Takeyuki Suzuki 研究室

主宰者：Takeyuki Suzuki

大阪大学

AI 要約（直近 5 年の研究成果）

鈴木武之研究室は、有機化学における触媒反応を駆使して、複雑な分子を効率的に合成する方法の開発に取り組んでいます。特に、光学活性な化合物を一段階で作る「不斉合成」や、遷移金属を用いた炭素間結合の形成反応に注力しており、医薬品や材料科学に有用な分子の構築を目指しています。パラジウム、ロジウム、ルテニウムなどの金属触媒を活用し、エンアンチオマー比（ee値）が高い製品を得られる条件の探索を進めています。さらに同研究室では、ナノ粒子状の金属触媒の合成と応用に関する研究も展開しており、不溶性の固体触媒として機能するマンガンやコバルトのナノ粒子を開発することで、反応の環境負荷低減と触媒の再利用性向上を実現しています。これらのナノ粒子は炭素–珪素結合の生成反応など、有機分子の官能基化に有効です。加えて、計算化学による反応機構解析や機械学習を活用した実験条件の最適化など、データ駆動型のアプローチも組み合わせながら、より効率的で汎用性の高い合成法を次々と報告しています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（77 件）

[2026] Stereodefined Synthesis of Acyclic meso -2,3-Diaryl Dialdehydes and Their Iridium-Catalyzed Enantioselective Desymmetrization
DOI: https://doi.org/10.1021/acs.joc.6c00927
[2026] Cycloheptatriene-Fused Benzosiloles: Synthesis and Reactivity
DOI: https://doi.org/10.1021/acs.orglett.6c02142
[2026] Recrystallization-induced tautomerism and selective imine formation of N -diphenylmethylene-serine methyl ester
DOI: https://doi.org/10.1093/bbb/zbag068
[2026] Hydrosilylation of ω-hydroxyalkenes catalysed with 2-methacryloyloxyethyl-phosphorylcholine-protected ruthenium nanoparticles
DOI: https://doi.org/10.1039/d6cc01831a
[2026] Stereochemical Stability of Phenylglycine in Peptide Synthesis: Stereoretentive Coupling and Deprotection Strategies
DOI: https://doi.org/10.3390/org7030027
[2026] Palladium-Catalyzed Diastereo- and Enantioselective Allenylation of Imines with Propargyl Nitriles via Cyano-Directed Activation Assisted by Machine-Learning-Guided Condition Screening
DOI: https://doi.org/10.1021/acscatal.6c03779
[2025] Design and Evaluation of Bivalent K‐Ras Inhibitors That Target the CAAX Binding Site and the Acidic Surface of Farnesyltransferase and Geranylgeranyltransferase I
DOI: https://doi.org/10.1002/chem.202500306
[2025] Dynamics of Cooperative Palladium/Copper Catalysis for Aerobic Oxidative Difunctionalization of 1,3-Dienes with Aniline and Disilane
DOI: https://doi.org/10.1021/acscatal.5c02118
[2025] Scalable preparation of furanosteroidal viridin, β-viridin and viridiol from Trichoderma virens
DOI: https://doi.org/10.1038/s41598-025-87070-z
[2025] Synthesis of Hydroxynitriles by N , N ‐Dimethylformamide‐Stabilized Ruthenium Nanoparticles‐Catalyzed α‐Alkylation of Arylacetonitriles with Diols
DOI: https://doi.org/10.1002/ajoc.202500610

続きを表示（残り 67 件）

[2025] Amine‐Ligated Boryl Radicals Enables Direct C─F Borylation and Cross‐Couplings of Polyfluoroarenes
DOI: https://doi.org/10.1002/ange.202514741
[2025] Design of Phosphine-Heteroarenesulfonamide Ligands as Dinuclear Silver Catalysts for Enantioselective Construction of α,β-Diamino Acids
DOI: https://doi.org/10.1021/jacs.5c18426
[2025] Diffusion and trapping of silicon in wurtzite gallium nitride
DOI: https://doi.org/10.1016/j.mssp.2025.110272
[2025] Amine‐Ligated Boryl Radicals Enables Direct C─F Borylation and Cross‐Couplings of Polyfluoroarenes
DOI: https://doi.org/10.1002/anie.202514741
[2025] Enantioselective modular synthesis of α-aryl-α-heteroaryl aminonitriles with parts per million organocatalyst loading: mechanistic investigation for stereochemical origins
DOI: https://doi.org/10.1039/d4qo02362e
[2025] Synthesis of Aryl and Alkyl Sulfonyl Cyanides Using KCN and NaOCl·5H 2 O in a Biphasic System
DOI: https://doi.org/10.1021/acs.joc.5c02290
[2025] Synthesis of Colloidal DMF-Protected Cobalt Nanoparticles for Alkene Hydrosilylation Catalyst: Effect of Cobalt Precursors and Recycling Process
DOI: https://doi.org/10.1021/acsomega.5c00230
[2025] Recyclable and air-stable colloidal manganese nanoparticles catalyzed hydrosilylation of alkenes with tertiary silane
DOI: https://doi.org/10.1039/d4ra08380f
[2025] Palladium nanoparticles for aerobic oxidative Heck arylation of alkenes
DOI: https://doi.org/10.1093/chemle/upaf068
[2024] Diffusion of oxygen in amorphous HfO2
DOI: https://doi.org/10.1016/j.jpcs.2024.112499
[2024] Enantioselective Addition of Thiols to Acyclic Ketiminoesters Using Cinchona Alkaloid Amide/Zinc(II) Catalysts
DOI: https://doi.org/10.1002/adsc.202400674
[2024] Synthesizing Silyl Arylsulfonyl Hydrazones as Silyldiazomethane Precursors and Their Use in Rhodium‐Catalyzed Reactions
DOI: https://doi.org/10.1002/adsc.202400172
[2024] General Synthesis of meso-1,4-Dialdehydes and Their Application in Ir-Catalyzed Asymmetric Tishchenko Reactions
DOI: https://doi.org/10.1021/acsomega.3c09381
[2024] Multitasking rhodium-catalyzed remote C(sp 3 )–H functionalization reactions of acyclic dienes to yield benzene-fused heterocycles
DOI: https://doi.org/10.1039/d4gc04927f
[2024] Star-Shaped Polymers with Helical Polyacetylene Arms. Comparison of Solution- and Solid-State Properties with Linear Helical Polyacetylenes
DOI: https://doi.org/10.1021/acs.macromol.4c01509
[2024] Absorption, Fluorescence, and Two‐Photon Excitation Ability of 5‐o‐Tolyl‐11 (or 13)‐o‐tolylisoindolo[2,1‐a]quinolines Prepared by Ring‐Closing Metathesis and [2+3] Cycloaddition
DOI: https://doi.org/10.1002/asia.202401073
[2024] Asymmetric Conjugate Addition of Phosphine Sulfides to α-Substituted β-Nitroacrylates Using Cinchona Alkaloid Amide Catalysts
DOI: https://doi.org/10.1021/acs.orglett.4c02643
[2024] Enantioselective One-Pot Synthesis of Cyclopropane-Fused Tetrahydroquinolines via a Ru-Catalyzed Intramolecular Cyclopropanation
DOI: https://doi.org/10.1021/acs.orglett.4c02416
[2024] Chiral Phosphoric Acid-Catalyzed Enantioselective Synthesis of 2,2-Disubstituted 2,3-Dihydro-4-quinolones from Isatins and 2′-Aminoacetophenones
DOI: https://doi.org/10.1021/acs.orglett.4c04249
[2024] Exploring Catalytic Intermediates in Pd-Catalyzed Aerobic Oxidative Amination of 1,3-Dienes: Multiple Metal Interactions of the Palladium Nanoclusters
DOI: https://doi.org/10.1021/jacs.4c02518
[2024] Synthesis of Dibenzoxasilepine Using Ring Expansion Reaction of a Pentacoordinate Silicon Intermediate
DOI: https://doi.org/10.1002/adsc.202401125
[2024] Synthesis of colloidal Pd nanoparticles immobilised on poly( N -vinylacetamide): characterisation and application in catalysis
DOI: https://doi.org/10.1039/d4ma00674g
[2024] Facile and size-controllable fabrication of copper nanoparticles on nitrogen-doped carbon dots using an N,N-dimethylformamide-based reduction approach
DOI: https://doi.org/10.1016/j.rechem.2024.101398
[2024] Catalytic Enantioselective Construction of an α-Thio-Substituted α-Aminonitriles-Bearing Tetrasubstituted Carbon Center
DOI: https://doi.org/10.1021/acscatal.3c05757
[2024] Organocatalytic Asymmetric Synthesis of 2,3-Dihydro-4H-imidazol-4-ones via Cyclocondensation of N-Silyl Iminoesters
DOI: https://doi.org/10.1021/acscatal.4c04230
[2023] Axially Chiral Borinic Acid Catalysts: Design, Synthesis, and Application in Alkylative Desymmetrization of 1,2-Diols
DOI: https://doi.org/10.1021/acs.joc.3c01143
[2023] Accumulation of squalene in filamentous fungi Trichoderma virens PS1-7 in the presence of butenafine hydrochloride, squalene epoxidase inhibitor: biosynthesis of 13C-enriched squalene
DOI: https://doi.org/10.1093/bbb/zbad102
[2023] Development of Cycloisomerization with Rearrangement of a Tosyl Group Using N-Tosyl-o-allenylaniline
DOI: https://doi.org/10.1021/acs.joc.3c00625
[2023] Design and synthesis of 4-acetoxypentanamide derivatives of spliceostatin A and their biological evaluation towards prostate cancer treatment
DOI: https://doi.org/10.1016/j.bmcl.2023.129333
[2023] Enantioselective Construction of Consecutive Tetrasubstituted Stereogenic Centers by Reaction of α-Substituted β-Nitroacrylates with Oxazol-5-(4H)-ones Catalyzed by Cinchona Alkaloid Sulfonamide Catalysts
DOI: https://doi.org/10.1021/acs.orglett.3c00783
[2023] Direct Catalytic Enantioselective Reaction of α-Isocyanoacetonitriles with Ketimines Using Cinchona Alkaloid Amide–Cu(II) Catalysts
DOI: https://doi.org/10.1021/acs.orglett.3c00259
[2023] Synthesis of a platinacycle: determination of the structure and examination of the photophysical properties based on DFT calculations
DOI: https://doi.org/10.1039/d2dt03524c
[2023] Catalytic Enantioselective Construction of trans-Fused 2,3,3a,4,5,9b-Hexahydro-1H-pyrrolo[3,2-c]quinoline Derivatives by Intramolecular [3+2]-Cycloaddition
DOI: https://doi.org/10.3987/com-22-14785
[2023] Photoluminescent supramolecular gels derived from phenylenediamine hydrochlorides
DOI: https://doi.org/10.1039/d3sm00299c
[2023] Organocatalytic Stereoselective Decarboxylative Addition of α‐Amido Malonic Acid Half Oxyesters to Isatins
DOI: https://doi.org/10.1002/adsc.202301100
[2022] Catalytic Asymmetric Synthesis of (‒)-Arctigenin Using a Chiral IR Complex
DOI: https://doi.org/10.2139/ssrn.4311164
[2022] Diffusion of boron in an amorphous iron-boron alloy
DOI: https://doi.org/10.1016/j.jnoncrysol.2022.122070
[2022] Design and synthesis of ether derivatives of spliceostatin A and their biological evaluation towards prostate cancer treatment
DOI: https://doi.org/10.1016/j.tetlet.2022.154288
[2022] Enantioselective Synthesis of Benzothiazolines from Fluoroalkyl Ketones Using Chiral Imidazoline−Phosphoric Acid Catalysts
DOI: https://doi.org/10.1002/adsc.202201039
[2022] Reagent‐Controlled Regioselective Intramolecular [2+2] Cycloaddition between Vinylsilanes and Allenes
DOI: https://doi.org/10.1002/chem.202203556
[2022] Substrate-Assisted Reductive Elimination Determining the Catalytic Cycle: A Theoretical Study on the Ni-Catalyzed 2,3-Disubstituted Benzofuran Synthesis via C–O Bond Activation
DOI: https://doi.org/10.1021/acs.organomet.2c00419
[2022] Enantioselective Reaction of N-Unprotected Activated Ketimines with Phosphine Oxides Catalyzed by Chiral Imidazoline-Phosphoric Acids
DOI: https://doi.org/10.1021/acs.orglett.2c03457
[2022] Hydrogen-deuterium exchange of indole-3-propionic acid with deuterated trifluoromethanesulfonic acid
DOI: https://doi.org/10.24820/ark.5550190.p011.836
[2022] Application to Electroluminescence Devices with Dimethylformamide-Stabilized Niobium Oxide Nanoparticles
DOI: https://doi.org/10.1021/acsanm.2c01357
[2022] Synthesis of 6,7-benzene-fused tropane derivatives from isoindoline-aminal hybrid compound
DOI: https://doi.org/10.1016/j.tetlet.2022.153724
[2022] Using α- and β-Epimerizations of cis-2,3-Bis(hydroxymethyl)-γ-butyrolactone for the Synthesis of Both Enantiomers of Enterolactone
DOI: https://doi.org/10.1021/acs.joc.1c02801
[2022] Enantioselective Pictet–Spengler Reaction of Acyclic α-Ketoesters Using Chiral Imidazoline-Phosphoric Acid Catalysts
DOI: https://doi.org/10.1021/acs.orglett.1c04316
[2022] N , N -Dimethylformamide-stabilized ruthenium nanoparticle catalyst for β-alkylated dimer alcohol formation via Guerbet reaction of primary alcohols
DOI: https://doi.org/10.1039/d2ra02381d
[2022] Ethynylene-linked multifunctional benzoxazines: the effect of the ethynylene group and packing on thermal behavior
DOI: https://doi.org/10.1039/d2py00840h
[2022] Dimethylacetamide-stabilized ruthenium nanoparticles for catalysing α-alkylations of amides with alcohols
DOI: https://doi.org/10.1039/d2cc04133b
[2022] DAST-mediated ring-opening of cyclopropyl silyl ethers in nitriles: facile synthesis of allylic amides via a Ritter-type process
DOI: https://doi.org/10.1039/d2ob00940d
[2022] Novel Synthesis and Properties of Optically Pure N-Trifluoroacetylphenylglycine Hydroxysuccinimide Ester
DOI: https://doi.org/10.3987/com-22-s(r)11
[2021] Enantioselective Vinylogous Mannich Reaction of Acyclic Vinylketene Silyl Acetals with Acyclic Ketimines
DOI: https://doi.org/10.1002/adsc.202100872
[2021] Carbon–Carbon Bond Formation between N-Heterocyclic Carbene Ligand on Ruthenium Carbene Catalysts and 1,4-Naphthoquinone via Intramolecular Carbon(sp3)–Hydrogen Bond Activation
DOI: https://doi.org/10.1021/acs.organomet.1c00350
[2021] Enantiodivergent Reaction of Ketimines with Malononitriles Using Single Cinchona Alkaloid Sulfonamide Catalysts
DOI: https://doi.org/10.1002/adsc.202101114
[2021] Double isomerization/cycloisomerization/aromatization of 1-(allyloxy)-2-(cyclopropylmethyl)benzenes to give 2-ethyl-3-isopropylbenzofurans using a multitasking single rhodium catalyst
DOI: https://doi.org/10.1039/d1cc06163a
[2021] Asymmetric synthesis of tetrasubstituted cyclic amines via aza-Henry reaction using cinchona alkaloid sulfonamide/zinc( <scp>ii</scp> ) catalysts
DOI: https://doi.org/10.1039/d1cc06492d
[2021] Synthesis of (Trifluoromethyldiazirinyl)phenylboronic Acid Derivatives for Photoaffinity Labeling
DOI: https://doi.org/10.3987/com-20-s(k)23
[2021] Catalytic and Diastereoselective Cascade Reaction for the Preparation of cis-1,3-Disubstituted Isoindoline-Aminal Hybrid Compounds
DOI: https://doi.org/10.3987/com-21-14404
[2021] N,N‐Dimethylformamide‐protected Fe2O3 Combined with Pt Nanoparticles: Characterization and Catalysis in Alkene Hydrosilylation
DOI: https://doi.org/10.1002/cctc.202101672
[2021] Product selective reaction controlled by the combination of palladium nanoparticles, continuous microwave irradiation, and a co-existing solid; ligand-free Buchwald–Hartwig amination vs. aryne amination
DOI: https://doi.org/10.1039/d1gc01782a
[2021] Catalytic enantioselective intramolecular Tishchenko reaction of meso -dialdehyde: synthesis of ( S )-cedarmycins
DOI: https://doi.org/10.1039/d1ra00915j
[2021] Cross β-arylmethylation of alcohols catalysed by recyclable Ti–Pd alloys not requiring pre-activation
DOI: https://doi.org/10.1039/d1cc01388b
[2021] N , N -Dimethylformamide-stabilised palladium nanoparticles combined with bathophenanthroline as catalyst for transfer vinylation of alcohols from vinyl ether
DOI: https://doi.org/10.1039/d1ob00369k
[2021] Cross β-alkylation of primary alcohols catalysed by DMF-stabilized iridium nanoparticles
DOI: https://doi.org/10.1039/d1ob00045d
[2021] Chemo- and enantioselective hetero-coupling of hydroxycarbazoles catalyzed by a chiral vanadium( <scp>v</scp> ) complex
DOI: https://doi.org/10.1039/d1qo00783a
[2021] Iridium-Catalyzed Isomerization/Cycloisomerization/Aromatization of N-Allyl-N-sulfonyl-o-(λ1-silylethynyl)aniline Derivatives to Give Substituted Indole Derivatives
DOI: https://doi.org/10.1021/acs.orglett.1c01231

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AI 要約（直近 5 年の研究成果）

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研究成果（77 件）

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