Shin Yamazaki 研究室

主宰者：Shin Yamazaki

国立環境研究所

AI 要約（直近 5 年の研究成果）

本研究室では、大規模な出生コホート調査である「環境と子どもの健康に関する全国調査」を活用して、妊娠期から幼少期における環境要因と健康転帰の関連を調べています。研究対象は、大気汚染物質や室内空気中の化学物質、重金属、食事成分といった多様な環境暴露要因です。これらの暴露が、妊娠中毒症などの妊娠転帰障害や、出生体重、発達遅延といった乳幼児の健康アウトカムにどのような影響を与えるかを明らかにすることを目指しています。手法として、大規模な妊産婦・乳幼児集団から採取した血液・食事・環境試料の化学分析、自記式質問票による曝露・食生活・生活習慣の評価、母子手帳や医学記録の情報収集、および発達評価スケールを用いた標準化された発達検査を組み合わせています。統計解析では、ロジスティック回帰分析や線形混合効果モデルといった多変量解析手法を適用しており、交絡因子の調整や層別解析も実施しています。研究の知見として、妊娠中の栄養摂取や生活習慣が妊娠高血圧や妊娠糖尿病のリスクと関連すること、室内環境汚染や化学物質暴露が血圧や甲状腺ホルモン値に影響する可能性があること、出産様式や父親の養育参与が幼児の発達や疾患リスクと関連することが報告されています。これらの知見は、妊娠期から出生後数年の環境保健対策の重要性を示唆しています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

外部リンク

研究成果（100 件）

[2026] Serum Manganese, Cobalt, Copper, Zinc, Selenium, and Iodine Levels, and the Incidence of Type 2 Diabetes: A Nested Case-control Study
DOI: https://doi.org/10.1007/s12011-026-05109-2
[2026] 中学校技術科における簡易的振動実験を取り入れた耐震構造学習プログラムの開発とその教育的効果
[2026] Genomic and transcriptomic analyses of melanoma in Japanese patients reveal candidate biomarkers for immune checkpoint inhibitor responders
DOI: https://doi.org/10.1038/s43856-025-01341-4
[2026] Associations of Indoor Carbonyl and Nitrogen Dioxide Exposure With Blood Pressure Levels Among Toddlers: The Japan Environment and Children′s Study
DOI: https://doi.org/10.1155/ina/8806085
[2025] Pre-pregnancy body mass index range and prevalence of hypertensive disorders of pregnancy: the Japan environment and children’s study
DOI: https://doi.org/10.1186/s12884-025-08459-2
[2025] The impact of pediatric constipation on appendicitis: a prospective birth cohort in the Japan Environment and Children’s Study
DOI: https://doi.org/10.1186/s12887-025-06263-7
[2025] Association of cesarean section with asthma and atopic dermatitis in infants from the Japan Environment and Children’s Study
DOI: https://doi.org/10.1038/s41598-025-23252-z
[2025] Association of postpartum weight retentions at 4 weeks with large-for-gestational-age infants in the second pregnancy: the Japan environment and children’s study
DOI: https://doi.org/10.1007/s40200-025-01749-8
[2025] Associations Between Blood Heavy Metal Concentrations and Hypertensive Disorders of Pregnancy in the Japan Environment and Children's Study
DOI: https://doi.org/10.1161/jaha.125.042183
[2025] Association between exposure to perfluoroalkyl compounds during early pregnancy and risk of late miscarriage: The Japan Environment and Children's Study
DOI: https://doi.org/10.1016/j.ijheh.2025.114673

続きを表示（残り 90 件）

[2025] Association Between Particulate Matter Exposure and Thyroid Hormone Levels in Early Childhood: Results From JECS
DOI: https://doi.org/10.1210/clinem/dgaf446
[2025] Dietary intake of omega-3 PUFAs and fish in relation to mother-to-infant bonding in the Japan Environment and Children’s Study
DOI: https://doi.org/10.1038/s41598-025-02983-z
[2025] Direct and indirect effects of smoking during pregnancy on child development: The Japan Environment and Children’s Study
DOI: https://doi.org/10.1038/s41598-025-02684-7
[2025] Prenatal mercury exposure and body mass index at 2 and 4 years: The Japan Environment and Children's Study
DOI: https://doi.org/10.1016/j.ijheh.2025.114566
[2025] Association between the duration of mothers’ digital media use while with their children and two-year-old children’s development from the Japan Environment and Children’s Study
DOI: https://doi.org/10.1038/s41598-025-87430-9
[2025] Association between paternal involvement in childcare and child injury: the Japan Environment and Children’s Study (JECS)
DOI: https://doi.org/10.1186/s12887-025-05453-7
[2024] Dietary intake of methylmercury by 0–5 years children using the duplicate diet method in Japan
DOI: https://doi.org/10.1265/ehpm.24-00048
[2024] Association of allergies in children younger than 3 years with levels of maternal intake of n-3 polyunsaturated fatty acids or fish during pregnancy: A nationwide birth cohort study, the Japan Environment and Children's Study
DOI: https://doi.org/10.1016/j.alit.2023.12.004
[2024] Association between maternal usage of volatile organic compounds and West syndrome, the Japan Environment and Children’s study
DOI: https://doi.org/10.1038/s41598-024-81913-x
[2024] Association of air purifier usage during pregnancy with adverse birth outcomes: the Japan Environment and Children’s Study
DOI: https://doi.org/10.1186/s12889-024-20802-4
[2024] Advanced maternal age elevates the prevalence of hypertensive disorders in women of Japanese, independent of blood pressure: a study from the Japan Environment and Children’s study
DOI: https://doi.org/10.1038/s41440-024-02019-5
[2024] Association Between Periconceptional Diet Quality and Hypertensive Disorders of Pregnancy: The Japan Environment and Children's Study
DOI: https://doi.org/10.1161/jaha.123.033702
[2024] Prenatal mercury exposure and the secondary sex ratio: The Japan Environment and Children's Study
DOI: https://doi.org/10.1016/j.reprotox.2024.108685
[2024] Infants’ early recovery from sleep disturbance is associated with a lower risk of developmental delay in the Japan Environment and Children’s Study
DOI: https://doi.org/10.1038/s41598-024-68672-5
[2024] Associations between paternal autism traits and parenting from the Japan environment and children’s study
DOI: https://doi.org/10.1038/s41598-024-67978-8
[2024] Association between general anesthesia in early childhood and neurodevelopment up to 4 years of age: the Japan Environment and Children’s Study
DOI: https://doi.org/10.1007/s00540-024-03359-9
[2024] Risk of Gestational Diabetes in Women With PCOS Based on Body Mass Index: The Japan Environment and Children's Study
DOI: https://doi.org/10.1210/clinem/dgae293
[2024] Prenatal risk factors of indoor environment and incidence of childhood eczema in the Japan Environment and Children's Study
DOI: https://doi.org/10.1016/j.envres.2024.118871
[2024] Association of maternal leukocyte, monocyte, and neutrophil counts with hypertensive disorders of pregnancy: the Japan Environment and Children’s Study (JECS)
DOI: https://doi.org/10.1038/s41598-024-55623-3
[2024] Association between daily breakfast habit during pregnancy and neurodevelopment in 3-year-old offspring: The Japan Environment and Children’s Study
DOI: https://doi.org/10.1038/s41598-024-55912-x
[2024] 総合的な学習の時間「未来創造科」を軸とした教科等横断的な学びの実現に関する実証的研究 ―教科等横断的な視点に立った資質・能力の育成及び統合を通して―
[2024] Hypertensive disorders of pregnancy increase the incidence of febrile seizures in offspring
DOI: https://doi.org/10.1038/s41390-024-03057-y
[2024] Maternal Autistic Traits and Adverse Birth Outcomes
DOI: https://doi.org/10.1001/jamanetworkopen.2023.52809
[2023] Neurodevelopmental Outcomes Among Offspring Exposed to Corticosteroid and B2-Adrenergic Agonists In Utero
DOI: https://doi.org/10.1001/jamanetworkopen.2023.39347
[2023] Maternal Serum Folic Acid Levels and Onset of Kawasaki Disease in Offspring During Infancy
DOI: https://doi.org/10.1001/jamanetworkopen.2023.49942
[2023] Impact of dog and/or cat ownership on functional constipation at 3 years of age: the Japan Environment and Children’s study
DOI: https://doi.org/10.1186/s12887-023-04412-4
[2023] Teenage and young adult pregnancy and depression: findings from the Japan environment and children’s study
DOI: https://doi.org/10.1007/s00737-023-01400-6
[2023] Impact of breastfeeding during infancy on functional constipation at 3 years of age: the Japan Environment and Children’s Study
DOI: https://doi.org/10.1186/s13006-023-00592-y
[2023] Caesarean section and childhood obesity at age 3 years derived from the Japan Environment and Children’s Study
DOI: https://doi.org/10.1038/s41598-023-33653-7
[2023] Prenatal metal concentrations and physical abnormalities in the Japan Environment and Children’s Study
DOI: https://doi.org/10.1038/s41390-023-02851-4
[2023] Tocolytic treatment and maternal characteristics, obstetric outcomes, and offspring childhood outcomes among births at and after 37 weeks of gestation: the Japan environment and children’s study
DOI: https://doi.org/10.1007/s00404-023-07203-5
[2023] Effect of nausea and vomiting during pregnancy on mother-to-infant bonding and the mediation effect of postpartum depression: the Japan Environment and Children’s Study
DOI: https://doi.org/10.1186/s12884-023-06014-5
[2023] Screen Time and Developmental Performance Among Children at 1-3 Years of Age in the Japan Environment and Children’s Study
DOI: https://doi.org/10.1001/jamapediatrics.2023.3643
[2023] Environments affect blood pressure in toddlers: The Japan Environment and Children’s Study
DOI: https://doi.org/10.1038/s41390-023-02796-8
[2023] Association between gestational age at threatened preterm birth diagnosis and incidence of preterm birth: the Japan Environment and Children’s Study
DOI: https://doi.org/10.1038/s41598-023-38524-9
[2023] Prenatal exposure to selenium, mercury, and manganese during pregnancy and allergic diseases in early childhood: The Japan Environment and Children's study
DOI: https://doi.org/10.1016/j.envint.2023.108123
[2023] Cord blood triglyceride and total cholesterol in preterm and term neonates: reference values and associated factors from the Japan Environment and Children’s Study
DOI: https://doi.org/10.1007/s00431-023-05118-6
[2023] Paternal involvement in infant care and developmental milestone outcomes at age 3 years: the Japan Environment and Children’s Study (JECS)
DOI: https://doi.org/10.1038/s41390-023-02723-x
[2023] Maternal antibiotic exposure and childhood allergies: The Japan Environment and Children’s Study
DOI: https://doi.org/10.1016/j.jacig.2023.100137
[2023] A nationwide, prospective, cohort study on exogenous oxytocin and delays in early child development: the Japan environment and children’s study
DOI: https://doi.org/10.1007/s00431-023-05079-w
[2023] Association between maternal cholesterol level during pregnancy and placental weight and birthweight ratio: data from the Japan Environment and Children’s Study
DOI: https://doi.org/10.1186/s12884-023-05810-3
[2023] Reference blood pressure values obtained using the auscultation method for 2-year-old Japanese children: from the Japan Environment and Children’s Study
DOI: https://doi.org/10.1007/s10157-023-02370-w
[2023] Association between Cesarean section and neurodevelopmental disorders in a Japanese birth cohort: the Japan Environment and Children’s Study
DOI: https://doi.org/10.1186/s12887-023-04128-5
[2023] Sleep quality and temperament in association with autism spectrum disorder among infants in Japan
DOI: https://doi.org/10.1038/s43856-023-00314-9
[2023] Prenatal folic acid supplement/dietary folate and cognitive development in 4-year-old offspring from the Japan Environment and Children’s Study
DOI: https://doi.org/10.1038/s41598-023-36484-8
[2023] Impact of Habitual Yogurt Intake in Mother–Child Dyads on Incidence of Childhood Otitis Media: The Japan Environment and Children’s Study (JECS)
DOI: https://doi.org/10.1007/s12602-023-10086-2
[2023] Evaluation of temperature-dependent fluctuations in skin microcirculation flow using a light-emitting diode based photoacoustic imaging device
DOI: https://doi.org/10.1007/s10877-023-01026-0
[2023] Longitudinal study of the relationship between number of prior miscarriages or stillbirths and changes in quality of life of pregnant women: the Japan Environment and Children’s Study (JECS)
DOI: https://doi.org/10.1186/s12884-023-05578-6
[2023] Maternal smoking status before and during pregnancy and bronchial asthma at 3 years of age: a prospective cohort study
DOI: https://doi.org/10.1038/s41598-023-30304-9
[2023] Season of birth and atopic dermatitis in early infancy: results from the Japan Environment and Children’s Study
DOI: https://doi.org/10.1186/s12887-023-03878-6
[2023] Maternal protein intake in early pregnancy and child development at age 3 years
DOI: https://doi.org/10.1038/s41390-022-02435-8
[2023] Research on utilization of buildings and sites after the withdrawal of department stores
DOI: https://doi.org/10.11361/cpijchubu.34.0_1
[2022] Association of labour duration in spontaneous deliveries with low neonatal Apgar scores and foetal acidosis: the Japan Environment and Children’s Study
DOI: https://doi.org/10.1038/s41598-022-24359-3
[2022] Maternal Metals Exposure and Infant Weight Trajectory: The Japan Environment and Children’s Study (JECS)
DOI: https://doi.org/10.1289/ehp10321
[2022] Factor structure of the Parenting Stress Index-Short Form used in the Japan Environment and Children’s Study
DOI: https://doi.org/10.1038/s41598-022-23849-8
[2022] Maternal hemoglobin levels and neonatal outcomes: the Japan Environment and Children’s Study
DOI: https://doi.org/10.1080/14767058.2022.2130237
[2022] No association between prenatal lead exposure and neurodevelopment during early childhood in the Japan Environment and Children’s Study
DOI: https://doi.org/10.1038/s41598-022-19509-6
[2022] Association between the ratio of placental weight to birthweight and the risk of neurodevelopmental delay in 3-year-Olds: The Japan environment and Children's study
DOI: https://doi.org/10.1016/j.placenta.2022.08.007
[2022] The association between early formula and reduced risk of cow’s milk allergy during the first three year of life: a Japanese cohort study
DOI: https://doi.org/10.1186/s13223-022-00712-z
[2022] Association between maternal fermented food consumption and child sleep duration at the age of 3 years: the Japan Environment and Children’s Study
DOI: https://doi.org/10.1186/s12889-022-13805-6
[2022] Impact of prenatal exposure to mercury and selenium on neurodevelopmental delay in children in the Japan environment and Children’s study using the ASQ-3 questionnaire: A prospective birth cohort
DOI: https://doi.org/10.1016/j.envint.2022.107448
[2022] Gestational weight gain mediates the effects of energy intake on birth weight among singleton pregnancies in the Japan Environment and Children’s Study
DOI: https://doi.org/10.1186/s12884-022-04898-3
[2022] Preconception vitamin D intake and obstetric outcomes in women using assisted reproductive technology: the Japan Environment and Children’s Study
DOI: https://doi.org/10.1186/s12884-022-04861-2
[2022] Impact of lumbar spinal stenosis on metabolic syndrome incidence in community-dwelling adults in Aizu cohort study (LOHAS)
DOI: https://doi.org/10.1038/s41598-022-15173-y
[2022] Association between prenatal cadmium exposure and child development: The Japan Environment and Children's study
DOI: https://doi.org/10.1016/j.ijheh.2022.113989
[2022] A Case-Crossover Analysis of the Association between Exposure to Total PM<sub>2.5</sub> and Its Chemical Components and Emergency Ambulance Dispatches in Tokyo
DOI: https://doi.org/10.1021/acs.est.1c08219
[2022] Maternal Chronic Disease and Congenital Anomalies of the Kidney and Urinary Tract in Offspring: A Japanese Cohort Study
DOI: https://doi.org/10.1053/j.ajkd.2022.03.003
[2022] Association of physical activity and sleep habits during pregnancy with autistic spectrum disorder in 3-year-old infants
DOI: https://doi.org/10.1038/s43856-022-00101-y
[2022] Long-term outcomes of children with neonatal transfer: the Japan Environment and Children’s Study
DOI: https://doi.org/10.1007/s00431-022-04450-7
[2022] Maternal BMI and allergy in children until 3 years of age (JECS)
DOI: https://doi.org/10.1016/j.jacig.2022.02.003
[2022] Baseline Complete Blood Count and Chemistry Panel Profile from the Japan Environment and Children’s Study (JECS)
DOI: https://doi.org/10.3390/ijerph19063277
[2022] Fluctuations of aeroallergen-specific immunoglobulins and children's allergic profiles: Japan Environment & Children's Study of a pilot cohort
DOI: https://doi.org/10.1016/j.alit.2022.01.002
[2022] Severity of low pre-pregnancy body mass index and perinatal outcomes: the Japan Environment and Children’s Study
DOI: https://doi.org/10.1186/s12884-022-04418-3
[2022] Association Between Screen Time Exposure in Children at 1 Year of Age and Autism Spectrum Disorder at 3 Years of Age
DOI: https://doi.org/10.1001/jamapediatrics.2021.5778
[2022] Association between maternal insecticide use and otitis media in one-year-old children in the Japan Environment and Children’s Study
DOI: https://doi.org/10.1038/s41598-022-05433-2
[2022] Association between a single mother family and childhood undervaccination, and mediating effect of household income: a nationwide, prospective birth cohort from the Japan Environment and Children’s Study (JECS)
DOI: https://doi.org/10.1186/s12889-022-12511-7
[2022] Effects of maternal exposure to lead on secondary sex ratio in Japan: The Japan Environment and Children’s Study
DOI: https://doi.org/10.1016/j.scitotenv.2021.152726
[2022] Maternal Exposure to Fine Particulate Matter and Its Chemical Components Increasing the Occurrence of Gestational Diabetes Mellitus in Pregnant Japanese Women
DOI: https://doi.org/10.31662/jmaj.2022-0141
[2022] A Study on the Reality of utilization of Sites after the Exit of Department Stores
DOI: https://doi.org/10.11361/cpijchubu.33.0_47
[2021] Dose–response relationships between maternal urinary cotinine and placental weight and ratio of placental weight to birth weight: The Japan Environment and Children's Study
DOI: https://doi.org/10.1016/j.envres.2021.112470
[2021] 25-Hydroxyvitamin D levels among 2-year-old children: findings from the Japan environment and Children’s study (JECS)
DOI: https://doi.org/10.1186/s12887-021-03005-3
[2021] Relations of mold, stove, and fragrance products on childhood wheezing and asthma: A prospective cohort study from the Japan Environment and Children's Study
DOI: https://doi.org/10.1111/ina.12931
[2021] Insufficient maternal gestational weight gain and infant neurodevelopment at 12 months of age: the Japan Environment and Children’s Study
DOI: https://doi.org/10.1007/s00431-021-04232-7
[2021] Prospective association of air purifier use during pregnancy with the neurodevelopment of toddlers in the Japan Environment and Children’s Study
DOI: https://doi.org/10.1038/s41598-021-98482-y
[2021] Association between the Concentrations of Metallic Elements in Maternal Blood during Pregnancy and Prevalence of Abdominal Congenital Malformations: The Japan Environment and Children’s Study
DOI: https://doi.org/10.3390/ijerph181910103
[2021] Association of cesarean birth with prevalence of functional constipation in toddlers at 3 years of age: results from the Japan Environment and Children’s Study (JECS)
DOI: https://doi.org/10.1186/s12887-021-02885-9
[2021] Decreased head circumference at birth associated with maternal tobacco smoke exposure during pregnancy on the Japanese prospective birth cohort study
DOI: https://doi.org/10.1038/s41598-021-98311-2
[2021] A prospective cohort study of the association between the Apgar score and developmental status at 3 years of age: the Japan Environment and Children’s Study (JECS)
DOI: https://doi.org/10.1007/s00431-021-04249-y
[2021] Association between mothers’ fish intake during pregnancy and infants’ sleep duration: a nationwide longitudinal study—The Japan Environment and Children’s Study (JECS)
DOI: https://doi.org/10.1007/s00394-021-02671-4
[2021] Maternal exposure to fine particulate matter over the first trimester and umbilical cord insertion abnormalities
DOI: https://doi.org/10.1093/ije/dyab192

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AI 要約（直近 5 年の研究成果）

外部リンク

関連研究室(8 件)

研究成果（100 件）

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