Masamichi Ito 研究室

主宰者：Masamichi Ito

東京大学

AI 要約（直近 5 年の研究成果）

本研究室は、心臓の疾患メカニズムと治療戦略の解明に取り組んでいます。特に、心不全や遺伝性心筋症、肺高血圧などの心血管疾患を対象として、細胞間相互作用や代謝シグナルがどのように心機能を制御するかを調べています。心臓を構成する心筋細胞だけでなく、血管内皮細胞や線維芽細胞といった周囲の細胞との相互作用に着目し、疾患の本体を理解しようとしています。研究の手法としては、遺伝子改変マウスモデルの作製と解析、単一細胞解析技術、代謝解析、および患者由来の細胞を用いた検証を組み合わせています。生きた動物の中で直接相互作用する細胞を同定する革新的なプラットフォームや、深層学習を活用した遺伝子発見システムなども開発・活用しており、基礎研究から臨床応用への橋渡しを目指しています。主な知見として、低酸素応答経路（HIF経路）の活性化が心機能の維持に関わること、心線維芽細胞が産生する物質が心筋細胞の収縮性を低下させること、遺伝子変異が心筋細胞の分化・成熟異常を引き起こすことなどが報告されています。これらの発見は、既存の薬物療法や新規治療標的の開発につながる可能性を持っています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

外部リンク

研究成果（65 件）

[2026] A Three-Stacked Switchable Hybrid-Shutter CMOS Image Sensor With 1.2- μ m-Pitch 50-Mpixel Rolling Shutter and 2.4- μ m-Pitch 12.5-Mpixel Global Shutter Modes for Mobile Applications
DOI: https://doi.org/10.1109/jssc.2026.3657843
[2026] PAH-former: Transfer learning for efficient discovery of pulmonary arterial hypertension-associated genes
DOI: https://doi.org/10.1371/journal.pone.0344084
[2026] Sustained HIF activation in adult cardiomyocytes show transient beneficial effect in murine HFpEF model
DOI: https://doi.org/10.1093/ehjopen/oeaf178
[2026] A 1.16 e-rms Temporal Random Noise, 123-dB High Dynamic Range, 2.988- μ m Pitch 3-Mpixel Three-Stacked Digital Pixel Sensor for Versatile Applications
DOI: https://doi.org/10.1109/jssc.2026.3663214
[2026] A 1.09e − -Random-Noise 1.5μm-Pixel-Pitch 12MP Global-Shutter-Equivalent CMOS Image Sensor with 3μm Digital Pixels Using Quad-Phase-Staggered Zigzag Readout and Motion Compensation
DOI: https://doi.org/10.1109/isscc49663.2026.11409255
[2026] Integrating ECG Into the Mayo Score Enhances Genotype Prediction in Hypertrophic Cardiomyopathy
DOI: https://doi.org/10.1161/jaha.125.044501
[2026] Sodium-glucose Co-transporter 2 (SGLT2) inhibitor dapagliflozin acutely activates cardiomyocyte HIF-1α signaling via succinate, a signaling metabolite
DOI: https://doi.org/10.1016/j.jphs.2026.01.008
[2026] The REFLEX system enables in vivo identification of perivascular angiogenic macrophages in the heart
DOI: https://doi.org/10.64898/2026.01.27.702189
[2026] A 1.16 e-rms Temporal Random Noise, 123-dB High Dynamic Range, 2.988- μ m Pitch 3-Mpixel Three-Stacked Digital Pixel Sensor for Versatile Applications
DOI: https://doi.org/10.1109/jssc.2026.3663214
[2026] A 1.09e − -Random-Noise 1.5μm-Pixel-Pitch 12MP Global-Shutter-Equivalent CMOS Image Sensor with 3μm Digital Pixels Using Quad-Phase-Staggered Zigzag Readout and Motion Compensation
DOI: https://doi.org/10.1109/isscc49663.2026.11409255

続きを表示（残り 55 件）

[2026] Integrating ECG Into the Mayo Score Enhances Genotype Prediction in Hypertrophic Cardiomyopathy
DOI: https://doi.org/10.1161/jaha.125.044501
[2026] Sodium-glucose Co-transporter 2 (SGLT2) inhibitor dapagliflozin acutely activates cardiomyocyte HIF-1α signaling via succinate, a signaling metabolite
DOI: https://doi.org/10.1016/j.jphs.2026.01.008
[2026] The REFLEX system enables in vivo identification of perivascular angiogenic macrophages in the heart
DOI: https://doi.org/10.64898/2026.01.27.702189
[2026] Sustained HIF activation in adult cardiomyocytes show transient beneficial effect in murine HFpEF model
DOI: https://doi.org/10.1093/ehjopen/oeaf178
[2026] A Three-Stacked Switchable Hybrid-Shutter CMOS Image Sensor With 1.2- μ m-Pitch 50-Mpixel Rolling Shutter and 2.4- μ m-Pitch 12.5-Mpixel Global Shutter Modes for Mobile Applications
DOI: https://doi.org/10.1109/jssc.2026.3657843
[2026] PAH-former: Transfer learning for efficient discovery of pulmonary arterial hypertension-associated genes
DOI: https://doi.org/10.1371/journal.pone.0344084
[2025] LPS induces limited activation of hypoxia-inducible factor-1α in macrophages
DOI: https://doi.org/10.5167/uzh-281707
[2025] LPS induces limited activation of hypoxia-inducible factor-1α in macrophages
DOI: https://doi.org/10.1016/j.jbc.2025.110932
[2025] Abstract 4366672: PAH-former: Transfer Learning for Efficient Discovery of Pulmonary Arterial Hypertension-Associated Genes
DOI: https://doi.org/10.1161/circ.152.suppl_3.4366672
[2025] LPS induces limited activation of hypoxia-inducible factor-1α in macrophages
DOI: https://doi.org/10.1016/j.jbc.2025.110932
[2025] LPS induces limited activation of hypoxia-inducible factor-1α in macrophages
DOI: https://doi.org/10.5167/uzh-281707
[2025] Abstract 4366672: PAH-former: Transfer Learning for Efficient Discovery of Pulmonary Arterial Hypertension-Associated Genes
DOI: https://doi.org/10.1161/circ.152.suppl_3.4366672
[2025] Abstract 4367850: In Vitro Investigation of the Pathophysiological Mechanisms Underlying Severe Cardiomyopathic Phenotypes Associated with Noonan Syndrome with Multiple Lentigines
DOI: https://doi.org/10.1161/circ.152.suppl_3.4367850
[2025] Heart failure-specific cardiac fibroblasts contribute to cardiac dysfunction via the MYC–CXCL1–CXCR2 axis
DOI: https://doi.org/10.1038/s44161-025-00698-y
[2025] A 1.22 e-rms Temporal Random Noise, 110 dB High Dynamic Range, 2.988 \mu\mathrm{m}$ Pixel-Pitch 3-Stacked Digital Pixel Sensor with On-Chip HDR Merger
DOI: https://doi.org/10.23919/vlsitechnologyandcir65189.2025.11074898
[2025] Genotype-Guided Cardiac Device Intervention in LMNA -Related Cardiac Conduction Disorder: The Need for Timely Genetic Testing
DOI: https://doi.org/10.1002/ejhf.3695
[2025] Preventive Effects of Prasugrel on Cerebrovascular Events Following Percutaneous Coronary Intervention
DOI: https://doi.org/10.1161/strokeaha.125.050366
[2025] Abstract 4367850: In Vitro Investigation of the Pathophysiological Mechanisms Underlying Severe Cardiomyopathic Phenotypes Associated with Noonan Syndrome with Multiple Lentigines
DOI: https://doi.org/10.1161/circ.152.suppl_3.4367850
[2025] Heart failure-specific cardiac fibroblasts contribute to cardiac dysfunction via the MYC–CXCL1–CXCR2 axis
DOI: https://doi.org/10.1038/s44161-025-00698-y
[2025] Genotype-Guided Cardiac Device Intervention in LMNA -Related Cardiac Conduction Disorder: The Need for Timely Genetic Testing
DOI: https://doi.org/10.1002/ejhf.3695
[2025] Preventive Effects of Prasugrel on Cerebrovascular Events Following Percutaneous Coronary Intervention
DOI: https://doi.org/10.1161/strokeaha.125.050366
[2025] 6.1 A 3-Stacked Hybrid-Shutter CMOS Image Sensor with Switchable $1.2\mu\mathrm{m}$ -Pitch 50Mpixel Rolling Shutter and $2.4\mu\mathrm{m}$ -Pitch 12.5Mpixel Global Shutter Modes for Mobile Applications
DOI: https://doi.org/10.1109/isscc49661.2025.10904571
[2025] Genetic Cardiomyopathy Mimicking Isolated Cardiac Sarcoidosis: Diagnostic Challenges with Positron Emission Tomography
DOI: https://doi.org/10.1002/ehf2.15185
[2025] 6.1 A 3-Stacked Hybrid-Shutter CMOS Image Sensor with Switchable $1.2\mu\mathrm{m}$ -Pitch 50Mpixel Rolling Shutter and $2.4\mu\mathrm{m}$ -Pitch 12.5Mpixel Global Shutter Modes for Mobile Applications
DOI: https://doi.org/10.1109/isscc49661.2025.10904571
[2025] Genetic Cardiomyopathy Mimicking Isolated Cardiac Sarcoidosis: Diagnostic Challenges with Positron Emission Tomography
DOI: https://doi.org/10.1002/ehf2.15185
[2024] Abstract 4145572: LMNA p.Q353R Mutation Causes Dilated Cardiomyopathy through Impaired Vitamin D Signaling
DOI: https://doi.org/10.1161/circ.150.suppl_1.4145572
[2024] [Para-anastomotic Aneurysm in the Ascending Aorta Late After Aortic Valve Replacement:Report of Two Cases].
[2024] Vaccine Therapy for Heart Failure Targeting the Inflammatory Cytokine Igfbp7
DOI: https://doi.org/10.1161/circulationaha.123.064719
[2024] Successful Treatment of Fulminant and Recurrent Lymphocytic Myocarditis with Calcineurin Inhibitors
DOI: https://doi.org/10.1002/ehf2.14896
[2024] Association Between Clonal Hematopoiesis and Left Ventricular Reverse Remodeling in Nonischemic Dilated Cardiomyopathy
DOI: https://doi.org/10.1016/j.jacbts.2024.04.010
[2024] A Pathogenic LAMP2 Non-Canonical Splice Site Mutation Caused Danon Disease Requiring Heart Transplantation
DOI: https://doi.org/10.1253/circj.cj-23-0938
[2024] [Para-anastomotic Aneurysm in the Ascending Aorta Late After Aortic Valve Replacement:Report of Two Cases].
[2024] Vaccine Therapy for Heart Failure Targeting the Inflammatory Cytokine Igfbp7
DOI: https://doi.org/10.1161/circulationaha.123.064719
[2024] Abstract 4143847: CRISPR screening identifies critical factors regulating DNA damage response in human cardiomyocytes under oxidative stress
DOI: https://doi.org/10.1161/circ.150.suppl_1.4143847
[2024] Association of Multiple Nonhypertrophic Cardiomyopathy–Related Genetic Variants and Outcomes in Patients With Hypertrophic Cardiomyopathy
DOI: https://doi.org/10.1016/j.jchf.2024.08.005
[2024] Abstract 4143847: CRISPR screening identifies critical factors regulating DNA damage response in human cardiomyocytes under oxidative stress
DOI: https://doi.org/10.1161/circ.150.suppl_1.4143847
[2024] Abstract 4145572: LMNA p.Q353R Mutation Causes Dilated Cardiomyopathy through Impaired Vitamin D Signaling
DOI: https://doi.org/10.1161/circ.150.suppl_1.4145572
[2024] Association of Multiple Nonhypertrophic Cardiomyopathy–Related Genetic Variants and Outcomes in Patients With Hypertrophic Cardiomyopathy
DOI: https://doi.org/10.1016/j.jchf.2024.08.005
[2023] How Can We Survive the Heart Failure Pandemic Era? Basic Research for Understanding the Pathophysiology of Heart Failure and Development of Novel Therapies
DOI: https://doi.org/10.15420/japsc.2022.37
[2023] TEAD1 trapping by the Q353R–Lamin A/C causes dilated cardiomyopathy
DOI: https://doi.org/10.1126/sciadv.ade7047
[2023] Myocardial DNA Damage Predicts Heart Failure Outcome in Various Underlying Diseases
DOI: https://doi.org/10.1016/j.jchf.2023.09.027
[2023] Myocardial DNA Damage Predicts Heart Failure Outcome in Various Underlying Diseases
DOI: https://doi.org/10.1016/j.jchf.2023.09.027
[2023] How Can We Survive the Heart Failure Pandemic Era? Basic Research for Understanding the Pathophysiology of Heart Failure and Development of Novel Therapies
DOI: https://doi.org/10.15420/japsc.2022.37
[2023] Emerging Hypotheses on the Pathogenesis of Rasopathy-Associated Cardiomyopathies
DOI: https://doi.org/10.9794/jspccs.39.192
[2023] Differential cardiomyocyte transcriptomic remodeling during in vitro Trypanosoma cruzi infection using laboratory strains provides implications on pathogenic host responses
DOI: https://doi.org/10.1186/s41182-023-00552-6
[2023] TEAD1 trapping by the Q353R–Lamin A/C causes dilated cardiomyopathy
DOI: https://doi.org/10.1126/sciadv.ade7047
[2022] Highly efficient hole injection from Au electrode to fullerene-doped triphenylamine derivative layer
DOI: https://doi.org/10.1038/s41598-022-10983-6
[2022] Spatiotemporal transcriptome analysis reveals critical roles for mechano-sensing genes at the border zone in remodeling after myocardial infarction
DOI: https://doi.org/10.1038/s44161-022-00140-7
[2022] Hemoglobin Alpha Chain Variant Zara Associated With Familial Asymptomatic Hypoxemia
DOI: https://doi.org/10.14740/jh1028
[2022] Spatiotemporal transcriptome analysis reveals critical roles for mechano-sensing genes at the border zone in remodeling after myocardial infarction
DOI: https://doi.org/10.1038/s44161-022-00140-7
[2022] Hemoglobin Alpha Chain Variant Zara Associated With Familial Asymptomatic Hypoxemia
DOI: https://doi.org/10.14740/jh1028
[2022] Cardiac fibroblasts regulate the development of heart failure via Htra3-TGF-β-IGFBP7 axis
DOI: https://doi.org/10.1038/s41467-022-30630-y
[2022] Highly efficient hole injection from Au electrode to fullerene-doped triphenylamine derivative layer
DOI: https://doi.org/10.1038/s41598-022-10983-6
[2022] Functional Evaluation of Human Bioengineered Cardiac Tissue Using iPS Cells Derived from a Patient with Lamin Variant Dilated Cardiomyopathy
DOI: https://doi.org/10.1536/ihj.21-790
[2022] Functional Evaluation of Human Bioengineered Cardiac Tissue Using iPS Cells Derived from a Patient with Lamin Variant Dilated Cardiomyopathy
DOI: https://doi.org/10.1536/ihj.21-790

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AI 要約（直近 5 年の研究成果）

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関連研究室(8 件)

研究成果（65 件）

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