Atsushi Matsuzawa 研究室

主宰者：Atsushi Matsuzawa

東北大学

AI 要約（直近 5 年の研究成果）

本研究室は、細胞が死に至るメカニズムを分子レベルで解明する研究を行っています。特に、アポトーシスやフェロトーシス、パルタナトースといった「制御された細胞死」に焦点を当てており、これらのプロセスがどのようなタンパク質やシグナル経路によって調節されているかを調査しています。細胞内のタンパク質分解システムであるユビキチン化や、細胞のストレス応答メカニズムが、こうした細胞死の選択肢を決定することを明らかにしています。研究手法としては、主にがん細胞や免疫細胞などの細胞培養系を用いた分子生物学的実験と、動物モデルを用いた in vivo 検証を組み合わせています。特定の物質や医薬品がどのように細胞に作用するかを追跡し、関連するタンパク質の機能喪失実験や過剰発現実験により、因果関係を検証しています。加えて、脂肪酸や微量栄養素といった生理活性物質の効果も調べており、これらの物質が細胞死の誘導に関わるメカニズムを明らかにしています。主要な発見として、複数の制御タンパク質（ユビキチン化酵素など）が細胞死の実行に中核的な役割を果たすこと、そして炎症応答や酸化ストレスが細胞死の選択肢を変化させることが共通して示されています。これらの知見は、がん治療や炎症性疾患、さらには医薬品の副作用メカニズム理解へと応用される可能性を持っています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（45 件）

[2026] Gene Therapy for Malignant Tumors: Focused on Immunostimulatory Oncolytic Coxsackievirus A11 (CVA11)
DOI: https://doi.org/10.21873/anticanres.18071
[2026] Identification of MKRN1 as a key modulator of the p53-MDM2 feedback loop
DOI: https://doi.org/10.1038/s41418-026-01662-4
[2026] Tocotrienols exhibit superior ferroptosis inhibition over tocopherols
DOI: https://doi.org/10.1038/s41598-025-34673-1
[2025] AMPK Limits MNNG-Induced Parthanatos by Inhibiting BH3-Only Protein Bim
DOI: https://doi.org/10.3390/ijms262110519
[2025] FBXO22 Suppresses Oxidative Stress-Induced ASK1 Activation and Cell Death via Ubiquitination-Dependent Degradation of TRIM48
DOI: https://doi.org/10.3390/ijms26199472
[2025] Elaidic acid drives cellular senescence and inflammation via lipid raft-mediated IL-1R signaling
DOI: https://doi.org/10.1016/j.isci.2025.113305
[2025] Truncated LKB1 nonenzymatically enhances Fas-induced apoptosis by acting as a surrogate of Smac
DOI: https://doi.org/10.1038/s41420-025-02570-1
[2025] The antirheumatic drug sulfasalazine ameliorates acute renal failure (ARF) induced by polymyxin B
DOI: https://doi.org/10.1038/s41429-025-00835-6
[2025] Frequency-Regulated Repeated Micro-Vibration Promotes Osteoblast Differentiation Through BMP Signaling in MC3T3-E1 Cells
DOI: https://doi.org/10.3390/life15040588
[2025] The Selective 3-MST Inhibitor I3MT-3 Works as a Potent Caspase-1 Inhibitor
DOI: https://doi.org/10.3390/ijms26052237

続きを表示（残り 35 件）

[2025] Benzalkonium chloride initiates proinflammatory responses via NLRP3 inflammasome activation
DOI: https://doi.org/10.2131/jts.50.11
[2025] Anti-cancer Activity of Conjugated Fatty Acids Mediated by Ferroptosis
DOI: https://doi.org/10.5650/oleoscience.25.481
[2025] The degree of caspase-3 aggregation determines the selectivity of arsenic-induced cell death
DOI: https://doi.org/10.2131/jts.50.351
[2025] Cephalothin, a First-Generation Cephem Antibiotic, Works as a Potent Inducer of Parthanatos
DOI: https://doi.org/10.1248/bpb.b25-00401
[2025] Time‐Resolved Leader Spectra of Downward Terrestrial Gamma‐Ray Flashes Observed at the Telescope Array Surface Detector
DOI: https://doi.org/10.1029/2025jd043812
[2024] First Time‐Resolved Leader Spectra Associated With a Downward Terrestrial Gamma‐Ray Flash Detected at the Telescope Array Surface Detector
DOI: https://doi.org/10.1029/2024jd041720
[2024] Generation of thiyl radicals in a spatiotemporal controlled manner by light: Applied for the cis to trans isomerization of unsaturated fatty acids/phospholipids
DOI: https://doi.org/10.1016/j.redox.2024.103475
[2024] Conjugated fatty acids drive ferroptosis through chaperone-mediated autophagic degradation of GPX4 by targeting mitochondria
DOI: https://doi.org/10.1038/s41419-024-07237-w
[2024] A Novel Oncolytic Viral Therapy Using Coxsackievirus B3 (CVB3) for Human Pancreatic Cancer Including Cancer-associated Fibroblasts
DOI: https://doi.org/10.21873/anticanres.17348
[2024] Roquin-2 promotes oxidative stress-induced cell death by ubiquitination-dependent degradation of TAK1
DOI: https://doi.org/10.1016/j.freeradbiomed.2024.05.009
[2024] The NLRP3 Inflammasome Is a Major Cause of Acute Renal Failure Induced by Polypeptide Antibiotics
DOI: https://doi.org/10.4049/jimmunol.2300193
[2024] The E3 Ubiquitin Protein Ligase LINCR Amplifies the TLR-Mediated Signals through Direct Degradation of MKP1
DOI: https://doi.org/10.3390/cells13080687
[2024] Aggregability of the SQSTM1/p62-based aggresome-like induced structures determines the sensitivity to parthanatos
DOI: https://doi.org/10.1038/s41420-024-01838-2
[2024] Industrially produced <i>trans</i>-fatty acids are potent promoters of DNA damage-induced apoptosis
DOI: https://doi.org/10.2131/jts.49.27
[2023] Ferroptosis Regulation via Mechanosensing
DOI: https://doi.org/10.2142/biophys.63.310
[2023] LLPS of SQSTM1/p62 and NBR1 as outcomes of lysosomal stress response limits cancer cell metastasis
DOI: https://doi.org/10.1073/pnas.2311282120
[2023] The NLRP3 Inflammasome Works as a Sensor for Detecting Hypoactivity of the Mitochondrial Src Family Kinases
DOI: https://doi.org/10.4049/jimmunol.2200611
[2023] Geometrical isomerization of arachidonic acid during lipid peroxidation interferes with ferroptosis
DOI: https://doi.org/10.1016/j.freeradbiomed.2023.05.026
[2023] Methylmercury directly modifies the 105th cysteine residue in oncostatin M to promote binding to tumor necrosis factor receptor 3 and inhibit cell growth
DOI: https://doi.org/10.1007/s00204-023-03520-5
[2023] Reactive sulfur species disaggregate the SQSTM1/p62-based aggresome-like induced structures via the HSP70 induction and prevent parthanatos
DOI: https://doi.org/10.1016/j.jbc.2023.104710
[2023] A comprehensive toxicological analysis of trans-fatty acids (TFAs) reveals a pro-apoptotic action specific to industrial TFAs counteracted by polyunsaturated FAs
DOI: https://doi.org/10.1038/s41598-023-32083-9
[2023] Lipid peroxidation increases membrane tension, Piezo1 gating, and cation permeability to execute ferroptosis
DOI: https://doi.org/10.1016/j.cub.2023.02.060
[2022] Lipid Peroxidation Accompanied by Increased Ion Permeability of the&nbsp;Plasma Membrane Engender Ferroptosis
DOI: https://doi.org/10.2139/ssrn.4102638
[2022] The Distinct Roles of LKB1 and AMPK in p53-Dependent Apoptosis Induced by Cisplatin
DOI: https://doi.org/10.3390/ijms231710064
[2022] Deubiquitinase USP54 attenuates methylmercury toxicity in human embryonic kidney 293 cells
DOI: https://doi.org/10.2131/fts.9.159
[2022] SP600125 Enhances Temperature-Controlled Repeated Thermal Stimulation-Induced Neurite Outgrowth in PC12-P1F1 Cells
DOI: https://doi.org/10.3390/ijms232415602
[2021] Mechanisms of gefitinib-induced interstitial pneumonitis: why and how the TKI perturbs innate immune systems?
DOI: https://doi.org/10.18632/oncotarget.27958
[2021] The E3 Ubiquitin-Protein Ligase RNF4 Promotes TNF-α-Induced Cell Death Triggered by RIPK1
DOI: https://doi.org/10.3390/ijms22115796
[2021] [Molecular Mechanisms Underlying Toxic Actions of trans-Fatty Acids and Prevention of Related Diseases].
DOI: https://doi.org/10.1248/yakushi.20-00243-2
[2021] Failure to Degrade CAT-Tailed Proteins Disrupts Neuronal Morphogenesis and Cell Survival
DOI: https://doi.org/10.1016/j.celrep.2020.108599
[2021] trans-Fatty acids promote p53-dependent apoptosis triggered by cisplatin-induced DNA interstrand crosslinks via the Nox-RIP1-ASK1-MAPK pathway
DOI: https://doi.org/10.1038/s41598-021-89506-8
[2021] Methylmercury induces neuronal cell death by inducing TNF-α expression through the ASK1/p38 signaling pathway in microglia
DOI: https://doi.org/10.1038/s41598-021-89210-7
[2021] Novel stress-induced cell death and the regulation of diseases
[2021] Gefitinib initiates sterile inflammation by promoting IL-1β and HMGB1 release via two distinct mechanisms
DOI: https://doi.org/10.1038/s41419-020-03335-7
[2021] The polypeptide antibiotic polymyxin B acts as a pro-inflammatory irritant by preferentially targeting macrophages
DOI: https://doi.org/10.1038/s41429-021-00490-7

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AI 要約（直近 5 年の研究成果）

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関連研究室(8 件)

研究成果（45 件）

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