Takashi Kunihara 研究室

主宰者：Takashi Kunihara

東京慈恵会医科大学

AI 要約（直近 5 年の研究成果）

本研究室は、大動脈疾患と心臓弁膜疾患を中心とした心臓血管外科領域の研究に従事しています。特に急性大動脈解離や大動脈瘤破裂といった緊急を要する症状について、臨床データと環境因子の関連性を調査し、予防や医療資源配分に向けた基礎情報を収集しています。また虚血性僧帽弁閉鎖不全症など二次的な弁疾患のメカニズムを解明し、手術的介入の効果を評価する取り組みも行っています。研究方法としては、大規模臨床レジストリ（東京急性大動脈スーパーネットワークデータベースなど）を活用した観察研究が主軸です。3次元経食道心エコーや心臓CTなどの画像診断技術により、弁や心腔の形態を詳細に解析しています。さらに脈動流シミュレータを用いた実験系では、弁修復術後の血流動態を検証し、手術手技の改善に必要な情報を得ています。主な知見としては、患者の転院状況や性別が急性大動脈疾患の予後に影響すること、また二尖大動脈弁の修復術では適切な形態調整が狭窄の発生を抑制することが報告されています。これらの研究成果は、心血管疾患患者の生命予後向上と治療戦略の最適化に貢献しています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（57 件）

[2026] “Flying Saucer”–Like Morphology in Infective Endocarditis Arising on a Stenotic Mitral Valve
DOI: https://doi.org/10.1016/j.jaccas.2026.106955
[2026] Distinct temporal effects of ambient temperature on acute aortic dissection and aneurysm rupture: a time-stratified case-crossover study
DOI: https://doi.org/10.1093/eurjpc/zwag049
[2026] Giant Calcified Right Coronary Artery-to-Right Atrial Fistula Associated with Tricuspid Regurgitation and Thrombocytopenia
DOI: https://doi.org/10.7793/jcad.32.25-00032
[2026] Rationale of functional tricuspid annular dilatation based on standardized intraoperative measurements
DOI: https://doi.org/10.1016/j.jtcvs.2026.05.016
[2026] Minimally Invasive Mitral Valve Repair Using the Seamless Patch for Catheter Ablation–Induced Mitral Regurgitation
DOI: https://doi.org/10.1016/j.athoracsur.2026.04.056
[2026] Blood management with preoperative autologous blood in valve-sparing root replacement: separated autologous red blood cells and plasma and fibrin sealant versus autologous whole blood
DOI: https://doi.org/10.1007/s11748-026-02349-w
[2026] Microwave Device-Assisted Pericardiectomy for Immunoglobulin G4–Related Constrictive Pericarditis: A Case Report
DOI: https://doi.org/10.70352/scrj.cr.26-0154
[2026] Haemodynamic Early Outcomes of Sinus Plication for Bicuspid Aortic Valve Repair
DOI: https://doi.org/10.1093/icvts/ivag103
[2025] Aortic valve repair with sinus plication for a regurgitant bicuspid aortic valve: a case report
DOI: https://doi.org/10.1186/s44215-024-00184-0
[2025] The Importance of CT Angiography in Detecting Impending Paradoxical Embolism in Patients With Pulmonary Embolism
DOI: https://doi.org/10.1016/j.jaccas.2025.103996

続きを表示（残り 47 件）

[2025] Trends of aortic valve-preserving surgery in japan: an updated five-year nationwide survey
DOI: https://doi.org/10.1007/s11748-025-02170-x
[2025] Impact of the frozen elephant trunk technique in operation for acute type A aortic dissection: from the Japan cardiovascular surgery database
DOI: https://doi.org/10.1007/s11748-025-02190-7
[2025] Interfacility Transfer and Mortality in Patients With Type A Acute Aortic Dissection　― Analysis of the Tokyo Acute Aortic Super-Network Database ―
DOI: https://doi.org/10.1253/circrep.cr-25-0207
[2025] Formula-Based Relocation of the Papillary Muscle in Patients With Ischemic Mitral Regurgitation
DOI: https://doi.org/10.1016/j.atssr.2025.11.016
[2025] Interfacility Transfer and Early Mortality in Type A Acute Aortic Dissection
DOI: https://doi.org/10.1016/j.jacasi.2025.08.021
[2025] Does Intercommissural Distance Shortening in Bicuspid Aortic Valve Repair Improve Valve Opening Area?
DOI: https://doi.org/10.1016/j.atssr.2025.08.010
[2025] Infective endocarditis with perforation of the anterior mitral valve leaflet due to mild aortic regurgitation: a case report
DOI: https://doi.org/10.1093/ehjcr/ytaf076
[2025] The significance of investigation into underlying coronary artery fistula in patients with tricuspid valve endocarditis: a case report
DOI: https://doi.org/10.1093/ehjcr/ytaf260
[2025] Efficacy and Safety of Edoxaban in Anticoagulant Therapy Early After Surgical Bioprosthetic Valve Replacement: A Randomized Clinical Trial
DOI: https://doi.org/10.1161/circinterventions.124.015108
[2024] Clinical Features of 544 Patients With Ruptured Aortic Aneurysm　― A Report From the Tokyo Acute Aortic Super Network Database ―
DOI: https://doi.org/10.1253/circj.cj-23-0636
[2024] Associations of interfacility transfer with clinical presentation and early mortality in patients with type a acute aortic dissection: a registry study
DOI: https://doi.org/10.1093/eurheartj/ehae666.2266
[2024] Haemodynamic Assessment and Outcomes of Aortic Valvuloplasty for Aortic Regurgitation in Patients with Bicuspid Aortic Valve
DOI: https://doi.org/10.3390/jcm13247544
[2024] Loeys-Dietz syndrome with a novel in-frame SMAD3 deletion diagnosed as a result of postpartum aortic dissection: A case report
DOI: https://doi.org/10.1016/j.tjog.2024.01.018
[2024] Clinical Features of 544 Patients With Ruptured Aortic Aneurysm
[2024] Exploratory Study of the Measurement of Geometric Height in 3D Transesophageal Echocardiography as a Predictor of Valve-Sparing Root Replacement for Aortic Regurgitation
DOI: https://doi.org/10.3390/jcm13247835
[2024] Interpapillary muscle distance independently predicts recurrent mitral regurgitation
DOI: https://doi.org/10.1186/s13019-024-02631-z
[2023] Sex Differences in DeBakey Type I/II Acute Aortic Dissection Outcomes
DOI: https://doi.org/10.1016/j.jacadv.2023.100661
[2023] Sex Differences in DeBakey Type I/II Acute Aortic Dissection Outcomes: The Tokyo Acute Aortic Super-network
[2023] Labyrinth in cardiac surgery: annuloplasty for aortic valvuloplasty
DOI: https://doi.org/10.1093/ejcts/ezad417
[2023] A new insight into superacute care for type A acute aortic dissection in the Tokyo Acute Aortic Super Network
DOI: https://doi.org/10.1016/j.jtcvs.2023.08.040
[2023] Multicenter Study of Surgical Ablation for Atrial Fibrillation in Aortic Valve Replacement
DOI: https://doi.org/10.1097/mat.0000000000001882
[2023] Blood flow characteristics of the bilateral internal thoracic artery: implications of optimal graft configuration for coronary artery bypass grafting to maximize blood supply
DOI: https://doi.org/10.1007/s11748-023-01930-x
[2023] Outcomes of type A acute aortic dissection with cardiopulmonary arrest: Tokyo Acute Aortic Super-network Registry
DOI: https://doi.org/10.1093/ejcts/ezad056
[2022] Comparison of hemodynamics and root configurations between remodeling and reimplantation methods for valve-sparing aortic root replacement: a pulsatile flow study
DOI: https://doi.org/10.1007/s00595-022-02622-4
[2022] Changes in Internal Thoracic Artery Blood Flow According to the Degree of Stenosis of the Anterior Descending Branch of the Left Coronary Artery
DOI: https://doi.org/10.5761/atcs.oa.22-00153
[2022] Impact of Steroid on Macrophage Migration Inhibitory Factor During and After Cardiopulmonary Bypass
DOI: https://doi.org/10.1097/mat.0000000000001836
[2022] Current controversies in aortic valve-preserving surgery
DOI: https://doi.org/10.1016/j.jjcc.2022.10.006
[2022] Right-to-left shunt via iatrogenic atrial septal defect requiring emergency surgical repair following cryoballoon atrial fibrillation ablation in a patient with arrhythmogenic right ventricular cardiomyopathy
DOI: https://doi.org/10.1016/j.jccase.2022.09.008
[2022] The effect of the COVID-19 outbreak on intensive care in northern Saitama, Japan (Original)
[2022] Optimal threshold score of aortic valve calcification for identification of significant aortic stenosis on non-electrocardiographic-gated computed tomography
DOI: https://doi.org/10.1007/s00330-022-09114-6
[2022] Forme Fruste Bicuspid Aortic Valve
DOI: https://doi.org/10.1016/j.athoracsur.2022.08.030
[2022] Giant aneurysm of left circumflex artery branch with fistula to the coronary sinus: a case report
DOI: https://doi.org/10.1186/s13019-022-01950-3
[2022] [Intraoperative Pulmonary Artery Rupture Induced by a Pulmonary Artery Catheter].
[2022] Sex‐Related Differences in Clinical Features and In‐Hospital Outcomes of Type B Acute Aortic Dissection: A Registry Study
DOI: https://doi.org/10.1161/jaha.121.024149
[2022] [True Ascending Aortic Aneurysm Late after Total Arch Replacement].
[2022] [Open Surgery after Zone 0 Debranch Thoracic Endovascular Aortic Repair with Fenestrated Stent Graft:Report of a Case].
[2022] In-Hospital Mortality of Patients With Acute Type A Aortic Dissection Hospitalized on Weekends Versus Weekdays
DOI: https://doi.org/10.1016/j.jacasi.2021.11.010
[2021] Successful Repair of a Forme Fruste Bicuspid Aortic Valve by the Raphe Suspension Technique
DOI: https://doi.org/10.1016/j.athoracsur.2021.10.068
[2021] Constrictive Pericarditis with Cardiac Ascites Caused Spontaneous Bacterial Peritonitis
DOI: https://doi.org/10.2169/internalmedicine.8332-21
[2021] A Nationwide Survey of Surgical Treatment for Severe Ischemic Mitral Regurgitation
DOI: https://doi.org/10.5761/atcs.oa.21-00048
[2021] Pulmonary Artery Intimal Sarcoma Diagnosed Preoperatively by Endovascular Biopsy and Treated via Right Pneumonectomy and Pulmonary Arterioplasty
DOI: https://doi.org/10.1155/2021/5573869
[2021] Lung ventilation/perfusion scintigraphy shows the efficacy of anticoagulant therapy and surgical treatment for papillary fibroelastoma originating from the tricuspid valve
DOI: https://doi.org/10.1016/j.jccase.2021.04.022
[2021] Risk analysis for early mortality in emergency acute type A aortic dissection surgery: experience of Tokyo Acute Aortic Super-network
DOI: https://doi.org/10.1093/ejcts/ezab146
[2021] A Case of Aortic Dissection with Bicuspid Aortopathy for Prosthetic Valve Dysfunction (Case Report)
[2021] Haemodynamic benefit of bridging use of bosentan prior to pulmonary endarterectomy
DOI: https://doi.org/10.1093/ejcts/ezab137
[2021] The efficacy of sinus plication in aortic valvuloplasty for bicuspid aortic valve: experiments in a pulsatile flow simulation model
DOI: https://doi.org/10.1093/ejcts/ezab115
[2021] Aortic root geometry following valve-sparing root replacement with reimplantation or remodeling: experimental investigation under static continuous pressure
DOI: https://doi.org/10.1007/s10047-020-01242-4

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AI 要約（直近 5 年の研究成果）

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研究成果（57 件）

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