Mamoru Watanabe 研究室
主宰者：Mamoru Watanabe
東京大学
AI 要約（直近 5 年の研究成果）
渡辺守研究室は、消化器疾患、特に炎症性腸疾患やがんといった腹部の疾患について、細胞や組織のレベルから臨床応用まで、多角的なアプローチで研究しています。研究の特徴は、患者由来の細胞を培養皿の中で立体的に組織化した「オルガノイド」という模型を活用している点です。これにより、生きた人間の組織で実際に起きている現象をより正確に再現し、病気のメカニズムや新しい治療法の効果を調べることができます。
同時に、感染症の側面からも疾患を研究しており、特にマダニが媒介するウイルスについて、次世代シーケンシング技術を用いた遺伝子解析を行っています。これまで正体が不明だったウイルスの特定や、日本国内における流行状況の把握に貢献しています。さらに、既存の医療現場のデータを活用した臨床研究も多数実施しており、新規治療薬の有効性・安全性の検証や、患者の特性に合わせた最適な治療方法の開発に取り組んでいます。このように基礎研究から臨床へと連携させるアプローチにより、患者にとってより良い治療法の実現を目指しています。
※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。
外部リンク
関連研究室(8 件)
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研究成果（169 件）
- Discovery and Theoretical Studies of Nonenzymatic Polyketide Dimerizations of ChaetophenolsDOI: https://doi.org/10.1021/acs.orglett.4c04346
- Once-Daily Oral Ozanimod for Japanese Patients With Ulcerative Colitis: Results From the Phase 2/3 J-True North StudyDOI: https://doi.org/10.1016/j.gastha.2025.100812
- Optimising carotegrast methyl use in ulcerative colitis: patient profiling, predictive biomarkers, and timing of efficacy evaluation (ASPECT study)DOI: https://doi.org/10.1007/s00535-025-02299-9
- Intestinal CD4−CD8αβ−TCRαβ+ T cells function as tolerogenic antigen presenting cells in miceDOI: https://doi.org/10.1038/s41467-025-62089-y
- Crosstalk via ICAM-1 enhances supportive phenotype of stellate cells and drives hepatocyte proliferation in iPSC-derived hepatic organoidsDOI: https://doi.org/10.1016/j.stemcr.2025.102642
- [2025] 兵庫県で採集されたヤマトマダニのRNA ウイルーム解析RNA Virome Analysis of <i>Haemaphysalis longicornis</i> Ticks Collected in Hyogo, JapanDOI: https://doi.org/10.7883/yoken.jjid.2025.027
- COI barcoding can distinguish bisexual and parthenogenetic populations of Haemaphysalis longicornis in Japan: Revisiting methods with SNP analysis as another possible methodDOI: https://doi.org/10.1016/j.ijppaw.2025.101083
- An Early Phase 2 Double-Blind, Placebo-Controlled Study of E6011, a Novel Anti-Fractalkine Antibody, in Patients with Crohn’s DiseaseDOI: https://doi.org/10.1159/000548232
- Occurrence of mosquitoes, in particular <i>Culex tritaeniorhynchus</i> in the Noto Peninsula, Honshu, JapanDOI: https://doi.org/10.7601/mez.75.59
- <scp>A20</scp> in hepatic stellate cells suppresses chronic hepatitis by inhibiting <scp>DCLK1</scp> – <scp>JNK</scp> pathway‐dependent chemokinesDOI: https://doi.org/10.1096/fj.202400109r
続きを表示（残り 159 件）閉じる
- Discovery of non-genomic drivers of YAP signaling modulating the cell plasticity in CRC tumor linesDOI: https://doi.org/10.1016/j.isci.2024.109247
- Inadequate Efficacy of Biologics for Treating Proximal Ileal Lesions in Crohn’s Disease: A Prospective Multicenter StudyDOI: https://doi.org/10.1016/j.cgh.2024.10.030
- Hepatitis B Virus-KMT2B Integration Drives Hepatic Oncogenic Processes in a Human Gene-edited Induced Pluripotent Stem Cells-derived ModelDOI: https://doi.org/10.1016/j.jcmgh.2024.101422
- Optimization of transplantation methods using isolated mesenchymal stem/stromal cells: clinical trials of inflammatory bowel diseases as an exampleDOI: https://doi.org/10.1186/s41232-024-00350-5
- Palliative use of self-expanding metal stents in initially anticancer treatment-intolerant patients with esophageal cancerDOI: https://doi.org/10.1186/s12876-024-03329-1
- Complaints caused by millipedes (Diplopoda) on the evidence of identification service and consultation by the Toyama Institute of Health in Toyama Prefecture, JapanDOI: https://doi.org/10.7601/mez.75.1
- Efficacy and safety of mirikizumab as induction and maintenance therapy for Japanese patients with moderately to severely active ulcerative colitis: a subgroup analysis of the global phase 3 LUCENT-1 and LUCENT-2 studiesDOI: https://doi.org/10.5217/ir.2023.00043
- [2024] 慢性結腸炎患者のT細胞におけるアペリン発現の低下P082 Downregulated apelin expression in T cells in the setting of Chronic ColitisDOI: https://doi.org/10.1093/ecco-jcc/jjad212.0212
- Su1795 OZANIMOD AS INDUCTION AND MAINTENANCE THERAPY FOR ULCERATIVE COLITIS: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY IN JAPAN (J-TRUE NORTH)DOI: https://doi.org/10.1016/s0016-5085(24)02359-x
- P687 Ozanimod as a once-daily oral therapy for Japanese patients with ulcerative colitis: results from the induction period of a Phase 2/3 study (J-True North)DOI: https://doi.org/10.1093/ecco-jcc/jjad212.0817
- Efficacy and safety of filgotinib as induction and maintenance therapy for Crohn's disease (DIVERSITY): a phase 3, double-blind, randomised, placebo-controlled trialDOI: https://doi.org/10.1016/s2468-1253(24)00272-3
- Identification of novel tick-associated RNA virus sequences from questing ticks collected in Ishikawa and Ehime Prefectures, JapanDOI: https://doi.org/10.7601/mez.75.191
- Identification and epidemiological study of an uncultured flavivirus from ticks using viral metagenomics and pseudoinfectious viral particlesDOI: https://doi.org/10.1073/pnas.2319400121
- [2024] 群馬県片品村オゼガハラ湿地で採集された蚊幼虫Mosquito larvae collected at the Ozegahara wetland in Katashina, Gunma, JapanDOI: https://doi.org/10.7601/mez.75.17
- [2024] 肝疾患患者の骨格筋量評価におけるESMIの有用性The utility of ESMI in assessing skeletal muscle mass in patients with liver diseaseDOI: https://doi.org/10.1016/j.clnesp.2024.07.367
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- DOI: https://doi.org/10.35848/1882-0786/acc005
- DOI: https://doi.org/10.1007/s00535-023-01959-y
- DOI: https://doi.org/10.1016/j.bbrc.2023.01.068
- DOI: https://doi.org/10.1186/s41232-022-00237-3
- DOI: https://doi.org/10.1002/jgh3.12857
- DOI: https://doi.org/10.2169/internalmedicine.0839-22
- [2022] Serum Leucine-Rich α2 Glycoprotein: A Novel Biomarker for Transmural Inflammation in Crohn's DiseaseDOI: https://doi.org/10.14309/ajg.0000000000002127
- DOI: https://doi.org/10.1093/ecco-jcc/jjac185
- DOI: https://doi.org/10.1002/jgh3.12857
- DOI: https://doi.org/10.2169/internalmedicine.0839-22
- [2022] Serum Leucine-Rich α2 Glycoprotein: A Novel Biomarker for Transmural Inflammation in Crohn's DiseaseDOI: https://doi.org/10.14309/ajg.0000000000002127
- DOI: https://doi.org/10.1093/ecco-jcc/jjac185
- DOI: https://doi.org/10.1186/s41232-022-00237-3
- [2022] Suspension culture in a rotating bioreactor for efficient generation of human intestinal organoidsDOI: https://doi.org/10.1016/j.crmeth.2022.100337
- DOI: https://doi.org/10.14309/01.ajg.0000859700.09368.7e
- DOI: https://doi.org/10.7601/mez.73.145
- [2022] Zranb1-mutant mice display abnormal colonic mucus production and exacerbation of DSS-induced colitisDOI: https://doi.org/10.1016/j.bbrc.2022.08.046
- DOI: https://doi.org/10.1002/ccr3.5981
- DOI: https://doi.org/10.1007/s00464-022-09240-8
- DOI: https://doi.org/10.1007/s00384-022-04161-3
- [2022] Suspension culture in a rotating bioreactor for efficient generation of human intestinal organoidsDOI: https://doi.org/10.1016/j.crmeth.2022.100337
- DOI: https://doi.org/10.14309/01.ajg.0000859700.09368.7e
- DOI: https://doi.org/10.7601/mez.73.145
- [2022] Zranb1-mutant mice display abnormal colonic mucus production and exacerbation of DSS-induced colitisDOI: https://doi.org/10.1016/j.bbrc.2022.08.046
- DOI: https://doi.org/10.1002/ccr3.5981
- DOI: https://doi.org/10.1007/s00464-022-09240-8
- DOI: https://doi.org/10.1007/s00384-022-04161-3
- [2022] Prognostic Impact of Immune-related Adverse Events in Gastric Cancer Patients Treated With NivolumabDOI: https://doi.org/10.21873/anticanres.15626
- DOI: https://doi.org/10.2463/mrms.mp.2021-0037
- DOI: https://doi.org/10.1186/s12876-022-02300-2
- [2022] 335: SPONTANEOUS INFLAMMATION SPECIFICALLY IN THE ILEUM IS INDUCED BY SELECTIVE IGA DEFICIENCYDOI: https://doi.org/10.1016/s0016-5085(22)60175-6
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- DOI: https://doi.org/10.1016/s2468-1253(22)00022-x
- DOI: https://doi.org/10.5217/ir.2021.00143
- DOI: https://doi.org/10.2463/mrms.mp.2021-0037
- DOI: https://doi.org/10.1186/s12876-022-02300-2
- [2022] 335: SPONTANEOUS INFLAMMATION SPECIFICALLY IN THE ILEUM IS INDUCED BY SELECTIVE IGA DEFICIENCYDOI: https://doi.org/10.1016/s0016-5085(22)60175-6
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- DOI: https://doi.org/10.1016/s2468-1253(22)00022-x
- DOI: https://doi.org/10.5217/ir.2021.00143
- [2022] Prognostic Impact of Immune-related Adverse Events in Gastric Cancer Patients Treated With NivolumabDOI: https://doi.org/10.21873/anticanres.15626
- DOI: https://doi.org/10.1053/j.gastro.2022.02.033
- DOI: https://doi.org/10.1016/j.bbrc.2021.12.111
- DOI: https://doi.org/10.1177/26317745221103735
- DOI: https://doi.org/10.1053/j.gastro.2022.02.033
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- DOI: https://doi.org/10.1177/26317745221103735
- DOI: https://doi.org/10.1016/j.bbrc.2021.01.023
- DOI: https://doi.org/10.1111/jgh.15399
- DOI: https://doi.org/10.1007/s11604-020-01082-5
- DOI: https://doi.org/10.3390/v13122547
- DOI: https://doi.org/10.1186/s12876-021-02043-6
- DOI: https://doi.org/10.1016/s2468-1253(21)00372-1
- DOI: https://doi.org/10.1016/j.bbrep.2021.101065
- DOI: https://doi.org/10.1093/ecco-jcc/jjab201
- DOI: https://doi.org/10.1136/gutjnl-2021-bsg.10
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- DOI: https://doi.org/10.3390/agriculture11100974
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- DOI: https://doi.org/10.1016/s0016-5085(21)01986-7
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- DOI: https://doi.org/10.1016/j.jcmgh.2021.08.018
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- [2021] Immunoglobulin A–specific deficiency induces spontaneous inflammation specifically in the ileumDOI: https://doi.org/10.1136/gutjnl-2020-322873
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- [2021] Immunoglobulin A–specific deficiency induces spontaneous inflammation specifically in the ileumDOI: https://doi.org/10.1136/gutjnl-2020-322873
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- DOI: https://doi.org/10.1111/apt.16310
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- [2021] Deep Neural Network Accurately Predicts Prognosis of Ulcerative Colitis Using Endoscopic ImagesDOI: https://doi.org/10.1053/j.gastro.2021.01.210
- DOI: https://doi.org/10.1016/j.bbrc.2021.01.021
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- [2021] Deep Neural Network Accurately Predicts Prognosis of Ulcerative Colitis Using Endoscopic ImagesDOI: https://doi.org/10.1053/j.gastro.2021.01.210
- DOI: https://doi.org/10.1016/j.bbrc.2021.01.021
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- DOI: https://doi.org/10.1016/s2468-1253(21)00372-1
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