Kiyofumi Yamada 研究室

主宰者：Kiyofumi Yamada

藤田医科大学・Fujita Health University Hospital

AI 要約（直近 5 年の研究成果）

本研究室は、神経精神疾患の発症メカニズムの解明と新規治療法の開発を目指して、遺伝学と神経生物学的手法を組み合わせた研究を行っています。統合失調症やアルツハイマー病、双極性障害などの疾患に関連する遺伝子変異に着目し、それらの変異を持つ遺伝子改変マウスモデルを作製・解析することで、病態の分子的基盤を明らかにしようとしています。特に、小分子Gタンパク質シグナルや神経可塑性に関わるシグナル伝達経路に焦点を当て、脊椎骨の形態変化や認知機能の障害との関連性を調べています。さらに、動物の行動解析や脳組織の遺伝子発現解析、電気生理学的測定といった多角的なアプローチにより、脳の構造と機能の変化を詳細に追跡しています。これらの基礎研究で得られた知見をもとに、既存薬の効果を検証したり新規薬剤標的を同定したりすることで、臨床応用を見据えた医薬品開発へと展開しています。同時に、臨床薬理学的研究も進め、患者の治療満足度向上や最適な用量設定の確立など、実際の医療現場での課題解決にも取り組んでいます。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

外部リンク

研究成果（63 件）

[2026] Medication Instruction and Mirogabalin Treatment Satisfaction in Patients with Neuropathic Pain due to Orthopedic Diseases: Results of MiroSearch, a Japanese Exploratory Interventional Study
DOI: https://doi.org/10.1007/s12325-026-03516-4
[2026] Involvement of orexin nerves in early stage of Alzheimer's disease model mice and preventive effect of orexin receptor antagonists
DOI: https://doi.org/10.1177/13872877261415630
[2026] Reward prediction is encoded by orexin neuron activity during motivated behavior
DOI: https://doi.org/10.1073/pnas.2520677123
[2025] Activation of orexin neurons changes reward-based decision-making strategies
DOI: https://doi.org/10.1093/pnasnexus/pgaf322
[2025] Acute systemic immune challenge induces cognitive impairments and anhedonia through interferon-induced transmembrane protein 3 in adult male mice
DOI: https://doi.org/10.1016/j.bbr.2025.115832
[2025] A hyper-activatable CAMK2A variant associated with intellectual disability causes exaggerated long-term potentiation and learning impairments
DOI: https://doi.org/10.1038/s41398-025-03316-4
[2025] ACTIVITIES OF OREXIN NEURONS IN MOTIVATIVE BEHAVIOR
DOI: https://doi.org/10.1093/ijnp/pyae059.043
[2025] Population pharmacokinetic model of tranexamic acid in patients who undergo cardiac surgery with cardiopulmonary bypass
DOI: https://doi.org/10.1007/s00228-025-03802-0
[2025] GLIA RESPONSES ARE ASSOCIATED WITH ABNORMAL BEHAVIORS IN AN ANIMAL MODEL OF TAU PATHOLOGIES
DOI: https://doi.org/10.1093/ijnp/pyae059.497
[2025] Abnormal behaviors and glial responses in an animal model of tau pathology
DOI: https://doi.org/10.1186/s13041-025-01252-4

続きを表示（残り 53 件）

[2025] Twinfilin-1 phosphorylation in reelin signaling regulates actin dynamics and spine development
DOI: https://doi.org/10.1016/j.phrs.2025.107986
[2024] Development of a rapid detection method for the macrolide resistance gene in Mycobacterium avium using the amplification refractory mutation system–loop-mediated isothermal amplification method
DOI: https://doi.org/10.1128/spectrum.02339-23
[2024] Effects of Drug-related Problem Interventions by Hospital Pharmacists in Patients with Mild-to-moderate COVID-19
DOI: https://doi.org/10.5649/jjphcs.50.614
[2024] Signal flow in the NMDA receptor–dependent phosphoproteome regulates postsynaptic plasticity for aversive learning
DOI: https://doi.org/10.1126/scisignal.ado9852
[2024] The Use of Text Mining to Obtain a Historical Overview of Research on Therapeutic Drug Monitoring
DOI: https://doi.org/10.1248/bpb.b24-00319
[2024] Mice with deficiency in Pcdh15, a gene associated with bipolar disorders, exhibit significantly elevated diurnal amplitudes of locomotion and body temperature
DOI: https://doi.org/10.1038/s41398-024-02952-6
[2024] Risk factors for nausea and vomiting requiring the daily administration of 5-HT3 receptor antagonists in radiotherapy combined with temozolomide for high-grade glioma.
DOI: https://doi.org/10.18999/nagjms.86.2.304
[2024] Phenotypes for general behavior, activity, and body temperature in 3q29 deletion model mice
DOI: https://doi.org/10.1038/s41398-023-02679-w
[2024] Effect of single-administration of d-sorbitol pretreatment on the bitterness and continued willingness to take asenapine: a randomized, single-blind, placebo-controlled, crossover trial
DOI: https://doi.org/10.1186/s12888-024-05549-x
[2023] Abnormal behavior and glial responses in an animal model of tau pathology
DOI: https://doi.org/10.1254/jpssuppl.97.0_2-b-p-037
[2023] Genomic and Reverse Translational Analysis Discloses a Role for Small GTPase RhoA Signaling in the Pathogenesis of Schizophrenia: Rho-Kinase as a Novel Drug Target
DOI: https://doi.org/10.3390/ijms242115623
[2023] Emotional behaviors as well as the hippocampal reelin expression in C57BL/6N male mice chronically treated with corticosterone
DOI: https://doi.org/10.1016/j.pbb.2023.173617
[2023] Rho kinase inhibitors ameliorate cognitive impairment in a male mouse model of methamphetamine-induced schizophrenia
DOI: https://doi.org/10.1016/j.phrs.2023.106838
[2023] Sensory evaluation of the bitterness of asenapine using D-sorbitol pretreatment: single-blind, placebo-controlled, crossover trial
DOI: https://doi.org/10.1186/s12888-023-04664-5
[2023] Retrospective Analysis of Neutrophil-to-Lymphocyte Ratio in Patients with Melanoma Who Received Ipilimumab Monotherapy or Ipilimumab in Combination with Nivolumab in Japan
DOI: https://doi.org/10.1248/bpb.b22-00750
[2023] Challenges to drug discovery and development based on the genomic analysis of schizophrenia
DOI: https://doi.org/10.1254/jpssuppl.97.0_2-b-sl11
[2023] Selective Rho-kinase 2 inhibitor ameliorates the decreased spine density in the medial prefrontal cortex of mice carrying the variants of Arhgap10 gene found in a Japanese schizophrenia patient
DOI: https://doi.org/10.1254/jpssuppl.97.0_1-b-yia2-5
[2022] Anthocyanin‐rich blackcurrant extract improves long‐term memory impairment and emotional abnormality in senescence‐accelerated mice
DOI: https://doi.org/10.1111/jfbc.14295
[2022] Rho-Kinase/ROCK Phosphorylates PSD-93 Downstream of NMDARs to Orchestrate Synaptic Plasticity
DOI: https://doi.org/10.3390/ijms24010404
[2022] An Analysis of the Relationship between Gene Polymorphisms in Serotonin-Related Genes and Chemotherapy-Induced Gastrointestinal Symptoms
DOI: https://doi.org/10.5649/jjphcs.48.529
[2022] Inhibition of Rho-kinase ameliorates decreased spine density in the medial prefrontal cortex and methamphetamine-induced cognitive dysfunction in mice carrying schizophrenia-associated mutations of the Arhgap10 gene
DOI: https://doi.org/10.1016/j.phrs.2022.106589
[2022] An evaluation method for developing abuse-deterrent opioid formulations with agonist and antagonist combinations using conditioned place preference
DOI: https://doi.org/10.1016/j.bbrc.2022.11.072
[2022] A Survey on the Actual Use of and Reasons for Heated Tobacco Products in Patients with Rheumatoid Arthritis
DOI: https://doi.org/10.3390/ijerph191912465
[2022] Investigating the Polypharmacy Prescription Status of Antidepressants and Anxiolytics for Psychiatric Outpatients
DOI: https://doi.org/10.5649/jjphcs.48.359
[2022] Dopamine drives neuronal excitability via KCNQ channel phosphorylation for reward behavior
DOI: https://doi.org/10.1016/j.celrep.2022.111309
[2022] Clinical Training of Pharmacists after Licensure and Career Paths in Medical Institutions
DOI: https://doi.org/10.1248/yakushi.22-00089-5
[2022] Antipsychotic-like effects of fasudil, a Rho-kinase inhibitor, in a pharmacologic animal model of schizophrenia
DOI: https://doi.org/10.1016/j.ejphar.2022.175207
[2022] ＜Editors' Choice＞ Clinical impact of standardized creatinine on dose adjustment of capecitabine.
DOI: https://doi.org/10.18999/nagjms.84.3.547
[2022] Phosphoproteomic of the acetylcholine pathway enables discovery of the PKC-β-PIX-Rac1-PAK cascade as a stimulatory signal for aversive learning
DOI: https://doi.org/10.1038/s41380-022-01643-2
[2022] Rho–Rho-Kinase Regulates Ras-ERK Signaling Through SynGAP1 for Dendritic Spine Morphology
DOI: https://doi.org/10.1007/s11064-022-03623-y
[2022] Influence of Antibiotic Use on the Effectiveness and Safety of Immune Checkpoint Inhibitors
DOI: https://doi.org/10.5649/jjphcs.48.173
[2022] A machine learning model that emulates experts’ decision making in vancomycin initial dose planning
DOI: https://doi.org/10.1016/j.jphs.2022.02.005
[2022] New Strategies for the Treatment of Neuropsychiatric Disorders Based on Reelin Dysfunction
DOI: https://doi.org/10.3390/ijms23031829
[2022] Efforts for Pharmacy Hospital Practical Training Using Information and Communication Technology and Evaluation from Students in the COVID-19 Pandemic
DOI: https://doi.org/10.5649/jjphcs.48.20
[2022] A patient-centered multidisciplinary collaboration in cancer chemotherapy
DOI: https://doi.org/10.1254/jpssuppl.95.0_1-s12-3
[2022] Establishment of an in vivo calcium imaging method to evaluate neuronal activity in mice carrying mutations of Arhgap10 gene
DOI: https://doi.org/10.1254/jpssuppl.95.0_2-p-168
[2022] Dynamic changes in orexin activities associated with reward-based motivative behavior
DOI: https://doi.org/10.1254/jpssuppl.95.0_1-ss-08
[2022] Promotion of multidisciplinary collaboration in cancer chemotherapy— basic knowledge of medicines for clinical nurses
DOI: https://doi.org/10.1254/fpj.22048
[2022] Changes in the expression of interferon-induced transmembrane protein-3 (IFITM3) in the brains of Alzheimer‘s disease model mice
DOI: https://doi.org/10.1254/jpssuppl.96.0_1-b-p-333
[2022] NMDA-induced activation of the CaMKII-RhoA-Rho-kinase pathway regulates aversive learning
DOI: https://doi.org/10.1254/jpssuppl.96.0_2-b-p-109
[2021] Additional file 1 of Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons
DOI: https://doi.org/10.6084/m9.figshare.13633080
[2021] Alzheimer’s Disease Animal Models: Elucidation of Biomarkers and Therapeutic Approaches for Cognitive Impairment
DOI: https://doi.org/10.3390/ijms22115549
[2021] Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice
DOI: https://doi.org/10.1038/s41598-021-92386-7
[2021] KANPHOS: A Database of Kinase-Associated Neural Protein Phosphorylation in the Brain
DOI: https://doi.org/10.3390/cells11010047
[2021] Muscarinic signaling regulates voltage‐gated potassium channel KCNQ2 phosphorylation in the nucleus accumbens via protein kinase C for aversive learning
DOI: https://doi.org/10.1111/jnc.15555
[2021] Mice with exonic RELN deletion identified from a patient with schizophrenia have impaired visual discrimination learning and reversal learning in touchscreen operant tasks
DOI: https://doi.org/10.1016/j.bbr.2021.113569
[2021] Early postnatal inhibition of GLAST causes abnormalities of psychobehaviors and neuronal morphology in adult mice
DOI: https://doi.org/10.1016/j.neuint.2021.105177
[2021] Survey of chemotherapy‑induced nausea and vomiting in patients with urothelial carcinoma
DOI: https://doi.org/10.3892/mco.2021.2384
[2021] Microinjection of Reelin into the mPFC prevents MK-801-induced recognition memory impairment in mice
DOI: https://doi.org/10.1016/j.phrs.2021.105832
[2021] Retrospective Study of Introducing Suvorexant to Long-term Users of Benzodiazepines
DOI: https://doi.org/10.5649/jjphcs.47.123
[2021] Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons
DOI: https://doi.org/10.1186/s13041-021-00735-4
[2021] The mice with exonic Reln deletion show cognitive dysfunction but not attention impairment in the touchscreen operant tasks
DOI: https://doi.org/10.1254/jpssuppl.94.0_3-y-f1-3
[2021] Effects of a Rho-kinase inhibitor, fasudil on schizophrenia-like behavior and neurotransmitter release in MK-801-treated mice
DOI: https://doi.org/10.1254/jpssuppl.94.0_1-y-f3-4

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AI 要約（直近 5 年の研究成果）

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関連研究室(8 件)

研究成果（63 件）

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