing impairment in Niemann–Pick C1 mice
  DOI: https://doi.org/10.1016/j.brainresbull.2026.111846
• [2025] Neutral sp2-iminosugars exploiting non-glycone interactions for selective acid α- and β-glucosidase activity modulation: Pharmacological chaperones for Gaucher and Pompe diseases
  DOI: https://doi.org/10.1016/j.ejmech.2025.118500
• [2025] Inability of α-cyclodextrins to accommodate cholesterol potentially underlies their lack of efficacy and ototoxicity in Niemann-Pick disease type C treatment
  DOI: https://doi.org/10.1038/s41598-025-15599-0
• [2024] Intracerebroventricular 2-hydroxypropyl-γ-cyclodextrin alleviates hepatic manifestations without distributing to the liver in a murine model of Niemann–Pick disease type C
  DOI: https://doi.org/10.1016/j.lfs.2024.122776
• [2023] Different solubilizing ability of cyclodextrin derivatives for cholesterol in Niemann–Pick disease type C treatment
  DOI: https://doi.org/10.1002/ctm2.1350
• [2022] Effects of 6-O-α-maltosyl-β cyclodextrin on lipid metabolism in Npc1-deficient Chinese hamster ovary cells
  DOI: https://doi.org/10.1016/j.ymgme.2022.09.007
• [2022] Fine-tuned cholesterol solubilizer, mono-6-O-α-D-maltosyl-γ-cyclodextrin, ameliorates experimental Niemann–Pick disease type C without hearing loss
  DOI: https://doi.org/10.1016/j.biopha.2022.113698
• [2022] Development of a Highly Sensitive and Rapid Liquid Chromatography–Tandem Mass Spectrometric Method Using a Basic Mobile Phase Additive to Determine the Characteristics of the Urinary Metabolites for Niemann–Pick Disease Type C
  DOI: https://doi.org/10.1248/bpb.b22-00185
• [2022] sp ² -Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease
  DOI: https://doi.org/10.1080/14756366.2022.2073444
• [2022] Metabolic Alteration Analysis of Steroid Hormones in Niemann–Pick Disease Type C Model Cell Using Liquid Chromatography/Tandem Mass Spectrometry
  DOI: https://doi.org/10.3390/ijms23084459

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所属学会・役職（0 件）

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