Takahiro Mimae 研究室

主宰者：Takahiro Mimae

広島大学

AI 要約（直近 5 年の研究成果）

Takahiro Mimae研究室は、肺がん患者の最適な手術治療法の確立を目指した臨床研究と基礎研究に取り組んでいます。早期段階の肺がんに対して、従来の広範な切除（葉切除）と臓器を温存する部分切除（区域切除）のどちらが患者にとってより有益かを、複数の大規模臨床試験データを用いて比較検討しています。特に、腫瘍の画像所見（充実度やすりガラス陰影の有無）、位置（中枢・末梢）、患者の筋肉量や喫煙歴といった多様な臨床因子との関連を統計的に分析し、患者ごとにより適切な手術術式を提案することを目指しています。並行して、肺がん患者の予後に影響する生物学的メカニズムの解明にも取り組んでいます。手術による免疫系や骨格筋への影響、腫瘍細胞の転移・治療耐性のメカニズム、さらには血液マーカーを用いた予後予測法の開発など、分子・細胞レベルの研究も実施しています。これらの臨床的課題と基礎的知見を統合することで、肺がん患者の治療成績向上と生活の質の改善に寄与する研究を展開しています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

外部リンク

研究成果（90 件）

[2026] Oncologic outcomes of segmentectomy in c-stage I non–small cell lung cancer with visceral pleural invasion: A multicenter retrospective study
DOI: https://doi.org/10.1016/j.xjon.2026.101871
[2026] Immunological impact of tumor-draining lymph node dissection on systemic Th1-like CD4+ T cells in patients with early-stage lung cancer
DOI: https://doi.org/10.1007/s00262-026-04357-4
[2026] Segmentectomy Versus Lobectomy in NSCLC With Pathologically Invasive Features: A Post Hoc Supplementary Analysis of Multicenter, Phase 3 Trial JCOG0802/WJOG4607L
DOI: https://doi.org/10.1016/j.jtho.2026.103916
[2026] Complex segmentectomy versus lobectomy in small-sized peripheral non–small cell lung cancer: A post-hoc supplemental analysis of a multicenter, open-label, phase 3 trial (JCOG0802/WJOG4607L).
DOI: https://doi.org/10.1200/jco.2026.44.16_suppl.8009
[2025] Plasminogen Activator Inhibitor-1 Mediates Tolerance to Anti–PD-1 Immunotherapy in Non–Small Cell Lung Cancer
DOI: https://doi.org/10.1158/1535-7163.mct-24-0890
[2025] EP.07.54 Lymphatic Permeation as a Key Risk Factor for Recurrence in Pathological Stage IIA NSCLC Under the 9Th TNM Classification
DOI: https://doi.org/10.1016/j.jtho.2025.09.1435
[2025] Lobectomy Induces Exercise-Induced Pulmonary Hypertension and Effort Intolerance Compared With Sublobar Resection
DOI: https://doi.org/10.1016/j.jtocrr.2025.100903
[2025] 1793P Differences in postoperative survival among patients with lung adenocarcinoma harboring common EGFR mutations
DOI: https://doi.org/10.1016/j.annonc.2025.08.2419
[2025] Lymph node dissection as a local control during segmentectomy for small-sized and radiologically solid dominant and pure solid tumors
DOI: https://doi.org/10.1093/jjco/hyaf126
[2025] Visceral Pleural Invasion as a Determinant of Surgical Strategy in Non–Small Cell Lung Cancer: A Multicenter Study
DOI: https://doi.org/10.3390/cancers17203382

続きを表示（残り 80 件）

[2025] Recurrence Risk Stratification by Station- and Zone-Based Nodal Classification in Resected Non-Small Cell Lung Cancer
DOI: https://doi.org/10.1093/ejcts/ezaf338
[2025] Quality comparison of mediastinal lymph node dissection between video-assisted thoracic surgery and open thoracotomy: a supplementary analysis of the phase 3 Japan Clinical Oncology Group 1413 trial
DOI: https://doi.org/10.1093/ejcts/ezaf206
[2025] Prognosis, imaging characteristics, and clinicopathological features of heavy smokers with clinical stage I lung adenocarcinoma: a multicenter study
DOI: https://doi.org/10.1007/s11748-025-02166-7
[2025] Impact of pectoralis major muscle mass decrease after lobectomy on the prognosis of lung cancer
DOI: https://doi.org/10.1093/jjco/hyaf072
[2025] Prognostic Benefit of Segmentectomy for Patients with Low Muscle Mass in Early-Stage Lung Cancer
DOI: https://doi.org/10.1245/s10434-024-16384-5
[2025] Segmentectomy versus lobectomy for centrally located small-sized and radiologically pure-solid non–small cell lung cancer
DOI: https://doi.org/10.1016/j.xjon.2025.03.028
[2025] Comparative oncological features of centrally and peripherally located small-sized radiologically solid-dominant non-small-cell lung cancer
DOI: https://doi.org/10.1093/ejcts/ezaf072
[2025] Relationship between walking distance within the first 24 h following lung cancer surgery and clinical outcomes
DOI: https://doi.org/10.1007/s11748-025-02139-w
[2025] Guidelines for preoperative pulmonary function assessment in patients with lung cancer who will undergo surgery (The Japanese Association for Chest Surgery)
DOI: https://doi.org/10.1007/s11748-025-02120-7
[2025] Role of guanylate-binding protein 1 in the proliferation of invasive lung adenocarcinoma cells
DOI: https://doi.org/10.3389/fonc.2025.1434249
[2025] Role of 18F-fluorodeoxyglucose accumulation in radiological ground-glass opacity of non-small cell lung cancer
DOI: https://doi.org/10.1093/jjco/hyae185
[2025] Segmentectomy versus lobectomy in younger patients with early-stage non-small cell lung cancer
DOI: https://doi.org/10.1093/icvts/ivaf024
[2025] Invited Editorial: Recurrence Risk Prediction in Lung Cancer
DOI: https://doi.org/10.1245/s10434-025-18936-9
[2025] Loco-regional Recurrence After Segmentectomy for Peripheral and Radiologically Solid-dominant Tumours
DOI: https://doi.org/10.1093/ejcts/ezaf416
[2025] Prognostic Impact of Ground-Glass Opacity in Clinical Stage IA Non-Small Cell Lung Cancer With Interstitial Lung Abnormalities
DOI: https://doi.org/10.1093/icvts/ivaf260
[2025] EP.07.01 Prediction of Pathologic Low-Grade Malignant Adenocarcinoma in Radiologically Invasive C-Stage IA Non-Small Cell Lung Cancer Measuring >2-3 Cm
DOI: https://doi.org/10.1016/j.jtho.2025.09.1382
[2024] Segmentectomy versus lobectomy in small-sized peripheral non-small-cell lung cancer with radiologically pure-solid appearance in Japan (JCOG0802/WJOG4607L): a post-hoc supplemental analysis of a multicentre, open-label, phase 3 trial
DOI: https://doi.org/10.1016/s2213-2600(23)00382-x
[2024] Sublobar Resection in Early Non-Small Cell Lung Cancer With Epidermal Growth Factor Receptor Mutant
DOI: https://doi.org/10.1016/j.athoracsur.2023.12.009
[2024] Clinical Significance of Preserving Pulmonary Function After Lung Resection in Early-Stage Non–Small-Cell Lung Cancer
DOI: https://doi.org/10.1016/j.cllc.2024.01.003
[2024] ASO Author Reflections: How Does Emphysema Contribute to Poor Prognosis After Lung Cancer Surgery?
DOI: https://doi.org/10.1245/s10434-024-15171-6
[2024] Prediction of Pathologic Complete Response in Esophageal Squamous Cell Carcinoma Using Preoperative Serum Small Ribonucleic Acid Obtained After Neoadjuvant Chemoradiotherapy
DOI: https://doi.org/10.1245/s10434-024-16247-z
[2024] Omitting Lymph Node Dissection for Small Ground-Glass Opacity–Dominant Tumors
DOI: https://doi.org/10.1016/j.athoracsur.2024.03.013
[2024] Risk Factors for Locoregional Relapse After Segmentectomy: Supplementary Analysis of the JCOG0802/WJOG4607L Trial
DOI: https://doi.org/10.1016/j.jtho.2024.10.002
[2024] P2.07B.07 Multi-Institutional Retrospective Analysis of Segmentectomy Versus Lobectomy for Non-Small Cell Lung Cancer Larger Than 3 cm in Diameter
DOI: https://doi.org/10.1016/j.jtho.2024.09.426
[2024] Differences in postoperative prognosis between early-stage lung adenocarcinoma and squamous cell carcinoma
DOI: https://doi.org/10.1093/jjco/hyae049
[2024] EP.06G.10 Comprehensive Analysis of the Clinicopathological Features, Targetable Profle, and Prognosis of Mucinous Adenocarcinoma of the Lung
DOI: https://doi.org/10.1016/j.jtho.2024.09.960
[2024] Feasibility and comparative prognosis of segmentectomy versus lobectomy in centrally located small and solid dominant cN0 non–small cell lung cancer
DOI: https://doi.org/10.1016/j.jtcvs.2024.06.016
[2024] The Role of Emphysema on Postoperative Prognosis in Early-Stage Nonsmall Cell Lung Cancer
DOI: https://doi.org/10.1245/s10434-024-15126-x
[2024] Postoperative pulmonary function of patients with lung cancer and interstitial lung abnormalities
DOI: https://doi.org/10.1007/s11748-024-02037-7
[2024] Effectiveness of pleurodesis for postoperative air leaks after lung resection
DOI: https://doi.org/10.1186/s13019-023-02444-6
[2024] Mitochondrial Metabolism as a Potential Novel Therapeutic Target for Lung Adenocarcinoma
DOI: https://doi.org/10.21873/anticanres.17352
[2024] ASO Visual Abstract: Prediction of Pathologic Complete Response in Esophageal Squamous Cell Carcinoma Using Preoperative Serum Small Ribonucleic Acid Obtained After Neoadjuvant Chemoradiotherapy
DOI: https://doi.org/10.1245/s10434-024-16432-0
[2024] ASO Author Reflections: Surgical Procedures for Early-Stage Lung Cancer Patients with Low Muscle Mass
DOI: https://doi.org/10.1245/s10434-024-16481-5
[2023] Wedge resection is an acceptable treatment option for radiologically low-grade lung cancer with solid predominance
DOI: https://doi.org/10.1093/icvts/ivac285
[2023] Hypoxia-inducible factor 1α modulates interstitial pneumonia-mediated lung cancer progression
DOI: https://doi.org/10.1186/s12967-023-04756-6
[2023] Lymph node dissection in small peripheral lung cancer: Supplemental analysis of JCOG0802/WJOG4607L
DOI: https://doi.org/10.1016/j.jtcvs.2023.11.023
[2023] Risk factors for loss of pulmonary function after wedge resection for peripheral ground-glass opacity dominant lung cancer
DOI: https://doi.org/10.1093/ejcts/ezad365
[2023] MA21.04 Novel Classification with Number or Zones of Involved Lymph Nodal Stations in Patients with Resected Non-Small Cell Lung Cancer
DOI: https://doi.org/10.1016/j.jtho.2023.09.270
[2023] A multicenter propensity score-matched analysis of lymphadenectomy in N1-positve lung cancer
DOI: https://doi.org/10.1093/jjco/hyad110
[2023] Segmentectomy for cancer control in radiologically pure-solid clinical stage IA3 lung cancer
DOI: https://doi.org/10.1093/icvts/ivad138
[2023] Anatomical segmentectomy versus wedge resection for small (≤2 cm) peripheral non-small cell lung cancer in 80 or more aged elderly patients: a randomized phase III study (JCOG2109, AWESOME)
DOI: https://doi.org/10.1093/jjco/hyad095
[2023] Tumor distance from the mediastinum predicts N2 upstaging in clinical stage I lower-lobe non–small cell lung cancer
DOI: https://doi.org/10.1016/j.jtcvs.2023.06.007
[2023] Sublobar Resection for Non-Small Cell Lung Cancer in Octogenarians: A Prospective, Multicenter Study
DOI: https://doi.org/10.1016/j.athoracsur.2023.02.061
[2023] Extracellular vesicle-associated microRNA signatures related to lymphovascular invasion in early-stage lung adenocarcinoma
DOI: https://doi.org/10.1038/s41598-023-32041-5
[2023] Segmentectomy for ground-glass-dominant lung cancer with a tumour diameter of 3 cm or less including ground-glass opacity (JCOG1211): a multicentre, single-arm, confirmatory, phase 3 trial
DOI: https://doi.org/10.1016/s2213-2600(23)00041-3
[2023] Risk Factors for Recurrence of Stage I Epidermal Growth Factor Receptor Mutated Lung Adenocarcinoma
DOI: https://doi.org/10.1016/j.athoracsur.2023.01.024
[2023] Segmentectomy preserves better immune-nutritional status than lobectomy in patients with early-stage lung cancer
DOI: https://doi.org/10.1093/ejcts/ezad019
[2023] [Dawn of Radical Segmentectomy for Small Sized Peripheral Non-small Cell Lung Cancer].
[2023] JACS-ESTS Joint Session 2023
DOI: https://doi.org/10.2995/jacsurg.37.s11
[2022] Tumour location predicts occult N1 nodal metastasis in clinical stage I non-small-cell lung cancer
DOI: https://doi.org/10.1093/ejcts/ezac575
[2022] Usefulness of serum <scp>S100A4</scp> and positron‐emission tomography on lung cancer accompanied by interstitial pneumonia
DOI: https://doi.org/10.1111/1759-7714.14757
[2022] Discrepancy Between Radiological and Pathological Tumor Size in Early-Stage Non-Small Cell Lung Cancer: A Multicenter Study
DOI: https://doi.org/10.1053/j.semtcvs.2022.12.001
[2022] Segmentectomy for clinically early‐stage primary squamous cell carcinoma of the lung
DOI: https://doi.org/10.1111/1759-7714.14707
[2022] Impact of the amount of preoperative erector spinae muscle in stage I non-small-cell lung cancer
DOI: https://doi.org/10.1093/ejcts/ezac510
[2022] Feasibility of repeated ipsilateral anatomical pulmonary resection
DOI: https://doi.org/10.1007/s00595-022-02604-6
[2022] The intersegmental pulmonary vein is not always located on the intersegmental plane of the lung: Evaluation with 3-dimensional volume-rendering image reconstruction
DOI: https://doi.org/10.1016/j.xjtc.2022.09.002
[2022] Complications and Survival After Lung Cancer Resection in Interstitial Lung Disease
DOI: https://doi.org/10.1016/j.athoracsur.2022.05.069
[2022] Possible Therapeutic Utility of anti-Cell Adhesion Molecule 1 Antibodies for Malignant Pleural Mesothelioma
DOI: https://doi.org/10.3389/fcell.2022.945007
[2022] Role of ground-glass opacity in pure invasive and lepidic component in pure solid lung adenocarcinoma for predicting aggressiveness
DOI: https://doi.org/10.1016/j.xjon.2022.04.041
[2022] A Multicenter Study of Complex Segmentectomy Versus Wedge Resection in Clinical Stage 0-IA Non-Small Cell Lung Cancer
DOI: https://doi.org/10.1016/j.cllc.2021.10.005
[2022] The prognostic impact of the ground-glass opacity component in nearly pure-solid stage IA non-small-cell lung cancer
DOI: https://doi.org/10.1093/ejcts/ezac166
[2022] Oncological outcome of segmentectomy for early-stage non-small-cell lung cancer with invasive characteristics: a multicentre study
DOI: https://doi.org/10.1093/ejcts/ezac055
[2022] Segmentectomy versus wedge resection for radiological solid predominant and low metabolic non-small cell lung cancer
DOI: https://doi.org/10.1093/icvts/ivac028
[2022] Interstitial pneumonia and advanced age negatively influence postoperative pulmonary function
DOI: https://doi.org/10.1093/icvts/ivac014
[2022] Psychological states regarding adjuvant chemotherapy in patients with non-small cell lung cancer
DOI: https://doi.org/10.1016/j.ctarc.2022.100591
[2022] Usefulness of Serum S100A4 and PET on Lung Cancer Accompanied with Interstitial Pneumonia
DOI: https://doi.org/10.2139/ssrn.4127866
[2022] 索引
DOI: https://doi.org/10.2995/jacsurg.36.349
[2021] Segmentectomy versus lobectomy for solid predominant cN0 lung cancer: analysis using visual evaluation of positron emission tomography
DOI: https://doi.org/10.1093/ejcts/ezab434
[2021] MA08.03 Adjuvant Chemotherapy for Patients with High-Risk Stage I Lung Adenocarcinoma Stratified by Epidermal Growth Factor Receptor Mutation Status
DOI: https://doi.org/10.1016/j.jtho.2021.08.148
[2021] Postoperative Pulmonary Function After Complex Segmentectomy
DOI: https://doi.org/10.1245/s10434-021-09828-9
[2021] Risk of death due to other causes is lower among octogenarians with non-small cell lung cancer after wedge resection than lobectomy/segmentectomy
DOI: https://doi.org/10.1093/jjco/hyab122
[2021] Systematic Versus Lobe-Specific Mediastinal Lymphadenectomy for Hypermetabolic Lung Cancer
DOI: https://doi.org/10.1245/s10434-021-10020-2
[2021] Role of Soluble Receptor for Advanced Glycation End Products in Postoperative Fibrotic Lung Injury
DOI: https://doi.org/10.1016/j.athoracsur.2021.05.059
[2021] Serum S100 calcium-binding protein A4 as a novel predictive marker of acute exacerbation of interstitial pneumonia after surgery for lung cancer
DOI: https://doi.org/10.1186/s12890-021-01554-y
[2021] The impact of pathological lymph node metastasis with lymphatic invasion on the survival of patients with clinically node-negative non-small cell lung cancer: A multicenter study
DOI: https://doi.org/10.1016/j.lungcan.2021.05.029
[2021] Complex Segmentectomy for Hypermetabolic Clinical Stage IA Non-Small Cell Lung Cancer
DOI: https://doi.org/10.1016/j.athoracsur.2021.04.083
[2021] Predictive role of circulatory HMGB1 in postoperative acute exacerbation of interstitial lung disease in lung cancer patients
DOI: https://doi.org/10.1038/s41598-021-89663-w
[2021] Prognostic role of interstitial pneumonia with or without emphysema in patients with clinical stage I lung cancer
DOI: https://doi.org/10.1093/jjco/hyab073
[2021] Survival of Octogenarians with Early-Stage Non-small Cell Lung Cancer is Comparable Between Wedge Resection and Lobectomy/Segmentectomy: JACS1303
DOI: https://doi.org/10.1245/s10434-021-09835-w
[2021] Preoperative nivolumab to evaluate pathological response in patients with stage I non-small cell lung cancer: a study protocol of phase II trial (POTENTIAL)
DOI: https://doi.org/10.1136/bmjopen-2020-043234

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AI 要約（直近 5 年の研究成果）

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研究成果（90 件）

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