Toshiaki Akashi 研究室

主宰者：Toshiaki Akashi

順天堂大学

AI 要約（直近 5 年の研究成果）

本研究室は、医療画像の解析と処理を中心に、人工知能を活用した診断支援技術の開発を進めています。具体的には、頭部CTスキャンにおける出血検出、脳腫瘍の遺伝子型予測、放射線科レポートの自動処理など、放射線医学の様々な課題に取り組んでいます。深層学習モデルやLLM（大規模言語モデル）などの機械学習技術を用いて、医師や放射線技師の診断業務を効率化し、診断精度を向上させるシステムの構築を目指しています。脳脊髄液の流動や脳の廃棄物排出システム（グリンパティックシステム）に着目した研究も特徴的です。拡散画像解析や脳活動測定を通じて、アルツハイマー病や外傷性脳損傷における脳内の流体動態の変化を明らかにし、これらが認知機能低下の予測因子となることを報告しています。また、複数施設で収集された医療画像データの標準化や、プライバシーを保護しながらローカル環境で動作するAIモデルの最適化にも注力しており、医療現場への実装を念頭に置いた実践的な研究を展開しています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（68 件）

[2026] Nationwide organ volume distributions and cross-sectional age-associated differences in abdominal CT from Japan
DOI: https://doi.org/10.1007/s11604-026-02028-z
[2026] Comparing artificial intelligence and physician performance in predicting IDH mutation status in glioma
DOI: https://doi.org/10.1038/s41746-026-02695-2
[2026] Context-Aware Sentence Classification of Radiology Reports Using Synthetic Data: Development and Validation Study
DOI: https://doi.org/10.2196/86365
[2026] Nationwide Organ Volume Reference Standards and Aging-Related Changes in Abdominal CT from Japan
DOI: https://doi.org/10.64898/2026.01.30.26345246
[2026] Left-right relationship-aware 3D volume classification method
DOI: https://doi.org/10.1007/s11548-025-03567-y
[2026] Bridging the performance gap: systematic optimization of local LLMs for Japanese medical PHI extraction
DOI: https://doi.org/10.1038/s41598-026-36904-5
[2026] Development and evaluation of a deep learning-assisted diagnostic support system for radiographer preliminary clinical evaluation of intracranial hemorrhage
DOI: https://doi.org/10.7717/peerj.21414
[2025] Magnetic resonance imaging indices for early Alzheimer’s disease detection: Brain clearance markers
DOI: https://doi.org/10.1177/0271678x251321305
[2025] Association between cognitive function and relaxation rates of the cerebral cortex
DOI: https://doi.org/10.1016/j.jns.2025.123466
[2025] Japan-Medical Image Database (J-MID): Medical Big Data Supporting Data Science
DOI: https://doi.org/10.14789/ejmj.jmj25-0004-p

続きを表示（残り 58 件）

[2025] Contralateral neurofluid dynamics predict survival in IDH wild-type glioblastoma: A DTI-ALPS and free water imaging study
DOI: https://doi.org/10.1093/neuonc/noaf242
[2025] Context-Aware Sentence Classification of Radiology Reports Using Synthetic Data (Preprint)
DOI: https://doi.org/10.2196/preprints.86365
[2025] Contralateral Neurofluid Dynamics Predict Survival in IDH Wild-type Glioblastoma: A DTI-ALPS and Free Water Imaging Study
DOI: https://doi.org/10.58530/2025/2543
[2025] The coupling of global brain activity and cerebrospinal fluid flow as a potential predictive marker of amyloid-β accumulation
DOI: https://doi.org/10.58530/2025/4584
[2025] Choroid Plexus Enlargement Mediates Cognitive Decline in Traumatic Brain Injury: UK Biobank Study
DOI: https://doi.org/10.58530/2025/1000
[2025] The relationship between tau protein and white matter structural changes in Alzheimer's disease using fixel-based analysis
DOI: https://doi.org/10.58530/2025/0755
[2025] Retrieval-augmented generation elevates local LLM quality in radiology contrast media consultation
DOI: https://doi.org/10.1038/s41746-025-01802-z
[2025] The coupling of global brain activity and cerebrospinal fluid flow as a potential predictive marker of brain amyloid-β accumulation
DOI: https://doi.org/10.1016/j.tjpad.2025.100228
[2024] Fully automatic summarization of radiology reports using natural language processing with large language models
DOI: https://doi.org/10.1016/j.imu.2024.101465
[2024] A case of middle-aged central sleep apnea due to Joubert syndrome with different treatment effects of oxygen and acetazolamide
DOI: https://doi.org/10.5664/jcsm.11224
[2024] Synthesizing 4D Magnetic Resonance Angiography From 3D Time-of-Flight Using Deep Learning: A Feasibility Study
DOI: https://doi.org/10.7759/cureus.60803
[2024] Performance improvement for medical image classification model by using gradient-based analytical feature selection
DOI: https://doi.org/10.1117/12.3006620
[2024] Assessing interstitial fluid dynamics in type 2 diabetes mellitus and prediabetes cases through diffusion tensor imaging analysis along the perivascular space
DOI: https://doi.org/10.3389/fnagi.2024.1362457
[2024] Identify the paraventricular thalamic nucleus in humans using a structural connectivity approach
DOI: https://doi.org/10.58530/2023/2684
[2024] Harmonization of the multisite ALPS-index based on DTI-ALPS using the combined association test
DOI: https://doi.org/10.58530/2023/3245
[2024] Evaluation of the relation between tau protein and white matter structural changes in Alzheimer's disease using fixel-based analysis
DOI: https://doi.org/10.58530/2024/3912
[2024] ComBat harmonization for multi-site fixel-based analysis using traveling subject dataset
DOI: https://doi.org/10.58530/2024/3002
[2024] Investigation of the ALDH2 genetic polymorphism effect in alcohol-related glymphatic dysfunction using DTI-ALPS
DOI: https://doi.org/10.58530/2023/3006
[2024] The evaluation of white matter lesion with 3D-T1 weighted imaging for predicting dementia
DOI: https://doi.org/10.58530/2024/3114
[2024] Optimizing GPT-4 Turbo Diagnostic Accuracy in Neuroradiology through Prompt Engineering and Confidence Thresholds
DOI: https://doi.org/10.3390/diagnostics14141541
[2023] A Structural Connectivity Approach to Identify Human Paraventricular Thalamic Nucleus [Presidential Award Proceedings]
DOI: https://doi.org/10.2463/jjmrm.2023-1787
[2023] Non-invasive MRI measures of glymphatic system activity associated with CSF-Aβ and FDG-PET uptakes in Alzheimer’s disease
DOI: https://doi.org/10.58530/2022/3589
[2023] Temporal Progression Patterns of White-Matter Degeneration in CBS and PSP Identified with Subtype & Stage Inference (SuStaIn) [Proceedings of the 2021 Young Investigator Award]
DOI: https://doi.org/10.2463/jjmrm.2023-1790
[2023] Glymphatic system impairment in corticobasal syndrome: diffusion tensor image analysis along the perivascular space (DTI-ALPS)
DOI: https://doi.org/10.1007/s11604-023-01454-7
[2023] Reproducibility of automated calculation technique for diffusion tensor image analysis along the perivascular space
DOI: https://doi.org/10.1007/s11604-023-01415-0
[2023] Deep Learning‐Driven Transformation: A Novel Approach for Mitigating Batch Effects in Diffusion MRI Beyond Traditional Harmonization
DOI: https://doi.org/10.1002/jmri.29088
[2023] Advancements in Diffusion MRI Tractography for Neurosurgery
DOI: https://doi.org/10.1097/rli.0000000000001015
[2023] Fixel-Based Analysis of White Matter Degeneration in Patients with Progressive Supranuclear Palsy and Corticobasal Syndrome
DOI: https://doi.org/10.58530/2022/2966
[2023] Harmonization of multi-site DTI and NODDI data using the combined association test
DOI: https://doi.org/10.58530/2022/3160
[2023] Glymphatic System Dysfunction in Myelin Oligodendrocyte Glycoprotein Immunoglobulin G Antibody–Associated Disorders: Association with Clinical Disability
DOI: https://doi.org/10.3174/ajnr.a8066
[2023] Fiber-specific micro- and macroscopic white matter alterations in progressive supranuclear palsy and corticobasal syndrome
DOI: https://doi.org/10.1038/s41531-023-00565-2
[2023] Harmonization of Multi-Site DTI and NODDI Data Using the Combined Association Test [Proceedings of the 2022 Young Investigator Award]
DOI: https://doi.org/10.2463/jjmrm.2023-1791
[2023] Glymphatic system impairment in sleep disruption: diffusion tensor image analysis along the perivascular space (DTI-ALPS)
DOI: https://doi.org/10.1007/s11604-023-01463-6
[2023] Improved method for COVID-19 classification of complex-architecture CNN from chest CT volumes using orthogonal ensemble networks
DOI: https://doi.org/10.1117/12.2653792
[2023] Classification of COVID-19 cases from chest CT volumes using hybrid model of 3D CNN and 3D MLP-mixer
DOI: https://doi.org/10.1117/12.2654706
[2023] Glymphatic system impairment in nonathlete older male adults who played contact sports in their youth associated with cognitive decline: A diffusion tensor image analysis along the perivascular space study
DOI: https://doi.org/10.3389/fneur.2023.1100736
[2023] Traveling Subject-Informed Harmonization Increases Reliability of Brain Diffusion Tensor and Neurite Mapping
DOI: https://doi.org/10.14336/ad.2023.1020
[2023] Review of Performance Improvement of a Noninvasive Brain-computer Interface in Communication and Motor Control for Clinical Applications
DOI: https://doi.org/10.14789/jmj.jmj23-0011-r
[2022] Classification and visual explanation for COVID-19 pneumonia from CT images using triple learning
DOI: https://doi.org/10.1038/s41598-022-24936-6
[2022] Attention induction for a CT volume classification of COVID-19
DOI: https://doi.org/10.1007/s11548-022-02769-y
[2022] Association of MRI Indices of Glymphatic System With Amyloid Deposition and Cognition in Mild Cognitive Impairment and Alzheimer Disease
DOI: https://doi.org/10.1212/wnl.0000000000201300
[2022] 2) Present and Future of AI-aided Radiological Diagnosis
DOI: https://doi.org/10.2169/naika.111.1770
[2022] Automated classification method of COVID-19 cases from chest CT volumes using 2D and 3D hybrid CNN for anisotropic volumes
DOI: https://doi.org/10.1117/12.2613317
[2022] Radiomics with 3-dimensional magnetic resonance fingerprinting: influence of dictionary design on repeatability and reproducibility of radiomic features
DOI: https://doi.org/10.1007/s00330-022-08555-3
[2022] Temporal Progression Patterns of Brain Atrophy in Corticobasal Syndrome and Progressive Supranuclear Palsy Revealed by Subtype and Stage Inference (SuStaIn)
DOI: https://doi.org/10.3389/fneur.2022.814768
[2022] 2) Present and Future of AI-aided Radiological Diagnosis
DOI: https://doi.org/10.2169/naika.111.115b
[2022] Development of a Deep Learning Algorithm to Generate MR Angiography from 3D Quantitative Synthetic MR Imaging [Proceedings of the 2019 Young Investigator Award]
DOI: https://doi.org/10.2463/jjmrm.2021-1747
[2022] A Validation Study of the Deep-Learning-Based Prostate Imaging Reporting and Data System Scoring Algorithm
DOI: https://doi.org/10.4236/ojrad.2022.123007
[2021] Extraction of lung and lesion regions from COVID-19 CT volumes using 3D fully convolutional networks
DOI: https://doi.org/10.1117/12.2581818
[2021] Corpus Callosum Swelling after Resection of Intraventricular Central Neurocytoma
DOI: https://doi.org/10.2176/nmccrj.cr.2020-0369
[2021] Automation of a Rule-based Workflow to Estimate Age from Brain MR Imaging of Infants and Children Up to 2 Years Old Using Stacked Deep Learning
DOI: https://doi.org/10.2463/mrms.mp.2021-0068
[2021] Aorta-aware GAN for non-contrast to artery contrasted CT translation and its application to abdominal aortic aneurysm detection
DOI: https://doi.org/10.1007/s11548-021-02492-0
[2021] Connectome analysis of male world‐class gymnasts using probabilistic multishell, multitissue constrained spherical deconvolution tracking
DOI: https://doi.org/10.1002/jnr.24912
[2021] Fiber-specific white matter alterations in early-stage tremor-dominant Parkinson’s disease
DOI: https://doi.org/10.1038/s41531-021-00197-4
[2021] Lung segmentation of thoracic CT volumes by combining slice-wise with pixel-wise classification
[2021] Lung infection and normal region segmentation from CT volumes of COVID-19 cases
DOI: https://doi.org/10.1117/12.2582066
[2021] Unsupervised segmentation of COVID-19 infected lung clinical CT volumes using image inpainting and representation learning
DOI: https://doi.org/10.1117/12.2580641
[2021] A Rare Case of Intracerebral Pneumocephalus Caused by Preexisting Multiple Bone Defects and Encephalocele after Resection of Meningioma
DOI: https://doi.org/10.2176/nmccrj.cr.2020-0074

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AI 要約（直近 5 年の研究成果）

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研究成果（68 件）

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