Shinji Yamashita 研究室

主宰者：Shinji Yamashita

立命館大学

AI 要約（直近 5 年の研究成果）

本研究室は、医薬品の経口投与時における吸収性を予測・評価することを主な研究課題としています。特に水に溶けにくい化合物を対象として、その溶解挙動と体内での吸収プロセスの相互関係を明らかにする研究に取り組んでいます。研究アプローチとしては、試験管内での溶解試験と動物実験を組み合わせた手法を用いています。具体的には、医薬品の製剤形態（固体分散物、脂質含有製剤、共結晶など）が消化管内でどのように溶解し、どの程度が吸収されるかを模擬する実験系を開発・改良しています。また、胃や小腸の pH 変化、液体移動、消化作用といった消化管内の生理現象を試験管内で再現する評価システムを構築し、医薬品の吸収性予測の精度向上に努めています。これらの研究を通じて、異なる製剤形態における医薬品の溶解挙動の違いが体内吸収に及ぼす影響が明らかになりつつあります。さらに、患者間での吸収性のばらつきを引き起こす消化管内環境の変動要因が特定されており、より適切な医薬品評価法の確立につながると期待されます。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（28 件）

[2025] Insights into In Vivo Performance of Amorphous Solid Dispersions: Evaluation Using a Surrogate Marker for Drug Release Profiles and Pharmacokinetic Analysis
DOI: https://doi.org/10.1021/acs.molpharmaceut.5c00879
[2025] Potential use of oral jelly formulations as supersaturable formulations: Acidified or alkalized jelly containing drugs with pH-dependent solubility
DOI: https://doi.org/10.1016/j.jddst.2025.106691
[2024] Effect of particle size on gastric emptying of enteric-coated granules in fasted beagle dogs: Relationship with interdigestive migrating motor complex
DOI: https://doi.org/10.1016/j.xphs.2024.07.018
[2024] In vitro demonstration of antedrug mechanism of a pharmacokinetic booster to improve CYP3A4 substrates by CYP3A4-mediated metabolism inhibition
DOI: https://doi.org/10.1016/j.dmpk.2024.101005
[2024] Assessment of in Vivo Performance of Lipid-Based Formulations: Correlation between in Vitro Drug Release Profiles and in Vivo Absorption Rate Profiles
DOI: https://doi.org/10.1248/bpb.b24-00458
[2024] Characterization of oral drug absorption from jelly formulations: Effects of membrane permeability and intestinal fluid volume
DOI: https://doi.org/10.1016/j.xphs.2024.07.016
[2023] The effects of degree and duration of supersaturation on in vivo absorption profiles for highly permeable drugs, dipyridamole and ketoconazole
DOI: https://doi.org/10.1016/j.ejpb.2023.06.002
[2023] Control of Dissolution and Supersaturation/Precipitation of Poorly Water-Soluble Drugs from Cocrystals Based on Solubility Products: A Case Study with a Ketoconazole Cocrystal
DOI: https://doi.org/10.1021/acs.molpharmaceut.3c00237
[2023] Contribution analysis of metabolic tissues on systemic exposure of an active metabolite after oral administration of verapamil using a stable isotope-labeled compound
DOI: https://doi.org/10.1016/j.dmpk.2023.100514
[2023] Development of New Sublingual Formulation for Transmucosal Delivery of Peptides
DOI: https://doi.org/10.1248/yakushi.22-00170-1

続きを表示（残り 18 件）

[2023] Near-infrared imaging of in vivo performance of orally administered solid forms to rats: Feasibility study with indocyanine green
DOI: https://doi.org/10.1016/j.ijpharm.2023.123677
[2023] Drug Dissolution in Oral Drug Absorption: Workshop Report
DOI: https://doi.org/10.1208/s12248-023-00865-8
[2023] Development of an In Vitro Methodology to Assess the Bioequivalence of Orally Disintegrating Tablets Taken without Water
DOI: https://doi.org/10.3390/pharmaceutics15092192
[2022] Mechanistic analysis for positive and negative food effects on oral absorption of poorly soluble drugs from cyclodextrin containing formulations: Study with a mini-scale in vitro system
DOI: https://doi.org/10.1016/j.jddst.2022.103440
[2022] Liposomal Formulation for Oral Delivery of Cyclosporine A: Usefulness as a Semisolid-Dispersion System
DOI: https://doi.org/10.1007/s11095-022-03276-0
[2022] Comparative acceptability of mini-tablets, fine granules, and liquid formulations in young children: An exploratory randomized crossover study
DOI: https://doi.org/10.1016/j.jddst.2022.103154
[2022] Effects of Ingested Water Volume on Oral Absorption of Fenofibrate, a BCS Class II Drug, from Micronized and Amorphous Solid Dispersion Formulations in Rats
DOI: https://doi.org/10.1248/bpb.b22-00219
[2022] Direction to which oral drug delivery science and technology should target
DOI: https://doi.org/10.2745/dds.37.282
[2022] Discovery of benzyloxyphenyl- and phenethylphenyl-imidazole derivatives as a new class of ante–drug type boosters
DOI: https://doi.org/10.1016/j.bmcl.2022.128868
[2022] Importance of Gastric Secretion and the Rapid Gastric Emptying of Ingested Water along the Lesser Curvature (“Magenstraße”) in Predicting the In Vivo Performance of Liquid Oral Dosage Forms in the Fed State Using a Modeling and Simulation
DOI: https://doi.org/10.1021/acs.molpharmaceut.1c00778
[2021] Interspecies differences in gastrointestinal physiology affecting the in vivo performance of oral pharmaceutical solid dosage forms
DOI: https://doi.org/10.1016/j.jddst.2021.102923
[2021] In Vitro–In Vivo Correlation in Cocrystal Dissolution: Consideration of Drug Release Profiles Based on Coformer Dissolution and Absorption Behavior
DOI: https://doi.org/10.1021/acs.molpharmaceut.1c00537
[2021] Maximizing the Oral Bioavailability of Poorly Water-Soluble Drugs Using Novel Oil-Like Materials in Lipid-Based Formulations
DOI: https://doi.org/10.1021/acs.molpharmaceut.1c00197
[2021] Bioequivalence of Oral Drug Products in the Healthy and Special Populations: Assessment and Prediction Using a Newly Developed In Vitro System “BE Checker”
DOI: https://doi.org/10.3390/pharmaceutics13081136
[2021] New biphasic system in side-by-side chambers for testing drug dissolution and permeation in vitro (BiDP system)
DOI: https://doi.org/10.1016/j.jddst.2021.102747
[2021] Small differences in acidic pH condition significantly affect dissolution equivalence between drug products of acidic drug salt
DOI: https://doi.org/10.1016/j.jddst.2021.102546
[2021] In vitro-in vivo correlation in the effect of cyclodextrin on oral absorption of poorly soluble drugs
DOI: https://doi.org/10.1016/j.ijpharm.2021.120494
[2021] In Vitro Sensitivity Analysis of the Gastrointestinal Dissolution Profile of Weakly Basic Drugs in the Stomach-to-Intestine Fluid Changing System: Explanation for Variable Plasma Exposure after Oral Administration
DOI: https://doi.org/10.1021/acs.molpharmaceut.0c01207

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AI 要約（直近 5 年の研究成果）

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関連研究室(8 件)

研究成果（28 件）

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