Takashi Murayama 研究室

主宰者：Takashi Murayama

順天堂大学

AI 要約（直近 5 年の研究成果）

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研究成果（83 件）

[2026] BPS2026 – High-throughput screening for ryanodine receptor modulators using a novel green ER Ca2+ sensor protein
DOI: https://doi.org/10.1016/j.bpj.2025.11.2436
[2026] Baculovirus-mediated gene transfer enables functional expression of the PIEZO1 ion channel in isolated muscle satellite cells
DOI: https://doi.org/10.1242/jcs.264416
[2026] Establishing the predictive validity and determining cutoff values of the capabilities of upper extremity test for predicting activities of daily living independence in cervical spinal cord injury
DOI: https://doi.org/10.1038/s41393-026-01221-1
[2026] A novel selective stabilizer of the ryanodine receptor 2 prevents stress‐induced ventricular arrhythmias without impairing cardiac function
DOI: https://doi.org/10.1111/bph.70459
[2025] Isoflurane activates the type 1 ryanodine receptor to induce anesthesia in mice
DOI: https://doi.org/10.1371/journal.pbio.3003172
[2025] Effect of Training Combining Hand-Arm Bimanual Intensive Therapy Concept and Postural Control Elements on Individuals With Chronic Incomplete Cervical Spinal Cord Injury: A Report of Two Cases
DOI: https://doi.org/10.7759/cureus.79695
[2025] Factors associated with home discharge for individuals with cervical spinal cord injuries: Analysis according to age group
DOI: https://doi.org/10.1080/10790268.2024.2432732
[2025] Crystal structures of Ryanodine Receptor reveal dantrolene and azumolene interactions guiding inhibitor development
DOI: https://doi.org/10.1038/s41467-025-65096-1
[2025] CCDC141 is a Connectin/Titin and Nesprin-1 binding protein that adapts cardiomyocytes to mechanical stress
DOI: https://doi.org/10.1038/s42003-025-09093-6
[2025] RyR1-mediated Ca 2+ -induced Ca 2+ release plays a negligible role in excitation–contraction coupling of normal skeletal muscle
DOI: https://doi.org/10.1073/pnas.2500449122

続きを表示（残り 73 件）

[2025] Non-invasive closed-loop spinal stimulation restores leg stepping control in humans with paraplegia
DOI: https://doi.org/10.1093/brain/awaf230
[2025] Development of selective RyR2 inhibitors with a pharmacophore containing a parabanic acid skeleton
DOI: https://doi.org/10.1039/d5md00183h
[2024] Pivotal role of S5 segment and S5–S6 luminal loop in the channel gating of type 1 ryanodine receptor (RyR1)
DOI: https://doi.org/10.1016/j.bpj.2023.11.1558
[2024] Dantrolene inhibition of ryanodine receptor 1 carrying the severe malignant hyperthermia mutation Y522S visualized by cryo-EM
DOI: https://doi.org/10.1016/j.str.2024.11.018
[2024] Cryo-EM structures of ryanodine receptors and diamide insecticides reveal the mechanisms of selectivity and resistance
DOI: https://doi.org/10.1038/s41467-024-53490-0
[2024] MG53’s non-physiologic interaction with insulin receptor: lack of effect on insulin-stimulated Akt phosphorylation in muscle, heart and liver tissues
DOI: https://doi.org/10.3389/fendo.2024.1425426
[2024] Carvedilol suppresses ryanodine receptor-dependent Ca2+ bursts in human neurons bearing PSEN1 variants found in early onset Alzheimer’s disease
DOI: https://doi.org/10.1371/journal.pone.0291887
[2024] Dual role of the S5 segment in type 1 ryanodine receptor channel gating
DOI: https://doi.org/10.1038/s42003-024-06787-1
[2024] Relationship between the amount of physical activity and brain structure in patients with chronic stroke
DOI: https://doi.org/10.1080/01616412.2024.2354619
[2024] Discovery and Structure–Activity Relationship of a Ryanodine Receptor 2 Inhibitor
DOI: https://doi.org/10.1248/cpb.c24-00114
[2024] Effects of a high-affinity and selective RyR2 inhibitor on Ca2+ signals in cardiomyocytes and arrhythmias in CPVT model mice
DOI: https://doi.org/10.1016/j.bpj.2023.11.247
[2024] Myosin phosphatase targeting subunit1 controls localization and motility of Rab7‐containing vesicles: Is myosin phosphatase a cytoplasmic dynein regulator?
DOI: https://doi.org/10.1002/cm.21871
[2024] An inherited life-threatening arrhythmia model established by screening randomly mutagenized mice
DOI: https://doi.org/10.1073/pnas.2218204121
[2024] Functional analysis of Ca2+ signaling in a mouse model of malignant hyperthermia
DOI: https://doi.org/10.1016/j.bpj.2023.11.1551
[2023] Construction of a screening platform based on integration of in silico and biochemical experiments
DOI: https://doi.org/10.1254/jpssuppl.97.0_2-b-p-086
[2023] Verification of the Reliability of the Japanese Version of the Clinical Trunk Control Test
DOI: https://doi.org/10.2490/jjrmc.23022
[2023] A potent and selective cis-amide inhibitor of ryanodine receptor 2 as a candidate for cardiac arrhythmia treatment
DOI: https://doi.org/10.1016/j.ejmech.2023.115910
[2023] The biophysical properties of TRIC-A and TRIC-B and their interactions with RyR2
DOI: https://doi.org/10.1085/jgp.202113070
[2023] Characterization of Six Diamide Insecticides on Ryanodine Receptor: Resistance and Species Selectivity
DOI: https://doi.org/10.1021/acs.jafc.3c01750
[2023] Screening for Novel Type 2 Ryanodine Receptor Inhibitors by Endoplasmic Reticulum Ca2+ Monitoring
DOI: https://doi.org/10.1124/molpharm.123.000720
[2023] Novel Calmodulin Variant p.E46K Associated With Severe Catecholaminergic Polymorphic Ventricular Tachycardia Produces Robust Arrhythmogenicity in Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes
DOI: https://doi.org/10.1161/circep.122.011387
[2023] Dysfunctional Ca2+ dynamics in primary skeletal myocytes from R2509C-RYR1 mice
DOI: https://doi.org/10.1016/j.bpj.2022.11.2072
[2023] Effects of a treatment program based on constraint-induced movement therapy for the lower extremities on gait and balance in chronic stroke: a 6-month follow-up pilot study
DOI: https://doi.org/10.1097/mrr.0000000000000578
[2023] Reconstitution of depolarization-induced Ca2+ release for validation of skeletal muscle disease mutations and drug discovery
DOI: https://doi.org/10.1016/j.bpj.2022.11.402
[2023] Arrhythmia severity in mouse models harboring RyR2 mutations with varied extent of channel activity
DOI: https://doi.org/10.1016/j.bpj.2022.11.1395
[2023] Effects of voluntary exercise and administration of renin angiotensin inhibitor on cardiac function in inherited dilated cardiomyopathy model
DOI: https://doi.org/10.1016/j.bpj.2022.11.833
[2023] Development of Ryanodine Receptor (RyR) Inhibitors for Skeletal Muscle and Heart Diseases
DOI: https://doi.org/10.14789/jmj.jmj22-0045-r
[2023] Effects of a novel RyR2 specific inhibitor on arrhythmias in catecholaminergic polymorphic ventricular tachycardia (CPVT) model mice
DOI: https://doi.org/10.1254/jpssuppl.97.0_1-b-o03-1
[2023] Novel CACNA1S mutations for malignant hyperthermia enhance depolarization-induced Ca2+ release
DOI: https://doi.org/10.1254/jpssuppl.97.0_3-b-o16-3
[2023] In silico prediction of RyR1 inhibitor binding structure
DOI: https://doi.org/10.1254/jpssuppl.97.0_2-b-p-087
[2022] High-resolution cryo-EM structures of the magnesium-inhibited and calcium-inactivated RyR1
DOI: https://doi.org/10.1016/j.bpj.2021.11.2648
[2022] Development of a water-soluble ryanodine receptor 1 inhibitor
DOI: https://doi.org/10.1016/j.bmc.2022.117027
[2022] Heat-hypersensitive mutants of ryanodine receptor type 1 revealed by microscopic heating
DOI: https://doi.org/10.1073/pnas.2201286119
[2022] Molecular mechanism of the severe MH/CCD mutation Y522S in skeletal ryanodine receptor (RyR1) by cryo-EM
DOI: https://doi.org/10.1073/pnas.2122140119
[2022] Mice with R2509C-RYR1 mutation exhibit dysfunctional Ca2+ dynamics in primary skeletal myocytes
DOI: https://doi.org/10.1085/jgp.202213136
[2022] A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery
DOI: https://doi.org/10.1085/jgp.202213230
[2022] Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations
DOI: https://doi.org/10.1038/s41467-022-30429-x
[2022] Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2
DOI: https://doi.org/10.1085/jgp.202112869
[2022] High-throughput platform of reconstituted skeletal muscle depolarization-induced Ca2+release in HEK293 cells
DOI: https://doi.org/10.1016/j.bpj.2021.11.2259
[2022] Structural characterization of MH/CCD NTD mutations in skeletal ryanodine receptor by cryo-EM
DOI: https://doi.org/10.1016/j.bpj.2021.11.2273
[2022] Differential impacts of arrhythmia-linked loss-of-function RyR2 mutations on Ca2+ signaling in cardiac cells
DOI: https://doi.org/10.1016/j.bpj.2021.11.1861
[2022] Phosphorylation of cardiac ryanodine receptor (RyR2): a structure-function study of phosphomimetic and phospho-null triple mutants
DOI: https://doi.org/10.1016/j.bpj.2021.11.867
[2022] Anti-arrhythmic effects of novel RyR2 inhibitors screened from well-characterized drug library by ER Ca2+ monitoring.
DOI: https://doi.org/10.1254/jpssuppl.95.0_3-o-107
[2022] Evaluation of RyR2 inhibitors as anti-arrhythmic drugs using novel CPVT model mice
DOI: https://doi.org/10.1254/jpssuppl.95.0_3-p-228
[2022] Reconstitution of skeletal muscle depolarization-induced Ca2+ release supramolecular complex
DOI: https://doi.org/10.1254/jpssuppl.95.0_1-s02-4
[2022] Loss-of-function RyR2 mutations cause various types of arrhythmias through divergent abnormal Ca2+ signaling
DOI: https://doi.org/10.1254/jpssuppl.95.0_3-o-108
[2022] Evaluation of antiarrhythmic agents for catecholaminergic polymorphic ventricular tachycardia (CPVT) using multiple lines of RyR2-mutant mouse models
DOI: https://doi.org/10.1254/jpssuppl.96.0_3-b-o08-3
[2022] Therapeutic effects of voluntary wheel running on cancer cachexia-induced cardiac dysfunction: Approach from the perspective of Cardio-oncology
DOI: https://doi.org/10.1254/jpssuppl.95.0_1-p-046
[2022] Development of a Water-Soluble Ryanodine Receptor 1 Inhibitor
DOI: https://doi.org/10.2139/ssrn.4189785
[2022] Establishment of reconstituted depolarization-induced Ca2+ release platform for drug discovery of skeletal muscle diseases
DOI: https://doi.org/10.1254/jpssuppl.96.0_4-b-o13-1
[2022] Comparison of voluntary exercise and renin angiotensin inhibitor administration in a mouse model of dilated cardiomyopathy
DOI: https://doi.org/10.1254/jpssuppl.96.0_3-b-p-216
[2021] Therapeutic effects of novel type1 ryanodine receptor inhibitor on skeletal muscle diseases
DOI: https://doi.org/10.1254/fpj.21068
[2021] Preface
DOI: https://doi.org/10.1254/fpj.21073
[2021] Biophysical characteristics of TRIC-A and TRIC-B channels and their regulation of RYR2
DOI: https://doi.org/10.1085/jgp.2021ecc13
[2021] Structural basis for diamide modulation of ryanodine receptor
DOI: https://doi.org/10.1085/jgp.2021ecc17
[2021] Cryo-EM reveals local and global structural rearrangements in RYR mutants
DOI: https://doi.org/10.1085/jgp.2021ecc44
[2021] Assessment of safety of self-controlled repetitive trans-vertebral magnetic stimulation
DOI: https://doi.org/10.1016/j.clinph.2021.09.016
[2021] Sudden death after inappropriate shocks of implantable cardioverter defibrillator in a catecholaminergic polymorphic ventricular tachycardia case with a novel RyR2 mutation
DOI: https://doi.org/10.1016/j.jelectrocard.2021.09.015
[2021] Loss-of-function mutations in cardiac ryanodine receptor channel cause various types of arrhythmias including long QT syndrome
DOI: https://doi.org/10.1093/europace/euab250
[2021] A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke
DOI: https://doi.org/10.1038/s41467-021-24644-1
[2021] Electron Microscope Studies on the Structural Complex of Transverse Tubules and Sarcoplasmic Reticulum in Scorpionfish Swimbladder Muscles
[2021] Inhibition of endothelin A receptor by a novel, selective receptor antagonist enhances morphine-induced analgesia: Possible functional interaction of dimerized endothelin A and μ-opioid receptors
DOI: https://doi.org/10.1016/j.biopha.2021.111800
[2021] Anatomical Increased/Decreased Changes in the Brain Area Following Individuals with Chronic Traumatic Complete Thoracic Spinal Cord Injury
DOI: https://doi.org/10.1298/ptr.e10076
[2021] Differential effects of the formin inhibitor SMIFH2 on contractility and Ca2+ handling in frog and mouse cardiomyocytes
DOI: https://doi.org/10.1111/gtc.12873
[2021] The zinc-binding motif of TRPM7 acts as an oxidative stress sensor to regulate its channel activity
DOI: https://doi.org/10.1085/jgp.202012708
[2021] Cryo-Em Studies of Phosphomimetic and Phospho-Null Triple Mutants of Cardiac Ryanodine Receptor (RyR2)
DOI: https://doi.org/10.1016/j.bpj.2020.11.1574
[2021] Structural Insights into the Diamide Modulation of Ryanodine Receptor
DOI: https://doi.org/10.1016/j.bpj.2020.11.1090
[2021] Gender differences in the effect of spontaneous exercise on heart failure in DCM model mice
DOI: https://doi.org/10.1254/jpssuppl.94.0_3-p2-10
[2021] Purification of Recombinant Wild Type and Mutant Ryanodine Receptors Expressed in HEK293 Cells
DOI: https://doi.org/10.21769/bioprotoc.4112
[2021] Cancer cachexia-induced myocardial impairment could be improved by voluntary wheel running
DOI: https://doi.org/10.1254/jpssuppl.94.0_1-o-d2-4
[2021] Characterization of novel RyR1 selective inhibitors identified by ER Ca2+ measurements
DOI: https://doi.org/10.1254/jpssuppl.94.0_3-p2-27
[2021] Identification of binding site for a novel RyR1-selective inhibitor
DOI: https://doi.org/10.1254/jpssuppl.94.0_3-p2-26
[2021] Effects of RyR2 specific inhibitors on arrhythmia in CPVT model mice
DOI: https://doi.org/10.1254/jpssuppl.94.0_1-o-d3-1

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AI 要約（直近 5 年の研究成果）

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研究成果（83 件）

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