Hirotaka Tomiyasu 研究室

主宰者：Hirotaka Tomiyasu

東京大学

AI 要約（直近 5 年の研究成果）

当研究室は、犬や猫における悪性腫瘍、特にリンパ腫や組織球肉腫といった血液系腫瘍の病態解明と治療開発に取り組んでいます。これらの疾患の分子的な異常メカニズムを明らかにするため、細胞株や組織サンプルを用いて遺伝子発現プロファイルやゲノム変異を解析しています。具体的には、RNA配列解析や次世代シーケンシング技術を活用して、腫瘍細胞がどのような遺伝子異常を持つのか、また異なる腫瘍間でどのような分子的な差異があるのかを調べています。さらに、大規模な化学物質スクリーニングを実施し、既存薬や新規化合物の中から腫瘍細胞に対する効果を示す治療候補物質を探索しています。同時に、消化管疾患や胆嚢疾患といった非腫瘍性疾患についても、腸内細菌叢や遺伝子発現の異常を調査し、健康な動物との比較から病態の特性を明らかにしています。これらの研究は、犬や猫の腫瘍疾患の診断・予後判定の精度向上と、より有効な治療法の開発につながることが期待されています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（102 件）

[2026] Red blood cell distribution width may help distinguish canine gastrointestinal lymphoma from chronic inflammatory enteropathy and be a prognostic indicator
DOI: https://doi.org/10.2460/javma.25.10.0684
[2026] Identification of Novel Therapeutic Agent Candidates Through High Throughput Screening With Chemical Library Based on Molecular Subclassification in Canine Histiocytic Sarcoma Cell Lines
DOI: https://doi.org/10.1111/vco.70077
[2026] Comprehensive analysis of gene expression profiles revealed increased expression of genes related to proteasome in feline nasal lymphoma
DOI: https://doi.org/10.1016/j.rvsc.2026.106185
[2026] Genetic variants of flavin-containing monooxygenase (FMO) 1 and FMO3 in 5887 dogs influenced oxygenations of probe substrates benzydamine, trimethylamine, and methyl p-tolyl sulfide
DOI: https://doi.org/10.1016/j.bcp.2026.117790
[2026] Red blood cell distribution width may help distinguish canine gastrointestinal lymphoma from chronic inflammatory enteropathy and be a prognostic indicator
DOI: https://doi.org/10.2460/javma.25.10.0684
[2026] Identification of Novel Therapeutic Agent Candidates Through High Throughput Screening With Chemical Library Based on Molecular Subclassification in Canine Histiocytic Sarcoma Cell Lines
DOI: https://doi.org/10.1111/vco.70077
[2026] Genetic variants of flavin-containing monooxygenase (FMO) 1 and FMO3 in 5887 dogs influenced oxygenations of probe substrates benzydamine, trimethylamine, and methyl p-tolyl sulfide
DOI: https://doi.org/10.1016/j.bcp.2026.117790
[2025] Genetic variants of cytochrome P450 2C21 identified by screening 6344 dogs influenced oxidations of the probe drug omeprazole
DOI: https://doi.org/10.1016/j.bcp.2025.117394
[2025] Generation of canine gallbladder cholangiocyte organoids from healthy and gallbladder mucocele patient dogs for functional analysis of anion channels
DOI: https://doi.org/10.1016/j.tvjl.2025.106417
[2025] Measurement and estimation of normal mitral annular size using computed tomography in 248 small-breed dogs
DOI: https://doi.org/10.1016/j.jvc.2025.06.005

続きを表示（残り 92 件）

[2025] Molecular Classification Based on the Gene Expression Profiles in Canine Histiocytic Sarcoma Cells
DOI: https://doi.org/10.1111/vco.13071
[2025] Comprehensive investigation of gene mutations in canine large cell gastrointestinal lymphoma
DOI: https://doi.org/10.3389/fvets.2025.1535446
[2025] Malignant peripheral nerve sheath tumor in the vagus nerve causing upper gastrointestinal signs in a dog
DOI: https://doi.org/10.1292/jvms.25-0152
[2025] Exploratory high-throughput screening of repurposed drugs for canine lymphoid malignancies
DOI: https://doi.org/10.1186/s12917-025-05053-8
[2025] Genetic variants of cytochrome P450 2C21 identified by screening 6344 dogs influenced oxidations of the probe drug omeprazole
DOI: https://doi.org/10.1016/j.bcp.2025.117394
[2025] Generation of canine gallbladder cholangiocyte organoids from healthy and gallbladder mucocele patient dogs for functional analysis of anion channels
DOI: https://doi.org/10.1016/j.tvjl.2025.106417
[2025] Molecular Classification Based on the Gene Expression Profiles in Canine Histiocytic Sarcoma Cells
DOI: https://doi.org/10.1111/vco.13071
[2025] Measurement and estimation of normal mitral annular size using computed tomography in 248 small-breed dogs
DOI: https://doi.org/10.1016/j.jvc.2025.06.005
[2025] Comprehensive investigation of gene mutations in canine large cell gastrointestinal lymphoma
DOI: https://doi.org/10.3389/fvets.2025.1535446
[2025] Malignant peripheral nerve sheath tumor in the vagus nerve causing upper gastrointestinal signs in a dog
DOI: https://doi.org/10.1292/jvms.25-0152
[2025] In response to ‘Factors associated with the development of gastrointestinal adverse events in dogs with multicentric lymphoma treated with <scp>CHOP</scp> or <scp>CEOP</scp> ‐based protocols: a multi‐institutional, retrospective study’ by Treggiari et al.
DOI: https://doi.org/10.1111/jsap.70041
[2025] Genetic variants in dog cytochrome P450 2B6 and their relevance to interindividual variability of oxidations of probe drug propofol
DOI: https://doi.org/10.1016/j.dmd.2025.100189
[2025] Genetic variants in dog cytochrome P450 2B6 and their relevance to interindividual variability of oxidations of probe drug propofol
DOI: https://doi.org/10.1016/j.dmd.2025.100189
[2025] Exploratory high-throughput screening of repurposed drugs for canine lymphoid malignancies
DOI: https://doi.org/10.1186/s12917-025-05053-8
[2024] Efficacy and adverse events of L-Asparaginase administration as a first-line treatment for feline large-cell gastrointestinal lymphoma
DOI: https://doi.org/10.1292/jvms.23-0453
[2024] Antitumor effects of inhibitors of ERK and Akt pathways in canine histiocytic sarcoma cell lines
DOI: https://doi.org/10.1016/j.tvjl.2024.106264
[2024] Transcriptomic analysis of bone marrow specimens collected from Miniature Dachshunds diagnosed with non-neoplastic bone marrow disorders
DOI: https://doi.org/10.1292/jvms.23-0371
[2024] Antitumor effects of inhibitors of ERK and Akt pathways in canine histiocytic sarcoma cell lines
DOI: https://doi.org/10.1016/j.tvjl.2024.106264
[2024] Efficacy and adverse events of L-Asparaginase administration as a first-line treatment for feline large-cell gastrointestinal lymphoma
DOI: https://doi.org/10.1292/jvms.23-0453
[2024] Comprehensive gene expression analysis in gallbladder mucosal epithelial cells of dogs with gallbladder mucocele
DOI: https://doi.org/10.1111/jvim.17157
[2024] Characterization of faecal microbiota and serum inflammatory markers in dogs diagnosed with chronic enteropathy or small-cell lymphoma: a pilot study
DOI: https://doi.org/10.1038/s41598-024-69923-1
[2024] Clinicopathologic findings of splenic marginal zone lymphoma with gallbladder involvement that progressed to diffuse large B‐cell lymphoma in a dog
DOI: https://doi.org/10.1111/vcp.13331
[2024] Investigation of the mutations in the genes involved in Janus kinase/signal transducer and activator of transcription pathway in canine large cell gastrointestinal lymphoma
DOI: https://doi.org/10.1292/jvms.24-0096
[2024] Efficacy of vincristine as a rescue therapy for canine histiocytic sarcoma
DOI: https://doi.org/10.1292/jvms.24-0218
[2024] Comprehensive gene expression analysis in gallbladder mucosal epithelial cells of dogs with gallbladder mucocele
DOI: https://doi.org/10.1111/jvim.17157
[2024] Characterization of faecal microbiota and serum inflammatory markers in dogs diagnosed with chronic enteropathy or small-cell lymphoma: a pilot study
DOI: https://doi.org/10.1038/s41598-024-69923-1
[2024] Clinicopathologic findings of splenic marginal zone lymphoma with gallbladder involvement that progressed to diffuse large B‐cell lymphoma in a dog
DOI: https://doi.org/10.1111/vcp.13331
[2024] Investigation of the mutations in the genes involved in Janus kinase/signal transducer and activator of transcription pathway in canine large cell gastrointestinal lymphoma
DOI: https://doi.org/10.1292/jvms.24-0096
[2024] Efficacy of vincristine as a rescue therapy for canine histiocytic sarcoma
DOI: https://doi.org/10.1292/jvms.24-0218
[2024] Transcriptomic analysis of bone marrow specimens collected from Miniature Dachshunds diagnosed with non-neoplastic bone marrow disorders
DOI: https://doi.org/10.1292/jvms.23-0371
[2023] Prognostic value of increased intraepithelial lymphocytes and lymphocytic clonality in dogs with chronic enteropathy or small-cell lymphoma
DOI: https://doi.org/10.1016/j.tvjl.2023.105993
[2023] Use of genome-wide DNA methylation analysis to identify prognostic CpG site markers associated with longer survival time in dogs with multicentric high-grade B-cell lymphoma
DOI: https://doi.org/10.1111/jvim.16931
[2023] Polyoxazoline-Conjugated <scp>l</scp>-Asparaginase: An Antibody-Production-Free Therapeutic Agent for Acute Lymphoblastic Leukemia
DOI: https://doi.org/10.1021/acsabm.3c00888
[2023] Use of genome-wide DNA methylation analysis to identify prognostic CpG site markers associated with longer survival time in dogs with multicentric high-grade B-cell lymphoma
DOI: https://doi.org/10.1111/jvim.16931
[2023] Polyoxazoline-Conjugated <scp>l</scp>-Asparaginase: An Antibody-Production-Free Therapeutic Agent for Acute Lymphoblastic Leukemia
DOI: https://doi.org/10.1021/acsabm.3c00888
[2023] Gene expression profiles associated with early relapse during first remission induction in canine multicentric high-grade B-cell lymphoma
DOI: https://doi.org/10.1292/jvms.23-0269
[2023] Canine diffuse large B-cell lymphoma downregulates the activity of CD8 + T-cells through tumor-derived extracellular vesicles
DOI: https://doi.org/10.1186/s12935-023-03104-4
[2023] Increased plasma DR-70 (fibrinogen-fibrin degradation products) concentrations as a diagnostic biomarker in dogs with neoplasms
DOI: https://doi.org/10.1111/jvim.16898
[2023] Poly(2-ethyl-2-oxazoline)-Conjugated Hemoglobins as a Red Blood Cell Substitute
DOI: https://doi.org/10.1021/acsabm.3c00392
[2023] Gene expression profiles associated with early relapse during first remission induction in canine multicentric high-grade B-cell lymphoma
DOI: https://doi.org/10.1292/jvms.23-0269
[2023] Canine diffuse large B-cell lymphoma downregulates the activity of CD8 + T-cells through tumor-derived extracellular vesicles
DOI: https://doi.org/10.1186/s12935-023-03104-4
[2023] Increased plasma DR-70 (fibrinogen-fibrin degradation products) concentrations as a diagnostic biomarker in dogs with neoplasms
DOI: https://doi.org/10.1111/jvim.16898
[2023] Poly(2-ethyl-2-oxazoline)-Conjugated Hemoglobins as a Red Blood Cell Substitute
DOI: https://doi.org/10.1021/acsabm.3c00392
[2023] Polyoxazoline-conjugated porcine serum albumin as an artificial plasma expander for dogs
DOI: https://doi.org/10.1038/s41598-023-35999-4
[2023] Whole exome and transcriptome analysis revealed the activation of ERK and Akt signaling pathway in canine histiocytic sarcoma
DOI: https://doi.org/10.1038/s41598-023-35813-1
[2023] Prognostic value of increased intraepithelial lymphocytes and lymphocytic clonality in dogs with chronic enteropathy or small-cell lymphoma
DOI: https://doi.org/10.1016/j.tvjl.2023.105993
[2023] Retrospective study of feline tracheal mass lesions
DOI: https://doi.org/10.1177/1098612x231164611
[2023] Serum level of apoptosis inhibitor of macrophage in dogs with histiocytic sarcoma and its association with the disease
DOI: https://doi.org/10.1111/vco.12897
[2023] Polyoxazoline-conjugated porcine serum albumin as an artificial plasma expander for dogs
DOI: https://doi.org/10.1038/s41598-023-35999-4
[2023] Whole exome and transcriptome analysis revealed the activation of ERK and Akt signaling pathway in canine histiocytic sarcoma
DOI: https://doi.org/10.1038/s41598-023-35813-1
[2023] Retrospective study of feline tracheal mass lesions
DOI: https://doi.org/10.1177/1098612x231164611
[2023] Serum level of apoptosis inhibitor of macrophage in dogs with histiocytic sarcoma and its association with the disease
DOI: https://doi.org/10.1111/vco.12897
[2023] Analysis of fecal microbial profiles in dogs with intestinal lymphangiectasia
DOI: https://doi.org/10.1292/jvms.22-0172
[2023] MUC5AC and MUC5B expression in canine gallbladder mucocele epithelial cells
DOI: https://doi.org/10.1292/jvms.23-0174
[2023] Analysis of fecal microbial profiles in dogs with intestinal lymphangiectasia
DOI: https://doi.org/10.1292/jvms.22-0172
[2023] MUC5AC and MUC5B expression in canine gallbladder mucocele epithelial cells
DOI: https://doi.org/10.1292/jvms.23-0174
[2022] A Survey Study on Factors Associated with Owner Satisfaction in the Treatment of Allergic Dermatitis in Dogs
DOI: https://doi.org/10.12935/jvma.75.e157
[2022] Clinical characteristics and outcomes of Mott cell lymphoma in nine miniature dachshunds
DOI: https://doi.org/10.1002/vms3.975
[2022] <scp>mRNA</scp> sequencing analysis and growth inhibitory effects of palbociclib on cell lines from canine histiocytic proliferative disorders
DOI: https://doi.org/10.1111/vco.12812
[2022] Canine transmissible venereal tumour established in immunodeficient mice reprograms the gene expression profiles associated with a favourable tumour microenvironment to enable cancer malignancy
DOI: https://doi.org/10.1186/s12917-021-03093-4
[2022] Evaluation of the degree and distribution of lymphangiectasia in full-thickness canine small intestinal specimens diagnosed with lymphoplasmacytic enteritis and granulomatous lymphangitis
DOI: https://doi.org/10.1292/jvms.21-0257
[2022] Effects of proportions of carbohydrates and fats in diets on mucin concentration and bile composition in gallbladder of dogs
DOI: https://doi.org/10.1292/jvms.22-0126
[2022] Changes in gene expression profiles and cytokine secretions in peripheral monocytes by treatment with small extracellular vesicles derived from a canine lymphoma cell line
DOI: https://doi.org/10.1292/jvms.21-0506
[2022] Successful treatment of a lung abscess without surgical intervention in a cat
DOI: https://doi.org/10.1177/20551169221086434
[2022] Clinical characteristics and outcomes of Mott cell lymphoma in nine miniature dachshunds
DOI: https://doi.org/10.1002/vms3.975
[2022] <scp>mRNA</scp> sequencing analysis and growth inhibitory effects of palbociclib on cell lines from canine histiocytic proliferative disorders
DOI: https://doi.org/10.1111/vco.12812
[2022] Canine transmissible venereal tumour established in immunodeficient mice reprograms the gene expression profiles associated with a favourable tumour microenvironment to enable cancer malignancy
DOI: https://doi.org/10.1186/s12917-021-03093-4
[2022] Evaluation of the degree and distribution of lymphangiectasia in full-thickness canine small intestinal specimens diagnosed with lymphoplasmacytic enteritis and granulomatous lymphangitis
DOI: https://doi.org/10.1292/jvms.21-0257
[2022] Effects of proportions of carbohydrates and fats in diets on mucin concentration and bile composition in gallbladder of dogs
DOI: https://doi.org/10.1292/jvms.22-0126
[2022] A Survey Study on Factors Associated with Owner Satisfaction in the Treatment of Allergic Dermatitis in Dogs
DOI: https://doi.org/10.12935/jvma.75.e157
[2022] Changes in gene expression profiles and cytokine secretions in peripheral monocytes by treatment with small extracellular vesicles derived from a canine lymphoma cell line
DOI: https://doi.org/10.1292/jvms.21-0506
[2022] Successful treatment of a lung abscess without surgical intervention in a cat
DOI: https://doi.org/10.1177/20551169221086434
[2021] Construction and validation of a scoring system to predict resistance to chemotherapeutic drugs using gene expression profiles in canine lymphoma
DOI: https://doi.org/10.1016/j.rvsc.2021.05.007
[2021] Genome-wide DNA methylation and RNA-seq analyses identify genes and pathways associated with doxorubicin resistance in a canine diffuse large B-cell lymphoma cell line
DOI: https://doi.org/10.1371/journal.pone.0250013
[2021] Prognostic factors for dogs with surgically resected gastrointestinal stromal tumors
DOI: https://doi.org/10.1292/jvms.20-0727
[2021] Prognostic factors for dogs with surgically resected gastrointestinal stromal tumors
DOI: https://doi.org/10.1292/jvms.20-0727
[2021] Genome-wide DNA methylation and RNA-seq analyses identify genes and pathways associated with doxorubicin resistance in a canine diffuse large B-cell lymphoma cell line
DOI: https://doi.org/10.1371/journal.pone.0250013
[2021] Efficacy of chemotherapy and palliative hypofractionated radiotherapy for cats with nasal lymphoma
DOI: https://doi.org/10.1292/jvms.20-0464
[2021] Changes in the coagulation parameters in dogs with protein-losing enteropathy between before and after treatment
DOI: https://doi.org/10.1292/jvms.21-0137
[2021] Changes in the coagulation parameters in dogs with protein-losing enteropathy between before and after treatment
DOI: https://doi.org/10.1292/jvms.21-0137
[2021] Development of an exosomal gene signature to detect residual disease in dogs with osteosarcoma using a novel xenograft platform and machine learning
DOI: https://doi.org/10.1038/s41374-021-00655-w
[2021] Association between intestinal lymphangiectasia and expression of inducible nitric oxide synthase in dogs with lymphoplasmacytic enteritis
DOI: https://doi.org/10.1292/jvms.21-0363
[2021] Association between intestinal lymphangiectasia and expression of inducible nitric oxide synthase in dogs with lymphoplasmacytic enteritis
DOI: https://doi.org/10.1292/jvms.21-0363
[2021] Development of an exosomal gene signature to detect residual disease in dogs with osteosarcoma using a novel xenograft platform and machine learning
DOI: https://doi.org/10.1038/s41374-021-00655-w
[2021] Outcomes and prognostic factors in canine epitheliotropic and nonepitheliotropic cutaneous T‐cell lymphomas
DOI: https://doi.org/10.1111/vco.12752
[2021] Efficacy and adverse events of continuous<scp>l</scp>‐asparaginase administration for canine large cell lymphoma of presumed gastrointestinal origin
DOI: https://doi.org/10.1111/vco.12749
[2021] Abstract 671: Development of an exosomal biomarker signature to detect minimal residual disease in dogs with osteosarcoma using a novel xenograft platform and machine learning
DOI: https://doi.org/10.1158/1538-7445.am2021-671
[2021] Construction and validation of a scoring system to predict resistance to chemotherapeutic drugs using gene expression profiles in canine lymphoma
DOI: https://doi.org/10.1016/j.rvsc.2021.05.007
[2021] Outcomes and prognostic factors in canine epitheliotropic and nonepitheliotropic cutaneous T‐cell lymphomas
DOI: https://doi.org/10.1111/vco.12752
[2021] Efficacy and adverse events of continuous<scp>l</scp>‐asparaginase administration for canine large cell lymphoma of presumed gastrointestinal origin
DOI: https://doi.org/10.1111/vco.12749
[2021] Abstract 671: Development of an exosomal biomarker signature to detect minimal residual disease in dogs with osteosarcoma using a novel xenograft platform and machine learning
DOI: https://doi.org/10.1158/1538-7445.am2021-671
[2021] Efficacy of chemotherapy and palliative hypofractionated radiotherapy for cats with nasal lymphoma
DOI: https://doi.org/10.1292/jvms.20-0464

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AI 要約（直近 5 年の研究成果）

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研究成果（102 件）

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