Takashi Sakurai 研究室

主宰者：Takashi Sakurai

順天堂大学・Juntendo University Hospital

AI 要約（直近 5 年の研究成果）

要約はまだ生成されていません。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

外部リンク

研究成果（68 件）

[2026] BPS2026 – Enhanced depolarization-induced calcium release by CaV1.1 variants associated with malignant hyperthermia susceptibility
DOI: https://doi.org/10.1016/j.bpj.2025.11.2440
[2026] BPS2026 – High-throughput screening for ryanodine receptor modulators using a novel green ER Ca2+ sensor protein
DOI: https://doi.org/10.1016/j.bpj.2025.11.2436
[2026] Cost-effectiveness of multimodal intervention for the prevention of dementia in Japan
DOI: https://doi.org/10.1016/j.tjpad.2025.100460
[2025] Feasibility of a Multidomain Intervention Program for Community‐Dwelling Older Adults Based on Implementation Science (J‐MINT Community)
DOI: https://doi.org/10.1002/alz70860_102524
[2025] An Empirical Study on Supporting Work‐Life Balance for Working Carers: Analysis of the Impact of Health Status, Work Environment, and Care Environment
DOI: https://doi.org/10.1002/alz70860_104505
[2025] Association between DPP‐4 inhibitor use and changes in dementia‐related plasma biomarkers in older adults with type 2 diabetes: post‐hoc analyses of J‐MINT
DOI: https://doi.org/10.1002/alz70856_101474
[2025] A Feasibility Study of a Non‐Professional‐Led Multi‐Component Psychosocial Support Program Incorporating Laughter and Music for People Living with Dementia and Their Families
DOI: https://doi.org/10.1002/alz70858_104279
[2025] CCDC141 is a Connectin/Titin and Nesprin-1 binding protein that adapts cardiomyocytes to mechanical stress
DOI: https://doi.org/10.1038/s42003-025-09093-6
[2025] Association Between Oral Frailty and Metrics Derived from Continuous Glucose Monitoring in Older Patients with Type 2 Diabetes
DOI: https://doi.org/10.1177/29986702251385558
[2025] Feasibility and effectiveness of a handbook-based multidomain lifestyle intervention for older adults with mild cognitive impairment: A quasi-experimental design with propensity score matching
DOI: https://doi.org/10.1177/13872877251372957

続きを表示（残り 58 件）

[2025] RyR1-mediated Ca 2+ -induced Ca 2+ release plays a negligible role in excitation–contraction coupling of normal skeletal muscle
DOI: https://doi.org/10.1073/pnas.2500449122
[2025] Investigation of Combustion Characteristics of Hydrogen Lifted Flames in a Small Hydrogen Combustion Chamber
DOI: https://doi.org/10.1115/gt2025-151113
[2025] Obituary: Tadashi Hirayama (1934 – 2025)
DOI: https://doi.org/10.1007/s11207-025-02479-z
[2024] Cost‐effectiveness analysis of the multimodal intervention for dementia prevention: post‐hoc sub‐group analyses of the J‐MINT
DOI: https://doi.org/10.1002/alz.086754
[2024] Dual role of the S5 segment in type 1 ryanodine receptor channel gating
DOI: https://doi.org/10.1038/s42003-024-06787-1
[2024] Carvedilol suppresses ryanodine receptor-dependent Ca2+ bursts in human neurons bearing PSEN1 variants found in early onset Alzheimer’s disease
DOI: https://doi.org/10.1371/journal.pone.0291887
[2024] CHCHD2 P14L, found in amyotrophic lateral sclerosis, exhibits cytoplasmic mislocalization and alters Ca2+ homeostasis
DOI: https://doi.org/10.1093/pnasnexus/pgae319
[2024] An inherited life-threatening arrhythmia model established by screening randomly mutagenized mice
DOI: https://doi.org/10.1073/pnas.2218204121
[2024] Effects of a high-affinity and selective RyR2 inhibitor on Ca2+ signals in cardiomyocytes and arrhythmias in CPVT model mice
DOI: https://doi.org/10.1016/j.bpj.2023.11.247
[2024] Pivotal role of S5 segment and S5–S6 luminal loop in the channel gating of type 1 ryanodine receptor (RyR1)
DOI: https://doi.org/10.1016/j.bpj.2023.11.1558
[2024] Nuclear SphK2/S1P signaling is a key regulator of ApoE production and Aβ uptake in astrocytes
DOI: https://doi.org/10.1016/j.jlr.2024.100510
[2024] Effect of hydrogen injection hole diameter on the burning condition of a lifted flame in a hydrogen burner
DOI: https://doi.org/10.38036/jgpp.15.4_v15n4tp07
[2023] A potent and selective cis-amide inhibitor of ryanodine receptor 2 as a candidate for cardiac arrhythmia treatment
DOI: https://doi.org/10.1016/j.ejmech.2023.115910
[2023] Screening for Novel Type 2 Ryanodine Receptor Inhibitors by Endoplasmic Reticulum Ca2+ Monitoring
DOI: https://doi.org/10.1124/molpharm.123.000720
[2023] Experimental Investigation of a Swirling-Oxidizer-Flow-Type Hybrid Rocket Engine Using Low-Melting-Point Thermoplastic Fuel and Oxygen
DOI: https://doi.org/10.3390/aerospace10080713
[2023] Novel Calmodulin Variant p.E46K Associated With Severe Catecholaminergic Polymorphic Ventricular Tachycardia Produces Robust Arrhythmogenicity in Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes
DOI: https://doi.org/10.1161/circep.122.011387
[2023] Specific AAV2/PHP.eB-mediated gene transduction of CA2 pyramidal cells via injection into the lateral ventricle
DOI: https://doi.org/10.1038/s41598-022-27372-8
[2023] Ex vivo analysis platforms for monitoring amyloid precursor protein cleavage
DOI: https://doi.org/10.3389/fnmol.2022.1068990
[2023] Novel CACNA1S mutations for malignant hyperthermia enhance depolarization-induced Ca2+ release
DOI: https://doi.org/10.1254/jpssuppl.97.0_3-b-o16-3
[2023] In silico prediction of RyR1 inhibitor binding structure
DOI: https://doi.org/10.1254/jpssuppl.97.0_2-b-p-087
[2023] Construction of a screening platform based on integration of in silico and biochemical experiments
DOI: https://doi.org/10.1254/jpssuppl.97.0_2-b-p-086
[2023] Effects of a novel RyR2 specific inhibitor on arrhythmias in catecholaminergic polymorphic ventricular tachycardia (CPVT) model mice
DOI: https://doi.org/10.1254/jpssuppl.97.0_1-b-o03-1
[2023] Single-molecule imaging within brain tissue
DOI: https://doi.org/10.1254/jpssuppl.97.0_2-b-o04-3
[2023] Construction of the ELISA assay to quantify Semaphorin 3A in the adult brain
DOI: https://doi.org/10.1254/jpssuppl.97.0_2-b-p-100
[2022] A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery
DOI: https://doi.org/10.1085/jgp.202213230
[2022] Multifaceted analysis of nanotoxicity using primary cultured neurons
DOI: https://doi.org/10.1088/2632-959x/ac7cfd
[2022] Evaluation of Pressure Gain and Turbine Inlet Conditions in a Pulse Combustion Gas Turbine
DOI: https://doi.org/10.1115/gt2022-83528
[2022] Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations
DOI: https://doi.org/10.1038/s41467-022-30429-x
[2022] Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2
DOI: https://doi.org/10.1085/jgp.202112869
[2022] Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease
DOI: https://doi.org/10.1016/j.isci.2022.103869
[2022] High-throughput platform of reconstituted skeletal muscle depolarization-induced Ca2+release in HEK293 cells
DOI: https://doi.org/10.1016/j.bpj.2021.11.2259
[2022] Differential impacts of arrhythmia-linked loss-of-function RyR2 mutations on Ca2+ signaling in cardiac cells
DOI: https://doi.org/10.1016/j.bpj.2021.11.1861
[2022] Regulation of function and metabolism of amyloid-beta precursor protein by Semaphorin3A-PlexinA signaling
DOI: https://doi.org/10.1254/jpssuppl.95.0_1-ss-28
[2022] Anti-arrhythmic effects of novel RyR2 inhibitors screened from well-characterized drug library by ER Ca2+ monitoring.
DOI: https://doi.org/10.1254/jpssuppl.95.0_3-o-107
[2022] Loss-of-function RyR2 mutations cause various types of arrhythmias through divergent abnormal Ca2+ signaling
DOI: https://doi.org/10.1254/jpssuppl.95.0_3-o-108
[2022] Evaluation of RyR2 inhibitors as anti-arrhythmic drugs using novel CPVT model mice
DOI: https://doi.org/10.1254/jpssuppl.95.0_3-p-228
[2022] Construction of the ELISA assay to quantify Semaphorin 3A in the adult brain
DOI: https://doi.org/10.1254/jpssuppl.95.0_3-p-216
[2022] Therapeutic effects of voluntary wheel running on cancer cachexia-induced cardiac dysfunction: Approach from the perspective of Cardio-oncology
DOI: https://doi.org/10.1254/jpssuppl.95.0_1-p-046
[2022] Heteromeric complex formation and crosstalk between type 1 metabotropic glutamate receptor and GABAB receptor
DOI: https://doi.org/10.1254/jpssuppl.95.0_3-o-122
[2022] Development of a method for single-molecule imaging in the brain tissue
DOI: https://doi.org/10.1254/jpssuppl.95.0_1-o-004
[2022] Potential effects of Semaphorin3A-PlexinA signaling on the function and metabolism of amyloid-beta precursor protein
DOI: https://doi.org/10.1254/jpssuppl.96.0_4-b-p-301
[2022] Evaluation of antiarrhythmic agents for catecholaminergic polymorphic ventricular tachycardia (CPVT) using multiple lines of RyR2-mutant mouse models
DOI: https://doi.org/10.1254/jpssuppl.96.0_3-b-o08-3
[2022] Construction of the ELISA assay to quantify Semaphorin 3A in the adult brain
DOI: https://doi.org/10.1254/jpssuppl.96.0_3-b-p-236
[2022] Comparison of voluntary exercise and renin angiotensin inhibitor administration in a mouse model of dilated cardiomyopathy
DOI: https://doi.org/10.1254/jpssuppl.96.0_3-b-p-216
[2022] Single-molecule imaging of synaptic molecules within the brain tissue
DOI: https://doi.org/10.1254/jpssuppl.96.0_3-b-hs03-2
[2022] Prevalence of Behavioral and Psychological Symptoms in Patients With Cognitive Decline Before and During the COVID-19 Pandemic
[2021] Loss-of-function mutations in cardiac ryanodine receptor channel cause various types of arrhythmias including long QT syndrome
DOI: https://doi.org/10.1093/europace/euab250
[2021] Peripheral endomorphins drive mechanical alloknesis under the enzymatic control of CD26/DPPIV
DOI: https://doi.org/10.1016/j.jaci.2021.08.003
[2021] A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke
DOI: https://doi.org/10.1038/s41467-021-24644-1
[2021] Inhibition of endothelin A receptor by a novel, selective receptor antagonist enhances morphine-induced analgesia: Possible functional interaction of dimerized endothelin A and μ-opioid receptors
DOI: https://doi.org/10.1016/j.biopha.2021.111800
[2021] Midbrain Slice Culture as an Ex Vivo Analysis Platform for Parkinson’s Disease
DOI: https://doi.org/10.1007/978-1-0716-1495-2_11
[2021] Cancer cachexia-induced myocardial impairment could be improved by voluntary wheel running
DOI: https://doi.org/10.1254/jpssuppl.94.0_1-o-d2-4
[2021] Analyses of Forming Hetero-oligomers and Regulating Signal transductions of G-Protein Coupled Receptors (GPCRs) Expressed in the Central Nervous System.
DOI: https://doi.org/10.1254/jpssuppl.94.0_3-o-b1-1
[2021] Gender differences in the effect of spontaneous exercise on heart failure in DCM model mice
DOI: https://doi.org/10.1254/jpssuppl.94.0_3-p2-10
[2021] Characterization of novel RyR1 selective inhibitors identified by ER Ca2+ measurements
DOI: https://doi.org/10.1254/jpssuppl.94.0_3-p2-27
[2021] Identification of binding site for a novel RyR1-selective inhibitor
DOI: https://doi.org/10.1254/jpssuppl.94.0_3-p2-26
[2021] Effects of RyR2 specific inhibitors on arrhythmia in CPVT model mice
DOI: https://doi.org/10.1254/jpssuppl.94.0_1-o-d3-1
[2021] Axonal targeting of TrkA-APP complex via transcytosis
DOI: https://doi.org/10.1254/jpssuppl.94.0_3-o-g5-2

科研費（0 件）

まだデータがありません（KAKEN 取り込み後に表示）。

所属学会・役職（0 件）

まだデータがありません（学会データ連携後に表示）。

AI 要約（直近 5 年の研究成果）

外部リンク

関連研究室(8 件)

研究成果（68 件）

科研費（0 件）

所属学会・役職（0 件）