Takeshi Wada 研究室

主宰者：Takeshi Wada

東京理科大学

AI 要約（直近 5 年の研究成果）

本研究室は、医療や診断に用いられる核酸医薬の合成方法の開発を主な研究対象としています。特に、遺伝子を制御するアンチセンス型核酸医薬として機能する様々な化学修飾DNAやRNA分子の効率的な製造技術を研究しています。従来の合成法では困難だった複数のタイプの化学修飾を含む核酸分子や、立体化学が厳密に制御された核酸医薬品の大量合成に取り組んでいます。具体的には、ホウ素原子を含む修飾リン酸エステル結合を持つ核酸、または特定の立体配置を持つ核酸誘導体などの合成技術を開発しており、様々な新しい反応方法やキー化合物を活用した効率的な合成戦略を報告しています。また、合成した核酸医薬のターゲットRNA への結合特性や生物活性を評価し、構造と機能の関係を明らかにする研究も行っています。さらに、多糖類由来の医療用生体高分子や核酸医薬の毒性を低減させるための技術開発にも取り組んでおり、より安全で有効な治療剤の実現を目指しています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（40 件）

[2026] Kinetic and thermodynamic properties of phosphorothioate and phosphorodiamidate morpholino oligonucleotides binding to target RNA
DOI: https://doi.org/10.1093/jb/mvag043
[2026] Stereocontrolled Synthesis of Dimethylamino Phosphorochloridate Monomers toward Stereopure Phosphorodiamidate Morpholino Oligonucleotides
DOI: https://doi.org/10.1021/acs.joc.5c02914
[2025] Stereocontrolled synthesis and nuclear magnetic resonance analysis of boranophosphate/phosphate chimeric oligonucleotides
DOI: https://doi.org/10.1098/rsos.241797
[2025] Synthesis of P-Modified Chimeric Oligonucleotides via Chemoselective Condensation of Nucleoside 3′-H-Phosphonothioate
DOI: https://doi.org/10.1021/acs.joc.5c01498
[2025] Solution-Phase Synthesis of Boranophosphate and Boranophosphate/Phosphorothioate/Phosphate Chimeric Oligonucleotides via the H-Boranophosphonate Method
DOI: https://doi.org/10.1021/acs.joc.5c00583
[2025] Stereoselective Synthesis of Nucleotide Analog Prodrugs (ProTides) via an Oxazaphospholidine Method
DOI: https://doi.org/10.1021/acs.joc.5c00240
[2025] Preparation of Boranophosphate DNA via the Boranophosphotriester Method and Synthesis of P‐modified DNAs from Boranophosphate DNA via an Acyl Phosphite Intermediate
DOI: https://doi.org/10.1002/cpz1.70117
[2025] Validation of the Japanese Association for Acute Medicine-2 disseminated intravascular coagulation criteria to predict critical bleeding in patients with trauma: A nationwide cohort study in Japan
DOI: https://doi.org/10.1016/j.thromres.2025.109532
[2025] Synthesis of Phosphorus-Containing Biomolecules Using Boranophosphates
DOI: https://doi.org/10.5059/yukigoseikyokaishi.83.885
[2024] <scp>ICLAMP</scp> : a novel technique to explore adenosine deamination via inosine chemical labeling and affinity molecular purification
DOI: https://doi.org/10.1002/1873-3468.14854

続きを表示（残り 30 件）

[2024] Development of cationic oligodiaminogalactoses specifically binding to duplex RNA, but not to duplex DNA
DOI: https://doi.org/10.1016/j.tca.2024.179789
[2024] α‐Selective Solid‐Phase Synthesis of Glycosyl Phosphate Repeating Structure Via the Phosphoramidite Method
DOI: https://doi.org/10.1002/chem.202401226
[2024] DNA/RNA heteroduplex technology with cationic oligopeptide reduces class-related adverse effects of nucleic acid drugs
DOI: https://doi.org/10.1016/j.omtn.2024.102289
[2023] Solid-phase synthesis of oligodeoxynucleotides using nucleobase N-unprotected oxazaphospholidine derivatives bearing a long alkyl chain
DOI: https://doi.org/10.1039/d3ob01255g
[2023] Development of Experimental Materials for Cooperative IoT Devices
DOI: https://doi.org/10.12792/iciae2023.010
[2023] Internucleotidic bond formation using H -phosphonamidate derivatives and acidic activators
DOI: https://doi.org/10.1039/d3ra06193k
[2023] Convergent synthesis of phosphorodiamidate morpholino oligonucleotides (PMOs) by the H-phosphonate approach
DOI: https://doi.org/10.1038/s41598-023-38698-2
[2023] Synthesis of P-Modified DNA from Boranophosphate DNA as a Precursor via Acyl Phosphite Intermediates
DOI: https://doi.org/10.1021/acs.joc.3c00659
[2023] Development of a quick preparation method for the analysis of 11-nor-9-carboxy-∆9-tetrahydrocannabinol in human urine by phenylboronic-acid solid-phase extraction
DOI: https://doi.org/10.1016/j.jpba.2023.115556
[2023] Analysis of Acetylated Hyaluronic Acid in Moisturizing Lotion and Milk Lotion by HPLC with Fluorescence Detection
DOI: https://doi.org/10.1248/cpb.c23-00094
[2023] Solid-Phase Synthesis of Glycosyl Phosphate Repeating Units via Glycosyl Boranophosphates as Stable Intermediates
DOI: https://doi.org/10.1021/acs.orglett.3c01293
[2023] Delayed neurologic improvement and long-term survival of patients with poor neurologic status after out-of-hospital cardiac arrest: A retrospective cohort study in Japan
DOI: https://doi.org/10.1016/j.resuscitation.2023.109790
[2023] Solid-phase synthesis and properties of stereocontrolled boranophosphate/phosphate and phosphorothioate/phosphate chimeric oligouridylates
DOI: https://doi.org/10.1098/rsos.230095
[2023] Fucosylated heparan sulfate from the midgut gland of Patinopecten yessoensis
DOI: https://doi.org/10.1016/j.carbpol.2023.120847
[2023] Properties of artificial cationic oligodiaminosaccharides and oligopeptides that bind to A-type oligonucleotide duplexes
DOI: https://doi.org/10.1080/15257770.2023.2182444
[2023] Development of a new synthetic method for oligodeoxynucleotides using 3′-H-phosphonamidate derivatives
DOI: https://doi.org/10.1039/d2ob02292c
[2023] Spindle Cell Variant of Ameloblastic Carcinoma: Another Example in a Japanese Male
DOI: https://doi.org/10.1155/2023/8755637
[2022] Ultrafine Nanoporous Intermetallic Catalysts by High-Temperature Liquid Metal Dealloying for Electrochemical Hydrogen Production
DOI: https://doi.org/10.5281/zenodo.6982712
[2022] Identification and Quantitative Analysis of 2-Fluoromethamphetamine and Its Metabolites in Human Urine
DOI: https://doi.org/10.1093/jat/bkac026
[2022] Solid-phase synthesis of N-trichloroacetyl mannosamine 1-phosphate repeating units mimicking capsular polysaccharide derived from Neisseria meningitidis serotype A
DOI: https://doi.org/10.1016/j.carres.2022.108585
[2022] Comprehensive analysis of chondroitin sulfate and aggrecan in the head cartilage of bony fishes: Identification of proteoglycans in the head cartilage of sturgeon
DOI: https://doi.org/10.1016/j.ijbiomac.2022.03.125
[2022] Synthesis and properties of oligodiaminogalactoses that bind to A-type oligonucleotide duplexes
DOI: https://doi.org/10.1039/d2ob01575g
[2021] Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood–brain barrier and knock down genes in the rodent CNS
DOI: https://doi.org/10.1038/s41587-021-00972-x
[2021] Solid-Phase Stereocontrolled Synthesis of Oligomeric P-Modified Glycosyl Phosphate Derivatives Using the Oxazaphospholidine Method
DOI: https://doi.org/10.1021/acsomega.1c03058
[2021] Synthesis of thioamides from thiocarboxylic acids using phosphonium-type condensing reagents
DOI: https://doi.org/10.1016/j.tetlet.2021.153179
[2021] Synthesis of Glycosyl Phosphate Repeats and Their Analogues
DOI: https://doi.org/10.5059/yukigoseikyokaishi.79.558
[2021] Inhibition of off-target cleavage by RNase H using an artificial cationic oligosaccharide
DOI: https://doi.org/10.1039/d1ob00983d
[2021] Solution-phase synthesis of oligodeoxyribonucleotides using the H-phosphonate method with N-unprotected 5′-phosphite monomers
DOI: https://doi.org/10.1039/d1ra06619f
[2021] Solid-Phase Synthesis of Boranophosphate/Phosphorothioate/Phosphate Chimeric Oligonucleotides and Their Potential as Antisense Oligonucleotides
DOI: https://doi.org/10.1021/acs.joc.1c01812
[2021] Solid-phase synthesis of oligouridine boranophosphates using the H-boranophosphonate method with 2′-O-(2-cyanoethoxymethyl) protection
DOI: https://doi.org/10.1016/j.tetlet.2021.153526

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AI 要約（直近 5 年の研究成果）

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研究成果（40 件）

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