Kazuo Nagasawa 研究室

主宰者：Kazuo Nagasawa

東京農工大学

AI 要約（直近 5 年の研究成果）

本研究室は、有機分子の設計・合成と、それを応用した生物活性物質の開発に取り組んでいます。特に、複雑な天然物の全合成や医薬品候補化合物の効率的な製造法の開発に力を入れており、酸化的フェノール結合反応やアザ-マイケル反応といった炭素-炭素結合形成反応を駆使して、多環式骨格を構築しています。また、キラル触媒を用いた不斉合成により、光学活性な化合物を高い選択性で得る方法を開発し、パーキンソン病治療薬など実際の医薬品合成への応用も実現しています。さらに本研究室は、G-四重鎖と呼ばれるDNA・RNA特有の構造や、ビタミンDの代謝・機能に関する化学的研究を展開しています。G-四重鎖に結合する小分子リガンドの合成や、その構造的特性を活かした新規な分子設計（例えば、特定のタンパク質の選択的な分解を誘導するPROTAC分子）を行うとともに、蛍光プローブの開発により細胞内での動的挙動を観察する手法を確立しました。ビタミンD関連では、その代謝産物の化学合成と同定、受容体との相互作用の解析を通じて、生理機能の制御メカニズムの解明を目指しています。これらの研究を通じ、化学合成の知見を基礎として、疾患理解と治療法開発につながる成果を生み出しています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（48 件）

[2026] Cooperative Chiral Induction in Aromatic N , N ′-Dialkylated Urea Organocatalyst Enables Asymmetric Aza-Henry Reaction
DOI: https://doi.org/10.1021/acs.joc.6c00003
[2025] Chromatographic separation of dihydroxylated vitamin D3 and accurate quantification of 1α,25(OH)2D3 in human serum
DOI: https://doi.org/10.1016/j.jpba.2025.117125
[2025] Vitamin D derivatives inhibit mesenchymal transition of mesothelial cells and mitigate peritoneal dissemination of ovarian cancer
DOI: https://doi.org/10.1007/s00795-025-00424-4
[2025] Development of an Environmentally Responsive Fluorescent Ligand for Vitamin D Receptor
DOI: https://doi.org/10.1002/cbic.202401038
[2025] Degradation of G‐Quadruplex‐Binding Proteins by G4L‐PROTAC via Quaternary Complex Formation
DOI: https://doi.org/10.1002/ange.202515045
[2025] Features of mismatch negativity in an at-risk mental state with the traits associated with the autistic spectrum
DOI: https://doi.org/10.3389/fpsyt.2025.1620954
[2025] Degradation of G‐Quadruplex‐Binding Proteins by G4L‐PROTAC via Quaternary Complex Formation
DOI: https://doi.org/10.1002/anie.202515045
[2025] Distinct and potent vitamin D hydroxylation activity acquired by the <scp>CYP3A4 I301T</scp> single amino acid substitution causes type 3 rickets
DOI: https://doi.org/10.1111/febs.70277
[2025] Enantioselective Gram‐Scale Synthesis of Rasagiline via Chiral Phosphoric Acid‐Catalyzed Reduction of Cyclic Imine
DOI: https://doi.org/10.1002/asia.70286
[2025] Covalent Plant Natural Product that Potentiates Antitumor Immunity
DOI: https://doi.org/10.1021/jacs.4c17837

続きを表示（残り 38 件）

[2025] Targeting G-Quadruplex with Bis-thiourea Compounds Inhibits SARS-CoV-2 Replication
DOI: https://doi.org/10.1021/acsinfecdis.5c00095
[2025] Synthesis of a Light-Up Probe with a Trioxazole Skeleton for Tracking G-Quadruplex Dynamic Behavior
DOI: https://doi.org/10.1021/acs.analchem.5c02500
[2024] Topology-selective photo-crosslinking of G-quadruplexes via dual G-quartet and groove recognition
DOI: https://doi.org/10.1039/d4cc04804k
[2024] Synthesis of Saxitoxin Biosynthetic Intermediates: Reveal the Mechanism for Formation of its Tricyclic Skeleton in Biosynthesis
DOI: https://doi.org/10.1002/asia.202400834
[2024] Discovery and Structural Analysis of Metabolites of Vitamin D3 Lactones
DOI: https://doi.org/10.1248/cpb.c24-00495
[2024] Synthesis and Identification of decarbamoyloxySaxitoxins in Toxic Microalgae and their Reactions with the Oxygenase, SxtT, Reveal Saxitoxin Biosynthesis
DOI: https://doi.org/10.1002/chem.202304238
[2023] Regulation of thrombin activity by ligand-induced topological alteration in a thrombin-binding aptamer
DOI: https://doi.org/10.1039/d3cc02308g
[2023] Guanidinium Hypoiodite-Catalyzed Intramolecular Oxidative Coupling Reaction of Oxindoles with β-Dicarbonyls
DOI: https://doi.org/10.1021/acs.joc.2c02500
[2023] Total Synthesis of Fused Polycyclic Alkaloids Based on Oxidative Phenolic Couplings and Aza-Michael Reactions
DOI: https://doi.org/10.1055/a-2007-9342
[2023] A 1,3-boron shift reaction of homoallenylboronates to synthesise 2-boryl-1,3-dienes
DOI: https://doi.org/10.1039/d2cc06600a
[2023] Differential gene regulation by a synthetic vitamin D receptor ligand and active vitamin D in human cells
DOI: https://doi.org/10.1371/journal.pone.0295288
[2023] Advances in the Administration of Vitamin D Analogues to Support Bone Health and Treat Chronic Diseases
DOI: https://doi.org/10.11005/jbm.2023.30.3.219
[2023] Chiral Hypoiodite Salt Catalysts for Enantioselective Oxidative Transformations
DOI: https://doi.org/10.1002/cctc.202300820
[2023] Approaches to Construction of the Medium-Sized Ring Structure in Zetekitoxin AB by Ring-Closing Metathesis
DOI: https://doi.org/10.1021/acs.joc.3c00580
[2023] Differential Metabolic Stability of 4α,25- and 4β,25-Dihydroxyvitamin D3 and Identification of Their Metabolites
DOI: https://doi.org/10.3390/biom13071036
[2023] Stereoselective Construction of Tertiary Alcohol at C11 of Zetekitoxin AB
DOI: https://doi.org/10.1002/ajoc.202300205
[2023] Synthesis of Pentacyclic Core Structure ofAspidospermaAlkaloids by Sequential Ring Construction via Oxidative Phenolic Coupling
DOI: https://doi.org/10.1246/cl.230106
[2023] Enantioselective Oxidative Enolate Coupling of Oxindoles Catalyzed by Chiral Guanidinium Hypoiodite
DOI: https://doi.org/10.1021/acscatal.2c05677
[2022] Stereodivergent Synthesis of 1,3-Dienes via Protodeboronation of Homoallenylboronic Esters
DOI: https://doi.org/10.1021/acs.joc.2c00744
[2022] Single-molecule displacement assay reveals strong binding of polyvalent dendrimer ligands to telomeric G-quadruplex
DOI: https://doi.org/10.1016/j.ab.2022.114693
[2022] Synthesis of Deuterium-Labeled Vitamin D Metabolites as Internal Standards for LC-MS Analysis
DOI: https://doi.org/10.3390/molecules27082427
[2022] Destabilization of DNA and RNA G-quadruplex structures formed by GGA repeat due to N6-methyladenine modification
DOI: https://doi.org/10.1016/j.bbrc.2022.01.123
[2022] Effects of G-Quadruplex Ligands on the Topology, Stability, and Immunostimulatory Properties of G-Quadruplex-Based CpG Oligodeoxynucleotides
DOI: https://doi.org/10.1021/acschembio.1c00904
[2022] Nontoxic Enantiomeric Reference Materials for Saxitoxins
DOI: https://doi.org/10.1021/acs.analchem.2c00836
[2022] Synthesis of C2-Alkoxy-Substituted 19-Nor Vitamin D3 Derivatives: Stereoselectivity and Biological Activity
DOI: https://doi.org/10.3390/biom12010069
[2021] Recent Advances in Synthetic Strategies for the C4a,C9a-Fused Tetracyclic Hydrocarbazole Core Structure of Minfiensine and Related Akuammiline Alkaloids
DOI: https://doi.org/10.3987/rev-20-sr(k)3
[2021] Vinylnaphthalene-bearing hexaoxazole as a fluorescence turn-on type G-quadruplex ligand
DOI: https://doi.org/10.1039/d1ob01500a
[2021] Controlled lipid β-oxidation and carnitine biosynthesis by a vitamin D metabolite
DOI: https://doi.org/10.1016/j.chembiol.2021.08.008
[2021] Mechanistic insights into entropy-driven 1,2-type Friedel-Crafts reaction with conformationally flexible guanidine-bisthiourea bifunctional organocatalysts
DOI: https://doi.org/10.1016/j.tet.2021.132281
[2021] Enantioselective Total Synthesis of Cepharatines via Bioinspired Ring Reconstruction
DOI: https://doi.org/10.1021/acs.joc.1c02371
[2021] Selective alkylation of parallel G-quadruplex structure
DOI: https://doi.org/10.1039/d0ob02365e
[2021] Enantioselective Total Synthesis of (+)-Stephadiamine through Bioinspired Aza-Benzilic Acid Type Rearrangement
DOI: https://doi.org/10.1021/jacs.1c00047
[2021] Stabilization of telomeric G-quadruplex by ligand binding increases susceptibility to S1 nuclease
DOI: https://doi.org/10.1039/d1cc03294a
[2021] Detection of CpG Methylation in G-Quadruplex Forming Sequences Using G-Quadruplex Ligands
DOI: https://doi.org/10.3390/ijms222313159
[2021] Two new skeletal analogues of saxitoxin found in the scallop, Patinopecten yessoensis, as possible metabolites of paralytic shellfish toxins
DOI: https://doi.org/10.1016/j.chemosphere.2021.130224
[2021] Total Synthesis of Saxitoxins
DOI: https://doi.org/10.5059/yukigoseikyokaishi.79.43
[2021] Discovery of a Vitamin D Receptor-Silent Vitamin D Derivative That Impairs Sterol Regulatory Element-Binding Protein In Vivo
DOI: https://doi.org/10.1021/acs.jmedchem.0c02179
[2021] Chemical Synthesis of Side‐Chain‐Hydroxylated Vitamin D3 Derivatives and Their Metabolism by CYP27B1
DOI: https://doi.org/10.1002/cbic.202100250

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AI 要約（直近 5 年の研究成果）

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関連研究室(8 件)

研究成果（48 件）

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