Motomu Kanai 研究室
主宰者：Motomu Kanai
東京大学
AI 要約（直近 5 年の研究成果）
本研究室は、光やラジカル反応を利用した化学触媒を開発し、生命現象の解明と治療法の開発に応用する研究を行っています。特に、生きた細胞や生体内で機能する触媒システムの設計に注力しており、遺伝子操作に頼らない化学的アプローチで生体分子を選択的に変化させる技術を追求しています。
主な研究の課題は、温和な条件で高い活性と選択性を兼ね備えた触媒を実現することです。例えば、光を当てるだけでタンパク質上の特定のアミノ酸を認識して化学修飾を加える触媒や、酵素のような精密性で有機分子を合成する触媒システムを開発しています。これらの触媒は、分子のどこをどのように変えるかを正確に制御でき、複雑な生体環境でも目的の反応を進めることができるよう設計されています。
さらに、本研究室は開発した触媒を実際の医療課題に応用する試みも展開しています。アルツハイマー病やATTR型アミロイドーシスなどの神経変性疾患において、異常に集積したタンパク質を光触媒で選択的に変性させることで、症状改善の可能性を示唆する成果も報告しています。化学的な道具立てで生命現象に直接働きかけ、基礎科学と応用医療の橋渡しを目指す研究室です。
※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。
外部リンク
関連研究室(8 件)
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研究成果（146 件）
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- DOI: https://doi.org/10.1002/anie.202503249
続きを表示（残り 136 件）閉じる
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- DOI: https://doi.org/10.1016/j.tet.2025.135008
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- DOI: https://doi.org/10.1016/j.tet.2025.135008
- DOI: https://doi.org/10.1126/science.adz0686
- DOI: https://doi.org/10.26434/chemrxiv-2025-r5qm4
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- DOI: https://doi.org/10.26434/chemrxiv-2025-r5qm4
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- DOI: https://doi.org/10.1021/jacs.5c11603
- DOI: https://doi.org/10.1149/ma2025-01161208mtgabs
- DOI: https://doi.org/10.1021/jacs.5c01699
- [2025] A Method for Constructing Nucleosome Arrays with Spatially Defined Histone PTMs and DNA DamageDOI: https://doi.org/10.1002/anie.202500162
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- DOI: https://doi.org/10.1002/ange.202405605
- DOI: https://doi.org/10.1002/advs.202401346
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- DOI: https://doi.org/10.1002/anie.202405605
- DOI: https://doi.org/10.1002/anie.202405605
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- DOI: https://doi.org/10.1021/acs.orglett.4c03449
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- DOI: https://doi.org/10.1149/ma2024-01131037mtgabs
- DOI: https://doi.org/10.1021/acs.orglett.4c03223
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- DOI: https://doi.org/10.1096/fj.202301533r
- DOI: https://doi.org/10.1038/s42004-023-01030-0
- DOI: https://doi.org/10.1021/acscentsci.3c00930
- DOI: https://doi.org/10.1016/j.pep.2023.106375
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- DOI: https://doi.org/10.1016/j.pep.2023.106375
- DOI: https://doi.org/10.1055/a-2182-7614
- DOI: https://doi.org/10.1038/s41467-023-41426-z
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- DOI: https://doi.org/10.1248/cpb.c22-00526
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- [2022] Catalysis medicine: Participating in the chemical networks of living organisms through catalystsDOI: https://doi.org/10.1016/j.tet.2022.133227
- DOI: https://doi.org/10.1055/a-1990-5102
- DOI: https://doi.org/10.1248/cpb.c22-00299
- DOI: https://doi.org/10.1016/j.snb.2022.132475
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- DOI: https://doi.org/10.1248/cpb.c22-00526
- DOI: https://doi.org/10.1111/cas.15565
- DOI: https://doi.org/10.1007/978-1-0716-2433-3_17
- DOI: https://doi.org/10.1111/cas.15565
- DOI: https://doi.org/10.1007/978-1-0716-2433-3_17
- [2022] Linear‐Selective Allylation of Aldehydes with Simple Alkenes Mediated by Quadruple Hybrid CatalysisDOI: https://doi.org/10.1002/adsc.202200704
- DOI: https://doi.org/10.1016/j.snb.2022.132475
- DOI: https://doi.org/10.1248/cpb.c22-00299
- DOI: https://doi.org/10.1149/ma2022-0113914mtgabs
- DOI: https://doi.org/10.1021/acs.joc.2c00603
- [2022] Synthesis and Astatine Labeling of a bis-iminobiotin derivative with enhanced plasma stabilityDOI: https://doi.org/10.1016/s0969-8051(22)00266-9
- [2022] A Germanium Catalyst Accelerates the Photoredox α-C(sp<sup>3</sup>)–H Alkylation of Primary AminesDOI: https://doi.org/10.1021/acs.orglett.2c00871
- DOI: https://doi.org/10.1016/j.bbrc.2022.04.035
- [2022] A Germanium Catalyst Accelerates the Photoredox α-C(sp<sup>3</sup>)–H Alkylation of Primary AminesDOI: https://doi.org/10.1021/acs.orglett.2c00871
- DOI: https://doi.org/10.1021/jacs.2c01705
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- DOI: https://doi.org/10.1149/ma2022-0113914mtgabs
- DOI: https://doi.org/10.1055/a-1990-5102
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- DOI: https://doi.org/10.1149/ma2021-0115734mtgabs
- DOI: https://doi.org/10.1016/j.jaci.2021.03.029
- DOI: https://doi.org/10.5059/yukigoseikyokaishi.79.391
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- [2021] Photo-oxygenation by a biocompatible catalyst reduces amyloid-β levels in Alzheimer’s disease miceDOI: https://doi.org/10.1093/brain/awab058
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- [2021] Knoevenagel Condensation between 2-Methyl-thiazolo[4,5-<i>b</i>]pyrazines and AldehydesDOI: https://doi.org/10.1248/cpb.c21-00780
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- DOI: https://doi.org/10.1016/j.tet.2021.132448
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- DOI: https://doi.org/10.1016/j.tet.2021.132448
- DOI: https://doi.org/10.1002/anie.202109788
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