Shouichi Ohga 研究室

主宰者：Shouichi Ohga

九州大学

AI 要約（直近 5 年の研究成果）

Shouichi Ohga研究室は、小児医学の幅広い領域において、発症メカニズムの解明と臨床的管理の改善に取り組んでいます。研究の主な対象は、先天性心疾患、血液凝固異常、遺伝性疾患、感染症といった小児期に発症する重篤な疾患です。これらの疾患について、患者由来の細胞やマウスモデルを用いた実験的手法、大規模コホート調査による疫学的分析、遺伝子解析といった多層的なアプローチで研究を進めています。特に、妊娠中の母体因子が胎児発達に与える影響や、遺伝子変異が神経発達や臓器機能に及ぼす影響に着目した研究が多くの論文に共通して見られます。例えば、高血糖が胎児の左右軸形成を障害するメカニズム、タンパク質合成に関わる遺伝子異常が細胞機能を低下させる仕組みなど、分子レベルでの病態機構を明らかにしようとしています。同時に、日本全国の大規模出生コホート調査から得られたデータを活用し、妊娠期の生活習慣や環境因子が小児の発育・発達に関連する知見も報告しています。これらの基礎研究と臨床研究の統合により、診断・治療戦略の最適化を目指す実践的な研究室として機能しています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

外部リンク

研究成果（100 件）

[2026] Sedentary time during pregnancy and fetal malpresentation in the Japan Environment and Children’s Study
DOI: https://doi.org/10.1038/s43856-026-01635-1
[2025] Prolonged Postoperative Wound Healing Due to Anti-IL-6 Autoantibody as a Phenocopy of Inborn Errors of Immunity
DOI: https://doi.org/10.1007/s10875-025-01894-y
[2025] Genome Analysis of Japanese Yersinia pseudotuberculosis Strains Isolated From Kawasaki Disease Patients and Other Sources and Their Phylogenetic Positions in the Global Y. pseudotuberculosis Population
DOI: https://doi.org/10.1111/1348-0421.13199
[2025] Gradual increase of plasma protein C activity levels in infants with newborn‐onset thromboembolism
DOI: https://doi.org/10.1111/ped.15885
[2025] Persistent lymphopenia in a Japanese boy with neuronal ceroid lipofuscinosis type 3
DOI: https://doi.org/10.1016/j.ejmg.2025.105058
[2024] Successful Kidney Transplantation for Bilateral Renal Hypoplasia With Ebstein Disease
DOI: https://doi.org/10.1111/petr.70001
[2024] HINODE study: haemophilia A in infancy and newborns – protocol for a prospective, multicentre, observational study evaluating the coagulation potential and safety of emicizumab prophylaxis
DOI: https://doi.org/10.1136/bmjopen-2024-087556
[2024] Comprehensive method for producing high-affinity mouse monoclonal antibodies of various isotypes against (4-hydroxy-3-nitrophenyl)acetyl (NP) hapten
DOI: https://doi.org/10.1016/j.heliyon.2024.e40837
[2024] Abstract 4134622: Hyperglycemia Induces Heterotaxy Syndrome by Lowering Intracellular pH
DOI: https://doi.org/10.1161/circ.150.suppl_1.4134622
[2024] Hyperglycaemia induces diet-dependent defects of the left-right axis by lowering intracellular pH
DOI: https://doi.org/10.1016/j.bbadis.2024.167550

続きを表示（残り 90 件）

[2024] Dural arteriovenous fistulae in a 6-year-old girl with trisomy 21 and congenital heart disease
DOI: https://doi.org/10.1016/j.clineuro.2024.108540
[2024] Infants’ early recovery from sleep disturbance is associated with a lower risk of developmental delay in the Japan Environment and Children’s Study
DOI: https://doi.org/10.1038/s41598-024-68672-5
[2024] Safety and efficacy of ripasudil eye drops in preterm infants with retinopathy of prematurity: phase 1/2, open label, single-arm trial
DOI: https://doi.org/10.1007/s10384-024-01100-3
[2024] Gnao1 is a molecular switch that regulates the Rho signaling pathway in differentiating neurons
DOI: https://doi.org/10.1038/s41598-024-68062-x
[2024] An N‐terminal and ankyrin repeat domain interactome of Shank3 identifies the protein complex with the splicing regulator Nono in mice
DOI: https://doi.org/10.1111/gtc.13142
[2024] Potential role of stem cells from human exfoliated deciduous teeth in inducing liver regeneration
DOI: https://doi.org/10.1111/jgh.16651
[2024] Epstein–Barr virus monitoring for preemptive re‐hematopoietic cell transplantation in CD3δ‐deficient siblings
DOI: https://doi.org/10.1002/pbc.31119
[2024] The immunoreactive signature of monocyte-derived dendritic cells from patients with Down syndrome
DOI: https://doi.org/10.1093/cei/uxae048
[2024] Acute liver failure worsened after respiratory syncytial virus infection in an infant with spinal muscular atrophy type I after receiving onasemnogene abeparvovec
DOI: https://doi.org/10.1016/j.bdcasr.2024.100022
[2024] ATP1A3 regulates protein synthesis for mitochondrial stability under heat stress
DOI: https://doi.org/10.1242/dmm.050574
[2024] Association of placental weight at birth with maternal whole blood concentration of heavy metals (cadmium, lead, mercury, selenium, and manganese): The Japan Environment and Children’s Study (JECS)
DOI: https://doi.org/10.1016/j.envint.2024.108725
[2024] The effect of parental age on child development at 36 months: Insights from the Japan environment and children's study
DOI: https://doi.org/10.1016/j.ridd.2024.104741
[2024] Launch of Board Certification in Pediatric Infectious Diseases in Japan
DOI: https://doi.org/10.1097/inf.0000000000004388
[2024] Risk of Gestational Diabetes in Women With PCOS Based on Body Mass Index: The Japan Environment and Children's Study
DOI: https://doi.org/10.1210/clinem/dgae293
[2024] Vitamin K prophylaxis in neonates: comparing two different oral regimens
DOI: https://doi.org/10.1038/s41372-024-01981-9
[2024] Skeletal Muscle Mass Assessment in Pediatric Patients: Development of a Normative Equation and Assessment of Factors Associated With a Low Skeletal Muscle Mass in PICU Patients
DOI: https://doi.org/10.1097/pcc.0000000000003511
[2024] Rapid and long‐lasting efficacy of high‐dose ambroxol therapy for neuronopathic Gaucher disease: A case report and literature review
DOI: https://doi.org/10.1002/mgg3.2427
[2024] Early hematopoietic cell transplantation for familial hemophagocytic lymphohistiocytosis in a regional treatment network in Japan
DOI: https://doi.org/10.1007/s12185-024-03721-3
[2024] High-Titer Anti-ZSCAN1 Antibodies in a Toddler Clinically Diagnosed with Apparent Rapid-Onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation Syndrome
DOI: https://doi.org/10.3390/ijms25052820
[2024] Adjunctive effects of eltrombopag on immunosuppressive therapy for childhood aplastic anemia
DOI: https://doi.org/10.1007/s12185-024-03903-z
[2023] Molecular diagnosis of 405 individuals with autism spectrum disorder
DOI: https://doi.org/10.1038/s41431-023-01335-7
[2023] Shank3a/b isoforms regulate the susceptibility to seizures and thalamocortical development in the early postnatal period of mice
DOI: https://doi.org/10.1016/j.neures.2023.03.001
[2023] Variant spectrum of PIEZO1 and KCNN4 in Japanese patients with dehydrated hereditary stomatocytosis
DOI: https://doi.org/10.1038/s41439-023-00235-y
[2023] <scp>CD14</scp> down‐modulation as a real‐time biomarker in Kawasaki disease
DOI: https://doi.org/10.1002/cti2.1482
[2023] The clinical and genetic landscape of early‐onset thrombophilia in Japan
DOI: https://doi.org/10.1002/pbc.30824
[2023] Successful mapping and ablation of a pediatric-onset non-reentrant fascicular tachycardia
DOI: https://doi.org/10.1016/j.jccase.2023.12.002
[2023] Adenovirus-associated Paroxysmal Cold Hemoglobinuria as Chilly Month Hemolytic Crisis
DOI: https://doi.org/10.1097/inf.0000000000004230
[2023] The Effectiveness of Deflux® Treatment for Vesicoureteral Reflux Following Pediatric Renal Transplantation: A Single-Institution Challenging Experience
DOI: https://doi.org/10.1016/j.jpedsurg.2023.12.005
[2023] Non‐conditioned cord blood transplantation for infection control in athymic CHARGE syndrome
DOI: https://doi.org/10.1002/pbc.30809
[2023] Progressive myoclonic epilepsy as an expanding phenotype of NGLY1-associated congenital deglycosylation disorder: A case report and review of the literature
DOI: https://doi.org/10.1016/j.ejmg.2023.104895
[2023] Williamsia muralis bacteraemia in a patient with Fanconi anaemia after haematopoietic cell transplantation
DOI: https://doi.org/10.1099/acmi.0.000679.v3
[2023] Long-Term Renal Involvement in Association with Fontan Circulation
DOI: https://doi.org/10.1007/s00246-023-03334-3
[2023] Pretransplant ribavirin and interferon-α therapy for rhinovirus interstitial pneumonia in a RAG1-deficient infant
DOI: https://doi.org/10.1016/j.jiac.2023.11.003
[2023] Clinical Features of Pediatric Uveitis at a Tertiary Referral Center in the Western Region of Japan
DOI: https://doi.org/10.1080/09273948.2023.2273363
[2023] STIM-mediated calcium influx regulates maintenance and selection of germinal center B cells
DOI: https://doi.org/10.1084/jem.20222178
[2023] Secondhand smoking and pediatric asthma after respiratory syncytial virus or human metapneumovirus infection
DOI: https://doi.org/10.1016/j.anai.2023.10.013
[2023] <scp>TRPV4</scp>‐mediated Ca2+ deregulation causes mitochondrial dysfunction via the <scp>AKT</scp>/α‐synuclein pathway in dopaminergic neurons
DOI: https://doi.org/10.1096/fba.2023-00057
[2023] Occupational exposure of pregnant women to refined oil and infant wheezing: Japan environment and children's study findings
DOI: https://doi.org/10.1111/cea.14404
[2023] Pediatric leukemia and maternal occupational exposure to anticancer drugs: the Japan Environment and Children’s Study
DOI: https://doi.org/10.1182/blood.2023021008
[2023] POT1a deficiency in mesenchymal niches perturbs B-lymphopoiesis
DOI: https://doi.org/10.1038/s42003-023-05374-0
[2023] Sex steroid hormones and allergic diseases in children: a pilot birth cohort study in the Japan Environment and Children’s Study cohort
DOI: https://doi.org/10.1186/s12887-023-04302-9
[2023] Effects of melatonin on dopaminergic neuron development via IP3-mediated mitochondrial Ca2+ regulation in autism spectrum disorder
DOI: https://doi.org/10.1016/j.bbrc.2023.09.050
[2023] Heterogeneity and mitochondrial vulnerability configurate the divergent immunoreactivity of human induced microglia-like cells
DOI: https://doi.org/10.1016/j.clim.2023.109756
[2023] Divergent neurodevelopmental profiles of very-low-birth-weight infants
DOI: https://doi.org/10.1038/s41390-023-02778-w
[2023] Japanese Society of Medical Oncology/Japan Society of Clinical Oncology/Japanese Society of Pediatric Hematology/Oncology-led clinical recommendations on the diagnosis and use of immunotherapy in patients with DNA mismatch repair deficient (dMMR) tumors, third edition
DOI: https://doi.org/10.1007/s10147-023-02397-9
[2023] Sleep quality and temperament in association with autism spectrum disorder among infants in Japan
DOI: https://doi.org/10.1038/s43856-023-00314-9
[2023] Japanese Society of Medical Oncology/Japan Society of Clinical Oncology/Japanese Society of Pediatric Hematology/Oncology-led clinical recommendations on the diagnosis and use of immunotherapy in patients with high tumor mutational burden tumors
DOI: https://doi.org/10.1007/s10147-023-02360-8
[2023] Human RELA dominant-negative mutations underlie type I interferonopathy with autoinflammation and autoimmunity
DOI: https://doi.org/10.1084/jem.20212276
[2023] Diagnostic and disease severity determination criteria for hydroa vacciniforme lymphoproliferative disorders and severe mosquito bite allergy
DOI: https://doi.org/10.1111/1346-8138.16842
[2023] Prenatal metal levels and congenital anomalies of the kidney and urinary tract: The Japan Environment and Children's Study
DOI: https://doi.org/10.1016/j.scitotenv.2023.164356
[2023] Japanese Society of Medical Oncology/Japan Society of Clinical Oncology/Japanese Society of Pediatric Hematology/Oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors
DOI: https://doi.org/10.1007/s10147-023-02345-7
[2023] Long-lasting pain and somatosensory disturbances in children with myelin oligodendrocyte glycoprotein antibody-associated disease
DOI: https://doi.org/10.1007/s00431-023-04989-z
[2023] Vasospastic angina in a boy with hereditary hemorrhagic telangiectasia due to heterogenous large deletion around <scp>ENG</scp>
DOI: https://doi.org/10.1111/ped.15500
[2022] Targeting hepatic oxidative stress rescues bone loss in liver fibrosis
DOI: https://doi.org/10.1016/j.molmet.2022.101599
[2022] Pseudo‐progressive bone lesion in an infant leukemia after chimeric antigen receptor‐<scp>T</scp> cell therapy
DOI: https://doi.org/10.1111/ped.15399
[2022] Post-transplant Schizophyllum commune abscess in a pediatric patient with chronic granulomatous disease
DOI: https://doi.org/10.1016/j.jiac.2022.10.015
[2022] Association of sleep quality with temperament among one-month-old infants in The Japan Environment and Children’s Study
DOI: https://doi.org/10.1371/journal.pone.0274610
[2022] No association between prenatal lead exposure and neurodevelopment during early childhood in the Japan Environment and Children’s Study
DOI: https://doi.org/10.1038/s41598-022-19509-6
[2022] The association between early formula and reduced risk of cow’s milk allergy during the first three year of life: a Japanese cohort study
DOI: https://doi.org/10.1186/s13223-022-00712-z
[2022] Mitochondrial Calcium-Triggered Oxidative Stress and Developmental Defects in Dopaminergic Neurons Differentiated from Deciduous Teeth-Derived Dental Pulp Stem Cells with MFF Insufficiency
DOI: https://doi.org/10.3390/antiox11071361
[2022] Critical vitamin deficiencies in autism spectrum disorder: Reversible and irreversible outcomes
DOI: https://doi.org/10.1038/s41430-022-01170-x
[2022] Maternal Chronic Disease and Congenital Anomalies of the Kidney and Urinary Tract in Offspring: A Japanese Cohort Study
DOI: https://doi.org/10.1053/j.ajkd.2022.03.003
[2022] Dopamine‐related oxidative stress and mitochondrial dysfunction in dopaminergic neurons differentiated from deciduous teeth‐derived stem cells of children with Down syndrome
DOI: https://doi.org/10.1096/fba.2021-00086
[2022] Association of physical activity and sleep habits during pregnancy with autistic spectrum disorder in 3-year-old infants
DOI: https://doi.org/10.1038/s43856-022-00101-y
[2022] High-dose immunoglobulin therapy for steroid-resistant myositis in juvenile localized scleroderma
DOI: https://doi.org/10.1016/j.pedneo.2022.01.006
[2022] Lack of catch-up in weight gain may intermediate between pregnancies with hyperemesis gravidarum and reduced fetal growth: the Japan Environment and Children’s Study
DOI: https://doi.org/10.1186/s12884-022-04542-0
[2022] Association of maternal hemoglobin levels during pregnancy with sleep and developmental problems in 1‐year‐old infants: A cohort study
DOI: https://doi.org/10.1002/hsr2.552
[2022] Fluctuations of aeroallergen-specific immunoglobulins and children's allergic profiles: Japan Environment & Children's Study of a pilot cohort
DOI: https://doi.org/10.1016/j.alit.2022.01.002
[2022] Case Report: Rotavirus Vaccination and Severe Combined Immunodeficiency in Japan
DOI: https://doi.org/10.3389/fimmu.2022.786375
[2022] The utility of core‐needle tumor biopsy for pediatric patients
DOI: https://doi.org/10.1111/ped.15228
[2022] The earliest enzyme replacement for infantile‐onset Pompe disease in Japan
DOI: https://doi.org/10.1111/ped.15286
[2022] Nivolumab therapy for a pediatric‐onset primary intracranial melanoma
DOI: https://doi.org/10.1111/ped.14956
[2022] Differential Presentation of Renal Disease in Adult Fontan Patients with or Without Liver Disease
DOI: https://doi.org/10.2139/ssrn.4139054
[2021] Current status of newborn screening for Pompe disease in Japan
DOI: https://doi.org/10.1186/s13023-021-02146-z
[2021] Biliary atresia-specific deciduous pulp stem cells feature biliary deficiency
DOI: https://doi.org/10.1186/s13287-021-02652-8
[2021] Efficient Screening Tests and Gene Mutation Spectrum for Hereditary Stomatocytosis in Japan
DOI: https://doi.org/10.1182/blood-2021-152599
[2021] Hepatocyte polarity establishment and apical lumen formation are organized by Par3, Cdc42, and aPKC in conjunction with Lgl
DOI: https://doi.org/10.1016/j.jbc.2021.101354
[2021] Optimal Teicoplanin Dosing Regimen in Neonates and Children Developed by Leveraging Real-World Clinical Information
DOI: https://doi.org/10.1097/ftd.0000000000000930
[2021] Progressive B cell depletion in human MALT1 deficiency
DOI: https://doi.org/10.1111/cei.13662
[2021] Measles antibody seropositivity among children with allergic diseases: A cross-sectional study in the Japan Environment & Children’s Pilot Study
DOI: https://doi.org/10.1371/journal.pone.0257721
[2021] 4. Genomic Medicine in the Neonatal and Pediatric Fields
DOI: https://doi.org/10.2169/naika.110.1898
[2021] Female-dominant estrogen production in healthy children before adrenarche
DOI: https://doi.org/10.1530/ec-21-0134
[2021] Granulocyte collection by polymorphonuclear cell-targeting apheresis with medium-molecular-weight hydroxyethyl starch
DOI: https://doi.org/10.1007/s12185-021-03207-6
[2021] Acute-phase electroencephalography for an infantile atypical teratoid/rhabdoid tumor
DOI: https://doi.org/10.1016/j.clineuro.2021.106922
[2021] Gestational Weight Gain Growth Charts Adapted to Japanese Pregnancies Using a Bayesian Approach in a Longitudinal Study: The Japan Environment and Children’s Study
DOI: https://doi.org/10.2188/jea.je20210049
[2021] Physical growth and neurodevelopment during the first year of life: a cohort study of the Japan Environment and Children’s Study
DOI: https://doi.org/10.1186/s12887-021-02815-9
[2021] Serum erythroferrone levels during the first month of life in premature infants
DOI: https://doi.org/10.1038/s41372-021-01184-6
[2021] Mitochondrial Reactive Oxygen Species Are Essential for the Development of Psoriatic Inflammation
DOI: https://doi.org/10.3389/fimmu.2021.714897
[2021] Breast feeding and infant development in a cohort with sibling pair analysis: the Japan Environment and Children’s Study
DOI: https://doi.org/10.1136/bmjopen-2020-043202
[2021] Maternal blood count parameters of chronic inflammation by gestational age and their associations with risk of preterm delivery in the Japan Environment and Children’s Study
DOI: https://doi.org/10.1038/s41598-021-93101-2

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AI 要約（直近 5 年の研究成果）

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関連研究室(8 件)

研究成果（100 件）

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