Koichi Mitsudo 研究室

主宰者：Koichi Mitsudo

岡山大学

AI 要約（直近 5 年の研究成果）

Mitsudo研究室は、電気を用いた有機合成化学を中心に研究を展開しています。電流を流すことで化学反応を進める電気化学合成は、従来の化学反応に必要な触媒や酸化剤を使わずに済むため、環境への負荷が少ない利点があります。研究室では、電極での直接的な電子移動を活用する方法と、電極で生成された活性な中間体（メディエーター）が基質に反応する間接的な方法の両者を用いています。こうした電気化学的なアプローチにより、複雑な炭素―炭素結合や炭素―窒素結合、炭素―硫黄結合を選択的に作成する方法を開発してきました。具体的には、含窒素芳香族化合物の還元によるアミン合成や、複素環化合物の効率的な構築法、さらには赤外線領域に光を吸収する色素分子の合成に取り組んでいます。特に、ハロゲンやヨウ化物などのメディエーターを活用した電気化学的環化反応は、従来法では困難だった多重結合の一段階での形成を実現しています。さらに近年では、フロー化学と機械学習などの解析手法を組み合わせ、反応条件を自動最適化するシステムの開発も進めており、電気化学合成を実用規模での工業プロセスへ展開することを目指しています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

外部リンク

研究成果（56 件）

[2026] Crystal structure of tris[4-(3,4-dimethoxythiophen-2-yl)phenyl]amine
DOI: https://doi.org/10.1107/s2056989026000058
[2026] Synthesis of boranils by iodide-mediated demethylative borylation and their properties
DOI: https://doi.org/10.1093/bulcsj/uoag070
[2026] Electrochemical Oxidation-Promoted Sequential Cyclization/Aromatization toward Carbazole Synthesis
DOI: https://doi.org/10.26434/chemrxiv.15003840/v1
[2026] Solution-Processable Near-Infrared-Absorbing Dye: Thiophene-Substituted N-Phenylphenothiazine Radical Cations for Stable Thin Films
DOI: https://doi.org/10.3390/colorants5020014
[2026] Electrochemical Synthesis of Benzo[ b ]Phosphole Oxides via Dehydrogenative Annulation Using 1,4‐Diazabicyclo [2.2.2]Octane as a Mediator
DOI: https://doi.org/10.1002/celc.70175
[2026] Redox-controlled near-infrared-to-near-infrared optical switching in TPA dimers
DOI: https://doi.org/10.1039/d5cp04771d
[2026] Informatics‐Driven and Automated Optimization in Flow Electrochemical Synthesis
DOI: https://doi.org/10.1002/ejoc.202501237
[2026] Side-chain engineering of oligothiophene-extended triphenylamines for stable radical cations with NIR-II to NIR-III absorption
DOI: https://doi.org/10.1016/j.orgel.2026.107415
[2026] Synthesis of Boranils via Iodide-Mediated Demethylative Borylation and Their Properties
DOI: https://doi.org/10.26434/chemrxiv.15000608/v2
[2026] Synthesis of Boranils via Iodide-Mediated Demethylative Borylation and Their Properties
DOI: https://doi.org/10.26434/chemrxiv.15000608/v1

続きを表示（残り 46 件）

[2025] Bioinspired Electrochemical Cyclization toward the Divergent Synthesis of Mavacurane- and Akuammiline-Type Alkaloids
DOI: https://doi.org/10.1021/acs.orglett.5c03645
[2025] Electrochemical Formation of Carbon-Heteroatom Bond for the Synthesis of Organic Functional Molecules
DOI: https://doi.org/10.5059/yukigoseikyokaishi.83.207
[2025] Cyanomethylation of Aldehydes on an Electrochemical Microflow System and Utility of Machine Learning‐Assisted Examination of the Reaction Conditions
DOI: https://doi.org/10.1002/chem.202501257
[2025] Transformation of α,β-Unsaturated Aldehydes with a Small Amount of Electricity: Cyanosilylation, Isomerization, and Nucleophilic Addition
DOI: https://doi.org/10.1021/acs.orglett.5c01790
[2025] Electrochemical Generation of Sulfonamidyl Radicals via Anodic Oxidation of Hydrogen Bonding Complexes: Applications to Electrosynthesis of Benzosultams
DOI: https://doi.org/10.1021/jacsau.5c00619
[2025] Synthesis of thienoacenes by electrochemical double C–S cyclization using a halogen mediator
DOI: https://doi.org/10.1038/s42004-025-01748-z
[2025] Synthesis of N,O-Bidentate Difluoroboron Complexes via Iodide-Promoted Demethylative Borylation
DOI: https://doi.org/10.1021/acs.orglett.5c02613
[2024] Electrocatalytic Hydrogenation of Pyridines and Other Nitrogen-Containing Aromatic Compounds
DOI: https://doi.org/10.1021/jacs.4c09107
[2024] Electrogenerated Lewis Acid-Catalyzed Claisen Rearrangement of Allyl Aryl Ethers
DOI: https://doi.org/10.1021/acs.orglett.4c03928
[2024] N-Phenylphenothiazine Radical Cation with Extended π-Systems: Enhanced Heat Resistance of Triarylamine Radical Cations as Near-Infrared Absorbing Dyes
DOI: https://doi.org/10.3390/colorants3040024
[2024] Electrocatalytic Hydrogenation of Nitrogen-Containing Compounds Using a Proton-Exchange Membrane Reactor
DOI: https://doi.org/10.1149/ma2024-02533610mtgabs
[2024] Synthesis of Thienoacenes By Electrochemical Double C–S Cyclization Promoted By a Halogen Mediator
DOI: https://doi.org/10.1149/ma2024-02533640mtgabs
[2024] Electrochemical Synthesis of Diarylsultones and Dibenzothiophene Dioxide Via C–O/C–S Bond Formation
DOI: https://doi.org/10.1149/ma2024-02533637mtgabs
[2024] SNAr hexafluoroisopropoxylation of electron-rich aryl fluoride with a catalytic electrical input
DOI: https://doi.org/10.1093/chemle/upae196
[2024] Electrochemical synthesis of heterocyclic compounds via carbon–heteroatom bond formation: direct and indirect electrolysis
DOI: https://doi.org/10.1093/chemle/upae146
[2024] Electrocatalytic hydrogenation of cyanoarenes, nitroarenes, quinolines, and pyridines under mild conditions with a proton-exchange membrane reactor
DOI: https://doi.org/10.3762/bjoc.20.139
[2024] Sequential Paired Electrochemical Transformation of Styrene Oxide via Anodic Meinwald Rearrangement and Cathodic Nitromethylation in an Electrochemical Flow Reactor with Catalytic Electrical Input
DOI: https://doi.org/10.1055/a-2309-6737
[2024] [1,2]-Retro-Brook rearrangement induced by electrochemical reduction of silyl enolates
DOI: https://doi.org/10.1093/bulcsj/uoae038
[2023] Cathodic N–O Bond Cleavage of N-Alkoxy Amide
DOI: https://doi.org/10.5796/electrochemistry.23-67079
[2023] Electrochemical Synthesis of Sultone Derivatives via Dehydrogenative C–O Bond Formation
DOI: https://doi.org/10.1021/acs.orglett.3c01062
[2023] Electrochemical Synthesis of Dibenzothiophene S,S-Dioxides from Biaryl Sulfonyl Hydrazides
DOI: https://doi.org/10.5796/electrochemistry.23-67078
[2023] Anodic Dehydrogenative Aromatization of Tetrahydrocarbazoles Leading to Carbazoles
DOI: https://doi.org/10.1021/acs.orglett.3c01914
[2023] Halogen Mediated Electrochemical Synthesis: Facial Accesses to Dibenzothiophenes and Spirooxindoles
DOI: https://doi.org/10.1149/ma2023-01412322mtgabs
[2023] Synthesis and properties of thieno[3,2-b]thiophene appended triarylamine radical cations: Near-infrared absorbing dye with absorption beyond 1400 nm
DOI: https://doi.org/10.1016/j.dyepig.2023.111916
[2023] Alkynylation of Aldehydes Initiated by Cathodic Reduction
DOI: https://doi.org/10.1002/celc.202300499
[2023] Electrochemical Synthesis of Dibenzothiophene S,S-Dioxides from Biaryl Sulfonyl Hydrazides
[2023] Cathodic N-O Bond Cleavage of N-Alkoxy Amide
[2023] Electrochemical Coupling Reactions Using Non‐Transition Metal Mediators: Recent Advances
DOI: https://doi.org/10.1002/ejoc.202300835
[2023] Electrochemical Cross-Coupling Reactions between Arylboronic Esters and Aryllithiums Using NaBr as a Halogen Mediator
DOI: https://doi.org/10.1055/a-2034-9821
[2023] Electrochemical Carbon-Ferrier Rearrangement Using a Microflow Reactor and Machine Learning-Assisted Exploration of Suitable Conditions
DOI: https://doi.org/10.1021/acs.oprd.2c00267
[2022] Substituent Control of Near-Infrared Absorption of Triphenylamine Radical Cation
DOI: https://doi.org/10.3390/colorants1030021
[2022] Electrochemical Synthesis of Dibenzothiophenes via Intramolecular C–S Cyclization with a Halogen Mediator
DOI: https://doi.org/10.1021/acs.orglett.2c03574
[2022] Electrochemical hydrogenation of enones using a proton-exchange membrane reactor: selectivity and utility
DOI: https://doi.org/10.3762/bjoc.18.107
[2022] (Digital Presentation) Electrochemical Cyanosilylation of Carbonyl Compounds: Machine Learning-Assisted Exploration of Suitable Reaction Conditions
DOI: https://doi.org/10.1149/ma2022-01421832mtgabs
[2022] An Efficient Protocol for Selective Silylation of Hydroxy Group Using N,O-Bis(tert-butyldimethylsilyl)acetamide and N,N-Dimethyl-4-aminopyridine N-Oxide
DOI: https://doi.org/10.1246/cl.220281
[2022] A Facile Access to Spirooxindoles by Halogen-mediated Electrochemical Semi-pinacol Rearrangement
DOI: https://doi.org/10.1246/cl.220368
[2022] (Digital Presentation) Electrochemical Dehydrogenative C–P Bond Formation for the Synthesis of Phosphacycles Using DABCO As a Mediator
DOI: https://doi.org/10.1149/ma2022-01421838mtgabs
[2022] Near-Infrared Absorbing Molecule Based on Triphenylamine Radical Cation with Extended Homoaryl π-System
DOI: https://doi.org/10.3390/colorants1020014
[2022] Electro-oxidative Trimerization of 1,2-Dimethoxybenzene: Reductive Workup Strategy and Alternating Current Electrolysis to Peel off the Precipitated Radical Cation Ion Pair
DOI: https://doi.org/10.1246/cl.220112
[2021] Electrosynthesis of Phosphacycles via Dehydrogenative C–P Bond Formation Using DABCO as a Mediator
DOI: https://doi.org/10.1021/acs.orglett.1c00807
[2021] 4,4’-ビベンゾ[c]チオフェン誘導体の合成,光学的および電気化学的性質【JST・京大機械翻訳】
[2021] Acylative Desymmetrization of Glycerol Derivatives by Chiral DMAP Derivatives
DOI: https://doi.org/10.3987/com-21-14433
[2021] Synthesis, optical and electrochemical properties of 4,4′-bibenzo[c]thiophene derivatives
DOI: https://doi.org/10.1039/d1ra01189h
[2021] Near-infrared absorption of a benzothiophene-appended triphenylamine radical cation: A novel molecular design of NIR-II dye
DOI: https://doi.org/10.1016/j.dyepig.2021.109929
[2021] Application of an Electrochemical Microflow Reactor for Cyanosilylation: Machine Learning-Assisted Exploration of Suitable Reaction Conditions for Semi-Large-Scale Synthesis
DOI: https://doi.org/10.1021/acs.joc.1c01242
[2021] Cu-Catalyzed Dehydrogenative C–O Cyclization for the Synthesis of Furan-Fused Thienoacenes
DOI: https://doi.org/10.1021/acs.orglett.1c01256

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AI 要約（直近 5 年の研究成果）

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研究成果（56 件）

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