Makoto Sako 研究室

主宰者：Makoto Sako

大阪大学

AI 要約（直近 5 年の研究成果）

佐古研究室は、遷移金属触媒を用いた有機合成化学に主に取り組んでいます。特にロジウムやパラジウムなどの触媒を利用して、複雑な分子骨格を効率的に構築する方法を開発しています。研究の中心は、長距離のアルケン異性化と結合の切断・形成を組み合わせた「連続反応」にあります。これにより、従来は難しかった位置で分子を活性化し、ベンゾフランなどの複素環化合物を一段階で合成できるようにしています。加えて、ホウ素やケイ素を含む有機触媒や、電気化学を利用した新規な合成手法の開発も進めています。例えば、ホウ素酸触媒による不斉反応や、電極を使った酸化カップリングと環化の連続反応により、らせん構造を持つ複素環化合物を合成しています。さらに、歪んだ環状化合物（シクロプロパンやビシクロブタンなど）の独特な反応性を利用して、新しい炭素骨格の構築法を実現しています。これらの基礎的な合成化学の研究と並行して、開発した方法を天然物合成や医薬品候補化合物の製造に応用する研究も行われています。酵素阻害活性や光学特性を有する分子の合成を通じて、創薬や機能性材料開発への貢献を目指しています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（35 件）

[2026] Cycloheptatriene-FusedBenzosiloles: Synthesis andReactivity
DOI: https://doi.org/10.1021/acs.orglett.6c02142.s001
[2026] Metal-Free Aerobic Radical Ring Opening–Cyclization of Bicyclo[1.1.0]butylamides to Oxazolidin-4-ones
DOI: https://doi.org/10.1248/cpb.c25-00744
[2026] Cycloheptatriene-Fused Benzosiloles: Synthesis and Reactivity
DOI: https://doi.org/10.1021/acs.orglett.6c02142
[2026] Chiral Borinic Acid-Catalyzed Enantioselective Passerini-type Multicomponent Reaction
DOI: https://doi.org/10.1021/acs.joc.5c03042
[2026] Long-range isomerisation/cyclopropane isomerisation/cycloisomerisation/aromatisation reactions using multifunctional rhodium catalysts
DOI: https://doi.org/10.1039/d6ob00534a
[2026] Rhodium Multitasking Catalysis Integrating Long‐Range Isomerization, Cycloisomerization, and Hydrosilylation of 1,n‐Dienes to Give 2,3‐Disubstituted Dihydrobenzofurans: Mechanistic Insight Into Functionalization‐Controlled Reactivity
DOI: https://doi.org/10.1002/adsc.70276
[2025] Diversity-oriented synthesis of poly-substituted benzofuran derivatives bearing amino groups at 2- or 3-positions: Rh- or Ni-catalyzed cycloisomerization between ynamides and enol ethers
DOI: https://doi.org/10.1039/d5qo01123j
[2025] Total Synthesis of (±)-Minimiflorin and Its Na+/K+-ATPase and H+/K+-ATPase Inhibitory Activities
DOI: https://doi.org/10.1021/acs.jnatprod.5c00463
[2024] Absorption, Fluorescence, and Two‐Photon Excitation Ability of 5‐o‐Tolyl‐11 (or 13)‐o‐tolylisoindolo[2,1‐a]quinolines Prepared by Ring‐Closing Metathesis and [2+3] Cycloaddition
DOI: https://doi.org/10.1002/asia.202401073
[2024] Oxidative Rearrangement Approach for the Ring Contraction of N−H Piperidines to Pyrrolidines
DOI: https://doi.org/10.1002/adsc.202400484

続きを表示（残り 25 件）

[2024] Synthesis of Dibenzoxasilepine Using Ring Expansion Reaction of a Pentacoordinate Silicon Intermediate
DOI: https://doi.org/10.1002/adsc.202401125
[2024] Multitasking rhodium-catalyzed remote C(sp 3 )–H functionalization reactions of acyclic dienes to yield benzene-fused heterocycles
DOI: https://doi.org/10.1039/d4gc04927f
[2024] Synthesizing Silyl Arylsulfonyl Hydrazones as Silyldiazomethane Precursors and Their Use in Rhodium‐Catalyzed Reactions
DOI: https://doi.org/10.1002/adsc.202400172
[2024] Brønsted acid-catalyzed synthesis of spirocyclobutanes via heteroannulation of vinyloxyphenylbicyclobutanes with water
DOI: https://doi.org/10.1039/d4ob00451e
[2023] Heteroannulation of bicyclobutane derivatives via Au-catalyzed hydration to enol ethers and intramolecular cyclization giving spirocyclobutanes
DOI: https://doi.org/10.1039/d3cc01955a
[2023] Palladium-Catalyzed Intramolecular Migratory Cycloisomerization of 3-Phenoxy Acrylic Acid Ester via C–O Bond Cleavage and C–O/C–C Bonds Formation for 2,3-Disubstituted Benzofurans Synthesis
DOI: https://doi.org/10.1248/cpb.c22-00555
[2023] Axially Chiral Borinic Acid Catalysts: Design, Synthesis, and Application in Alkylative Desymmetrization of 1,2-Diols
DOI: https://doi.org/10.1021/acs.joc.3c01143
[2023] Electrochemical Synthesis of Hetero[7]helicenes Containing Pyrrole and Furan Rings via an Oxidative Heterocoupling and Dehydrative Cyclization Sequence
DOI: https://doi.org/10.1002/adsc.202201262
[2022] Double Ring Expansion Strategy for Fused 3-Benzazepines: Alternative Synthesis of the Dolby–Weinreb Enamine
DOI: https://doi.org/10.1021/acs.joc.2c02475
[2022] Electrochemical synthesis of heterodehydro[7]helicenes
DOI: https://doi.org/10.1038/s42004-022-00780-7
[2022] Carbon(sp2)‐carbon(sp3) Bond‐forming Cross‐coupling Reactions Using Sulfur‐Modified Au‐Supported Nickel Nanoparticle Catalyst
DOI: https://doi.org/10.1002/ajoc.202200229
[2022] Design, Synthesis, and Monoamine Oxidase B Selective Inhibitory Activity of N-Arylated Heliamine Analogues
DOI: https://doi.org/10.1021/acsmedchemlett.2c00228
[2022] Carbon(sp2)-carbon(sp3) Bond-forming Cross-coupling Reactions Using Sulfur-Modified Au-Supported Nickel Nanoparticle Catalyst
[2022] Metal-free C(aryl)–P bond cleavage: experimental and computational studies of the Michael addition/aryl migration of triarylphosphines to alkynyl esters
DOI: https://doi.org/10.1039/d2qo00028h
[2022] Total Synthesis of Ansellone G and Phorbadione
DOI: https://doi.org/10.1021/acs.joc.2c02278
[2021] Product selective reaction controlled by the combination of palladium nanoparticles, continuous microwave irradiation, and a co-existing solid; ligand-free Buchwald–Hartwig amination vs. aryne amination
DOI: https://doi.org/10.1039/d1gc01782a
[2021] Chemo- and enantioselective hetero-coupling of hydroxycarbazoles catalyzed by a chiral vanadium( <scp>v</scp> ) complex
DOI: https://doi.org/10.1039/d1qo00783a
[2021] Iridium-Catalyzed Isomerization/Cycloisomerization/Aromatization of N-Allyl-N-sulfonyl-o-(λ1-silylethynyl)aniline Derivatives to Give Substituted Indole Derivatives
DOI: https://doi.org/10.1021/acs.orglett.1c01231
[2021] Recent Advances in Metal-Nanoparticle-Catalyzed Coupling Reactions Assisted by Microwave Irradiation
DOI: https://doi.org/10.1055/a-1505-0916
[2021] Preparation of Optically Pure Dinuclear Cobalt(III) Complex with Λ-Configuration as a Dianionic Chiral Catalyst
DOI: https://doi.org/10.3987/com-20-s(k)41
[2021] Chemo- and enantioselective hetero-coupling of hydroxycarbazoles catalyzed by a chiral vanadium(v) complex
[2021] Double isomerization/cycloisomerization/aromatization of 1-(allyloxy)-2-(cyclopropylmethyl)benzenes to give 2-ethyl-3-isopropylbenzofurans using a multitasking single rhodium catalyst
DOI: https://doi.org/10.1039/d1cc06163a
[2021] Carbon–Carbon Bond Formation between N-Heterocyclic Carbene Ligand on Ruthenium Carbene Catalysts and 1,4-Naphthoquinone via Intramolecular Carbon(sp3)–Hydrogen Bond Activation
DOI: https://doi.org/10.1021/acs.organomet.1c00350
[2021] Chiral Vanadium(V)-catalyzed Oxidative Coupling of 4-Hydroxycarbazoles
DOI: https://doi.org/10.1246/cl.210367
[2021] Chemo- and regioselective cross-dehydrogenative coupling reaction of 3-hydroxycarbazoles with arenols catalyzed by a mesoporous silica-supported oxovanadium
DOI: https://doi.org/10.1039/d1ra07723f

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AI 要約（直近 5 年の研究成果）

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関連研究室(8 件)

研究成果（35 件）

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