Sachiko Tsukamoto 研究室

主宰者：Sachiko Tsukamoto

熊本大学

AI 要約（直近 5 年の研究成果）

本研究室では、天然物由来の化学物質が生命現象に与える影響を明らかにすることを目指しています。植物、菌類、海洋生物などから単離された有機化合物の構造を決定し、それらの生物活性を評価することで、疾病の治療に応用できる新規医薬品候補物質の発掘を進めています。特に、複雑な立体構造を持つ天然物の全合成を行い、構造と機能の関係を詳細に調べる研究に取り組んでいます。研究の主な対象は、がん関連タンパク質や骨代謝に関わる細胞、神経変性疾患に関連するタンパク質分解システムなど、多岐にわたります。具体的には、がん治療に向けた異常なタンパク質p53の改変、骨粗鬆症の予防と治療につながる破骨細胞分化の抑制、プロテアソームを介したタンパク質の異常な蓄積の抑制などを対象としています。研究手法としては、細胞培養を用いた生物活性評価、機械学習を活用した高速スクリーニング、質量分析やNMRなどの分析技術を組み合わせた構造決定が行われています。これらの研究を通じて、天然物化学と合成有機化学、生物学を融合させた学際的なアプローチで、基礎科学と応用医学をつなぐ重要な発見が継続的に報告されています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

外部リンク

研究成果（28 件）

[2025] Bioinspired Total Synthesis and Structural Reidentification of Alstrostines
DOI: https://doi.org/10.1002/chem.202500069
[2025] Pestones A and B from a Fungus Pestalotiopsis sp. Bound to Mutant p53 and Changed Its Conformation
DOI: https://doi.org/10.1021/acs.jnatprod.4c01440
[2025] New ferrichrome-type siderophores produced by Fusarium lateritium cultured on sodium nitrate-supplemented rice medium
DOI: https://doi.org/10.1007/s11418-025-01954-y
[2025] Colletofragarone A2 from the fungus Colletotrichum sp. promoted the degradation and aggregation of mutant p53
DOI: https://doi.org/10.1016/j.phytol.2025.103112
[2025] Natural products that suppress 2-deoxy-d-glucose-induced cell death as potential drug seeds for mitochondrial diseases
DOI: https://doi.org/10.1016/j.bmc.2025.118478
[2024] Machine Learning Accelerates Screening of Osteoclast Differentiation Inhibitors from Natural Products
DOI: https://doi.org/10.1021/acs.jnatprod.4c00640
[2024] A new linear peptide, higapeptin, isolated from the mud flat-derived fungus Acremonium persicinum inhibits mitochondrial energy metabolism
DOI: https://doi.org/10.1007/s11418-024-01784-4
[2024] Neopetromin, a Cyclic Tripeptide with a C–N Cross-Link, from the Marine Sponge Neopetrosia sp., That Causes Vacuole Fragmentation in Tobacco BY-2 Cells
DOI: https://doi.org/10.1021/acs.jnatprod.4c00158
[2023] A monoacylglyceryltrimethylhomoserine, 21F121-A, containing a branched acyl group from Penicillium glaucoroseum
DOI: https://doi.org/10.1007/s11418-023-01735-5
[2023] Divergent Total Syntheses of Hetero-Oligomeric Iridoid Glycosides
DOI: https://doi.org/10.1021/acs.orglett.2c03965

続きを表示（残り 18 件）

[2023] Syrosingopine Enhances 20S Proteasome Activity and Degradation of α-Synuclein
DOI: https://doi.org/10.1021/acs.jnatprod.3c00661
[2023] The Search for Inhibitors of the Ubiquitin-proteasome System from Natural Sources by Cell-based Screening in Reporter-expressing Cells
DOI: https://doi.org/10.5059/yukigoseikyokaishi.81.1073
[2023] Akanthomins A–C, aphidicolin analogs from a fungus Akanthomyces sp., that inhibit cell cycle
DOI: https://doi.org/10.1016/j.phytochem.2023.113885
[2023] Synthesis and Biological Evaluation of Siladenoserinol A Analogs Possessing a Diastereomeric 6,8-Dioxabicyclo[3.2.1]octane Skeleton
DOI: https://doi.org/10.1246/bcsj.20230197
[2023] Aaptocarbamates A−G, chlorinated terpene carbamates with antiosteoclastogenic activities from the marine sponge Aaptos sp.
DOI: https://doi.org/10.1016/j.phytochem.2023.113872
[2023] CyclosporinA Derivative as Therapeutic Candidate for Alport Syndrome by Inducing Mutant Type IV Collagen Secretion
DOI: https://doi.org/10.34067/kid.0000000000000134
[2022] Data Science-Driven Analysis of Substrate-Permissive Diketopiperazine Reverse Prenyltransferase NotF: Applications in Protein Engineering and Cascade Biocatalytic Synthesis of (−)-Eurotiumin A
DOI: https://doi.org/10.1021/jacs.2c06631
[2022] Isolation, Synthesis, and Structure–Activity Relationship Study on Daphnane and Tigliane Diterpenes as HIV Latency-Reversing Agents
DOI: https://doi.org/10.1021/acs.jmedchem.1c01973
[2022] Cell-based screening of extracts of natural sources to search for inhibitors of the ubiquitin–proteasome system and identification of proteasome inhibitors from the fungus Remotididymella sp.
DOI: https://doi.org/10.1016/j.bmcl.2022.128566
[2022] Arteperoxides A–C, tris-normonoterpene–sesquiterpene conjugates with peroxide-bridges from Artemisia judaica exhibiting antiosteoclastogenic activity
DOI: https://doi.org/10.1016/j.phytochem.2022.113548
[2022] Combinatorial screening for therapeutics in ATTRv amyloidosis identifies naphthoquinone analogues as TTR-selective amyloid disruptors
DOI: https://doi.org/10.1016/j.jphs.2022.11.004
[2022] Cyclopsammocinamides A and B, Enantiomeric Cyclic Peptides of Cyclocinamide A, from the Marine Sponge Psammocinia sp.
DOI: https://doi.org/10.1248/cpb.c22-00523
[2022] Colletofragarone A2 Inhibits Cancer Cell Growth In Vivo and Leads to the Degradation and Aggregation of Mutant p53
DOI: https://doi.org/10.1021/acs.chemrestox.2c00202
[2021] Neopetrosidines A–D, pyridine alkaloids isolated from the marine sponge Neopetrosia chaliniformis and their cell cycle elongation activity
DOI: https://doi.org/10.1016/j.bmc.2021.116461
[2021] Halichonic Acid B, a Rearranged Nitrogenous Bisabolene-Type Sesquiterpene from a Marine Sponge Axinyssa sp.
DOI: https://doi.org/10.1248/cpb.c21-00392
[2021] Amakusamine from a Psammocinia sp. Sponge: Isolation, Synthesis, and SAR Study on the Inhibition of RANKL-Induced Formation of Multinuclear Osteoclasts
DOI: https://doi.org/10.1021/acs.jnatprod.1c00758
[2021] Colletofragarone A2 and Colletoins A–C from a Fungus Colletotrichum sp. Decrease Mutant p53 Levels in Cells
DOI: https://doi.org/10.1021/acs.jnatprod.1c00913
[2021] Taichunins E–T, Isopimarane Diterpenes and a 20-nor-Isopimarane, from Aspergillus taichungensis (IBT 19404): Structures and Inhibitory Effects on RANKL-Induced Formation of Multinuclear Osteoclasts
DOI: https://doi.org/10.1021/acs.jnatprod.1c00486

科研費（0 件）

まだデータがありません（KAKEN 取り込み後に表示）。

所属学会・役職（0 件）

まだデータがありません（学会データ連携後に表示）。

AI 要約（直近 5 年の研究成果）

外部リンク

関連研究室(8 件)

研究成果（28 件）

科研費（0 件）

所属学会・役職（0 件）