Haruchika Yamamoto 研究室

主宰者：Haruchika Yamamoto

岡山大学・Okayama University Hospital

AI 要約（直近 5 年の研究成果）

当研究室は、肺疾患および肺移植に関連する多角的な臨床・研究課題に取り組んでいます。特に肺移植の周辺領域では、移植前後に生じる複雑な生理学的変化と合併症の解明を目指しており、提供肺の評価・最適化から移植後の長期予後管理まで、包括的なアプローチを採用しています。肺移植関連の研究では、体外肺灌流システムを利用して提供肺の質を評価・改善する手法を開発しており、ゲノム編集技術の応用による臓器の遺伝子改変、提供肺から採取した遺伝物質による移植肺の状態監視、ならびに移植後に生じる腎機能低下などの合併症の遺伝学的背景の解明を進めています。加えて、肺虚血再灌流傷害の機構解析を分子レベルで行い、炎症反応を制御する治療法の開発に取り組んでいます。肺癌領域では、特に膵臓がん既往患者に生じた肺腫瘍や、肺線維症を背景とした肺扁平上皮癌など、複雑な背景を持つ症例の分子診断と病態解明を重点としています。単一細胞解析や空間遺伝子発現解析といった先進的なオミクス技術を活用し、腫瘍と周囲の線維化微小環境との相互作用を明らかにしながら、新たな治療戦略の基礎を構築しています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（31 件）

[2026] Wnt3-mediated fibrosis and carcinogenesis of lung squamous cell carcinoma in idiopathic pulmonary fibrosis
DOI: https://doi.org/10.1016/j.isci.2026.115667
[2026] Abstract 773: Single-cell and spatial transcriptomic profiling reveal fibrosis-related tumor states in lung squamous cell carcinoma associated with idiopathic pulmonary fibrosis.
DOI: https://doi.org/10.1158/1538-7445.am2026-773
[2026] Abstract 4166: Molecular diagnosis of lung tumors with a history of pancreatic cancer: Spatial profiling-based differential markers and functional insights into invasive mucinous adenocarcinoma
DOI: https://doi.org/10.1158/1538-7445.am2026-4166
[2026] Risk Factors for Waiting List Mortality in Lung Transplant Candidates With Post‐Hematopoietic Stem Cell Transplantation Non‐Infectious Pulmonary Complications
DOI: https://doi.org/10.1111/ctr.70582
[2026] Analysis report of the association between pre-transplant body mass index and mortality and primary graft dysfunction after lung transplantation
DOI: https://doi.org/10.17605/osf.io/nszyc
[2026] Tailored Management of Anomalous Systemic Arterial Supply to the Basal Segment of the Lung: A Case Report and Literature Review
DOI: https://doi.org/10.70352/scrj.cr.26-0288
[2025] Survival and functional outcomes of single lung transplantation in secondary pulmonary hypertension
DOI: https://doi.org/10.1016/j.resinv.2025.09.022
[2025] Late Recurrence of Empyema More Than a Decade after Window Thoracostomy: Secondary <i>Aspergillus</i> Infection Superimposed on Prior MRSA Empyema, Successfully Managed by Stepwise Surgical and Endobronchial Definitive Closure
DOI: https://doi.org/10.1177/10962964251407580
[2025] The role of video-assisted thoracoscopic surgery in blunt and penetrating chest trauma: timing of intervention and clinical outcomes—a review of the current evidence
DOI: https://doi.org/10.21037/vats-25-32
[2025] Rapid donor-specific single nucleotide variation detection by nanopore sequencing of ex vivo lung perfusate
DOI: https://doi.org/10.1016/j.jhlto.2025.100433

続きを表示（残り 21 件）

[2025] Cell-free DNA in ex-vivo lung perfusate is associated with low-quality lungs and lung transplant outcome
DOI: https://doi.org/10.1016/j.healun.2025.02.1693
[2024] CRISPR-Cas Genome Editing in <i>Ex Vivo</i> Human Lungs to Rewire the Translational Path of Genome-Targeting Therapeutics
DOI: https://doi.org/10.1089/hum.2023.223
[2023] Elderly lung transplant recipients show acceptable long-term outcomes for lung transplantation: A propensity score-matched analysis
DOI: https://doi.org/10.1007/s00595-023-02699-5
[2023] Restrictive allograft dysfunction rather than bronchiolitis obliterans syndrome had a major impact on the overall survival after living-donor lobar lung transplantation
DOI: https://doi.org/10.1007/s00595-023-02729-2
[2023] Ex vivo lung perfusion moderates gene expression differences between cardiac death and brain death donor lungs
DOI: https://doi.org/10.1016/j.jhlto.2023.100027
[2023] In vivo lung perfusion for prompt recovery from primary graft dysfunction after lung transplantation
DOI: https://doi.org/10.1016/j.healun.2023.10.011
[2023] Identification of genetic loci associated with renal dysfunction after lung transplantation using an ethnic-specific single-nucleotide polymorphism array
DOI: https://doi.org/10.1038/s41598-023-36143-y
[2023] Diagnostic value of circulating microRNA-21 in chronic lung allograft dysfunction after bilateral cadaveric and living-donor lobar lung transplantation
DOI: https://doi.org/10.1016/j.heliyon.2023.e14903
[2022] The impact of prognostic nutrition index on the waitlist mortality of lung transplantation
DOI: https://doi.org/10.1007/s11748-022-01895-3
[2022] Functional Blockage of S100A8/A9 Ameliorates Ischemia–Reperfusion Injury in the Lung
DOI: https://doi.org/10.3390/bioengineering9110673
[2022] Paediatric lung transplantation: the impact of age on the survival
DOI: https://doi.org/10.1007/s00595-022-02492-w
[2022] Diagnostic Value of Circulating Microrna-21 in Chronic Lung Allograft Dysfunction after Bilateral Cadaveric and Living-Donor Lobar Lung Transplantation
DOI: https://doi.org/10.2139/ssrn.4268760
[2021] Effect of preoperative long-term use of corticosteroids on the development of post-transplant lymphoproliferative disorders after lung transplantation: a single-center experience in Japan
DOI: https://doi.org/10.1007/s00595-021-02390-7
[2021] Meticulous closure of collateral vessels in the perihilar mediastinal pleura to control intraoperative bleeding during lung transplantation for pulmonary hypertension
DOI: https://doi.org/10.21037/jtd-21-1119
[2021] Emphysematous changes and lower levels of plasma irisin are associated with bronchiolitis obliterans syndrome after bilateral living-donor lobar lung transplantation
DOI: https://doi.org/10.1007/s00595-021-02339-w
[2021] Lung Transplantation for Bronchiectasis Due to Hyperimmunoglobulin E Syndrome
DOI: https://doi.org/10.1016/j.athoracsur.2021.05.088
[2021] Pediatric Lung Transplantation−Intermediate Outcomes of a Japanese Center
DOI: https://doi.org/10.1016/j.healun.2021.01.995
[2021] Post-Transplant Lymphoproliferative Disorder in Lung Transplantation: A Single-Center Experience in Japan
DOI: https://doi.org/10.1016/j.healun.2021.01.884
[2021] The UNCX Polymorphism is Associated with the Development of Renal Dysfunction after Lung Transplantation
DOI: https://doi.org/10.1016/j.healun.2021.01.977
[2021] The prognostic nutritional index is correlated negatively with the lung allocation score and predicts survival after both cadaveric and living-donor lobar lung transplantation
DOI: https://doi.org/10.1007/s00595-021-02244-2
[2021] Drainage tube management after pancreaticoduodenectomy using fistulography findings
DOI: https://doi.org/10.1016/j.hpb.2020.11.694

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AI 要約（直近 5 年の研究成果）

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関連研究室(8 件)

研究成果（31 件）

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