Ichio Shimada 研究室

AI 要約（直近 5 年の研究成果）

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

研究成果（19 件）

• [2025] Cell Permeability and Target Engagement of Middle-Sized Molecules Quantified by In-Cell NMR
  DOI: https://doi.org/10.1021/acs.analchem.5c01494
• [2025] Multistate Structure Determination and Dynamics Analysis Reveals a Unique Ubiquitin-Recognition Mechanism in Ubiquitin C-terminal Hydrolase
  DOI: https://doi.org/10.1021/jacs.5c06502
• [2025] Structural basis of the residence time of adenosine A _2A receptor ligands revealed by NMR
  DOI: https://doi.org/10.1039/d5sc02398j
• [2025] Structural and Dynamic Insights into the Activation of the μ-opioid Receptor by an Allosteric Modulator
  DOI: https://doi.org/10.2142/biophys.65.145
• [2024] Real-Time Monitoring of RAS Activity Using In Vitro and In-Cell NMR Spectroscopy
  DOI: https://doi.org/10.1007/978-1-0716-3822-4_17
• [2023] Evaluation of Drug Responses to Human β₂AR Using Native Mass Spectrometry
  DOI: https://doi.org/10.1021/acsomega.3c02737
• [2023] Real-time monitoring of the reaction of KRAS G12C mutant specific covalent inhibitor by in vitro and in-cell NMR spectroscopy
  DOI: https://doi.org/10.1038/s41598-023-46623-w
• [2023] NMR Characterization of the Papain-like Protease from SARS-CoV-2 Identifies the Conformational Heterogeneity in Its Inhibitor-Binding Site
  DOI: https://doi.org/10.1021/jacs.3c04115
• [2022] Activation mechanism of the μ-opioid receptor by an allosteric modulator
  DOI: https://doi.org/10.1073/pnas.2121918119
• [2022] Paip2A inhibits translation by competitively binding to the RNA recognition motifs of PABPC1 and promoting its dissociation from the poly(A) tail
  DOI: https://doi.org/10.1016/j.jbc.2022.101844

科研費（0 件）

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所属学会・役職（0 件）

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