Hiroyuki Nakamura 研究室

主宰者：Hiroyuki Nakamura

東京工業大学

AI 要約（直近 5 年の研究成果）

中村研究室では、がん治療と医薬品開発を主軸とした多面的な研究を展開しています。特に力を入れているのは、ホウ素中性子捕捉療法（BNCT）という新しい放射線治療法の実現です。この治療法は、ホウ素化合物をがん細胞に集積させた後、中性子を照射することで選択的にがん細胞を破壊する仕組みです。研究室では、既存の標準的なホウ素キャリア分子に代わる新規のホウ素運搬体を開発しており、生物活性評価や体内動態の検証を細胞レベルから動物モデルまで幅広く実施しています。加えて、タンパク質間の相互作用を制御する小分子化学品の開発にも注力しています。HIF-1αやHSP90などの疾患関連タンパク質の機能を阻害する化合物の探索・設計を行い、これらが低酸素環境やストレス応答に関わる生物学的プロセスに与える影響を調べています。さらに、光熱療法やドラッグデリバリーシステムなど、物理化学的な刺激応答性材料の開発も進めており、磁場や超音波、光などの外部刺激で薬物放出を制御するナノ粒子やリポソーム系の研究も展開しています。これらの研究を通じて、より効果的で副作用の少ないがん治療法の実現を目指しています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

外部リンク

研究成果（89 件）

[2025] Unravelling physical and radiobiological effects of proton boron fusion reaction with anionic metallacarboranes ([o-COSAN]-) in breast cancer cells
DOI: https://doi.org/10.1186/s13550-025-01199-6
[2025] Discovery of niclosamide as a p300/transcription factor protein–protein interaction inhibitor
DOI: https://doi.org/10.1016/j.bmc.2025.118114
[2025] A Case of Complete Epithelialization of an Extensive Foot Wound With Exposed Calcaneus Using Topical Cadexomer Iodine (CIOD) Monotherapy
DOI: https://doi.org/10.7759/cureus.95425
[2025] Assessment of Carrier-Free Metallacarboranes for Targeted Radiation Therapies PBFT and BNCT: Comparative Cellular Effects and Dosimetry Studies with [o-FESAN]− in Breast Cancer Cells
DOI: https://doi.org/10.3390/ph18101491
[2025] The Moment I Met a Nucleophilic π-Allylpalladium Complex
DOI: https://doi.org/10.5059/yukigoseikyokaishi.83.932
[2025] Discovery of trisubstituted meta-carboranes as T cell activators by regulating CD28 cytoplasmic region and SH2 domains of Grb2 and PI3K interactions
DOI: https://doi.org/10.1016/j.bmc.2025.118293
[2025] Discovery of structurally diverse diazatricyclododecenes as lysosomotropic autophagy inhibitors
DOI: https://doi.org/10.1016/j.bmc.2025.118200
[2025] EVALUATION OF A NOVEL ASCT2-TARGETING BORON COMPOUND, GLUB-2, FOR ENHANCED BORON NEUTRON CAPTURE THERAPY (BNCT)
DOI: https://doi.org/10.1016/j.ijpt.2025.101054
[2025] Comparative efficacy of reactor vs. accelerator-based boron neutron capture therapy in U87MG glioblastoma models
DOI: https://doi.org/10.1016/j.apradiso.2025.111833
[2025] Boron neutron capture therapy with pteroyl-closo-dodecaborate-conjugated 4-(p-iodophenyl)butyric acid (PBC-IP) for a head and neck squamous cell carcinoma (SAS) model mice
DOI: https://doi.org/10.1016/j.apradiso.2025.111837

続きを表示（残り 79 件）

[2025] BODIPY-Based Photothermal Agent Incorporating Azulene for Enhanced NIR Absorption and Tumor Ablation
DOI: https://doi.org/10.1021/acs.molpharmaceut.5c00071
[2025] Visualization and quantification of RANK-RANKL binding for application to disease investigations and drug discovery
DOI: https://doi.org/10.1016/j.bone.2025.117473
[2025] Magnetically Triggered Drug-Release System and Magnetic Caged Calcium Using Iron Oxide Nanoparticles and Hydrogels
DOI: https://doi.org/10.1021/acsapm.5c00652
[2024] Potential for boron neutron capture therapy (BNCT) with ASCT2-targeted boron agents.
DOI: https://doi.org/10.1200/jco.2024.42.23_suppl.233
[2024] Evaluation of the Safety of Folate Receptor-Targeted Boron Carrier in Boron Neutron Capture Therapy (BNCT) for Malignant Gliomas Using CED Administration
DOI: https://doi.org/10.3390/proceedings2024100015
[2024] BORON NEUTRON CAPTURE THERAPY USING DIRECT INTRATUMORAL ADMINISTRATION OF A FOLATE RECEPTOR TARGETING NOVEL BORON CARRIER
DOI: https://doi.org/10.1016/j.ijpt.2024.100197
[2024] Nonclinical pharmacodynamics of boron neutron capture therapy using direct intratumoral administration of a folate receptor targeting novel boron carrier
DOI: https://doi.org/10.1093/noajnl/vdae062
[2024] Discovery of Disubstituted Carboranes as Inhibitors of Heat Shock Protein 90–Heat Shock Factor 1 Interaction
DOI: https://doi.org/10.1021/acsmedchemlett.4c00022
[2024] Early Stage In Vitro Bioprofiling of Potential Low-Molecular-Weight Organoboron Compounds for Boron Neutron Capture Therapy (BNCT)—Proposal for a Guide
DOI: https://doi.org/10.3390/cells13100798
[2024] A Water-Soluble Small Molecule Boron Carrier Targeting Biotin Receptors for Neutron Capture Therapy
DOI: https://doi.org/10.1021/acsomega.4c09388
[2024] Intracellular Photocatalytic Proximity Labeling (iPPL) for Dynamic Analysis of Chromatin-Binding Proteins Targeting Histone H3
DOI: https://doi.org/10.1021/acschembio.4c00680
[2024] 10112- ET-10 EVALUATING PBC-IP AS A NOVEL BORON CARRIER IN BNCT
DOI: https://doi.org/10.1093/noajnl/vdae173.019
[2024] Synthesis and Optimization of Ethylenediamine-Based Zwitterion on Polymer Side Chain for Recognizing Narrow Tumorous pH Windows
DOI: https://doi.org/10.1021/acs.biomac.4c01086
[2024] Discovery of sp3-rich diazatricycloundecanes as lysosomotropic autophagy inhibitors
DOI: https://doi.org/10.1016/j.ejmech.2024.116923
[2024] Outcome of immune checkpoint inhibitor treatment in non-small cell lung cancer patients with interstitial lung abnormalities: clinical utility of subcategorizing interstitial lung abnormalities
DOI: https://doi.org/10.1007/s00262-024-03792-5
[2024] Zinc Carbenoid-Promoted Methylene Insertion in Saturated Heterocycles: Mechanistic Insights and Reactivity Profiles
DOI: https://doi.org/10.1055/s-0043-1775381
[2024] Development of carbonic anhydrase IX-targeting molecular-targeted photodynamic therapy
DOI: https://doi.org/10.1016/j.bmcl.2024.129821
[2024] Exploring SSEA3 as an emerging biomarker for assessing the regenerative potential of dental pulp-derived stem cells
DOI: https://doi.org/10.1016/j.reth.2024.05.004
[2023] Peptide Cyclization by the Use of Acylammonium Species
DOI: https://doi.org/10.1002/anie.202300647
[2023] Proposal of recommended experimental protocols for in vitro and in vivo evaluation methods of boron agents for neutron capture therapy
DOI: https://doi.org/10.1093/jrr/rrad064
[2023] Methylene Insertion into Nitrogen‐Heteroatom Single Bonds of 1,2‐Azoles via a Zinc Carbenoid: An Alternative Tool for Skeletal Editing
DOI: https://doi.org/10.1002/advs.202307563
[2023] Chemoselective α-Trifluoroacetylation of Amides Using Highly Electrophilic Trifluoroacetic Anhydrides and 2,4,6-Collidine
DOI: https://doi.org/10.1021/acs.orglett.3c03719
[2023] Development of a Gadolinium–Boron-Conjugated Albumin for MRI-Guided Neutron Capture Therapy
DOI: https://doi.org/10.1021/acs.molpharmaceut.3c00726
[2023] Evaluation of the Effectiveness of Boron Neutron Capture Therapy with Iodophenyl-Conjugated closo-Dodecaborate on a Rat Brain Tumor Model
DOI: https://doi.org/10.3390/biology12091240
[2023] Boron neutron capture therapy anti-tumor effect of nanostructured boron carbon nitride: A new potential candidate
DOI: https://doi.org/10.1016/j.inoche.2023.111318
[2023] The efficacy of boron neutron capture therapy with folate receptor targeted novel boron carrier in F98 rat brain tumor models.
DOI: https://doi.org/10.1200/go.2023.9.supplement_1.21
[2023] Efficient neutron capture therapy of glioblastoma with pteroyl-closo-dodecaborate-conjugated 4-(p-iodophenyl)butyric acid (PBC-IP)
DOI: https://doi.org/10.1016/j.jconrel.2023.06.022
[2023] Mangostin enhances efficacy of aminolevulinic acid-photodynamic therapy against cancer through inhibition of ABCG2 activity
DOI: https://doi.org/10.1016/j.pdpdt.2023.103798
[2023] Discovery of three-dimensional bicyclo[3.3.1]nonanols as novel heat shock protein 90 inhibitors
DOI: https://doi.org/10.1016/j.bmc.2023.117463
[2023] Exploring stage‑specific embryonic antigen 3 involvement in oral cancer progression and as a potential target for taxane‑based chemotherapy
DOI: https://doi.org/10.3892/or.2023.8619
[2023] Asymmetric Synthesis of Bicyclic Isoxazolines via Dearomative Cycloaddition of 4-Nitroisoxazoles with Zwitterionic π-Allyl Palladium Species
DOI: https://doi.org/10.1021/acs.orglett.3c01324
[2023] Peptide Cyclization by the Use of Acylammonium Species
DOI: https://doi.org/10.1002/ange.202300647
[2023] Cross-Linked Crystals of Dirhodium Tetraacetate/RNase A Adduct Can Be Used as Heterogeneous Catalysts
DOI: https://doi.org/10.1021/acs.inorgchem.3c00852
[2023] Development of a Peptide Sensor Derived from Human ACE2 for Fluorescence Polarization Assays of the SARS-CoV-2 Receptor Binding Domain
DOI: https://doi.org/10.1021/acs.analchem.2c05818
[2023] Intracellular Molecular-Targeted Photodynamic Therapy
DOI: https://doi.org/10.2530/jslsm.jslsm-44_0005
[2023] Development of Novel Methodologies for Functionalization of Isoxazoles
DOI: https://doi.org/10.5059/yukigoseikyokaishi.81.244
[2023] Improved Boron Neutron Capture Therapy Using Integrin αvβ3-Targeted Long-Retention-Type Boron Carrier in a F98 Rat Glioma Model
DOI: https://doi.org/10.3390/biology12030377
[2023] Acoustic-responsive carbon dioxide-loaded liposomes for efficient drug release
DOI: https://doi.org/10.1016/j.ultsonch.2023.106326
[2023] Synthesis of the diazatricycloundecane scaffold via gold(<scp>i</scp>)-catalysed Conia-ene-type 5-exo-dig cyclization and stepwise substituent assembly for the construction of an sp3-rich compound library
DOI: https://doi.org/10.1039/d3ob01534c
[2022] Photodynamic Therapy by Glucose Transporter 1-Selective Light Inactivation
DOI: https://doi.org/10.1021/acsomega.2c05042
[2022] Iodophenyl-conjugated closo-dodecaborate as a promising small boron molecule that binds to serum albumin and accumulates in tumor
DOI: https://doi.org/10.1016/j.bmcl.2022.128869
[2022] Cover Feature: Sequential Nucleophilic Substitution of Phosphorus Trichloride with Alcohols in a Continuous‐Flow Reactor and Consideration of a Mechanism for Reduced Over‐reaction through the Addition of Imidazole (Chem. Eur. J. 37/2022)
DOI: https://doi.org/10.1002/chem.202201646
[2022] Sequential Nucleophilic Substitution of Phosphorus Trichloride with Alcohols in a Continuous‐Flow Reactor and Consideration of a Mechanism for Reduced Over‐reaction through the Addition of Imidazole
DOI: https://doi.org/10.1002/chem.202200932
[2022] Effects of salicylate derivatives on localization of p.H723R allele product of SLC26A4
DOI: https://doi.org/10.1016/j.anl.2022.03.009
[2022] BODIPY Catalyzes Proximity‐Dependent Histidine Labelling
DOI: https://doi.org/10.1002/cctc.202200077
[2022] Intracellular photocatalytic-proximity labeling for profiling protein–protein interactions in microenvironments
DOI: https://doi.org/10.1039/d1cc05764b
[2022] Detoxification of amyloid β fibrils by curcumin derivatives and their verification in a Drosophila Alzheimer's model
DOI: https://doi.org/10.1039/d1cc07000b
[2022] Synthesis of isoxazoloazaborines via gold(<scp>i</scp>)-catalyzed propargyl aza-Claisen rearrangement/borylative cyclization cascade
DOI: https://doi.org/10.1039/d1cc07002a
[2022] Development of an MRI contrast agent for both detection and inhibition of the amyloid-β fibrillation process
DOI: https://doi.org/10.1039/d2ra00614f
[2022] Asymmetric construction of densely functionalized three-dimensional aza-tetracyclic scaffolds for drug discovery
DOI: https://doi.org/10.1039/d2cc05700j
[2022] A preclinical boron neutron capture therapy (BNCT) evaluation using a maleimide-functionalized closo-dodecaborate albumin conjugate induced an efficient neutron capture reaction to an experimental F98 rat glioma bearing brain tumor model
DOI: https://doi.org/10.14791/btrt.2022.10.f-1327
[2022] DeepCubist: Molecular Generator for Designing Peptidomimetics based on Complex three-dimensional scaffolds
DOI: https://doi.org/10.1007/s10822-022-00493-y
[2022] ET-4 BASIC RESEARCH OF BORON NEUTRON CAPTURE THERAPY USING A NOVEL BORON COMPOUND TARGETED TO INTEGRIN
DOI: https://doi.org/10.1093/noajnl/vdac167.016
[2022] Regulation of CD28 binding to SH2 domains of Grb2 and PI3K by trisubstituted carboranes for T-cell activation
DOI: https://doi.org/10.1016/j.bmcl.2022.129049
[2022] Characterization and Structure of Alternatively Spliced Transcript Variant of Human Intestinal Alkaline Phosphatase (ALPI) Gene
DOI: https://doi.org/10.3177/jnsv.68.284
[2022] Boron Neutron Capture Therapy (BNCT) Mediated by Maleimide-Functionalized Closo-Dodecaborate Albumin Conjugates (MID:BSA) for Oral Cancer: Biodistribution Studies and In Vivo BNCT in the Hamster Cheek Pouch Oral Cancer Model
DOI: https://doi.org/10.3390/life12071082
[2021] Cover Feature: Rapid and Mild Lactamization Using Highly Electrophilic Triphosgene in a Microflow Reactor (Chem. Eur. J. 27/2021)
DOI: https://doi.org/10.1002/chem.202101330
[2021] Fluorescent boron carbide quantum dots synthesized with a low-temperature solvothermal approach for boron neutron capture therapy
DOI: https://doi.org/10.1016/j.physe.2021.114766
[2021] Synthesis of Bis(Carboranyl)amides 1,1′-μ-(CH2NH(O)C(CH2)n-1,2-C2B10H11)2 (n = 0, 1) and Attempt of Synthesis of Gadolinium Bis(Dicarbollide)
DOI: https://doi.org/10.3390/molecules26051321
[2021] Rapid and Mild Lactamization Using Highly Electrophilic Triphosgene in a Microflow Reactor
DOI: https://doi.org/10.1002/chem.202100059
[2021] Suppression of Tumor Growth in a Rabbit Hepatic Cancer Model by Boron Neutron Capture Therapy With Liposomal Boron Delivery Systems
DOI: https://doi.org/10.21873/invivo.12607
[2021] Synthesis of 4-amino-5-allenylisoxazoles via gold(<scp>i</scp>)-catalysed propargyl aza-Claisen rearrangement
DOI: https://doi.org/10.1039/d0ob02544e
[2021] Preparation of an antigen-responsive fluorogenic immunosensor by tyrosine chemical modification of the antibody complementarity determining region
DOI: https://doi.org/10.1039/d1cc03231c
[2021] Enantioselective Synthesis of Oxazaborolidines by Palladium‐Catalyzed N−H/B−H Double Activation of 1,2‐Azaborines
DOI: https://doi.org/10.1002/anie.202113558
[2021] Comprehensive exploration of chemical space using trisubstituted carboranes
DOI: https://doi.org/10.1038/s41598-021-03459-6
[2021] Enantioselective Synthesis of Oxazaborolidines by Palladium‐Catalyzed N−H/B−H Double Activation of 1,2‐Azaborines
DOI: https://doi.org/10.1002/ange.202113558
[2021] Synthesis of sp3-rich chiral bicyclo[3.3.1]nonanes for chemical space expansion and study of biological activities
DOI: https://doi.org/10.1016/j.bmc.2021.116561
[2021] Capsaicin inhibits HIF-1α accumulation through suppression of mitochondrial respiration in lung cancer cells
DOI: https://doi.org/10.1016/j.biopha.2021.112500
[2021] Copper(<scp>i</scp>)-catalysed intramolecular hydroarylation-redox cross-dehydrogenative coupling of N-propargylanilines with phosphites
DOI: https://doi.org/10.1039/d1ob02091a
[2021] Development of curcumin-based amyloid β aggregation inhibitors for Alzheimer's disease using the SAR matrix approach
DOI: https://doi.org/10.1016/j.bmc.2021.116357
[2021] Chronic pathophysiological changes in the normal brain parenchyma caused by radiotherapy accelerate glioma progression
DOI: https://doi.org/10.1038/s41598-021-01475-0
[2021] MRI-based Glucose Assay Using Magnetic Nanoparticle Sensors.
[2021] Boron neutron capture therapy using dodecaborated albumin conjugates with maleimide is effective in a rat glioma model
DOI: https://doi.org/10.1007/s10637-021-01201-7
[2021] Carborane as an Alternative Efficient Hydrophobic Tag for Protein Degradation
DOI: https://doi.org/10.1021/acs.bioconjchem.1c00431
[2021] Total synthesis and biological evaluation of 7-hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy
DOI: https://doi.org/10.1016/j.bmcl.2021.128338
[2021] Rapid and Mild One‐Flow Synthetic Approach to Unsymmetrical Sulfamides Guided by Bayesian Optimization
DOI: https://doi.org/10.1002/cmtd.202100053
[2021] Synthesis of Three‐Dimensional (Di)Azatricyclododecene Scaffold and Its Application to Peptidomimetics
DOI: https://doi.org/10.1002/chem.202101440
[2021] Suzuki-Miyaura cross-coupling of 3,4-disubstituted 5-bromoisoxazoles: An efficient access to trisubstituted isoxazoles
DOI: https://doi.org/10.1016/j.tetlet.2021.153185
[2021] Proximity Histidine Labeling by Umpolung Strategy Using Singlet Oxygen
DOI: https://doi.org/10.1021/jacs.1c01626

科研費（0 件）

まだデータがありません（KAKEN 取り込み後に表示）。

所属学会・役職（0 件）

まだデータがありません（学会データ連携後に表示）。

AI 要約（直近 5 年の研究成果）

外部リンク

関連研究室(8 件)

研究成果（89 件）

科研費（0 件）

所属学会・役職（0 件）