Kazuaki Ishihara 研究室

主宰者：Kazuaki Ishihara

名古屋大学

AI 要約（直近 5 年の研究成果）

当研究室は、有機合成化学における触媒反応の開発に取り組んでいます。特に、医療に用いられる薬剤や天然物の効率的な合成法、および環境負荷の低い化学反応の実現を目指しています。研究の中心課題は、複雑な分子構造をいかに正確に・選択的に構築するかという点にあります。手法としては、金属触媒や有機分子を活用した触媒設計が中心です。具体的には、ホウ素やヨウ素、銅などの元素を含む触媒を用いた不斉反応（光学活性な分子を合成する反応）、酸化還元反応、環化反応など多様なアプローチを採用しています。特に、キラル（鏡像体が存在する）な空間構造を持つ触媒により、複数の反応経路が存在する場合でも目的の生成物を選択的に得る工夫が特徴的です。芳香環を含む化合物の脱芳香化反応や、多段階の連続反応も重要なテーマです。これまでの研究成果として、天然物の全合成、医薬品合成の鍵となる炭素骨格の構築法、および金属フリー（金属を使わない）な触媒反応の開発が報告されています。これらの成果は、より持続可能で安全性の高い化学合成技術の実現に貢献しています。

※ AI（Claude）が、公開されている論文要旨から研究の問い・手法・主要な発見を事実情報として抽出・再構成して自動生成しています。誤りを含む可能性があるため、正確性は研究室公式情報でご確認ください。

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研究成果（44 件）

[2026] Divergent Asymmetric Total Synthesis of (+)-Panduratin I, (+)-Nicolaioidesin B, (+)-Isopanduratin A1, and (+)-2-Hydroxyisopanduratin A via Enantioselective Radical Cation (4 + 2) Cycloaddition
DOI: https://doi.org/10.1021/acs.orglett.6c02169
[2025] Enantio- and E-selective Carbonyl–Ene Cyclization of 5-Substituted 5-Hexenals Catalyzed by Tris(pentafluorophenyl)borane-Assisted Chiral Phosphoric Acids
DOI: https://doi.org/10.1021/acs.orglett.5c02136
[2025] Enantioselective Oxidative Spirocyclization of Biaryl Hydroxy Carboxylic Acids: Enantioselective Synthesis of (–)‐Arnottin II
DOI: https://doi.org/10.1002/asia.70374
[2025] Performance of multimodal prediction models for intracerebral hemorrhage outcomes using real-world data
DOI: https://doi.org/10.1016/j.ijmedinf.2025.105989
[2025] Dehydration has no direct effect on appetite loss during a 160 km trail running race
DOI: https://doi.org/10.1017/s0029665125001156
[2025] Worsening Heart Failure From Decreased Atrioventricular Synchronization Rate of a Leadless Pacemaker
DOI: https://doi.org/10.1016/j.jaccas.2025.103862
[2025] The Latest Insights into Multiply Selective Diels–Alder Reactions Using a Chiral‐Cavity‐Structured Lewis‐Acidic Boron Catalyst
DOI: https://doi.org/10.1002/adsc.202401560
[2025] Electrochemical oxidative dearomatization of electron-deficient phenols using Br + /Br − catalysis
DOI: https://doi.org/10.1039/d4cc06472k
[2025] The low-temperature selective oxidation of alcohols and a one-pot oxidative esterification using an IBS( <scp>iii</scp> / <scp>v</scp> )/oxone catalysis
DOI: https://doi.org/10.1039/d5gc01737h
[2024] Dehydrative Condensation of Carboxylic Acids with Amines Promoted by HBF4/MS 5A
DOI: https://doi.org/10.1002/ajoc.202300660

続きを表示（残り 34 件）

[2024] Dehydrative Condensation of Carboxylic Acids with Amines Promoted by HBF4/MS 5A
[2024] Chiral π–Cu( <scp>ii</scp> )-catalyzed site-, exo / endo -, and enantioselective dearomative (3 + 2) cycloadditions of isoquinolinium ylides with enamides, dienamides, and a trienamide
DOI: https://doi.org/10.1039/d4sc02946a
[2024] Unraveling Alcohol Additive Effects on Hypervalent Iodine(III)-Catalyzed Asymmetric Phenolic Dearomatization: Ligand Substitution and Low-Barrier Hydrogen Bonds
DOI: https://doi.org/10.1021/acscatal.4c06557
[2024] Machine Learning–Based Prediction for In‐Hospital Mortality After Acute Intracerebral Hemorrhage Using Real‐World Clinical and Image Data
DOI: https://doi.org/10.1161/jaha.124.036447
[2024] Inner-Bond-Cleavage Approach to Figure-Eight Macrocycles from Planar Aromatic Hydrocarbons
DOI: https://doi.org/10.1021/jacs.4c07985
[2024] Oxidative Dearomative Coupling of Electron-Deficient Arenols Using Hypohalite Catalysis
DOI: https://doi.org/10.1021/acs.orglett.4c02787
[2024] Clinical Course of Residual Ventricular Septal Defects After Congenital Heart Disease Repair
DOI: https://doi.org/10.1007/s00246-024-03542-5
[2024] Effect of the U-Shaped Cavity of Conformationally Flexible Chiral Lewis-Acidic Boron-Based Catalysts in Multiselective Diels–Alder Reactions
DOI: https://doi.org/10.1021/acs.orglett.4c01060
[2023] Catalyst-Substrate Helical Character Matching Determines the Enantioselectivity in the Ishihara-Type Iodoarenes Catalyzed Asymmetric Kita-Dearomative Spirolactonization
DOI: https://doi.org/10.1021/jacs.2c13295
[2023] Comparing the Robustness of ResNet, Swin-Transformer, and MLP-Mixer under Unique Distribution Shifts in Fundus Images
DOI: https://doi.org/10.3390/bioengineering10121383
[2023] Tandem Isomerization/α,β-Site-Selective and Enantioselective Addition Reactions of N-(3-Butynoyl)-3,5-dimethylpyrazole Induced by Chiral π–Cu(II) Catalysts
DOI: https://doi.org/10.1021/jacs.3c10820
[2023] Chiral Macrocyclic Catalysts for the Enantioselective Addition of Lithium Acetylides to Ketones
DOI: https://doi.org/10.1021/jacs.3c08905
[2023] Recent Progress of Iodine Catalysis Directed toward Environmentally more Benign and Sustainable Chemistry
DOI: https://doi.org/10.1002/adsc.202300821
[2023] Hypoiodite‐Catalyzed Oxidative α‐C−N Coupling of Ketones with Imides and Azoles
DOI: https://doi.org/10.1002/adsc.202300716
[2023] Highly Enantioselective Radical Cation [2 + 2] and [4 + 2] Cycloadditions by Chiral Iron(III) Photoredox Catalysis
DOI: https://doi.org/10.1021/jacs.3c04010
[2023] Modified Gersony-Malm procedure with sutureless technique for postoperative right-sided branch pulmonary venous obstruction after primary sutureless repair
DOI: https://doi.org/10.1016/j.xjtc.2023.05.011
[2023] A Lewis Base–Silyl Lewis Acid Cooperative Catalyst for the Iodochlorination of Tetrasubstituted Alkenes
DOI: https://doi.org/10.1002/ajoc.202300228
[2023] Influence of Halogen Bonding in Catalytic Enantioselective α-Halogenation Reaction
DOI: https://doi.org/10.5059/yukigoseikyokaishi.81.474
[2023] 1,3-Migrative Ring Expansion of Spiroindolenines to Azepino[3,4-b]indoles
DOI: https://doi.org/10.1021/acs.orglett.3c00207
[2023] Catalytic Site‐, Diastereo‐, and Enantioselective Cascade Iodocyclization of 2‐Geranylarenols
DOI: https://doi.org/10.1002/asia.202300019
[2023] Enantioselective aromatic Claisen rearrangement of allyl 2-naphthyl ethers catalyzed by π–Cu( <scp>ii</scp> ) complexes
DOI: https://doi.org/10.1039/d2sc06771d
[2022] Bulky magnesium( <scp>ii</scp> ) and sodium( <scp>i</scp> ) bisphenoxide catalysts for chemoselective transesterification of methyl (meth)acrylates
DOI: https://doi.org/10.1039/d2sc05413b
[2022] Chiral π–Cu(II) Catalysts for the Enantioselective α-Amination of N-Acyl-3,5-dimethylpyrazoles
DOI: https://doi.org/10.1021/acs.orglett.2c03249
[2022] Multiselective Diels–Alder Reaction of α-Arylacroleins Catalyzed by Boron Tribromide-Assisted Chiral Phosphoric Acids
DOI: https://doi.org/10.1021/acs.orglett.2c02747
[2022] Hypoiodite-Catalyzed Oxidative Umpolung of Indoles for Enantioselective Dearomatization
DOI: https://doi.org/10.1021/jacs.2c01852
[2022] Thorpe–Ingold Effect on High-Performance Chiral π–Copper(II) Catalyst
DOI: https://doi.org/10.1055/a-1750-8481
[2022] A π–Cu(II)−π Complex as an Extremely Active Catalyst for Enantioselective α-Halogenation of N-Acyl-3,5-dimethylpyrazoles
DOI: https://doi.org/10.1021/acscatal.1c05500
[2021] I^+/TBHP Catalysis For Tandem Oxidative Cyclization To Indolo[2,3-b]quinolines
[2021] Cp*RhIII/Chiral Disulfonate/CuOAc Catalyst System for the Enantioselective Intramolecular Oxyamination of Alkenes
DOI: https://doi.org/10.1021/acscatal.1c04699
[2021] Radical Cation [4+2] Cycloaddition of Non‐Conjugated Tetrasubstituted Alkenes by an FeCl3/AgSbF6 Co‐Initiator
DOI: https://doi.org/10.1002/ajoc.202100473
[2021] Enantio- and Diastereoselective Carbonyl-Ene Cyclization–Acetalization Tandem Reaction Catalyzed by Tris(pentafluorophenyl)borane-Assisted Chiral Phosphoric Acids
DOI: https://doi.org/10.1021/acscatal.1c01242
[2021] Insight into the Mechanism of the Acylation of Alcohols with Acid Anhydrides Catalyzed by Phosphoric Acid Derivatives
DOI: https://doi.org/10.1021/acs.joc.1c00102
[2021] Oxidative Ritter‐type Chloroamidation of Alkenes Using NaCl and Oxone
DOI: https://doi.org/10.1002/ajoc.202100575
[2021] Hypoiodite-catalysed oxidative homocoupling of arenols and tandem oxidation/cross-coupling of hydroquinones with arenes
DOI: https://doi.org/10.1039/d1cc05171g

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AI 要約（直近 5 年の研究成果）

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関連研究室(8 件)

研究成果（44 件）

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